Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis

Journal of Neuropathology and Experimental Neurology

Volumn 72, Issue 8, 2013, Pages 745-757

  Hoffmann, Dorit B ^a   Williams, Sarah K ^b   Bojcevski, Jovana ^b   Müller, Andreas ^a   Stadelmann, Christine ^c   Naidoo, Vinogran ^d,e   Bahr, Ben A ^d   Diem, Ricarda ^b   Fairless, Richard ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d UNIVERSITY OF NORTH CAROLINA AT PEMBROKE   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Calcium; Calpain; Neurodegeneration; Optic neuritis; Retinal ganglion cells

Indexed keywords

CALPAIN; CALPEPTIN; MANGANESE; MYELIN; SPECTRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL LOSS; CONTROLLED STUDY; FEMALE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; OPTIC NEURITIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; RAT; RETINA DEGENERATION; RETINA GANGLION CELL;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM; CALPAIN; CHLORIDES; DIPEPTIDES; DISEASE MODELS, ANIMAL; ECTODYSPLASINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MAGNETIC RESONANCE IMAGING; MANGANESE COMPOUNDS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NERVE DEGENERATION; NEUROPROSTANES; OPTIC NERVE; OPTIC NEURITIS; RATS; RETINA; RETINAL GANGLION CELLS; TIME FACTORS;

EID: 84880920434     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31829c7370     Document Type: Article

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