The effects of sildenafil citrate on ischemic colonic anastomotic healing in rats: Its relationship between nitric oxide and oxidative stress

World Journal of Surgery

Volumn 32, Issue 9, 2008, Pages 2107-2113

  Uzun, Hafize ^a,b   Konukoglu, D ^a   Nuri, M K ^a   Ersoy, E Y ^a   Ozcevik S ^a   Yavuz, N ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; NITRIC OXIDE; SILDENAFIL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; COLON ANASTOMOSIS; COLON ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ERYTHROCYTE; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; POSTOPERATIVE PERIOD; RAT; TISSUE LEVEL; WOUND HEALING;

ANASTOMOSIS, SURGICAL; ANIMALS; BIOLOGICAL MARKERS; COLON; GLUTATHIONE; ISCHEMIA; MALE; NITRIC OXIDE; OXIDATIVE STRESS; PIPERAZINES; PURINES; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; SULFONES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; WOUND HEALING;

EID: 49749127265     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-008-9661-2     Document Type: Article

References (33)

1. GA Khoury BP Waxman 1983 Large bowel anastomosis. I. The healing process and sutured anastomosis. A review Br J Surg 70 61 63
2. MF Angel SS Ramasastry WM Swartz 1988 The critical relationship between free radicals and degrees of ischemia: evidence for tissue intolerance of marginal perfusion Plast Reconstr Surg 81 233 259
3. GM Chisolm D Steinberg 2000 The oxidative modification hypothesis of atherogenesis: an overview Free Radic Biol Med 28 1815 1826
4. H Li U Forstermann 2000 Nitric oxide in pathogenesis of vascular disease J Pathol 190 224 254
5. RH Boger SM Bode-Boger JC Frolich 1996 The arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications Atherosclerosis 127 1 11
6. ®) Exp Gerontol 34 305 318
7. JD Corbin SH Francis 1999 Cyclic GMP phosphodiesterase-5: target of sildenafil J Biol Chem 274 13729 13732
8. M Boolell 1996 Sildenafil: an orally type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction Int J Impot Resb 8 47 52
9. E Michelakis W Tymchak D Lien 2002 Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide Circulation 105 2398 2403
10. GR Spollett 1999 Assessment and management of erectile dysfunction in men with diabetes Diabetes Educ 25 65 73
11. C Hultling F Giuliano F Quirk 2000 Quality of life in patients with spinal cord injury receiving Viagra (sildenafil citrate) for the treatment of erectile dysfunction Spinal Cord 38 363 370
12. MA Mittleman DB Glasser J Orazem 2003 Clinical trials of sildenafil citrate (Viagra) demonstrate no increase in risk of myocardial infarction and cardiovascular death compared with placebo Int J Clin Pract 57 597 600
13. GD Lewis MJ Semigran 2006 The emerging role for type 5 phosphodiesterase inhibition in heart failure Curr Heart Fail Rep 3 123 128
14. HS Shin SK Bae MG Lee 2006 Pharmacokinetics of sildenafil after intravenous and oral administration in rats: hepatic and intestinal first-pass effects Int J Pharm 320 64 70
15. E Beutler O Duran MB Kelly 1963 Improved method for the determination of blood glutathione J Lab Clin Med 61 882 888
16. GL Ellman 1959 Tissue sulfhydryl groups Arch Biochem Biophys 82 70 77
17. JD Luo AF Chen 2005 Nitric oxide: a newly discovered function on wound healing Acta Pharmacol Sin 26 259 264
18. G Broughton 2nd JE Janis CE Attinger 2006 The basic science of wound healing Plast Reconstr Surg 117 12S 34S
19. DT Efron FJ Thornton C Steulten 1999 Expression and function of inducible nitric oxide synthase during rat colon anastomotic healing J Gastrointest Surg 3 592 601
20. JL Zweier MA Talukder 2006 The role of oxidants and free radicals in reperfusion injury Cardiovasc Res 70 181 190
21. AS Weyrich XI Ma AM Lefer 1992 The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat Circulation 79 279 288
22. JL Zweier MA Talukder 2006 The role of oxidants and free radicals in reperfusion injury Cardiovasc Res 70 181 190
23. JA Attard MJ Raval GR Martin 2005 The effects of systemic hypoxia on colon anastomotic healing: an animal model Dis Colon Rectum 48 1460 1470
24. E Mori N Haramaki H Ikeda 1998 Intra-coronary administration of L-arginine aggravates myocardial stunning through production of peroxynitrite in dogs Cardiovasc Res 34 113 123
25. Y Wahida KD Strynadka R Schulz 1997 Generation of peroxynitrite contributes to ischaemia-reperfusion injury in isolated rat hearts Cardiovasc Res 33 422 432
26. C Aydin Z Teke F Aytekin 2007 Tempol prevents harmful effects of remote ischemia reperfusion injury on healing of experimental colonic anastomosis Int J Colorectal Dis 22 325 331
27. F Salloum R Ockaili M Wittkamp 2006 Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial KATP channels in rabbits J Mol Cell Cardiol 40 405 411
28. RC Kukreja R Ockaili F Salloum 2004 Cardioprotection with phosphodiesterase-5 inhibition: a novel preconditioning strategy J Mol Cell Cardiol 36 165 173
29. AR McCullough 2002 Four-year review of sildenafil citrate Rev Urol 4 S26 S38
30. ®) Exp Gerontol 34 305 318
31. C Polat Y ArIkan C Gökce 2007 The effect of NG-nitro L-arginine methyl ester on colonic anastomosis after increased intra-abdominal pressure Langenbecks Arch Surg 392 197 202
32. Y Erbil A CalIs E Berber S Mercan 2000 The effect of intraoperative colonic lavage with NG-nitro-L-arginine methyl ester (L-NAME) on anastomotic healing in the presence of left-sided colonic obstruction in the rat Surg Today 30 421 425
33. PV Araujo CM Clemente JR da Graca 2005 Inhibitory effect of sildenafil on rat duodenal contractility in vitro: putative cGMP involvement Clin Exp Pharmacol Physiol 32 191 195