-
1
-
-
79955473943
-
Chronic lowering of blood pressure by carotid baroreflex activation: Mechanisms and potential for hypertension therapy
-
21357283 10.1161/HYPERTENSIONAHA.108.119859 1:CAS:528: DC%2BC3MXkvFartr8%3D
-
Lohmeier TE, Iliescu R. Chronic lowering of blood pressure by carotid baroreflex activation: mechanisms and potential for hypertension therapy. Hypertension. 2011;57:880-6.
-
(2011)
Hypertension
, vol.57
, pp. 880-886
-
-
Lohmeier, T.E.1
Iliescu, R.2
-
2
-
-
77149139150
-
Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients
-
20101001 10.1161/HYPERTENSIONAHA.109.140665 1:CAS:528: DC%2BC3cXitVKku7k%3D
-
Heusser K, Tank J, Engeli S, et al. Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients. Hypertension. 2010;55:619-26.
-
(2010)
Hypertension
, vol.55
, pp. 619-626
-
-
Heusser, K.1
Tank, J.2
Engeli, S.3
-
3
-
-
64049084640
-
Catheter-based renal sympathetic denervation for resistant hypertension: A multicentre safety and proof-of-principle cohort study
-
19332353 10.1016/S0140-6736(09)60566-3
-
• Krum H, Schlaich M, Whitbourn R, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275-81. Landmark study that translated the idea of renal denervation performed in hypertensive rats in the 1980s for the treatment of human drug resistant hypertension. The study reports that the majority of patients responded (after 3 months) exhibiting a reduction of systolic blood pressure of XX mmHg and ZZ mmHg by 6 months.
-
(2009)
Lancet
, vol.373
, Issue.9671
, pp. 1275-1281
-
-
Krum, H.1
Schlaich, M.2
Whitbourn, R.3
-
4
-
-
84877151078
-
Resistant hypertension
-
23438928 10.1161/HYPERTENSIONAHA.111.00601 1:CAS:528:DC%2BC3sXktVGnsrg%3D
-
Carey RM. Resistant hypertension. Hypertension. 2013;61:746-50.
-
(2013)
Hypertension
, vol.61
, pp. 746-750
-
-
Carey, R.M.1
-
5
-
-
12344282783
-
Global burden of hypertension: Analysis of worldwide data
-
15652604
-
Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-23.
-
(2005)
Lancet
, vol.365
, pp. 217-223
-
-
Kearney, P.M.1
Whelton, M.2
Reynolds, K.3
-
6
-
-
79959334521
-
A scientific statement from the American Heart Association professional education committee of the council for high blood pressure research. Resistant hypertension: Diagnosis, evaluation, and treatment
-
A scientific statement from the American Heart Association professional education committee of the council for high blood pressure research. Resistant hypertension: diagnosis, evaluation, and treatment. Circulation. 2008;117:e510-26.
-
(2008)
Circulation
, vol.117
-
-
-
7
-
-
0033652992
-
Sympathetic nervous system activation in essential hypertension, cardiac failure and psychosomatic heart disease
-
11346214 10.1097/00005344-200000004-00001 1:CAS:528:DC%2BD3cXotlWkur8%3D
-
Esler M, Kaye D. Sympathetic nervous system activation in essential hypertension, cardiac failure and psychosomatic heart disease. J Cardiovasc Pharmacol. 2000;35(7 Suppl 4):S1-7.
-
(2000)
J Cardiovasc Pharmacol
, vol.35
, Issue.7 SUPPL. 4
, pp. 1-7
-
-
Esler, M.1
Kaye, D.2
-
8
-
-
6344289585
-
Sympathetic and baroreflex function in hypertension: Implications for current and new drugs
-
15579055 10.2174/1381612043382756 1:CAS:528:DC%2BD2cXosl2isLY%3D
-
Grassi G. Sympathetic and baroreflex function in hypertension: implications for current and new drugs. Curr Pharm Des. 2004;10:3579-89.
-
(2004)
Curr Pharm des
, vol.10
, pp. 3579-3589
-
-
Grassi, G.1
-
9
-
-
4344707700
-
Counteracting the sympathetic nervous system in essential hypertension
-
15300157 10.1097/00041552-200409000-00006
-
Grassi G. Counteracting the sympathetic nervous system in essential hypertension. Curr Opin Nephrol Hypertens. 2004;13:513-9.
-
(2004)
Curr Opin Nephrol Hypertens
, vol.13
, pp. 513-519
-
-
Grassi, G.1
-
10
-
-
59749088675
-
Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: Does it contribute to hypertension?
-
19064613 10.1113/jphysiol.2008.165902 1:CAS:528:DC%2BD1MXitlGjtbY%3D
-
• Simms AE, Paton JF, Pickering AE, et al. Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension? J Physiol. 2009;587:597-610. First study to show that sympathetic activity is heightened in the spontaneously hypertensive rat before it develops hypertension, and that this was due to its elevated respiratory modulation. Importantly, the study demonstrated the contribution of this elevated respiratory-sympathetic modulation to vascular resistance and arterial pressure.
-
(2009)
J Physiol
, vol.587
, pp. 597-610
-
-
Simms, A.E.1
Paton, J.F.2
Pickering, A.E.3
-
11
-
-
0037014645
-
Sympathetic neural mechanisms in white-coat hypertension
-
12103266 10.1016/S0735-1097(02)01931-9
-
Smith PA, Graham LN, Mackintosh AF, et al. Sympathetic neural mechanisms in white-coat hypertension. J Am Coll Cardiol. 2002;40:126-32.
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 126-132
-
-
Smith, P.A.1
Graham, L.N.2
MacKintosh, A.F.3
-
12
-
-
1442348281
-
Relationship between central sympathetic activity and stages of human hypertension
-
15001194 10.1016/j.amjhyper.2003.10.010
-
Smith PA, Graham LN, Mackintosh AF, et al. Relationship between central sympathetic activity and stages of human hypertension. Am J Hypertens. 2004;17:217-22.
-
(2004)
Am J Hypertens
, vol.17
, pp. 217-222
-
-
Smith, P.A.1
Graham, L.N.2
MacKintosh, A.F.3
-
13
-
-
77049137730
-
Total thoracic and partial to total lumbar sympathectomy, splanchnicectomy and celiac ganglionectomy for hypertension
-
13092784 10.1097/00000658-195310000-00006 1:STN:280: DyaG2c%2FhtlGmtw%3D%3D
-
Grimson KS, Orgain ES, Anderson B, et al. Total thoracic and partial to total lumbar sympathectomy, splanchnicectomy and celiac ganglionectomy for hypertension. Ann Surg. 1953;138:532-47.
-
(1953)
Ann Surg
, vol.138
, pp. 532-547
-
-
Grimson, K.S.1
Orgain, E.S.2
Anderson, B.3
-
14
-
-
0000220091
-
Splanchnicectomy for essential hypertension; Results in 1,266 cases
-
13061307 10.1001/jama.1953.03690160001001 1:STN:280: DyaG3s%2Fos1artg%3D%3D
-
Smithwick RH. Splanchnicectomy for essential hypertension; results in 1,266 cases. J Am Med Assoc. 1953;152:1501-4.
-
(1953)
J Am Med Assoc
, vol.152
, pp. 1501-1504
-
-
Smithwick, R.H.1
-
15
-
-
0020538596
-
Comparison of guanadrel and guanethidine efficacy and side effects
-
6850722 1:STN:280:DyaL3s3gs1yjug%3D%3D
-
Malinow SH. Comparison of guanadrel and guanethidine efficacy and side effects. Clin Ther. 1983;5:284-9.
-
(1983)
Clin Ther
, vol.5
, pp. 284-289
-
-
Malinow, S.H.1
-
16
-
-
78649876825
-
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial
-
21093036 10.1016/S0140-6736(10)62039-9
-
Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903-9.
-
(2010)
Lancet
, vol.376
, pp. 1903-1909
-
-
Esler, M.D.1
Krum, H.2
Sobotka, P.A.3
Schlaich, M.P.4
Schmieder, R.E.5
Böhm, M.6
-
17
-
-
84875228822
-
Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation
-
23381790 10.1161/HYPERTENSIONAHA.111.00474 1:CAS:528:DC%2BC3sXktVGnsb4%3D
-
• Foss JD, Fink GD, Osborn JW. Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation. Hypertension. 2013;61:806-11. The importance of sympathetic inputs to the kidney and splanchnic vascular bed in the generation of neurogenic hypertension were demonstrated. In Dahl salt-sensitive rats on high salt, the evoked hypertension was lowered after the targeted sympathectomy. The additive effect of combined sympathectomy indicates distinct mechanisms are involved.
-
(2013)
Hypertension
, vol.61
, pp. 806-811
-
-
Foss, J.D.1
Fink, G.D.2
Osborn, J.W.3
-
18
-
-
0021286975
-
The central projections of carotid baroreceptors and chemoreceptors in the cat: A neurophysiological study
-
6707961 1:STN:280:DyaL2c7msVGmsA%3D%3D
-
Donoghue S, Felder RB, Jordan D, et al. The central projections of carotid baroreceptors and chemoreceptors in the cat: a neurophysiological study. J Physiol. 1984;347:397-409.
-
(1984)
J Physiol
, vol.347
, pp. 397-409
-
-
Donoghue, S.1
Felder, R.B.2
Jordan, D.3
-
19
-
-
0028335924
-
Peripheral chemoreceptors and cardiovascular regulation
-
8036247 1:CAS:528:DyaK2cXmsFWqtrg%3D
-
Marshall JM. Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev. 1994;74:543-94.
-
(1994)
Physiol Rev
, vol.74
, pp. 543-594
-
-
Marshall, J.M.1
-
20
-
-
0033067880
-
Reflex response and convergence of pharyngoesophageal and peripheral chemo- receptors in the nucleus of the solitary tract
-
10430479 10.1016/S0306-4522(99)00098-6 1:CAS:528:DyaK1MXktlentbk%3D
-
Paton JFR, Li Y-W, Kasparov S. Reflex response and convergence of pharyngoesophageal and peripheral chemo- receptors in the nucleus of the solitary tract. Neuroscience. 1999;93:143-54.
-
(1999)
Neuroscience
, vol.93
, pp. 143-154
-
-
Paton, J.F.R.1
Li, Y.-W.2
Kasparov, S.3
-
21
-
-
0024259862
-
Measurement of carotid body blood flow in cats by use of radioactive microspheres
-
3215848 1:STN:280:DyaL1M7gvV2qug%3D%3D
-
Barnett S, Mulligan E, Wagerle LC, et al. Measurement of carotid body blood flow in cats by use of radioactive microspheres. J Appl Physiol. 1988;65:2484-9.
-
(1988)
J Appl Physiol
, vol.65
, pp. 2484-2489
-
-
Barnett, S.1
Mulligan, E.2
Wagerle, L.C.3
-
22
-
-
67651210931
-
Fifty years of progress in carotid body physiology-invited article
-
19536461 10.1007/978-90-481-2259-2-2 1:CAS:528:DC%2BC3cXhtlWrsLfN
-
Fitzgerald RS, Eyzaguirre C, Zapata P. Fifty years of progress in carotid body physiology-invited article. Adv Exp Med Biol. 2009;648:19-28.
-
(2009)
Adv Exp Med Biol
, vol.648
, pp. 19-28
-
-
Fitzgerald, R.S.1
Eyzaguirre, C.2
Zapata, P.3
-
24
-
-
0024333757
-
Bilateral carotid body resection for the relief of dyspnea in severe chronic obstructive pulmonary disease. Physiologic and clinical observations in three patients
-
2495905 10.1378/chest.95.5.1123 1:STN:280:DyaL1M3htVSlsQ%3D%3D
-
Stulbarg MS, Winn WR, Kellett LE. Bilateral carotid body resection for the relief of dyspnea in severe chronic obstructive pulmonary disease. Physiologic and clinical observations in three patients. Chest. 1989;95:1123-8.
-
(1989)
Chest
, vol.95
, pp. 1123-1128
-
-
Stulbarg, M.S.1
Winn, W.R.2
Kellett, L.E.3
-
25
-
-
0020004351
-
The pattern of cardiovascular response to carotid chemoreceptor stimulation in the cat
-
7108808 1:STN:280:DyaL383mvVKmtA%3D%3D
-
Hilton SM, Marshall JM. The pattern of cardiovascular response to carotid chemoreceptor stimulation in the cat. J Physiol. 1982;326:495-513.
-
(1982)
J Physiol
, vol.326
, pp. 495-513
-
-
Hilton, S.M.1
Marshall, J.M.2
-
26
-
-
0031812873
-
The effect of chemoreceptor stimulation on the centripetal transfer of somatosensory information in the urethane-anaesthetized rat
-
9692765 10.1016/S0306-4522(97)00633-7 1:CAS:528:DyaK1cXktFCntbs%3D
-
Angel A, Harris MC. The effect of chemoreceptor stimulation on the centripetal transfer of somatosensory information in the urethane-anaesthetized rat. Neuroscience. 1998;86:321-35.
-
(1998)
Neuroscience
, vol.86
, pp. 321-335
-
-
Angel, A.1
Harris, M.C.2
-
27
-
-
0001483615
-
An analysis of the primary cardiovascular reflex effects of stimulation of the carotid body chemoreceptors in the dog
-
De Burgh Daly M, Scott MJ. An analysis of the primary cardiovascular reflex effects of stimulation of the carotid body chemoreceptors in the dog. J Physiol. 1962;162:555-73.
-
(1962)
J Physiol
, vol.162
, pp. 555-573
-
-
De Burgh Daly, M.1
Scott, M.J.2
-
28
-
-
0001717707
-
The cardiovascular responses to stimulation of the carotid body chemoreceptors in the dog
-
14024792 1:STN:280:DyaF383hs1Olug%3D%3D
-
Daly MD, Scott MJ. The cardiovascular responses to stimulation of the carotid body chemoreceptors in the dog. J Physiol. 1963;165:179-97.
-
(1963)
J Physiol
, vol.165
, pp. 179-197
-
-
Daly, M.D.1
Scott, M.J.2
-
29
-
-
27544469178
-
The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited
-
16269319 10.1016/j.brainresrev.2005.02.005 1:STN:280: DC%2BD2MrptVamsw%3D%3D
-
Paton JFR, Boscan P, Pickering AE, et al. The yin and yang of cardiac autonomic control: vago-sympathetic interactions revisited. Brain Res Rev. 2005;49:555-65.
-
(2005)
Brain Res Rev
, vol.49
, pp. 555-565
-
-
Paton, J.F.R.1
Boscan, P.2
Pickering, A.E.3
-
30
-
-
0026058707
-
Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans
-
2040688 10.1172/JCI115221 1:CAS:528:DyaK3MXksVKkuro%3D
-
Somers VK, Mark AL, Abboud FM. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest. 1991;87:1953-7.
-
(1991)
J Clin Invest
, vol.87
, pp. 1953-1957
-
-
Somers, V.K.1
Mark, A.L.2
Abboud, F.M.3
-
31
-
-
0019862232
-
Interaction between the responses to stimulation of peripheral chemoreceptors and baroreceptors: The importance of chemoreceptor activation of the defence areas
-
6268688 10.1016/0165-1838(81)90077-1 1:CAS:528:DyaL3MXktVCntrc%3D
-
Marshall JM. Interaction between the responses to stimulation of peripheral chemoreceptors and baroreceptors: the importance of chemoreceptor activation of the defence areas. J Auton Nerv Syst. 1981;3:389-400.
-
(1981)
J Auton Nerv Syst
, vol.3
, pp. 389-400
-
-
Marshall, J.M.1
-
32
-
-
0024421468
-
Neural mechanisms involved in cardiovascular control during affective behaviour
-
2480666 10.1016/0166-2236(89)90111-2 1:STN:280:DyaK3c%2FosFeltw%3D%3D
-
Spyer KM. Neural mechanisms involved in cardiovascular control during affective behaviour. Trends Neurosci. 1989;12:506-13.
-
(1989)
Trends Neurosci
, vol.12
, pp. 506-513
-
-
Spyer, K.M.1
-
33
-
-
0020285127
-
Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats
-
1:CAS:528:DyaL3sXksFWhtL4%3D
-
Przybylski J, Trzebski A, Czyzewski T, et al. Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats. Bull Eur Physiopathol Respir Clin Respir Physiol. 1982;18:145-54.
-
(1982)
Bull Eur Physiopathol Respir Clin Respir Physiol
, vol.18
, pp. 145-154
-
-
Przybylski, J.1
Trzebski, A.2
Czyzewski, T.3
-
34
-
-
0026573655
-
Arterial chemoreceptor reflex and hypertension
-
1592451 10.1161/01.HYP.19.6.562 1:STN:280:DyaK383nsFOhtA%3D%3D
-
Trzebski A. Arterial chemoreceptor reflex and hypertension. Hypertension. 1992;19:562-6.
-
(1992)
Hypertension
, vol.19
, pp. 562-566
-
-
Trzebski, A.1
-
35
-
-
0023789771
-
Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects
-
3391673 10.1161/01.HYP.11.6.608 1:STN:280:DyaL1c3nt1Cgtw%3D%3D
-
Somers VK, Mark AL, Abboud FM. Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension. 1988;11:608-12.
-
(1988)
Hypertension
, vol.11
, pp. 608-612
-
-
Somers, V.K.1
Mark, A.L.2
Abboud, F.M.3
-
36
-
-
85047680004
-
Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension
-
6805956 10.1093/cvr/16.3.163 1:STN:280:DyaL383gvVCmtg%3D%3D
-
Trzebski A, Tafil M, Zoltowski M. Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res. 1982;16:163-72.
-
(1982)
Cardiovasc Res
, vol.16
, pp. 163-172
-
-
Trzebski, A.1
Tafil, M.2
Zoltowski, M.3
-
37
-
-
0022318868
-
Augmented chemoreceptor reflex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension
-
3834754 1:STN:280:DyaL283htFaksw%3D%3D
-
Tafil-Klawe M, Trzebski A, Klawe J, et al. Augmented chemoreceptor reflex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension. Acta Physiol Pol. 1985;36:51-8.
-
(1985)
Acta Physiol Pol
, vol.36
, pp. 51-58
-
-
Tafil-Klawe, M.1
Trzebski, A.2
Klawe, J.3
-
38
-
-
84860718911
-
Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension
-
22158114 10.1038/hr.2011.209 1:CAS:528:DC%2BC38Xms1yhu78%3D
-
• Sinski M, Lewandowski J, Przybylski J. Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension. Hypertens Res. 2012;35:487-91. This study reveals an oxygen sensitive tonically active excitatory drive from the carotid body in humans with hypertension. The authors show reductions in arterial pressure and muscle sympathetic nerve activity when hypertensive patients are given 100 % oxygen to breathe. The authors conclude that there is a major role for the carotid body in human essential hypertension.
-
(2012)
Hypertens Res
, vol.35
, pp. 487-491
-
-
Sinski, M.1
Lewandowski, J.2
Przybylski, J.3
-
39
-
-
0032436673
-
Postexercise decrease in arterial blood pressure, total peripheral resistance and in circulatory responses to brief hyperoxia in subjects with mild essential hypertension
-
9883709 10.1038/sj.jhh.1000716 1:CAS:528:DyaK1MXhslWjsQ%3D%3D
-
Izdebska E, Cybulska I, Sawicki I. Postexercise decrease in arterial blood pressure, total peripheral resistance and in circulatory responses to brief hyperoxia in subjects with mild essential hypertension. J Hum Hypertens. 1998;12:855-60.
-
(1998)
J Hum Hypertens
, vol.12
, pp. 855-860
-
-
Izdebska, E.1
Cybulska, I.2
Sawicki, I.3
-
40
-
-
77649120606
-
Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR
-
20019330 10.1161/CIRCRESAHA.109.206946 1:CAS:528:DC%2BC3cXitFCks7Y%3D
-
•• Tan ZY, Lu Y, Whiteis CA, et al. Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res. 2010;106:536-45. This study reports the relative roles of acid sensitive and sodium and potassium channels in the detection of low pH. There was a significant increase in the depolarizing effect of low pH in glomus cells from spontaneously hypertensive rats versus normotensive rats, which was caused by overexpression of 2 acid-sensing non-voltage-gated channels. It also shows that these channels were over expressed prior to the onset of hypertension in spontaneously hypertensive rats and that these immature animals have heightened chemosensitivity,as revealed by greater sympatho-excitatory responses relative to age-matched and sex-matched normotensive rats.
-
(2010)
Circ Res
, vol.106
, pp. 536-545
-
-
Tan, Z.Y.1
Lu, Y.2
Whiteis, C.A.3
-
41
-
-
0035979393
-
Peripheral chemoreceptor hypersensitivity: An ominous sign in patients with chronic heart failure
-
11479251 10.1161/hc3101.093699 1:STN:280:DC%2BD3MvjtFGksw%3D%3D
-
Ponikowski P, Chua TP, Anker SD, et al. Peripheral chemoreceptor hypersensitivity: an ominous sign in patients with chronic heart failure. Circulation. 2001;104:544-9.
-
(2001)
Circulation
, vol.104
, pp. 544-549
-
-
Ponikowski, P.1
Chua, T.P.2
Anker, S.D.3
-
42
-
-
0026656461
-
Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea
-
1601808 1:CAS:528:DyaK38XksVGksLk%3D
-
Fletcher EC, Lesske J, Behm R, et al. Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea. J Appl Physiol. 1992;72:1978-84.
-
(1992)
J Appl Physiol
, vol.72
, pp. 1978-1984
-
-
Fletcher, E.C.1
Lesske, J.2
Behm, R.3
-
43
-
-
47249118848
-
Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity
-
18450774 10.1113/jphysiol.2008.154187 1:CAS:528:DC%2BD1cXovVSmtro%3D
-
• Zoccal DB, Simms AE, Bonagamba LG, et al. Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity. J Physiol. 2008;586:3253-65. This is the first study to show that the hypertension evoked by chronic intermittent hypoxia is generated, in part, by elevated respiratory modulation of sympathetic activity. This was shown to be due to: (i) enhanced magnitude of the coupling seen in control rats and (ii) a novel respiratory related sympathetic burst of activity generated late in the expiratory interval. The latter sympathetic burst was coupled with expiratory abdominal motor activity, suggesting that chronic intermittent hypoxia also caused active expiration.
-
(2008)
J Physiol
, vol.586
, pp. 3253-3265
-
-
Zoccal, D.B.1
Simms, A.E.2
Bonagamba, L.G.3
-
44
-
-
0037342849
-
Chemoreflexes - Physiology and clinical implications
-
12609009 10.1046/j.1365-201X.2003.01083.x 1:CAS:528:DC%2BD3sXitlOru7o%3D
-
Kara T, Narkiewicz K, Somers VK. Chemoreflexes - physiology and clinical implications. Acta Physiol Scand. 2003;177:377-84.
-
(2003)
Acta Physiol Scand
, vol.177
, pp. 377-384
-
-
Kara, T.1
Narkiewicz, K.2
Somers, V.K.3
-
45
-
-
0037338877
-
Sympathetic nerve activity in obstructive sleep apnoea
-
12609010 10.1046/j.1365-201X.2003.01091.x 1:CAS:528:DC%2BD3sXitlOru7s%3D
-
Narkiewicz K, Somers VK. Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand. 2003;177:385-90.
-
(2003)
Acta Physiol Scand
, vol.177
, pp. 385-390
-
-
Narkiewicz, K.1
Somers, V.K.2
-
46
-
-
0032539896
-
Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea
-
9529260 10.1161/01.CIR.97.10.943 1:STN:280:DyaK1c7ovVWjuw%3D%3D
-
•• Narkiewicz K, van de Borne PJH, Montano N, et al. Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation. 1998;97:943-5. Using 100 % oxygen to inactivate the carotid bodies, this study showed that patients with sleep apnea have highly active carotid bodies that participate in the generation of their high blood pressure and high sympathetic nerve activity.
-
(1998)
Circulation
, vol.97
, pp. 943-945
-
-
Narkiewicz, K.1
Van De Borne, P.J.H.2
Montano, N.3
-
47
-
-
0033653247
-
What drives the tonic activity of presympathetic neurons in the rostral ventrolateral medulla?
-
11117229 10.1046/j.1440-1681.2000.03375.x 1:CAS:528:DC%2BD3cXovVWru7w%3D
-
Dampney RAL, Tagawa T, Horiuchi J, Potts PD, Fontes M, Polson JW. What drives the tonic activity of presympathetic neurons in the rostral ventrolateral medulla? Clin Exp Pharmacol Physiol. 2000;27:1049-53.
-
(2000)
Clin Exp Pharmacol Physiol
, vol.27
, pp. 1049-1053
-
-
Dampney, R.A.L.1
Tagawa, T.2
Horiuchi, J.3
Potts, P.D.4
Fontes, M.5
Polson, J.W.6
-
48
-
-
0021943571
-
Comparative pathology of the enlarged carotid body
-
3837795 10.1016/0021-9975(85)90012-X 1:STN:280:DyaL28zgsFWiug%3D%3D
-
Heath D, Smith P, Fitch R, et al. Comparative pathology of the enlarged carotid body. J Comp Pathol. 1985;95:259-71.
-
(1985)
J Comp Pathol
, vol.95
, pp. 259-271
-
-
Heath, D.1
Smith, P.2
Fitch, R.3
-
49
-
-
0027136055
-
Vascular analysis of the carotid body in the spontaneously hypertensive rat
-
G. Data (eds) Plenum Press New York
-
Clarke JA, de Burgh Daly M, Ead HW. Vascular analysis of the carotid body in the spontaneously hypertensive rat. In: Data PG, editor. Neurobiology and cell physiology of chemoreception. New York: Plenum Press; 1993. p. 3-8.
-
(1993)
Neurobiology and Cell Physiology of Chemoreception
, pp. 3-8
-
-
Clarke, J.A.1
De Burgh Daly, M.2
Ead, H.W.3
-
50
-
-
84862563664
-
Gaseous messengers in oxygen sensing
-
10.1007/s00109-012-0876-1 1:CAS:528:DC%2BC38Xjs1SrsL8%3D
-
Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. J Mol Med (Berl). 2012;90:265-72.
-
(2012)
J Mol Med (Berl)
, vol.90
, pp. 265-272
-
-
Prabhakar, N.R.1
Semenza, G.L.2
-
51
-
-
79954417934
-
Angiotensin and carotid body chemoreception in heart failure
-
21242106 10.1016/j.coph.2010.12.004 1:CAS:528:DC%2BC3MXksFymsL4%3D
-
Schultz HD. Angiotensin and carotid body chemoreception in heart failure. Curr Opin Pharmacol. 2011;11:144-9.
-
(2011)
Curr Opin Pharmacol
, vol.11
, pp. 144-149
-
-
Schultz, H.D.1
-
52
-
-
1542329714
-
Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: Involvement of nitric oxide
-
14673183 10.1113/jphysiol.2003.057422 1:CAS:528:DC%2BD2cXhvFOrt7o%3D
-
Li YL, Sun SY, Overholt JL, et al. Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide. J Physiol. 2004;555:219-29.
-
(2004)
J Physiol
, vol.555
, pp. 219-229
-
-
Li, Y.L.1
Sun, S.Y.2
Overholt, J.L.3
-
53
-
-
78650404479
-
Role of blood flow in carotid body chemoreflex function in heart failure
-
21078591 10.1113/jphysiol.2010.200584 1:CAS:528:DC%2BC3MXls1Ontg%3D%3D Using microspheres in rabbits, blood flow to the carotid body was modulated by carotid artery occlusion. By reducing carotid body blood flow, chemoreceptor reflex sensitivity and tonicity was elevated and associated with a decrease in neuronal nitric oxide synthase, increased angiotensin type 1 receptor expression and angiotensin II concentration, as well as decreased outward potassium current. These changes were consistent with those found in rabbits with heart failure, supporting the notion that reduction of carotid body perfusion may itself heighten carotid body signaling
-
• Ding Y, Li YL, Schultz HD. Role of blood flow in carotid body chemoreflex function in heart failure. J Physiol. 2011;589:245-58. Using microspheres in rabbits, blood flow to the carotid body was modulated by carotid artery occlusion. By reducing carotid body blood flow, chemoreceptor reflex sensitivity and tonicity was elevated and associated with a decrease in neuronal nitric oxide synthase, increased angiotensin type 1 receptor expression and angiotensin II concentration, as well as decreased outward potassium current. These changes were consistent with those found in rabbits with heart failure, supporting the notion that reduction of carotid body perfusion may itself heighten carotid body signaling.
-
(2011)
J Physiol
, vol.589
, pp. 245-258
-
-
Ding, Y.1
Li, Y.L.2
Schultz, H.D.3
-
54
-
-
38449112248
-
Key roles for AMP-activated protein kinase in the function of the carotid body?
-
18085248 10.1007/978-0-387-73693-8-11
-
Wyatt CN, Pearson SA, Kumar P, et al. Key roles for AMP-activated protein kinase in the function of the carotid body? Adv Exp Med Biol. 2008;605:63-8.
-
(2008)
Adv Exp Med Biol
, vol.605
, pp. 63-68
-
-
Wyatt, C.N.1
Pearson, S.A.2
Kumar, P.3
-
55
-
-
84857625513
-
Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways
-
22187044 10.1007/s00418-011-0900-5
-
Lam SY, Liu Y, Ng KM, et al. Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways. Histochem Cell Biol. 2011;137:303-17.
-
(2011)
Histochem Cell Biol
, vol.137
, pp. 303-317
-
-
Lam, S.Y.1
Liu, Y.2
Ng, K.M.3
-
56
-
-
84861460117
-
Increased total volume and dopamine β-hydroxylase immunoreactivity of carotid body in spontaneously hypertensive rats
-
10.1016/j.autneu.2012.03.005 1:CAS:528:DC%2BC38Xmt1OitLk%3D
-
• Kato K, Wakai J, Matsuda H, et al. Increased total volume and dopamine β-hydroxylase immunoreactivity of carotid body in spontaneously hypertensive rats. Auton Neurosci Basic Clin. 2012;169:49-55. This paper shows that spontaneously hypertensive rats have an enlarged carotid body and enhanced immunoreactivity for dopamine b-hydroxylase. The authors propose that the morphology of the carotid body may be affected by the sympathetic nervous system, and that carotid body signal transduction is regulated by NA in glomus cells of hypertensive rats.
-
(2012)
Auton Neurosci Basic Clin
, vol.169
, pp. 49-55
-
-
Kato, K.1
Wakai, J.2
Matsuda, H.3
-
57
-
-
85027944703
-
Structural and neurochemical changes in the maturation of the carotid body
-
22728582 10.1016/j.resp.2012.06.012
-
De Caro R, Macchi V, Sfriso MM, et al. Structural and neurochemical changes in the maturation of the carotid body. Respir Physiol Neurobiol. 2013;185:9-19.
-
(2013)
Respir Physiol Neurobiol
, vol.185
, pp. 9-19
-
-
De Caro, R.1
MacChi, V.2
Sfriso, M.M.3
-
58
-
-
79954421374
-
The central nervous system and inflammation in hypertension
-
21196131 10.1016/j.coph.2010.12.001 1:CAS:528:DC%2BC3MXksFymsLw%3D
-
Marvar PJ, Lob H, Vinh A, et al. The central nervous system and inflammation in hypertension. Curr Opin Pharmacol. 2011;11:156-61.
-
(2011)
Curr Opin Pharmacol
, vol.11
, pp. 156-161
-
-
Marvar, P.J.1
Lob, H.2
Vinh, A.3
-
59
-
-
84863880029
-
The sympathetic nervous system and blood pressure in humans: Implications for hypertension
-
21734720 10.1038/jhh.2011.66 1:CAS:528:DC%2BC38XhtVeltLjO
-
Fisher JP, Paton JFR. The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens. 2012;26:463-75.
-
(2012)
J Hum Hypertens
, vol.26
, pp. 463-475
-
-
Fisher, J.P.1
Paton, J.F.R.2
-
60
-
-
79956370451
-
Autonomic-immune-vascular interaction: An emerging concept for neurogenic hypertension
-
21536990 10.1161/HYPERTENSIONAHA.111.169748 1:CAS:528: DC%2BC3MXmt1Ghsbs%3D
-
Zubcevic J, Waki H, Raizada MK, et al. Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension. Hypertension. 2011;57:1026-33.
-
(2011)
Hypertension
, vol.57
, pp. 1026-1033
-
-
Zubcevic, J.1
Waki, H.2
Raizada, M.K.3
-
61
-
-
84878554218
-
Peripheral neural detection of danger-associated and pathogen-associated molecular patterns
-
Epub ahead of print
-
• Ackland GL, Kazymov V, Marina N, et al. Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. Crit Care Med. 2013;[Epub ahead of print]. Data are presented that the carotid body glomus cells act to detect pathogen and danger associated molecules. Toll-like receptor activation resulted in inflammasome-dependent mechanism within glomus cells similar to that described in immune cells. The result of this was IL-1b release, which acted in an autocrine manner to raise carotid body activity.
-
(2013)
Crit Care Med
-
-
Ackland, G.L.1
Kazymov, V.2
Marina, N.3
-
62
-
-
84871609238
-
The carotid body as a therapeutic target for treatment of sympathetically mediated diseases
-
23172927 10.1161/HYPERTENSIONAHA.111.00064 1:CAS:528:DC%2BC38XhvVahsrvK
-
Paton JFR, Sobotka PA, Fudim M, et al. The carotid body as a therapeutic target for treatment of sympathetically mediated diseases. Hypertension. 2013;61:5-13.
-
(2013)
Hypertension
, vol.61
, pp. 5-13
-
-
Paton, J.F.R.1
Sobotka, P.A.2
Fudim, M.3
-
63
-
-
83455259405
-
Carotid chemoreceptor modulation of blood flow during exercise in healthy humans
-
22025661 1:CAS:528:DC%2BC38XpvFOjtg%3D%3D
-
Stickland MK, Fuhr DP, Haykowsky MJ, et al. Carotid chemoreceptor modulation of blood flow during exercise in healthy humans. J Physiol. 2011;589:6219-30.
-
(2011)
J Physiol
, vol.589
, pp. 6219-6230
-
-
Stickland, M.K.1
Fuhr, D.P.2
Haykowsky, M.J.3
-
64
-
-
84880917790
-
A novel and translatable approach for the treatment of neurogenic hypertension
-
in revision
-
•• McBryde FD, Abdala AP, Hendy EB, et al. A novel and translatable approach for the treatment of neurogenic hypertension. Nat Commun. 2013;(in revision). This study demonstrates the mechanisms underpinning the hypotensive response to carotid body ablation in spontaneously hypertensive rats. These include substantial reductions in renal sympathetic activity, improved baroreceptor reflex gain, improved renal function and reduced tissue inflammation. The study also shows that there is a summative interaction between renal denervation and carotid body ablation.
-
(2013)
Nat Commun
-
-
McBryde, F.D.1
Abdala, A.P.2
Hendy, E.B.3
-
65
-
-
84865597119
-
Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat
-
22687617 10.1113/jphysiol.2012.237800 1:CAS:528:DC%2BC38XhsVKhs7jE
-
Abdala AP, McBryde FD, Marina N, et al. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol. 2012;590:4269-77.
-
(2012)
J Physiol
, vol.590
, pp. 4269-4277
-
-
Abdala, A.P.1
McBryde, F.D.2
Marina, N.3
-
66
-
-
0000003602
-
Surgical removal of the carotid body for bronchial asthma
-
14478244 10.1378/chest.40.6.595 1:STN:280:DyaF38%2FnvFOgtw%3D%3D
-
Nakayama K. Surgical removal of the carotid body for bronchial asthma. Dis Chest. 1961;40:595-604.
-
(1961)
Dis Chest
, vol.40
, pp. 595-604
-
-
Nakayama, K.1
-
67
-
-
11144338833
-
Immediate effects of bilateral carotid body resection on total respiratory resistance and compliance in humans
-
15602939 10.1007/0-387-27023-X-3
-
Winter B, Whipp BJ. Immediate effects of bilateral carotid body resection on total respiratory resistance and compliance in humans. Adv Exp Med Biol. 2004;551:15-21.
-
(2004)
Adv Exp Med Biol
, vol.551
, pp. 15-21
-
-
Winter, B.1
Whipp, B.J.2
-
68
-
-
84873727737
-
Responses of glomus cells to hypoxia and acidosis are uncoupled, reciprocal and linked to ASIC3 expression: Selectivity of chemosensory transduction
-
23165770 10.1113/jphysiol.2012.247189 1:CAS:528:DC%2BC3sXlsV2itbs%3D
-
Lu Y, Whiteis CA, Sluka KA, et al. Responses of glomus cells to hypoxia and acidosis are uncoupled, reciprocal and linked to ASIC3 expression: selectivity of chemosensory transduction. J Physiol. 2013;591:919-32.
-
(2013)
J Physiol
, vol.591
, pp. 919-932
-
-
Lu, Y.1
Whiteis, C.A.2
Sluka, K.A.3
-
69
-
-
0032055971
-
Convergence properties of solitary tract neurones driven synaptically by cardiac vagal afferents in the mouse
-
9490844 10.1111/j.1469-7793.1998.237br.x 1:CAS:528:DyaK1cXis1Cqsb4%3D
-
Paton JFR. Convergence properties of solitary tract neurones driven synaptically by cardiac vagal afferents in the mouse. J Physiol. 1998;508:237-52.
-
(1998)
J Physiol
, vol.508
, pp. 237-252
-
-
Paton, J.F.R.1
-
70
-
-
0031841240
-
Pattern of cardiorespiratory afferent convergence to solitary tract neurons driven by pulmonary vagal C-fiber stimulation in the mouse
-
9582212 1:STN:280:DyaK1c3kvVCmtQ%3D%3D
-
Paton JFR. Pattern of cardiorespiratory afferent convergence to solitary tract neurons driven by pulmonary vagal C-fiber stimulation in the mouse. J Neurophysiol. 1998;79:2365-73.
-
(1998)
J Neurophysiol
, vol.79
, pp. 2365-2373
-
-
Paton, J.F.R.1
-
71
-
-
0015956639
-
The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels
-
4207655 1:STN:280:DyaE2c7ltlKiug%3D%3D
-
Ponte J, Purves MJ. The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels. J Physiol. 1974;237:315-40.
-
(1974)
J Physiol
, vol.237
, pp. 315-340
-
-
Ponte, J.1
Purves, M.J.2
-
72
-
-
0027196083
-
Ventrolateral medulla and sympathetic chemoreflex in the rat
-
8508301 10.1016/0006-8993(93)90871-J 1:CAS:528:DyaK3sXisFaht7s%3D
-
Koshiya N, Huangfu D, Guyenet PG. Ventrolateral medulla and sympathetic chemoreflex in the rat. Brain Res. 1993;609:174-84.
-
(1993)
Brain Res
, vol.609
, pp. 174-184
-
-
Koshiya, N.1
Huangfu, D.2
Guyenet, P.G.3
|