Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in adriamycin-resistant human breast cancer cells

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33289-33300

  Kanagasabai, Ragu ^a   Krishnamurthy, Karthikeyan ^a   Druhan, Lawrence J ^b   Ilangovan, Govindasamy ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRIAMYCIN; ATP-BINDING CASSETTE; BREAST CANCER; DNA BINDING ACTIVITY; DOXORUBICIN; DRUG RESISTANCE; ECTOPIC EXPRESSIONS; GAIN-OF FUNCTION; HEAT SHOCK PROTEIN; HEAT-SHOCK FACTOR 1; HUMAN BREAST CANCER CELLS; MCF-7 CELLS; MULTIDRUG RESISTANCE; NUCLEAR FACTORS; OVER-EXPRESSION; P-GLYCOPROTEIN; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL ACTIVITY; TRANSCRIPTIONALLY ACTIVE;

CELL DEATH; DISEASES; GLYCOPROTEINS; HEAT RESISTANCE; PROTEINS;

GENE EXPRESSION;

DOXORUBICIN; HEAT SHOCK PROTEIN 27; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN P53;

APOPTOSIS; ARTICLE; BIOACCUMULATION; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; GAIN OF FUNCTION MUTATION; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MDR1 GENE; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HSP27 HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR SPACE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTANT PROTEINS; NF-KAPPA B; P-GLYCOPROTEIN; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80053018877     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.249102     Document Type: Article

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