메뉴 건너뛰기




Volumn 82, Issue 9, 2012, Pages 969-979

Kidney-infiltrating CD4 T-cell clones promote nephritis in lupus-prone mice

Author keywords

glomerulonephritis; immunology and pathology; lupus nephritis

Indexed keywords

DNA ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE 2ALPHA; MIXED LINEAGE KINASE 2BETA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 84867512198     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.242     Document Type: Article
Times cited : (58)

References (46)
  • 1
    • 0037144519 scopus 로고    scopus 로고
    • Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    • William J, Euler C, Christensen S. et al. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002; 297: 2066-2070
    • (2002) Science , vol.297 , pp. 2066-2070
    • William, J.1    Euler, C.2    Christensen, S.3
  • 2
    • 21544463136 scopus 로고    scopus 로고
    • The evolution of human antidouble-stranded DNA autoantibodies
    • Wellmann U, Letz M, Herrmann M. et al. The evolution of human antidouble-stranded DNA autoantibodies. Proc Natl Acad Sci USA 2005; 102: 9258-9263
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9258-9263
    • Wellmann, U.1    Letz, M.2    Herrmann, M.3
  • 3
    • 0027477318 scopus 로고
    • Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan C, Adams S, Stanik V. et al. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 1993; 177: 1367-1381
    • (1993) J Exp Med , vol.177 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3
  • 4
    • 27144519105 scopus 로고    scopus 로고
    • Selective modulation of CD4+ T cells from lupus patients by a promiscuous, protective peptide analog
    • Monneaux F, Hoebeke J, Sordet C. et al. Selective modulation of CD4+ T cells from lupus patients by a promiscuous, protective peptide analog. J Immunol 2005; 175: 5839-5847
    • (2005) J Immunol , vol.175 , pp. 5839-5847
    • Monneaux, F.1    Hoebeke, J.2    Sordet, C.3
  • 5
    • 0032907825 scopus 로고    scopus 로고
    • T cell receptor beta-chain third complementarity-determining region gene usage is highly restricted among Sm-B autoantigen-specific human T cell clones derived from patients with connective tissue disease
    • Talken BL, Holyst MM, Lee DR. et al. T cell receptor beta-chain third complementarity-determining region gene usage is highly restricted among Sm-B autoantigen-specific human T cell clones derived from patients with connective tissue disease. Arthritis Rheum 1999; 42: 703-709
    • (1999) Arthritis Rheum , vol.42 , pp. 703-709
    • Talken, B.L.1    Holyst, M.M.2    Lee, D.R.3
  • 6
    • 0026343952 scopus 로고
    • Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: Possible selection by cationic autoantigens
    • Adams S, Leblanc P, Datta SK. Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens. Proc Natl Acad Sci USA 1991; 88: 11271-11275
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11271-11275
    • Adams, S.1    Leblanc, P.2    Datta, S.K.3
  • 7
    • 69549106587 scopus 로고    scopus 로고
    • Pathogenesis of kidney disease in systemic lupus erythematosus
    • Bagavant H, Fu SM. Pathogenesis of kidney disease in systemic lupus erythematosus. Curr Opin Rheumatol 2009; 21: 489-494
    • (2009) Curr Opin Rheumatol , vol.21 , pp. 489-494
    • Bagavant, H.1    Fu, S.M.2
  • 8
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan OT, Hannum LG, Haberman AM. et al. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999; 189: 1639-1648
    • (1999) J Exp Med , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3
  • 9
    • 0037868032 scopus 로고    scopus 로고
    • Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition
    • Schiffer L, Sinha J, Wang X. et al. Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. J Immunol 2003; 171: 489-497
    • (2003) J Immunol , vol.171 , pp. 489-497
    • Schiffer, L.1    Sinha, J.2    Wang, X.3
  • 10
    • 33751554877 scopus 로고    scopus 로고
    • Role for nephritogenic T cells in lupus glomerulonephritis: Progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes
    • Bagavant H, Deshmukh US, Wang H. et al. Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes. J Immunol 2006; 177: 8258-8265
    • (2006) J Immunol , vol.177 , pp. 8258-8265
    • Bagavant, H.1    Deshmukh, U.S.2    Wang, H.3
  • 11
    • 0031155269 scopus 로고    scopus 로고
    • IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice
    • Haas C, Ryffel B, Le Hir M. IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J Immunol 1997; 158: 5484-5491
    • (1997) J Immunol , vol.158 , pp. 5484-5491
    • Haas, C.1    Ryffel, B.2    Le Hir, M.3
  • 12
    • 0032518439 scopus 로고    scopus 로고
    • Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
    • Balomenos D, Rumold R, Theofilopoulos AN. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 1998; 101: 364-371
    • (1998) J Clin Invest , vol.101 , pp. 364-371
    • Balomenos, D.1    Rumold, R.2    Theofilopoulos, A.N.3
  • 13
    • 0031831859 scopus 로고    scopus 로고
    • IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice
    • Schwarting A, Wada T, Kinoshita K. et al. IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice. J Immunol 1998; 161: 494-503
    • (1998) J Immunol , vol.161 , pp. 494-503
    • Schwarting, A.1    Wada, T.2    Kinoshita, K.3
  • 14
    • 0023571873 scopus 로고
    • In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon
    • Jacob CO, van der Meide PH, McDevitt HO. In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med 1987; 166: 798-803
    • (1987) J Exp Med , vol.166 , pp. 798-803
    • Jacob, C.O.1    Van Der Meide, P.H.2    McDevitt, H.O.3
  • 15
    • 0028963222 scopus 로고
    • Experimental therapy of systemic lupus erythematosus: The treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis
    • Ozmen L, Roman D, Fountoulakis M. et al. Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis. Eur J Immunol 1995; 25: 6-12
    • (1995) Eur J Immunol , vol.25 , pp. 6-12
    • Ozmen, L.1    Roman, D.2    Fountoulakis, M.3
  • 16
    • 0033509042 scopus 로고    scopus 로고
    • Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus
    • Akahoshi M, Nakashima H, Tanaka Y. et al. Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum 1999; 42: 1644-1648
    • (1999) Arthritis Rheum , vol.42 , pp. 1644-1648
    • Akahoshi, M.1    Nakashima, H.2    Tanaka, Y.3
  • 17
    • 0038038551 scopus 로고    scopus 로고
    • Predominance of Th1 immune response in diffuse proliferative lupus nephritis
    • Masutani K, Akahoshi M, Tsuruya K. et al. Predominance of Th1 immune response in diffuse proliferative lupus nephritis. Arthritis Rheum 2001; 44: 2097-2106
    • (2001) Arthritis Rheum , vol.44 , pp. 2097-2106
    • Masutani, K.1    Akahoshi, M.2    Tsuruya, K.3
  • 18
    • 0032784571 scopus 로고    scopus 로고
    • The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus
    • Nakashima H, Inoue H, Akahoshi M. et al. The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus. FEBS Lett 1999; 453: 187-190
    • (1999) FEBS Lett , vol.453 , pp. 187-190
    • Nakashima, H.1    Inoue, H.2    Akahoshi, M.3
  • 19
    • 0036264279 scopus 로고    scopus 로고
    • Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritis
    • Miyake K, Nakashima H, Akahoshi M. et al. Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritis. Rheumatology (Oxford) 2002; 41: 518-524
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 518-524
    • Miyake, K.1    Nakashima, H.2    Akahoshi, M.3
  • 20
    • 0032445491 scopus 로고    scopus 로고
    • CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
    • Azzam HS, Grinberg A, Lui K. et al. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med 1998; 188: 2301-2311
    • (1998) J Exp Med , vol.188 , pp. 2301-2311
    • Azzam, H.S.1    Grinberg, A.2    Lui, K.3
  • 21
    • 0037460071 scopus 로고    scopus 로고
    • Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells
    • Kassiotis G, Zamoyska R, Stockinger B. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med 2003; 197: 1007-1016
    • (2003) J Exp Med , vol.197 , pp. 1007-1016
    • Kassiotis, G.1    Zamoyska, R.2    Stockinger, B.3
  • 22
    • 33745247205 scopus 로고    scopus 로고
    • Impact of effector cell differentiation on CD4+ T cells that evade negative selection by a self-peptide
    • Boesteanu A, Rankin AL, Caton AJ. Impact of effector cell differentiation on CD4+ T cells that evade negative selection by a self-peptide. Int Immunol 2006; 18: 1017-1027
    • (2006) Int Immunol , vol.18 , pp. 1017-1027
    • Boesteanu, A.1    Rankin, A.L.2    Caton, A.J.3
  • 23
    • 0024442946 scopus 로고
    • Activators of protein kinase C upregulate the cell surface expression of CD2 and CD5 T cell glycoproteins
    • Carrera AC, Cardenas L, Tugores A. et al. Activators of protein kinase C upregulate the cell surface expression of CD2 and CD5 T cell glycoproteins. J Biol Chem 1989; 264: 15650-15655
    • (1989) J Biol Chem , vol.264 , pp. 15650-15655
    • Carrera, A.C.1    Cardenas, L.2    Tugores, A.3
  • 24
    • 0025111830 scopus 로고
    • Protein kinase C-dependent up-regulation of CD5 surface expression on normal and lymphoblastoid T cells
    • Lozano F, Alberola-Ila J, Places L. et al. Protein kinase C-dependent up-regulation of CD5 surface expression on normal and lymphoblastoid T cells. Immunology 1990; 70: 434-439
    • (1990) Immunology , vol.70 , pp. 434-439
    • Lozano, F.1    Alberola-Ila, J.2    Places, L.3
  • 25
    • 0026526513 scopus 로고
    • Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis
    • Yamamoto K, Sakoda H, Nakajima T. et al. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int Immunol 1992; 4: 1219-1223
    • (1992) Int Immunol , vol.4 , pp. 1219-1223
    • Yamamoto, K.1    Sakoda, H.2    Nakajima, T.3
  • 26
    • 0042134777 scopus 로고    scopus 로고
    • Reconstitution of CD8+ T cells by retroviral transfer of the TCR alpha beta-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte
    • Tahara H, Fujio K, Araki Y. et al. Reconstitution of CD8+ T cells by retroviral transfer of the TCR alpha beta-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte. J Immunol 2003; 171: 2154-2160
    • (2003) J Immunol , vol.171 , pp. 2154-2160
    • Tahara, H.1    Fujio, K.2    Araki, Y.3
  • 27
    • 80054020840 scopus 로고    scopus 로고
    • Peripheral education of the immune system by colonic commensal microbiota
    • Lathrop SK, Bloom SM, Rao SM. et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 2011; 478: 250-254
    • (2011) Nature , vol.478 , pp. 250-254
    • Lathrop, S.K.1    Bloom, S.M.2    Rao, S.M.3
  • 28
    • 3242805018 scopus 로고    scopus 로고
    • Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease
    • Fujio K, Okamoto A, Tahara H. et al. Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease. J Immunol 2004; 173: 2118-2125
    • (2004) J Immunol , vol.173 , pp. 2118-2125
    • Fujio, K.1    Okamoto, A.2    Tahara, H.3
  • 29
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-969
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 30
    • 0037378016 scopus 로고    scopus 로고
    • IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology
    • Kikawada E, Lenda DM, Kelley VR. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 2003; 170: 3915-3925
    • (2003) J Immunol , vol.170 , pp. 3915-3925
    • Kikawada, E.1    Lenda, D.M.2    Kelley, V.R.3
  • 31
    • 0033402848 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice
    • Tesch GH, Maifert S, Schwarting A. et al. Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice. J Exp Med 1999; 190: 1813-1824
    • (1999) J Exp Med , vol.190 , pp. 1813-1824
    • Tesch, G.H.1    Maifert, S.2    Schwarting, A.3
  • 32
    • 1642458745 scopus 로고    scopus 로고
    • The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis
    • Kawakami N, Lassmann S, Li Z. et al. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med 2004; 199: 185-197
    • (2004) J Exp Med , vol.199 , pp. 185-197
    • Kawakami, N.1    Lassmann, S.2    Li, Z.3
  • 33
    • 0025720780 scopus 로고
    • Interferon-gamma transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes
    • Cassatella MA, Bazzoni F, Calzetti F. et al. Interferon-gamma transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes. J Biol Chem 1991; 266: 22079-22082
    • (1991) J Biol Chem , vol.266 , pp. 22079-22082
    • Cassatella, M.A.1    Bazzoni, F.2    Calzetti, F.3
  • 34
    • 0025721125 scopus 로고
    • Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: Conserved complementarity determining region 3
    • Gold DP, Offner H, Sun D. et al. Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med 1991; 174: 1467-1476
    • (1991) J Exp Med , vol.174 , pp. 1467-1476
    • Gold, D.P.1    Offner, H.2    Sun, D.3
  • 35
    • 0027523064 scopus 로고
    • Characterization of the T cell receptor repertoire causing collagen arthritis in mice
    • Osman GE, Toda M, Kanagawa O. et al. Characterization of the T cell receptor repertoire causing collagen arthritis in mice. J Exp Med 1993; 177: 387-395
    • (1993) J Exp Med , vol.177 , pp. 387-395
    • Osman, G.E.1    Toda, M.2    Kanagawa, O.3
  • 36
    • 0035003202 scopus 로고    scopus 로고
    • Antigen-specific T cellmediated gene therapy in collagen-induced arthritis
    • Nakajima A, Seroogy CM, Sandora MR. et al. Antigen-specific T cellmediated gene therapy in collagen-induced arthritis. J Clin Invest 2001; 107: 1293-1301
    • (2001) J Clin Invest , vol.107 , pp. 1293-1301
    • Nakajima, A.1    Seroogy, C.M.2    Sandora, M.R.3
  • 37
    • 0035881597 scopus 로고    scopus 로고
    • Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit
    • Costa GL, Sandora MR, Nakajima A. et al. Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit. J Immunol 2001; 167: 2379-2387
    • (2001) J Immunol , vol.167 , pp. 2379-2387
    • Costa, G.L.1    Sandora, M.R.2    Nakajima, A.3
  • 38
    • 0034046944 scopus 로고    scopus 로고
    • Plat-E: An efficient and stable system for transient packaging of retroviruses
    • Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 2000; 7: 1063-1066
    • (2000) Gene Ther , vol.7 , pp. 1063-1066
    • Morita, S.1    Kojima, T.2    Kitamura, T.3
  • 39
    • 33751567024 scopus 로고    scopus 로고
    • Gene therapy of arthritis with TCR isolated from the inflamed paw
    • Fujio K, Okamoto A, Araki Y. et al. Gene therapy of arthritis with TCR isolated from the inflamed paw. J Immunol 2006; 177: 8140-8147
    • (2006) J Immunol , vol.177 , pp. 8140-8147
    • Fujio, K.1    Okamoto, A.2    Araki, Y.3
  • 40
    • 54049150366 scopus 로고    scopus 로고
    • Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice
    • Okamoto A, Fujio K, van Rooijen N. et al. Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice. J Immunol 2008; 181: 5264-5271
    • (2008) J Immunol , vol.181 , pp. 5264-5271
    • Okamoto, A.1    Fujio, K.2    Van Rooijen, N.3
  • 41
    • 0037868952 scopus 로고    scopus 로고
    • Single-cell microarray analysis in hippocampus CA1: Demonstration and validation of cellular heterogeneity
    • Kamme F, Salunga R, Yu J. et al. Single-cell microarray analysis in hippocampus CA1: demonstration and validation of cellular heterogeneity. J Neurosci 2003; 23: 3607-3615
    • (2003) J Neurosci , vol.23 , pp. 3607-3615
    • Kamme, F.1    Salunga, R.2    Yu, J.3
  • 42
    • 0030175637 scopus 로고    scopus 로고
    • Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals
    • Yamamoto K, Masuko-Hongo K, Tanaka A. et al. Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals. Hum Immunol 1996; 48: 23-31
    • (1996) Hum Immunol , vol.48 , pp. 23-31
    • Yamamoto, K.1    Masuko-Hongo, K.2    Tanaka, A.3
  • 43
    • 0034234527 scopus 로고    scopus 로고
    • Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex
    • Fujio K, Misaki Y, Setoguchi K. et al. Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex. J Immunol 2000; 165: 528-532
    • (2000) J Immunol , vol.165 , pp. 528-532
    • Fujio, K.1    Misaki, Y.2    Setoguchi, K.3
  • 44
    • 18644366549 scopus 로고    scopus 로고
    • Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice
    • Inoue A, Hasegawa H, Kohno M. et al. Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice. Arthritis Rheum 2005; 52: 1522-1533
    • (2005) Arthritis Rheum , vol.52 , pp. 1522-1533
    • Inoue, A.1    Hasegawa, H.2    Kohno, M.3
  • 45
    • 33750955300 scopus 로고    scopus 로고
    • IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice
    • Muraoka M, Hasegawa H, Kohno M. et al. IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice. Arthritis Rheum 2006; 54: 3591-3600
    • (2006) Arthritis Rheum , vol.54 , pp. 3591-3600
    • Muraoka, M.1    Hasegawa, H.2    Kohno, M.3
  • 46
    • 33845236216 scopus 로고    scopus 로고
    • Ligands to nucleic acid-specific Tolllike receptors and the onset of lupus nephritis
    • Pawar RD, Patole PS, Ellwart A. et al. Ligands to nucleic acid-specific Tolllike receptors and the onset of lupus nephritis. J Am Soc Nephrol 2006; 17: 3365-3373.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3365-3373
    • Pawar, R.D.1    Patole, P.S.2    Ellwart, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.