Key roles for AMP-activated protein kinase in the function of the carotid body?

Advances in Experimental Medicine and Biology

Volumn 605, Issue , 2008, Pages 63-68

  Wyatt, Christopher N ^a   Pearson, Selina A ^b   Kumar, Prem ^b   Peers, Chris ^c   Hardie, D Grahame ^d   Evans, A Mark ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; AMP ACTIVATED PROTEIN KINASES; AMP-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEX; PROTEIN SERINE THREONINE KINASE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; CAROTID BODY CHEMORECEPTOR; CONFERENCE PAPER; CONTROLLED STUDY; HYPOXIA; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; ANOXIA; ARTICLE; CAROTID BODY; ENZYMOLOGY; METABOLISM; MICROCIRCULATION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; CAROTID BODY; MICROCIRCULATION; MULTIENZYME COMPLEXES; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 38449112248     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-73693-8_11     Document Type: Conference Paper

References (29)

1. Buckler, K.J. (1997) A novel oxygen-sensitive potassium current in rat carotid body type I cells. J. Physiol. 498 (Pt. 3), 649-662.
2. Buckler, K.J. and Vaughan-Jones, R.D. (1994) Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J. Physiol. 476, 423-428.
3. Buckler, K.J. and Vaughan-Jones, R.D. (1998) Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells. J. Physiol. 513 (Pt. 3), 819-833.
4. Duchen, M.R. and Biscoe, T.J. (1992a) Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. J. Physiol. 450, 13-31.
5. +]i in type I cells isolated from the rabbit carotid body. J. Physiol. 450, 33-61.
6. 2-sensing cells? J. Biol. Chem. 280, 41504-41511.
7. Eyzaguirre, C., Koyano, H. and Taylor, J.R. (1965) Presence of acetylcholine and transmitter release from carotid body chemoreceptors. J. Physiol. 178, 463-476.
8. Fidone, S.J., Gonzalez, C., Dinger, B.G. and Hanson, G.R. (1988) Mechanisms of chemotransmission in the mammalian carotid body. Prog. Brain Res. 74, 169-179.
9. Hardie, D.G. (2004). The AMP-activated protein kinase pathway-new players upstream and downstream. J. Cell Sci. 117, 5479-5487.
10. Hescheler, J., Delpiano, M.A., Acker, H. and Pietruschka, F. (1989) Ionic currents on type-I cells of the rabbit carotid body measured by voltage-clamp experiments and the effect of hypoxia. Brain Res. 486, 79-88.
11. Hwang, J.T., Lee, M., Jung, S.N., Lee, H.J., Kang, I., Kim, S.S. and Ha, J. (2004) AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis 25, 2497-2507.
12. 2 in the cat carotid body chemotransduction. J. Appl. Physiol. 75, 1035-1043.
13. Lee, M., Hwang, J.T., Lee, H.J., Jung, S.N., Kang, I., Chi, S.G., Kim, S.S. and Ha, J. (2003) AMP- activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J. Biol. Chem. 278, 39653-39661.
14. Lopez-Barneo, J., Lopez-Lopez, J.R., Urena, J. and Gonzalez, C. (1988) Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells. Science 241, 580-582.
15. Mills, E. and Jobsis, F.F. (1970) Simultaneous measurement of cytochrome a3 reduction and chemoreceptor afferent activity in the carotid body. Nature 225, 1147-1149.
16. Mills, E. and Jobsis, F.F. (1972). Mitochondrial respiratory chain of carotid body and chemo-receptor response to changes in oxygen tension. J. Neurophysiol. 35, 405-428.
17. Mosqueira, M. and Iturriaga, R. (2002). Carotid body chemosensory excitation induced by nitric oxide: involvement of oxidative metabolism. Respir. Physiol. Neurobiol. 131, 175-187.
18. 2 chemoreception and mitochondrial oxidative phosphorylation. J. Appl. Physiol. 51, 438-446.
19. Peers, C. (1990) Hypoxic suppression of K+ currents in type I carotid body cells: selective effect on the Ca2(+)-activated K+ current. Neurosci. Lett. 119, 253-256.
20. 2 interaction in the rat carotid body in vitro. J. Physiol. 485 (Pt. 2), 531-541.
21. Perez-Garcia, M.T., Colinas, O., Miguel-Velado, E., Moreno-Dominguez, A. and Lopez-Lopez, J.R. (2004) Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing. J. Physiol. 557, 457-471.
22. Prabhakar, N.R., Peng, Y.J., Jacono, F.J., Kumar, G.K. and Dick, T.E. (2005) Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Clin. Exp. Pharmacol. Physiol. 32, 447-449.
23. Salt, I., Celler, J.W., Hawley, S.A., Prescott, A., Woods, A., Carling, D. and Hardie, D.G. (1998) AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem. J. 334 (Pt. 1), 177-187.
24. 2-sensitive rat carotid body cells grown in short- and long-term culture. Pflugers Arch. 418, 93-101.
25. Wyatt, C.N. and Buckler, K.J. (2004) The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells. J. Physiol. 556, 175-191.
26. Wyatt, C.N., Kumar, P., Aley, P., Peers, C., Hardie, D.G. and Evans, A.M. (2006a) Does AMP- activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? Adv. Exp. Med. Biol. 580, 191-196; discussion 351-199.
27. Wyatt, C.N., Mustard, K.J., Pearson, S.A., Dallas, M.L., Atkinson, L., Kumar, P., Peers, C., Hardie, D.G. and Evans, A.M. (2007) AMP-activated protein kinase mediates carotid body excitation by hypoxia. J. Biol. Chem. 282, 8092-8098.
28. Wyatt, C.N., Peers, C., Kumar, P., Hardie, D.G. and Evans, A.M. (2006b) The effect of AMP- kinase activators on oxygen-sensing type-I cells of the rat carotid body. British Journal of Pharmacology pA23, 049P.
29. 2-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction. Proc. Natl. Acad. Sci. USA 92, 295-299.