Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: An in vivo assessment in rats employing intracerebral microdialysis

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 2, 2008, Pages 223-229

  Apparaju, Sandhya Kiran ^a   Gudelsky, Gary A ^a   Desai, Pankaj B ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Brain; ECF; Gemcitabine; Glioma; Microdialysis; Pharmacokinetics

Indexed keywords

GEMCITABINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BRAIN TUMOR; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; EXTRACELLULAR FLUID; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; GLIOMA; INJECTIONS, INTRAVENOUS; MALE; MICRODIALYSIS; NEOPLASM TRANSPLANTATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 36349021902     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0464-1     Document Type: Article

References (18)

1. Davis JR, Fernandes C, Zalcberg JR (1999) Gemcitabine and the blood brain barrier. Aust N Z J Med 29:831-832
2. Devineni D, Klein-Szanto A, Gallo JM (1996) In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats. Cancer Chemother Pharmacol 38:499-507
3. Dukic SF, Heurtaux T, Kaltenbach ML, Hoizey G, Lallemand A, Vistelle R (2000) Influence of schedule of administration on methotrexate penetration in brain tumours. Eur J Cancer 36:1578-1584
4. Fehlauer F, Muench M, Smid EJ, Slotman B, Richter E, Van d V, Sminia P (2006) Combined modality therapy of gemcitabine and irradiation on human glioma spheroids derived from cell lines and biopsy tissue. Oncol Rep 15:97-105
5. Genc M, Castro KN, Barten-van RA, Stalpers LJ, Haveman J (2004) Enhancement of effects of irradiation by gemcitabine in a glioblastoma cell line and cell line spheroids. J Cancer Res Clin Oncol 130:45-51
6. Gertler SZ, MacDonald D, Goodyear M, Forsyth P, Stewart DJ, Belanger K, Perry J, Fulton D, Steward W, Wainman N, Seymour L (2000) NCIC-CTG phase II study of gemcitabine in patients with malignant glioma (IND.94). Ann Oncol 11:315-318
7. Kerr JZ, Berg SL, Dauser R, Nuchtern J, Egorin MJ, McGuffey L, Aleksic A, Blaney S (2001) Plasma and cerebrospinal fluid pharmacokinetics of gemcitabine after intravenous administration in nonhuman primates. Cancer Chemother Pharmacol 47:411-414
8. Maraveyas A, Sgouros J, Upadhyay S, bdel-Hamid AH, Holmes M, Lind M (2005) Gemcitabine twice weekly as a radiosensitiser for the treatment of brain metastases in patients with carcinoma: a phase I study. Br J Cancer 92:815-819
9. Nakashima M, Shibata S, Tokunaga Y, Fujita H, Anda T, Arizono K, Tomiyama N, Sasaki H, Ichikawa M (1997) In-vivo microdialysis study of the distribution of cisplatin into brain tumour tissue after intracarotid infusion in rats with 9L malignant glioma. J Pharm Pharmacol 49:777-780
10. Pestieau SR, Stuart OA, Chang D, Jacquet P, Sugarbaker PH (1998) Pharmacokinetics of intraperitoneal gemcitabine in a rat model. Tumori 84:706-711
11. Plunkett W, Huang P, Xu YZ, Heinemann V, Grunewald R, Gandhi V (1995) Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin Oncol 22:3-10
12. Protzel C, Zimmermann U, Asse E, Kallwellis G, Klebingat KJ (2002) Gemcitabine and radiotherapy in the treatment of brain metastases from transitional cell carcinoma of the bladder: a case report. J Neurooncol 57:141-145
13. Rieger J, Durka S, Streffer J, Dichgans J, Weller M (1999) Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone. Eur J Pharmacol 365:301-308
14. Shipley LA, Brown TJ, Cornpropst JD, Hamilton M, Daniels WD, Culp HW (1992) Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs. Drug Metab Dispos 20:849-855
15. Ungerstedt U (1991) Microdialysis-principles and applications for studies in animals and man. J Intern Med 230:365-373
16. Weller M, Streffer J, Wick W, Kortmann RD, Heiss E, Kuker W, Meyermann R, Dichgans J, Bamberg M (2001) Preirradiation gemcitabine chemotherapy for newly diagnosed glioblastoma. A phase II study. Cancer 91:423-427
17. Wick W, Hermisson M, Kortmann RD, Kuker WM, Duffner F, Dichgans J, Bamberg M, Weller M (2002) Neoadjuvant gemcitabine/treosulfan chemotherapy for newly diagnosed glioblastoma: a phase II study. J Neurooncol 59:151-155
18. Yamamoto BK, Pehek EA (1990) A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis. Brain Res 506:236-242