A lactose-binding lectin from the marine sponge Cinachyrella Apion (cal) induces cell death in human cervical adenocarcinoma cells

Marine Drugs

Volumn 10, Issue 4, 2012, Pages 727-743

  Rabelo, Luciana ^a   Monteiro, Norberto ^a   Serquiz, Raphael ^a   Santos, Paula ^a   Oliveira, Ruth ^a   Oliveira, Adeliana ^a   Rocha, Hugo ^a   Morais, Ana Heloneida ^a   Uchoa, Adriana ^a   Santos, Elizeu ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

Author keywords

Antitumor; Cinachyrella apion; HeLa; Lectin; Marine sponge

Indexed keywords

LECTIN; NATURAL PRODUCT; PROTEIN BAX;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CINACHYRELLA APION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; SPONGE (PORIFERA); WESTERN BLOTTING;

ANIMALIA; CINACHYRELLA APION;

EID: 84860636921     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md10040727     Document Type: Article

References (42)

1. Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70. (Pubitemid 30046295)
2. Clardy, J.; Walsh, C. Lessons from natural molecules. Nature 2004, 432, 829-837. (Pubitemid 40037138)
3. Hatakeyama, T.; Nagatomo, H.; Yamasaki, N. Interaction of the hemolytic lectin CEL-III from the marine invertebrate Cucumaria echinata with the erythrocyte membrane. J. Biol. Chem. 1995, 270, 3560-3564.
4. Muta, T.; Miyata, T.; Misumi, Y.; Tokunaga, F.; Nakamura, T.; Toh, Y.; Ikehara, Y.; Iwanaga, S. Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains. J. Biol. Chem. 1991, 266, 6554-6561. (Pubitemid 21906253)
5. Takagi, T.; Nakamura, A.; Deguchi, R.; Kyozuka, K. Isolation, characterization, and primary structure of three major proteins obtained from Mytilus edulis sperm. J. Biochem. 1994, 116, 598-605. (Pubitemid 24294788)
6. Giga, Y.; Ikai, A.; Takahashi, K. The complete amino acid sequence of echinoidin, a lectin from the coelomic fluid of the sea urchin Anthocidaris crassispina. Homologies with mammalian and insect lectins. J. Biol. Chem. 1987, 262, 6197-6203.
7. Atta, A.M.; Barralnetto, M.; Peixinho, S.; Sousaatta, M.L.B. Isolation and functional-characterization of a mitogenic lectin from the marine sponge cinachyrella-alloclada. Braz. J. Med. Biol. Res. 1989, 22, 379-385.
8. Bretting, H.; Donadey, C.; Vacelet, J.; Jacobs, G. Investigations on the occurrence of lectins in marine sponges with special regard to some species of the family axinellidae. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 1981, 70, 69-76.
9. Engel, M.; Bachmann, M.; Schroder, H.C.; Rinkevich, B.; Kljajic, Z.; Uhlenbruck, G.; Muller, W.E.G. A novel galactose-specific and arabinose-specific lectin from the sponge pellina-semitubulosa - Isolation, characterization and immunobiological properties. Biochimie 1992, 74, 527-537.
10. Pajic, I.; Kljajic, Z.; Dogovic, N.; Sladic, D.; Juranic, Z.; Gasic, M.J. A novel lectin from the sponge Haliclona cratera: Isolation, characterization and biological activity. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2002, 132, 213-221. (Pubitemid 34775065)
11. Xiong, C.N.; Li, W.; Liu, H.; Zhang, W.; Dou, J.L.; Bai, X.F.; Du, Y.G.; Ma, X.J. A normal mucin-binding lectin from the sponge Craniella australiensis. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2006, 143, 9-16.
12. Queiroz, A.F.S.; Silva, R.A.; Moura, R.M.; Dreyfuss, J.L.; Paredes-Gamero, E.J.; Souza, A.C.S.; Tersariol, I.L.S.; Santos, E.A.; Nader, H.B.; Justo, G.Z.; et al. Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells. Cancer Chemother. Pharmacol. 2009, 63, 1023-1033.
13. Renan, M.J. How many mutations are required for tumorigenesis? Implications from human cancer data. Mol. Carcinog. 1993, 7, 139-146. (Pubitemid 23161701)
14. Green, D.R.; Kroemer, G. Pharmacological manipulation of cell death: Clinical applications in sight? J. Clin. Investig. 2005, 115, 2610-2617. (Pubitemid 41434383)
15. Newman, D.J.; Cragg, G.M. Natural products from marine invertebrates and microbes as modulators of antitumor targets. Curr. Drug Targets 2006, 7, 279-304. (Pubitemid 43744847)
16. Ferreira, C.V.; Justo, G.Z.; Souza, A.C.; Queiroz, K.C.; Zambuzzi, W.F.; Aoyama, H.; Peppelenbosch, M.P. Natural compounds as a source of protein tyrosine phosphatase inhibitors: Application to the rational design of small-molecule derivatives. Biochimie 2006, 88, 1859-1873. (Pubitemid 44881192)
17. Strohl, W.R. The role of natural products in a modern drug discovery program. Drug Discov. Today 2000, 5, 39-41. (Pubitemid 30084700)
18. Justo, G.Z.; Ferreira, C.V. Coagulation and cancer therapy: The potential of natural compounds. Curr. Genomics 2005, 6, 461-469. (Pubitemid 41671665)
19. Bantel, H.; Engels, I.H.; Voelter, W.; Schulze-Osthoff, K.; Wesselborg, S. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res. 1999, 59, 2083-2090. (Pubitemid 29217669)
20. Hajto, T.; Hostanska, K.; Berki, T.; Palinkas, L.; Boldizsar, F.; Nemeth, P. Oncopharmacological perspectives of a plant lectin (viscum album agglutinin-I): Overview of recent results from in vitro experiments and in vivo animal models, and their possible relevance for clinical applications. Evid. Based Complement. Alternat. Med. 2005, 2, 59-67. (Pubitemid 41399515)
21. Kim, Y.A.; Lee, W.H.; Choi, T.H.; Rhee, S.H.; Park, K.Y.; Choi, Y.H. Involvement of p21WAF1/CIP1, pRB, Bax and NF-κB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells. Int. J. Oncol. 2003, 23, 1143-1149.
22. Lavastre, V.; Pelletier, M.; Saller, R.; Hostanska, K.; Girard, D. Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases. J. Immunol. 2002, 168, 1419-1427. (Pubitemid 34094514)
23. Miyoshi, N.; Koyama, Y.; Katsuno, Y.; Hayakawa, S.; Mita, T.; Ohta, T.; Kaji, K.; Isemura, M. Apoptosis induction associated with cell cycle dysregulation by rice bran agglutinin. J. Biochem. 2001, 130, 799-805. (Pubitemid 34024130)
24. Ohba, H.; Moriwaki, S.; Bakalova, R.; Yasuda, S.; Yamasaki, N. Plant-derived abrin-a induces apoptosis in cultured leukemic cell lines by different mechanisms. Toxicol. Appl. Pharmacol. 2004, 195, 182-193. (Pubitemid 38293150)
25. Park, R.; Kim, M.S.; So, H.S.; Jung, B.H.; Moon, S.R.; Chung, S.Y.; Ko, C.B.; Kim, B.R.; Chung, H.T. Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells. Biochem. Pharmacol. 2000, 60, 1685-1691.
26. Rao, P.V.; Jayaraj, R.; Bhaskar, A.S.; Kumar, O.; Bhattacharya, R.; Saxena, P.; Dash, P.K.; Vijayaraghavan, R. Mechanism of ricin-induced apoptosis in human cervical cancer cells. Biochem. Pharmacol. 2005, 69, 855-865. (Pubitemid 40248627)
27. Medeiros, D.S.; Medeiros, T.L.; Ribeiro, J.K.; Monteiro, N.K.; Migliolo, L.; Uchoa, A.F.; Vasconcelos, I.M.; Oliveira, A.S.; de Sales, M.P.; Santos, E.A. A lactose specific lectin from the sponge Cinachyrella apion: Purification, characterization, N-terminal sequences alignment and agglutinating activity on Leishmania promastigotes. Comp. Biochem. Physiol. 2010, 155, 211-216.
28. Zhao, C.; Sun, H.; Tong, X.; Qi, Y. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem. J. 2003, 374, 321-327. (Pubitemid 37094091)
29. Yan, Z.; Hang, D.; Guo, C.; Chen, Z. Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J. Orthop. Res. 2009, 27, 442-446.
30. Ren, R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat. Rev. Cancer 2005, 5, 172-183. (Pubitemid 40314949)
31. Priyadarsini, R.V.; Murugan, R.S.; Maitreyi, S.; Ramalingam, K.; Karunagaran, D.; Nagini, S. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur. J. Pharmacol. 2010, 649, 84-91.
32. Ogden, C.A.; deCathelineau, A.; Hoffmann, P.R.; Bratton, D.; Ghebrehiwet, B.; Fadok, V.A.; Henson, P.M. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 2001, 194, 781-795. (Pubitemid 32983014)
33. Hadari, Y.R.; Arbel-Goren, R.; Levy, Y.; Amsterdam, A.; Alon, R.; Zakut, R.; Zick, Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. J. Cell Sci. 2000, 113, 2385-2397. (Pubitemid 30599342)
34. Schwarz, R.E.; Wojciechowicz, D.C.; Picon, A.I.; Schwarz, M.A.; Paty, P.B. Wheatgerm agglutinin-mediated toxicity in pancreatic cancer cells. Br. J. Cancer 1999, 80, 1754-1762. (Pubitemid 29389628)
35. Kessel, D.; Luo, Y. Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis. Cancer Lett. 2000, 151, 25-29. (Pubitemid 30155581)
36. Liua, W.; Ho, J.C.; Ng, T. Suppression of cell cycle progression by a fungal lectin: Activation of cyclin-dependent kinase inhibitors. Biochem. Pharmacol. 2001, 61, 33-37. (Pubitemid 32013051)
37. Lin, S.Y.; Lai, W.W.; Chou, C.C.; Kuo, H.M.; Li, T.M.; Chung, J.G.; Yang, J.H. Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells. Melanoma Res. 2006, 16, 509-519.
38. Fuke, H.; Shiraki, K.; Sugimoto, K.; Tanaka, J.; Beppu, T.; Yoneda, K.; Yamamoto, N.; Ito, K.; Masuya, M.; Takei, Y. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochem. Biophys. Res. Commun. 2007, 363, 738-744. (Pubitemid 47513692)
39. FlowJo, version 7.6.3; Tree Star, Inc.: Ashland, OR, USA 1997.
40. Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227, 680-685.
41. Ferreira, C.V.; Bos, C.L.; Versteeg, H.H.; Justo, G.Z.; Duran, N.; Peppelenbosch, M.P. Molecular mechanism of violacein-mediated human leukemia cell death. Blood 2004, 104, 1459-1464. (Pubitemid 39166525)
42. GraphPad InStat, version 3.05 for Windows; GraphPad Software: San Diego, CA, USA, 2000.