Disturbed Th1, Th2, Th17 and T reg balance in patients with systemic lupus erythematosus

Clinical Immunology

Volumn 141, Issue 2, 2011, Pages 197-204

  Dolff, Sebastian ^a,b   Bijl, Marc ^a   Huitema, Minke G ^a   Limburg, Pieter C ^a   Kallenberg, Cees G M ^a   Abdulahad, Wayel H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

IL 17; Regulatory T cells; SLE; T helper cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ADULT; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HOMEOSTASIS; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-4; INTRACELLULAR FLUID; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TH2 CELLS;

EID: 80054841791     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2011.08.005     Document Type: Article

References (28)

1. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793.
2. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005, 6:345-352.
3. Abdulahad W.H., Stegeman C.A., van der Geld Y.M., Doornbos-van der Meer B., Limburg P.C., Kallenberg C.G. Functional defect of circulating regulatory CD4+ T cells in patients with Wegener's granulomatosis in remission. Arthritis Rheum. 2007, 56:2080-2091.
4. Abdulahad W.H., Stegeman C.A., Limburg P.C., Kallenberg C.G. Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission. Arthritis Rheum. 2008, 58:2196-2205.
5. van Amelsfort J.M., van Roon J.A., Noordegraaf M., Jacobs K.M., Bijlsma J.W., Lafeber F.P., Taams L.S. Proinflammatory mediator-induced reversal of CD4+, CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum. 2007, 56:732-742.
6. Venken K., Hellings N., Broekmans T., Hensen K., Rummens J.L., Stinissen P. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J. Immunol. 2008, 180:6411-6420.
7. Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., Nochy D., Debre P., Piette J.C., Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J. Immunol. 2005, 175:8392-8400.
8. Valencia X., Yarboro C., Illei G., Lipsky P.E. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 2007, 178:2579-2588.
9. Stockinger B., Veldhoen M. Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 2007, 19:281-286.
10. Wong C.K., Lit L.C., Tam L.S., Li E.K., Wong P.T., Lam C.W. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin. Immunol. 2008, 127:385-393.
11. Yang J., Chu Y., Yang X., Gao D., Zhu L., Yang X., Wan L., Li M. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 2009, 60:1472-1483.
12. Viallard J.F., Pellegrin J.L., Ranchin V., Schaeverbeke T., Dehais J., Longy-Boursier M., Ragnaud J.M., Leng B., Moreau J.F. Th1 (IL-2, interferon-gamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). Clin. Exp. Immunol. 1999, 115:189-195.
13. Bonelli M., von Dalwigk K., Savitskaya A., Smolen J.S., Scheinecker C. Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis. Ann. Rheum. Dis. 2008, 67:664-671.
14. Crispin J.C., Martinez A., Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J. Autoimmun. 2003, 21:273-276.
15. Koenen H.J., Smeets R.L., Vink P.M., van Rijssen E., Boots A.M., Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008, 112:2340-2352.
16. Voo K.S., Wang Y.H., Santori F.R., Boggiano C., Wang Y.H., Arima K., Bover L., Hanabuchi S., Khalili J., Marinova E., Zheng B., Littman D.R., Liu Y.J. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc. Natl. Acad. Sci. U S A 2009, 106:4793-4798.
17. Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997, 40:1725.
18. Hagiwara E., Gourley M.F., Lee S., Klinman D.K. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood. Arthritis Rheum. 1996, 39:379-385.
19. Lit L.C., Wong C.K., Li E.K., Tam L.S., Lam C.W., Lo Y.M. Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus. J. Rheumatol. 2007, 34:89-96.
20. Zhang Z., Kyttaris V.C., Tsokos G.C. The role of IL-23/IL-17 axis in lupus nephritis. J. Immunol. 2009, 183:3160-3169.
21. Steinmetz O.M., Turner J.E., Paust H.J., Lindner M., Peters A., Heiss K., Velden J., Hopfer H., Fehr S., Krieger T., Meyer-Schwesinger C., Meyer T.N., Helmchen U., Mittrucker H.W., Stahl R.A., Panzer U. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J. Immunol. 2009, 183:4693-4704.
22. Crispin J.C., Oukka M., Bayliss G., Cohen R.A., Van Beek C.A., Stillman I.E., Kyttaris V.C., Juang Y.T., Tsokos G.C. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 2008, 181:8761-8766.
23. Crispin J.C., Tsokos G.C. Human TCR-alpha beta+CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J. Immunol. 2009, 183:4675-4681.
24. Shah K., Lee W.W., Lee S.H., Kim S.H., Kang S.W., Craft J., Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res. Ther. 2010, 12:R53.
25. Wang Y., Ito S., Chino Y., Goto D., Matsumoto I., Murata H., Tsutsumi A., Hayashi T., Uchida K., Usui J., Yamagata K., Sumida T. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin. Exp. Immunol. 2010, 159:1-10.
26. Doreau A., Belot A., Bastid J., Riche B., Trescol-Biemont M.C., Ranchin B., Fabien N., Cochat P., Pouteil-Noble C., Trolliet P., Durieu I., Tebib J., Kassai B., Ansieau S., Puisieux A., Eliaou J.F., Bonnefoy-Berard N. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 2009, 10:778-785.
27. de Leeuw K., Freire B., Smit A.J., Bootsma H., Kallenberg C.G., Bijl M. Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus. Lupus 2006, 15:675-682.
28. Luczynski W., Statsiak-Barmuta A., Juchniewicz A., Wawrusiewicz-Kuurylonek N., Ilendo Elzbieta, Kos J., Kretowski A., Gorska M., Chyczewski L., Bossowski A. The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes. Folia Histochem Cytobiol. 2010, 48:93-100.