Phase i clinical trial assessing temozolomide and tamoxifen with concomitant radiotherapy for treatment of high-grade glioma

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 2, 2012, Pages 739-742

  Patel, Shilpen ^a   Dibiase, Steven ^b   Meisenberg, Barry ^c   Flannery, Todd ^d   Patel, Ashish ^e   Dhople, Anil ^f   Cheston, Sally ^g   Amin, Pradip ^g  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c DeCesaris Cancer Institute   (United States)

^d Princeton Radiation Oncology   (United States)

^e ABINGTON MEMORIAL HOSPITAL   (United States)

^f MIMA Cancer Center   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Glioblastoma multiforme; High grade glioma; Phase I; Tamoxifen; Temozolomide

Indexed keywords

GLIOBLASTOMA MULTIFORME; HIGH-GRADE GLIOMAS; PHASE I; TAMOXIFEN; TEMOZOLOMIDE;

CHEMOTHERAPY; ENZYMES; RADIOTHERAPY;

TUMORS;

TAMOXIFEN; TEMOZOLOMIDE;

ADULT; AGED; ARTICLE; ATAXIA; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER PATIENT; CANCER SURVIVAL; CHEMORADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED RADIOTHERAPY; DEEP VEIN THROMBOSIS; DEHYDRATION; DIARRHEA; DISEASE SEVERITY; DRUG DOSE ESCALATION; DRUG ERUPTION; DRUG INDUCED HEADACHE; FATIGUE; FEMALE; GLIOBLASTOMA; GLIOMA; HEARING DISORDER; HIGH GRADE GLIOMA; HOT FLUSH; HUMAN; MALE; MAXIMUM TOLERATED DOSE; MENTAL DISEASE; NAUSEA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; QT PROLONGATION; RADIATION DOSE; SEIZURE; THROMBOCYTOPENIA; THRUSH; VISUAL DISORDER;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CHEMORADIOTHERAPY; COHORT STUDIES; DACARBAZINE; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLIOBLASTOMA; GLIOMA; HUMANS; KARNOFSKY PERFORMANCE STATUS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; PROTEIN KINASE C; SURVIVAL RATE; TAMOXIFEN; THROMBOCYTOPENIA; VENOUS THROMBOSIS; YOUNG ADULT;

EID: 84855861207     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.12.053     Document Type: Article

References (21)

1. W.J. Curran Jr., C.B. Scott, and J. Horton Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials J Natl Cancer Inst 85 1993 704 710
2. L.M. DeAngelis Brain tumors N Engl J Med 344 2001 114 123
3. J.C. Buckner Factors influencing survival in high-grade gliomas Semin Oncol 30 2003 10 14
4. R. Stupp, W.P. Mason, and M.J. van den Bent Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial Lancet Oncol 10 2009 459 466
5. M.D. Walker, E. Alexander Jr., and W.E. Hunt Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas: A cooperative clinical trial J Neurosurg 49 1978 333 343
6. M.D. Walker, S.B. Green, and D.P. Byar Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery N Engl J Med 303 1980 1323 1329
7. I.F. Pollack, M.S. Randall, and M.P. Kristofik Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways J Neurosurg 73 1990 98 105
8. I.F. Pollack, M.S. Randall, and M.P. Kristofik Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro Cancer Res 50 1990 7134 7138
9. I.F. Pollack, S. Kawecki, and J.S. Lazo Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor J Neurosurg 84 1996 1024 1032
10. G.H. Baltuch, W.T. Couldwell, and J.G. Villemure Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines: A comparison between staurosporine and tamoxifen Neurosurgery 33 1993 495 501
11. C.A. O'Brian, R.M. Liskamp, and D.H. Solomon Triphenylethylenes: A new class of protein kinase C inhibitors J Natl Cancer Inst 76 1986 1243 1246
12. C.A. O'Brian, R.M. Liskamp, and D.H. Solomon Inhibition of protein kinase C by tamoxifen Cancer Res 45 1985 2462 2465
13. F.T. Vertosick Jr., R.G. Selker, and M.S. Randall A comparison of the relative chemosensitivity of human gliomas to tamoxifen and N-desmethyltamoxifen in vitro J Neurooncol 19 1994 97 103
14. L. Mastronardi, J.O. Farah, and F. Puzzilli Tamoxifen modulation of carboplatin cytotoxicity in a human U-138 glioma cell line Clin Neurol Neurosurg 100 1998 89 93
15. C. Rohlff, M.V. Blagosklonny, and E. Kyle Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21(waf1/cip1) Prostate 37 1998 51 59
16. A.B. da Rocha, D.R. Mans, and E.A. Bernard Tamoxifen inhibits particulate-associated protein kinase C activity and sensitizes cultured human glioblastoma cells not to etoposide but to gamma-radiation and BCNU Eur J Cancer 35 1999 833 839
17. Fine R. In: DiBiase S, editor; 2000.
18. A.M. Donson, M.D. Weil, and N.K. Foreman Tamoxifen radiosensitization in human glioblastoma cell lines J Neurosurg 90 1999 533 536
19. W. Akerley, J.E. Herndon Jr., and A.P. Lyss Induction paclitaxel/carboplatin followed by concurrent chemoradiation therapy for unresectable stage III non-small-cell lung cancer: A limited-access study - CALGB 9534 Clin Lung Cancer 7 2005 47 53
20. H.I. Robins, M. Won, and W.F. Seiferheld Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme: RTOG protocol BR-0021 Neuro-Oncology 8 2006 47 52
21. D.R. MacDonald, T.L. Cascino, and S.C. Schold Jr. Response criteria for phase II studies of supratentorial malignant glioma J Clin Oncol 8 1990 1277 1280