Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis

Pulmonary Pharmacology and Therapeutics

Volumn 23, Issue 3, 2010, Pages 215-221

  Yildirim, Alper ^a   Ersoy, Yasemin ^b   Ercan, Feriha ^b   Atukeren, Pinar ^c   Gumustas, Koray ^c   Uslu, Unal ^a   Alican, Inci ^b  

^a YEDITEPE UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Bleomycin; Inflammation; Lung fibrosis; Phosphodiesterase; Rat; Sildenafil citrate

Indexed keywords

BLEOMYCIN; CYTOKINE; GLUTATHIONE; INTERLEUKIN 1BETA; MALONALDEHYDE; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHODIESTERASE V; SILDENAFIL; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; FEMALE; LIPID PEROXIDATION; LUNG FIBROSIS; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BLEOMYCIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE; INTERLEUKIN-1BETA; LUNG; MALE; MALONDIALDEHYDE; NEUTROPHILS; NG-NITROARGININE METHYL ESTER; PEROXIDASE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PULMONARY FIBROSIS; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950339316     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2009.11.002     Document Type: Article

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