Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity

Oncogene

Volumn 32, Issue 29, 2013, Pages 3452-3460

  Zhen, C ^a   Chen, L ^a   Zhao, Q ^a   Liang, B ^a   Gu, Y X ^a   Bai, Z F ^a   Wang, K ^a   Xu, X ^a   Han, Q Y ^a   Fang, D F ^a   Wang, S X ^a   Zhou, T ^a   Xia, Q ^a   Gong, W L ^a   Wang, N ^a   Li, H Y ^a   Jin, B F ^a   Man, J H ^a  

^a NATIONAL CENTER OF BIOMEDICAL ANALYSIS   (China)

Author keywords

Adhesion; Gankyrin; Metastasis; Rac; RhoA

Indexed keywords

GANKYRIN; PROTEIN; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; FOCAL ADHESION; HUMAN; HUMAN CELL; LUNG METASTASIS; LYMPH NODE METASTASIS; MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRESS FIBER; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS; RAC1 GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA;

EID: 84880919355     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.356     Document Type: Article

References (38)

1. Christofori G. New signals from the invasive front. Nature 2006; 441: 444-450. (Pubitemid 44050139)
2. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70. (Pubitemid 30046295)
3. Mareel M, A. Leroy. Clinical cellular, and molecular aspects of cancer invasion. Physiol Rev 2003; 83: 337-376. (Pubitemid 36382891)
4. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895-904. (Pubitemid 44175140)
5. Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol 2010; 11: 633-643.
6. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629-635. (Pubitemid 36764489)
7. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998; 279: 509-514. (Pubitemid 28067271)
8. Frank SR, Adelstein MR, Hansen SH. GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J 2006; 25: 1848-1859.
9. Hirsch DS, Shen Y, Wu WJ. Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42. Cancer Res 2006; 66: 3523-3530.
10. Wang SE, Shin I, Wu FY, Friedman DB, Arteaga CL. HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res 2006; 66: 9591-9600. (Pubitemid 44623658)
11. Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol Cell Biol 2006; 26: 831-842. (Pubitemid 43146479)
12. Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 1997; 390: 632-636. (Pubitemid 28016201)
13. Minard ME, Kim LS, Price JE, Gallick GE. The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat 2004; 84: 21-32. (Pubitemid 38388857)
14. Dawson S, Higashitsuji H, Wilkinson AJ, Fujita J, Mayer RJ. Gankyrin: a new oncoprotein and regulator of pRb and p53. Trends Cell Biol 2006; 16: 229-233. (Pubitemid 43728872)
15. Higashitsuji H, Itoh K, Nagao T, Dawson S, Nonoguchi K, Kido T et al. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat Med 2000; 6: 96-99. (Pubitemid 30048534)
16. Tang S, Yang G, Meng Y, Du R, Li X, Fan R et al. Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer. Cancer Biol Ther 2010; 9: 88-95.
17. Ortiz CM, Ito T, Tanaka E, Tsunoda S, Nagayama S, Sakai Y et al. Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance. Int J Cancer 2008; 122: 325-332. (Pubitemid 350234718)
18. Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T et al. Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. J Clin Invest 2010; 120: 2829-2841.
19. DerMardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 2005; 15: 356-363. (Pubitemid 40943524)
20. Boulter E, Garcia-Mata R, Guilluy C, Dubash A, Rossi G, Brennwald PJ et al. Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol 2010; 12: 477-483.
21. Fukata M, Kaibuchi K. Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol 2001; 2: 887-897. (Pubitemid 33674088)
22. Yang S, Zhang JJ, Orai1 Huang XY and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 2009; 15: 124-134.
23. Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again. Nat Cell Biol 2002; 4: E97-100.
24. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT et al. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 2004; 6: 154-161. (Pubitemid 38425715)
25. Katsumi A, Milanini J, Kiosses WB, del Pozo MA, Kaunas R, Chien S et al. Effects of cell tension on the small GTPase Rac. J Cell Biol 2002; 158: 153-164.
26. Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S et al. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008; 135: 510-523.
27. Jin BF, He K, Wang HX, Bai B, Zhou T, Li HY et al. Proteomics analysis reveals insight into the mechanism of H-Ras-mediated transformation. J Proteome Res 2006; 5: 2815-2823. (Pubitemid 44595182)
28. Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y et al. Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature 2009; 459: 861-865.
29. Saeki Y, Toh EA, Kudo T, Kawamura H, Tanaka K. Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell 2009; 137: 900-913.
30. Higashitsuji H, Itoh K, Sakurai T, Nagao T, Sumitomo Y, Masuda T et al. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell 2005; 8: 75-87. (Pubitemid 40991816)
31. Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY et al. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology 2011; 54: 1259-1272.
32. Lee K, Liu Y, Mo JQ, Zhang J, Dong Z, Lu S. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. BMC Cancer 2008; 8: 158.
33. Ridley AJ. Rho GTPases and cell migration. J Cell Sci 2001; 114: 2713-2722. (Pubitemid 32785451)
34. Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P et al. Coordination of Rho GTPase activities during cell protrusion. Nature 2009; 461: 99-103.
35. Pan X, Zhou T, Tai YH, Wang C, Zhao J, Cao Y et al. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nat Med 2011; 17: 708-714.
36. Wu K, Katiyar S, Li A, Liu M, Ju X, Popov VM et al. Dachshund inhibits oncogeneinduced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc Natl Acad Sci USA 2008; 105: 6924-6929. (Pubitemid 351754506)
37. Li Z, Wang C, Jiao X, Katiyar S, Casimiro MC, Prendergast GC et al. Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem 2008; 283: 7007-7015.
38. Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD et al. Genes that mediate breast cancer metastasis to lung. Nature 2005; 436: 518-524. (Pubitemid 41112921)