Carotid chemoreceptor modulation of blood flow during exercise in healthy humans

Journal of Physiology

Volumn 589, Issue 24, 2011, Pages 6219-6230

  Stickland, Michael K ^a,b   Fuhr, Desi P ^a   Haykowsky, Mark J ^a   Jones, Kelvin E ^a   Paterson, D Ian ^a   Ezekowitz, Justin A ^a   Mcmurtry, M Sean ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Centre for Lung Health Covenant Health   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE;

ADULT; ARTICLE; BLOOD PRESSURE; BREATHING; CAROTID BODY CHEMORECEPTOR; CONDUCTANCE; EXERCISE; FEMALE; FEMORAL ARTERY FLOW; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; MUSCLE BLOOD FLOW; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REST; SKELETAL MUSCLE; VASODILATATION;

ADULT; ANOXIA; BLOOD PRESSURE; CAROTID BODY; DOPAMINE; EXERCISE; FEMALE; FEMORAL ARTERY; HEART RATE; HUMANS; LEG; MALE; MUSCLE, SKELETAL; REGIONAL BLOOD FLOW; VASODILATION;

EID: 83455259405     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.218099     Document Type: Article

References (54)

1. Aggarwal D, Milhorn HT Jr & Lee LY (1976). Role of the carotid chemoreceptors in the hyperpnea of exercise in the cat. Respir Physiol 26, 147-155.
2. Balkowiec A, Revenko S & Szulczyk P (1993). Reflex carotid body chemoreceptor control of phrenic sympathetic neurons. Respir Physiol 92, 91-100.
3. Biscoe TJ & Purves MJ (1967). Factors affecting the cat carotid chemoreceptor and cervical sympathetic activity with special reference to passive hind-limb movements. J Physiol 190, 425-441.
4. Britton SL & Metting PJ (1999). Reflex regulation of skeletal muscle blood flow. In Reflex Control of the Circulation. ed. Zucker IH & Gilmore JP, pp. 736-764. CRC Press, Boca Raton
5. Buckwalter JB & Clifford PS (1999). α-Adrenergic vasoconstriction in active skeletal muscles during dynamic exercise. Am J Physiol Heart Circ Physiol 277, H33-H39.
6. Buckwalter JB & Clifford PS (2001). The paradox of sympathetic vasoconstriction in exercising skeletal muscle. Exerc Sport Sci Rev 29, 159-163.
7. Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD & Saltin B (2003). Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284, R291-R303.
8. Casey DP, Curry TB, Wilkins BW & Joyner MJ (2011a). Nitric oxide-mediated vasodilation becomes independent of β-adrenergic receptor activation with increased intensity of hypoxic exercise. J Appl Physiol 110, 687-694.
9. Casey DP, Joyner MJ, Claus PL & Curry TB (2011b). Hyperbaric hyperoxia reduces exercising forearm blood flow in humans. Am J Physiol Heart Circ Physiol 300, H1892-H1897.
10. Clark BJ & Menninger K (1980). Peripheral dopamine receptors. Circ Res 46, I59-I63.
11. Curran AK, Rodman JR, Eastwood PR, Henderson KS, Dempsey JA & Smith CA (2000). Ventilatory responses to specific CNS hypoxia in sleeping dogs. J Appl Physiol 88, 1840-1852.
12. Davies RO & Lahiri S (1973). Absence of carotid chemoreceptor response during hypoxic exercise in the cat. Respir Physiol 18, 92-100.
13. Dean JB, Mulkey DK, Henderson RA 3rd, Potter SJ & Putnam RW (2004). Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons. J Appl Physiol 96, 784-791.
14. 2 uptake, leg blood flow and muscle deoxygenation during single-leg knee-extension exercise. Exp Physiol 89, 293-302.
15. Dinenno FA, Joyner MJ & Halliwill JR (2003). Failure of systemic hypoxia to blunt α-adrenergic vasoconstriction in the human forearm. J Physiol 549, 985-994.
16. Forster HV, Dempsey JA, Vidruk E & Do Pico G (1974). Evidence of altered regulation of ventilation during exposure to hypoxia. Respir Physiol 20, 379-392.
17. Gilman AG, Goodman LS, Rall TW & Murad F (1985). Goodman and Gilman's The Pharmacological Basis of Therapeutics. Seventh Edition. Macmillan Publishing Company, New York
18. Goldberg LI (1989). The role of dopamine receptors in the treatment of congestive heart failure. J Cardiovasc Pharmacol 14, S19-S27.
19. Gonzalez-Alonso J, Olsen DB & Saltin B (2002). Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP. Circ Res 91, 1046-1055.
20. Guyenet PG (2000). Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol 121, 147-162.
21. Halliwill JR, Morgan BJ & Charkoudian N (2003). Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans. J Physiol 552, 295-302.
22. Hanada A, Sander M & Gonzalez-Alonso J (2003). Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise. J Physiol 551, 635-647.
23. Hansen J, Sander M, Hald CF, Victor RG & Thomas GD (2000). Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: role of tissue hypoxia. J Physiol 527, 387-396.
24. Hansen M & Madsen J (1973). Estimation of relative changes in resting muscle blood flow by 133Xe washout: the effect of oxygen. Scand J Clin Lab Invest 31, 133-139.
25. Heistad DD & Wheeler RC (1970). Effect of acute hypoxia on vascular responsiveness in man. I. Responsiveness to lower body negative pressure and ice on the forehead. II. Responses to norepinephrine and angiotensin. III. Effect of hypoxia and hypocapnia. J Clin Invest 49, 1252-1265.
26. Houssiere A, Najem B, Cuylits N, Cuypers S, Naeije R & Van De Borne P (2006). Hyperoxia enhances metaboreflex sensitivity during static exercise in humans. Am J Physiol Heart Circ Physiol 291, H210-H215.
27. 2 uptake in rhythmically contracting human forearm muscles. Am J PhysiolHeart Circ Physiol 263, H1078-H1083.
28. Koskolou MD, Calbet JA, Radegran G & Roach RC (1997). Hypoxia and the cardiovascular response to dynamic knee-extensor exercise. Am J PhysiolHeart Circ Physiol 272, H2655-H2663.
29. Lahiri S, Mokashi A, Mulligan E & Nishino T (1981). Comparison of aortic and carotid chemoreceptor responses to hypercapnia and hypoxia. J Appl Physiol 51, 55-61.
30. 2 chemoreception in carotid body. J Appl Physiol 49, 45-51.
31. Macdonald MJ, Shoemaker JK, Tschakovsky ME & Hughson RL (1998). Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J Appl Physiol 85, 1622-1628.
32. 2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain. J Appl Physiol 99, 1822-1834.
33. Olson EB Jr, Vidruk EH & Dempsey JA (1988). Carotid body excision significantly changes ventilatory control in awake rats. J Appl Physiol 64, 666-671.
34. Radegran G (1997). Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans. J Appl Physiol 83, 1383-1388.
35. Radegran G & Saltin B (1998). Muscle blood flow at onset of dynamic exercise in humans. Am J Physiol Heart Circ Physiol 274, H314-H322.
36. Reich T, Tuckman J, Naftchi NE & Jacobson JH (1970). Effect of normo- and hyperbaric oxygenation on resting and postexercise calf blood flow. J Appl Physiol 28, 275-278.
37. Remensnyder JP, Mitchell JH & Sarnoff SJ (1962). Functional sympatholysis during muscular activity. Observations on influence of carotid sinus on oxygen uptake. Circ Res 11, 370-380.
38. Rowell LB & O'leary DS (1990). Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes. J Appl Physiol 69, 407-418.
39. Rowell LB, Saltin B, Kiens B & Christensen NJ (1986). Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia? Am J Physiol Heart Circ Physiol 251, H1038-H1044.
40. Rutherford JD & Vatner SF (1978). Integrated carotid chemoreceptor and pulmonary inflation reflex control of peripheral vasoactivity in conscious dogs. Circ Res 43, 200-208.
41. Seals DR, Johnson DG & Fregosi RF (1991a). Hyperoxia lowers sympathetic activity at rest but not during exercise in humans. Am J Physiol Regul Integr Comp Physiol 260, R873-R878.
42. Seals DR, Johnson DG & Fregosi RF (1991b). Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J Appl Physiol 71, 1032-1040.
43. 2 chemoreflex drive of ventilation in man: effects of hyperoxia and sex differences. Respiration 57, 264-267.
44. Shoemaker JK, Herr MD & Sinoway LI (2000). Dissociation of muscle sympathetic nerve activity and leg vascular resistance in humans. Am J Physiol Heart Circ Physiol 279, H1215-H1219.
45. Solin P, Roebuck T, Johns DP, Walters EH & Naughton MT (2000). Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. Am J Respir Crit Care Med 162, 2194-2200.
46. Stickland MK, Miller JD, Smith CA & Dempsey JA (2007). Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure. Circ Res 100, 1371-1378.
47. Stickland MK, Morgan BJ & Dempsey JA (2008). Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans. J Physiol 586, 1743-1754.
48. Stickland MK, Smith CA, Soriano BJ & Dempsey JA (2009). Sympathetic restraint of muscle blood flow during hypoxic exercise. Am J Physiol Regul Integr Comp Physiol 296, R1538-R1546.
49. Sun MK & Reis DJ (1994). Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia. Prog Neurobiol 44, 197-219.
50. Weil JV, Byrne-Quinn E, Sodal IE, Kline JS, Mccullough RE & Filley GF (1972). Augmentation of chemosensitivity during mild exercise in normal man. J Appl Physiol 33, 813-819.
51. Weisbrod CJ, Minson CT, Joyner MJ & Halliwill JR (2001). Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. J Physiol 537, 613-621.
52. Welch HG, Bonde-Petersen F, Graham T, Klausen K & Secher N (1977). Effects of hyperoxia on leg blood flow and metabolism during exercise. J Appl Physiol 42, 385-390.
53. Wilkins BW, Schrage WG, Liu Z, Hancock KC & Joyner MJ (2006). Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle. J Appl Physiol 101, 1343-1350.
54. 2 on the susceptibility to posthyperventilation apnea during sleep. J Appl Physiol 100, 171-177.