IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophages

Biochemical and Biophysical Research Communications

Volumn 419, Issue 4, 2012, Pages 748-753

  Li, Yan ^a,b   Ohms, Stephen J ^b   Shannon, Frances M ^b,c   Sun, Chao ^a   Fan, Jun Y ^b  

^a NORTHWEST A F UNIVERSITY   (China)

^b Australian National University   (Australia)

^c UNIVERSITY OF CANBERRA   (Australia)

Author keywords

Cell activation; Cytokine expression; DNA demethylation; Immune cells

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; DNA METHYLATION; GENE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSCRIPTION INITIATION;

ANIMALS; B-LYMPHOCYTES; CELL LINE; DNA METHYLATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; T-LYMPHOCYTES;

EID: 84862780150     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.094     Document Type: Article

References (45)

1. Grolleau-Julius A., Ray D., Yung R.L. The role of epigenetics in aging and autoimmunity. Clin. Rev. Allergy Immunol. 2010, 39:42-50.
2. Zheng Y., Josefowicz S., Chaudhry A., et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
3. Murayama A., Sakura K., Nakama M., et al. A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J. 2006, 25:1081-1092.
4. Campanero M.R., Armstrong M.I., Flemington E.K. CpG methylation as a mechanism for the regulation of E2F activity. Proc. Natl. Acad. Sci. 2000, 97:6481-6486.
5. Iguchi-Ariga S.M., Schaffner W. CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev. 1989, 3:612-619.
6. Fuks F., Hurd P.J., Wolf D., et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem. 2003, 278:4035-4040.
7. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16:6-21.
8. Wade P.A., Gegonne A., Jones P.L., et al. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat. Genet. 1999, 23:62-66.
9. Morgan H.D., Santos F., Green K., et al. Epigenetic reprogramming in mammals. Hum. Mol. Genet. 2005, 14:R47-R58.
10. Feng S., Jacobsen S.E., Reik W. Epigenetic reprogramming in plant and animal development. Science 2010, 330:622-627.
11. Reik W., Dean W., Walter J. Epigenetic reprogramming in mammalian development. Science 2001, 293:1089-1093.
12. Law J.A., Jacobsen S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat. Rev. Genet. 2010, 11:204-220.
13. Goll M.G., Bestor T.H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 2005, 74:481-514.
14. Riggs A.D. X-inactivation, differentiation, and DNA methylation. Cytogenet. Cell Genet. 1975, 14:9-25.
15. Bird A.P. Use of restriction enzymes to study eukaryotic DNA methylation. 2. Symmetry of methylated sites supports semi-conservative copying of methylation pattern. J. Mol. Biol. 1978, 118:49-60.
16. Holliday R., Pugh J.E. DNA modification mechanisms and gene activity during development. Science 1975, 187:226-232.
17. Okano M., Bell D.W., Haber D.A., et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257.
18. Zhu J.-K. Active DNA Demethylation Mediated by DNA Glycosylases. Annu. Rev. Genet. 2009, 43:143-166.
19. Niehrs C. Active DNA demethylation and DNA repair. Differentiation 2009, 77:1-11.
20. Ma D.K., Guo J.U., Ming G.L., et al. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle 2009, 8:1526-1531.
21. Gehring M., Reik W., Henikoff S. DNA demethylation by DNA repair. Trends Genet. 2009, 25:82-90.
22. Kapoor A., Agius F., Zhu J.-K. Preventing transcriptional gene silencing by active DNA demethylation. FEBS Lett. 2005, 579:5889-5898.
23. Ma D.K., Jang M.-H., Guo J.U., et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 2009, 323:1074-1077.
24. Rai K., Huggins I.J., James S.R., et al. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 2008, 135:1201-1212.
25. Ito S., D'Alessio A.C., Taranova O.V., et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010, 466:1129-1133.
26. Nebert D.W., Galvez-Peralta M., Shi Z., et al. Inbreeding and epigenetics: beneficial as well as deleterious effects. Nat. Rev. Genet. 2010, 11:662.
27. Smith K. Interleukin-2: inception, impact, and implications. Science 1988, 240:1169-1176.
28. Smith K.A., Lachman L.B., Oppenheim J.J., et al. The functional relationship of the interleukins. J. Exp. Med. 1980, 151:1551-1556.
29. Hamilton J.A., Anderson G.P. GM-CSF Biology. Growth Factors 2004, 22:225-231.
30. Lister R., Pelizzola M., Dowen R.H., et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009, 462:315-322.
31. Kobayashi H., Sakurai T., Imai M., et al. Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet. 2012, 8:e1002440.
32. M. Tahiliani, K.P. Koh, Y. Shen, et al., Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by the MLL fusion partner TET1, Science (2009) 1170116.
33. Bruniquel D., Schwartz R.H. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol. 2003, 4:235-240.
34. Santangelo S., Cousins D.J., Triantaphyllopoulos K., et al. Chromatin structure and DNA methylation of the IL-4 gene in human T(H)2 cells. Chromosome Res. 2009, 17:485-496.
35. Makar K.W., Perez-Melgosa M., Shnyreva M., et al. Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells. Nat. Immunol. 2003, 4:1183-1190.
36. Winders B.R., Schwartz R.H., Bruniquel D. A distinct region of the murine IFN-γ promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J. Immunol. 2004, 173:7377-7384.
37. Yano S., Ghosh P., Kusaba H., et al. Effect of promoter methylation on the regulation of IFN-γ gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J. Immunol. 2003, 171:2510-2516.
38. Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007, 447:425-432.
39. + T cells from patients with systemic lupus erythematosus. Immunology 2008, 124:339-347.
40. + lupus T cells. J. Immunol. 2004, 172:3652-3661.
41. Zhang Z., Deng C., Lu Q., et al. Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter. Mech. Ageing Develop. 2002, 123:1257-1268.
42. Yang J., Zhu H., Murphy T.L., et al. IL-18-stimulated GADD45[beta] required in cytokine-induced, but not TCR-induced, IFN-[gamma] production. Nat. Immunol. 2001, 2:157-164.
43. Lu B., Ferrandino A.F., Flavell R.A. Gadd45[beta] is important for perpetuating cognate and inflammatory signals in T cells. Nat. Immunol. 2004, 5:38-44.
44. 3 mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 2001, 14:583-590.
45. Cimmino L., Abdel-Wahab O., Levine Ross L., et al. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell 2011, 9:193-204.