Solid-State 13C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-synuclein

Journal of Molecular Biology

Volumn 425, Issue 16, 2013, Pages 2973-2987

  Leftin, Avigdor ^a   Job, Constantin ^a   Beyer, Klaus ^a   Brown, Michael F ^a,b  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

magic angle spinning; membrane lipid raft; Parkinson's disease; residual dipolar coupling; segmental order parameter

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; ALPHA SYNUCLEIN; CHOLESTEROL; MEMBRANE LIPID; CARBON; PROTEIN BINDING;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; HUMAN; LIPID BILAYER; LIPID MEMBRANE; MEMBRANE FUSION; NERVE CELL MEMBRANE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID STATE; SYNAPTIC MEMBRANE; WILD TYPE; Α-SYNUCLEIN; ΑS; 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 2D; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CHOL; DIPOLAR RECOUPLING ON-AXIS WITH SCALING AND SHAPE PRESERVATION; DROSS; EGG YOLK SPHINGOMYELIN; ESYM; INEPT; INSENSITIVE NUCLEI ENHANCED BY POLARIZATION TRANSFER; MAGIC-ANGLE SPINNING; MAS; MEMBRANE LIPID RAFT; METABOLISM; N-ΑS; N-TERMINAL Α-SYNUCLEIN (1-25); NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POPC; PROTEIN BINDING; PROTEIN CONFORMATION; RDC; RESIDUAL DIPOLAR COUPLING; SEGMENTAL ORDER PARAMETER; SEPARATED LOCAL-FIELD; SLF; STAINING; TWO-DIMENSIONAL; WILD-TYPE Α-SYNUCLEIN; WT-ΑS;

Α-SYNUCLEIN; ΑS; 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 2D; CHOL; CHOLESTEROL; DIPOLAR RECOUPLING ON-AXIS WITH SCALING AND SHAPE PRESERVATION; DROSS; EGG YOLK SPHINGOMYELIN; ESYM; INEPT; INSENSITIVE NUCLEI ENHANCED BY POLARIZATION TRANSFER; MAGIC-ANGLE SPINNING; MAS; MEMBRANE LIPID RAFT; N-ΑS; N-TERMINAL Α-SYNUCLEIN (1-25); PARKINSON'S DISEASE; POPC; RDC; RESIDUAL DIPOLAR COUPLING; SEGMENTAL ORDER PARAMETER; SEPARATED LOCAL-FIELD; SLF; TWO-DIMENSIONAL; WILD-TYPE Α-SYNUCLEIN; WT-ΑS;

ALPHA-SYNUCLEIN; CARBON ISOTOPES; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE MICRODOMAINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; STAINING AND LABELING;

EID: 84880919761     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.04.002     Document Type: Article

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