Short- and long-term effects of sildenafil on skin flap survival in rats

Laryngoscope

Volumn 116, Issue 4, 2006, Pages 522-528

  Hart, Kristopher ^a   Baur, Dale ^a   Hodam, Jason ^a   Lesoon Wood, Leslie ^a   Parham, Mary ^a   Keith, Karen ^a   Vazquez, Raymond ^b   Ager, Edward ^c   Pizarro, Jose ^a  

^a EISENHOWER ARMY MEDICAL CENTER   (United States)

^b TRIPLER ARMY MEDICAL CENTER   (United States)

^c MADIGAN ARMY MEDICAL CENTER   (United States)

Author keywords

Necrosis; Orthogonal polarization spectral imaging; Phosphodiesterase inhibitors; Reconstructive surgery; Sildenafil; Skin flaps

Indexed keywords

PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; CYCLIC GMP PHOSPHODIESTERASE; PIPERAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HEMOSTASIS; MALE; NONHUMAN; PHARMACODYNAMICS; PHOTOGRAPHY; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; RAT; SKIN FLAP SURVIVAL; SKIN NECROSIS; SURVIVAL RATE; ANIMAL; BLOOD FLOW VELOCITY; COMPARATIVE STUDY; DISEASE MODEL; DRUG ANTAGONISM; FOLLOW UP; MICROCIRCULATION; NECROSIS; PATHOLOGY; PLASTIC SURGERY; SKIN; SPRAGUE DAWLEY RAT; TIME; TREATMENT OUTCOME; VASCULARIZATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BLOOD FLOW VELOCITY; DISEASE MODELS, ANIMAL; FOLLOW-UP STUDIES; MALE; MICROCIRCULATION; NECROSIS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SURGICAL FLAPS; TIME FACTORS; TREATMENT OUTCOME;

EID: 33645911151     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mlg.0000200792.67802.3b     Document Type: Article

References (35)

1. Vural E, Key M. Complications, Salvage, and Enhancement of Local Flaps in Facial Reconstruction. 2001;34:739-751.
2. Slate RK, Ryan M, Bongard FS. Dependence of tissue oxygen on oxygen delivery. J Surg Res 1996;61:201-205.
3. Tuz M, Eroglu E, Dogru H, Delibas N, Tunc B, Uygur K. The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats. Clin Otolaryngol 2004;29:80-83.
4. Myers B. Understanding flap necrosis. Plast Reconstr Surg 1986;78:813-814.
5. Pang CY, Forrest CR, Morris SF. Pharmacological augmentation of skin flap viability: a hypothesis to mimic the surgical delay phenomenon or a wishful thought. Ann Plast Surg 1989;22:293-306.
6. Sloan GM, Reinisch JF. Flap physiology and the prediction of flap viability. Hand Clin 1985;1:609-619.
7. Chepeha DB, Nussenbaum B, Bradford CR, Teknos TN. Leech therapy for patients with surgically unsalvageable venous obstruction after revascularized free tissue transfer. Arch Otolaryngol Head Neck Surg 2002;128:960-965.
8. Perrins DJ. Influence of hyperbaric oxygen on the survival of split skin grafts. Lancet 1967;1:868-871.
9. Kindwall EP, Gottlieb LJ, Larson DL. Hyperbaric oxygen therapy in plastic surgery: a review article. Plast Reconstr Surg 1991;88:898-908.
10. Kindwall EP. Creating a hyperbaric oxygen treatment unit in a major medical center: a personal experience. Ann Plast Surg 1992;29:543-549.
11. Khan A, Ashrafpour H, Huang N, et al. Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. Am J Physiol Regul Integr Comp Physiol 2004;287:R1219-R1229.
12. Davis RE, Cohen JI, Robinson JE, Urben SL, Cook TA. Ketorolac (Toradol) and acute random-pattern skin flap survival in rat. Arch Otolaryngol Head Neck Surg 1995;121:673-677.
13. Karacal N, Ambarcioglu O, Topal U, Mamedov T, Kutlu N. Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): enhancement of flap survival by EMLA. J Surg Res 2005;124:134-138.
14. Kargi E, Deren O, Babuccu O, Hosnuter M, Erdogan B. Dual synergistic effect: the effect of dexamethasone plus carnitine on skin flap survival. Ann Plast Surg 2004;53:488-491.
15. Lineaweaver WC, Lei MP, Mustain W, Oswald TM, Cui D, Zhang F. Vascular endothelium growth factor, surgical delay, and skin flap survival. Ann Surg 2004;239:866-873.
16. Um SC, Suzuki S, Toyokuni S, et al. Involvement of nitric oxide in survival of random pattern skin flap. Plast Reconstr Surg 1998;101:785-792.
17. Kerrigan CL, Daniel RK. Pharmacologic treatment of the failing skin flap. Plast Reconstr Surg 1982;70:541-549.
18. Utley DS, Koch RJ, Goode RL. The failing flap in facial plastic and reconstructive surgery: role of the medicinal leech. Laryngoscope 1998;108:1129-1135.
19. Milton SH. Pedicled skin-flaps: the fallacy of the length: width ratio. Br J Surg 1970;57:502-508.
20. Knight KR, Lepore DA, O'Brien BM. Interrelationships between prostanoids and skin flap survival: a review. Prostaglandins Leukot Essent Fatty Acids 1991;44:195-200.
21. Knight KR, Kawabata H, Coe SA, Angus JA, O'Brien BM, Sakai K. Prostacyclin and prostanoid modifiers aid ischemic skin flap survival. J Surg Res 1991;50:119-123.
22. Kulkarni SK, Patil CS. Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects. Methods Find Exp Clin Pharmacol 2004;26:789-799.
23. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med 1994;120:227-237.
24. Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circulation Res 2003;93:280-291.
25. Voelkel NF, Lobel K, Westcott JY, Burke TJ. Nitric oxide-related vasoconstriction in lungs perfused with red cell lysate. FASEB J 1995;9:379-386.
26. Voelkel NF, Allard JD, Anderson SM, Burke TJ. cGMP and cAMP cause pulmonary vasoconstriction in the presence of hemolysate. J Appl Physiol 1999;86:1715-1720.
27. Cordeiro PG, Santamaria E, Hu QY. Use of a nitric oxide precursor to protect pig myocutaneous flaps from ischemia-reperfusion injury. Plast Reconstr Surg 1998;102:2040-2048.
28. Khiabani KT, Kerrigan CL. Presence and activity of nitric oxide synthase isoforms in ischemia-reperfusion-injured flaps. Plast Reconstr Surg 2002;109:1638-1645.
29. Mittermayr R, Valentini D, Fitzal F, Hallstrom S, Gasser H, Redl H. Protective effect of a novel NO-donor on ischemia/reperfusion injury in a rat epigastric flap model. Wound Repair Regen 2003;11:3-10.
30. Brindis RG, Kloner RA. Sildenafil in patients with cardiovascular disease. Am J Cardiol 2003;92:26M-36M.
31. Olivier WA, Hazen A, Levine JP, Soltanian H, Chung S, Gurtner GC. Reliable assessment of skin flap viability using orthogonal polarization imaging. Plast Reconstr Surg 2003;112:547-555.
32. McFarlane RM, DeYoung G, Henry RA. The design of a pedicle flap in the rat to study necrosis and its prevention. Plast Reconstr Surg 1965;35:177-182.
33. Campbell SP, Moss ML, Hugo NE. When does a random flap die? Plast Reconstr Surg 1992;89:718-721.
34. Sarifakioglu N, Gokrem S, Ates L, Akbuga UB, Aslan G. The influence of sildenafil on random skin flap survival in rats: an experimental study. Br J Plast Surg 2004;57:769-772.
35. Knox LK, Stewart AG, Hayward PG, Morrison WA. Nitric oxide synthase inhibitors improve skin flap survival in the rat. Microsurgery 1994;15:708-711.