-
1
-
-
38649125210
-
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
-
10.1038/ng.81, 18204446, International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)
-
Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD, Nath SK, Guthridge JM, Cobb BL, Mirel DB, Marion MC, Williams AH, Divers J, Wang W, Frank SG, Namjou B, Gabriel SB, Lee AT, Gregersen PK, Behrens TW, Taylor KE, Fernando M, Zidovetzki R, Gaffney PM, Edberg JC, Rioux JD, et al. International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008, 40:204-210. 10.1038/ng.81, 18204446, International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN).
-
(2008)
Nat Genet
, vol.40
, pp. 204-210
-
-
Harley, J.B.1
Alarcón-Riquelme, M.E.2
Criswell, L.A.3
Jacob, C.O.4
Kimberly, R.P.5
Moser, K.L.6
Tsao, B.P.7
Vyse, T.J.8
Langefeld, C.D.9
Nath, S.K.10
Guthridge, J.M.11
Cobb, B.L.12
Mirel, D.B.13
Marion, M.C.14
Williams, A.H.15
Divers, J.16
Wang, W.17
Frank, S.G.18
Namjou, B.19
Gabriel, S.B.20
Lee, A.T.21
Gregersen, P.K.22
Behrens, T.W.23
Taylor, K.E.24
Fernando, M.25
Zidovetzki, R.26
Gaffney, P.M.27
Edberg, J.C.28
Rioux, J.D.29
more..
-
2
-
-
38649138296
-
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
-
10.1038/ng.79, 18204447
-
Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, Sanchez E, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, Pons-Estel BA, Witte T, D'Alfonso S, Barizzone N, Danieli MG, Gutierrez C, Suarez A, Junker P, Laustrup H, González-Escribano MF, Martin J, Abderrahim H, Alarcón-Riquelme ME. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet 2008, 40:211-216. 10.1038/ng.79, 18204447.
-
(2008)
Nat Genet
, vol.40
, pp. 211-216
-
-
Kozyrev, S.V.1
Abelson, A.K.2
Wojcik, J.3
Zaghlool, A.4
Linga Reddy, M.V.5
Sanchez, E.6
Gunnarsson, I.7
Svenungsson, E.8
Sturfelt, G.9
Jönsen, A.10
Truedsson, L.11
Pons-Estel, B.A.12
Witte, T.13
D'Alfonso, S.14
Barizzone, N.15
Danieli, M.G.16
Gutierrez, C.17
Suarez, A.18
Junker, P.19
Laustrup, H.20
González-Escribano, M.F.21
Martin, J.22
Abderrahim, H.23
Alarcón-Riquelme, M.E.24
more..
-
3
-
-
40049108936
-
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
-
10.1056/NEJMoa0707865, 18204098
-
Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008, 358:900-909. 10.1056/NEJMoa0707865, 18204098.
-
(2008)
N Engl J Med
, vol.358
, pp. 900-909
-
-
Hom, G.1
Graham, R.R.2
Modrek, B.3
Taylor, K.E.4
Ortmann, W.5
Garnier, S.6
Lee, A.T.7
Chung, S.A.8
Ferreira, R.C.9
Pant, P.V.10
Ballinger, D.G.11
Kosoy, R.12
Demirci, F.Y.13
Kamboh, M.I.14
Kao, A.H.15
Tian, C.16
Gunnarsson, I.17
Bengtsson, A.A.18
Rantapää-Dahlqvist, S.19
Petri, M.20
Manzi, S.21
Seldin, M.F.22
Rönnblom, L.23
Syvänen, A.C.24
Criswell, L.A.25
Gregersen, P.K.26
Behrens, T.W.27
more..
-
4
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
10.1038/nature08494, 2831613, 19812666
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009, 461:747-753. 10.1038/nature08494, 2831613, 19812666.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.A.5
Hunter, D.J.6
McCarthy, M.I.7
Ramos, E.M.8
Cardon, L.R.9
Chakravarti, A.10
Cho, J.H.11
Guttmacher, A.E.12
Kong, A.13
Kruglyak, L.14
Mardis, E.15
Rotimi, C.N.16
Slatkin, M.17
Valle, D.18
Whittemore, A.S.19
Boehnke, M.20
Clark, A.G.21
Eichler, E.E.22
Gibson, G.23
Haines, J.L.24
Mackay, T.F.25
McCarroll, S.A.26
Visscher, P.M.27
more..
-
5
-
-
70349326221
-
Epigenetic inheritance and the missing heritability problem
-
10.1534/genetics.109.102798, 2710163, 19416939
-
Slatkin M. Epigenetic inheritance and the missing heritability problem. Genetics 2009, 182:845-850. 10.1534/genetics.109.102798, 2710163, 19416939.
-
(2009)
Genetics
, vol.182
, pp. 845-850
-
-
Slatkin, M.1
-
6
-
-
34249337761
-
Perceptions of epigenetics
-
10.1038/nature05913, 17522671
-
Bird A. Perceptions of epigenetics. Nature 2007, 447:396-398. 10.1038/nature05913, 17522671.
-
(2007)
Nature
, vol.447
, pp. 396-398
-
-
Bird, A.1
-
7
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
10.1016/S0092-8674(00)81656-6, 10555141
-
Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257. 10.1016/S0092-8674(00)81656-6, 10555141.
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
8
-
-
77649267695
-
Dynamic changes in the human methylome during differentiation
-
10.1101/gr.101907.109, 2840979, 20133333
-
Laurent L, Wong E, Li G, Huynh T, Tsirigos A, Ong CT, Low HM, Kin Sung KW, Rigoutsos I, Loring J, Wei CL. Dynamic changes in the human methylome during differentiation. Genome Res 2010, 20:320-331. 10.1101/gr.101907.109, 2840979, 20133333.
-
(2010)
Genome Res
, vol.20
, pp. 320-331
-
-
Laurent, L.1
Wong, E.2
Li, G.3
Huynh, T.4
Tsirigos, A.5
Ong, C.T.6
Low, H.M.7
Kin Sung, K.W.8
Rigoutsos, I.9
Loring, J.10
Wei, C.L.11
-
9
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
10.1038/nature08514, 2857523, 19829295
-
Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009, 462:315-322. 10.1038/nature08514, 2857523, 19829295.
-
(2009)
Nature
, vol.462
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
Hawkins, R.D.4
Hon, G.5
Tonti-Filippini, J.6
Nery, J.R.7
Lee, L.8
Ye, Z.9
Ngo, Q.M.10
Edsall, L.11
Antosiewicz-Bourget, J.12
Stewart, R.13
Ruotti, V.14
Millar, A.H.15
Thomson, J.A.16
Ren, B.17
Ecker, J.R.18
-
10
-
-
58849091905
-
A human B cell methylome at 100-base pair resolution
-
10.1073/pnas.0812399106, 2621253, 19139413
-
Rauch TA, Wu X, Zhong X, Riggs AD, Pfeifer GP. A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci USA 2009, 106:671-678. 10.1073/pnas.0812399106, 2621253, 19139413.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 671-678
-
-
Rauch, T.A.1
Wu, X.2
Zhong, X.3
Riggs, A.D.4
Pfeifer, G.P.5
-
11
-
-
77958150358
-
DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks
-
10.1038/gene.2010.24, 2948060, 20463746
-
Hughes T, Webb R, Fei Y, Wren JD, Sawalha AH. DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks. Genes Immun 2010, 11:554-560. 10.1038/gene.2010.24, 2948060, 20463746.
-
(2010)
Genes Immun
, vol.11
, pp. 554-560
-
-
Hughes, T.1
Webb, R.2
Fei, Y.3
Wren, J.D.4
Sawalha, A.H.5
-
12
-
-
18244365863
-
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
10.1016/S1074-7613(01)00227-8, 11728338
-
Lee PP, Fitzpatrick DR, Beard C, Jessup HK, Lehar S, Makar KW, Pérez-Melgosa M, Sweetser MT, Schlissel MS, Nguyen S, Cherry SR, Tsai JH, Tucker SM, Weaver WM, Kelso A, Jaenisch R, Wilson CB. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 2001, 15:763-774. 10.1016/S1074-7613(01)00227-8, 11728338.
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
Fitzpatrick, D.R.2
Beard, C.3
Jessup, H.K.4
Lehar, S.5
Makar, K.W.6
Pérez-Melgosa, M.7
Sweetser, M.T.8
Schlissel, M.S.9
Nguyen, S.10
Cherry, S.R.11
Tsai, J.H.12
Tucker, S.M.13
Weaver, W.M.14
Kelso, A.15
Jaenisch, R.16
Wilson, C.B.17
-
13
-
-
36749029364
-
Demethylation of a specific hypersensitive site in the Th2 locus control region
-
10.1073/pnas.0708293104, 2040439, 17940027
-
Kim ST, Fields PE, Flavell RA. Demethylation of a specific hypersensitive site in the Th2 locus control region. Proc Natl Acad Sci USA 2007, 104:17052-17057. 10.1073/pnas.0708293104, 2040439, 17940027.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17052-17057
-
-
Kim, S.T.1
Fields, P.E.2
Flavell, R.A.3
-
14
-
-
33745022567
-
T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent
-
10.1084/jem.20060066, 2118309, 16717115
-
Zhang F, Boothby M. T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent. J Exp Med 2006, 203:1493-1505. 10.1084/jem.20060066, 2118309, 16717115.
-
(2006)
J Exp Med
, vol.203
, pp. 1493-1505
-
-
Zhang, F.1
Boothby, M.2
-
15
-
-
34147138648
-
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
-
Akimzhanov AM, Yang XO, Dong C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem 2007, 282:5969-5972.
-
(2007)
J Biol Chem
, vol.282
, pp. 5969-5972
-
-
Akimzhanov, A.M.1
Yang, X.O.2
Dong, C.3
-
16
-
-
0037100265
-
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation
-
Fields PE, Kim ST, Flavell RA. Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol 2002, 169:647-650.
-
(2002)
J Immunol
, vol.169
, pp. 647-650
-
-
Fields, P.E.1
Kim, S.T.2
Flavell, R.A.3
-
17
-
-
10344234192
-
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
-
10.1016/j.immuni.2004.10.015, 15589174
-
Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 2004, 21:865-876. 10.1016/j.immuni.2004.10.015, 15589174.
-
(2004)
Immunity
, vol.21
, pp. 865-876
-
-
Fields, P.E.1
Lee, G.R.2
Kim, S.T.3
Bartsevich, V.V.4
Flavell, R.A.5
-
18
-
-
20444494936
-
Interchromosomal associations between alternatively expressed loci
-
10.1038/nature03574, 15880101
-
Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature 2005, 435:637-645. 10.1038/nature03574, 15880101.
-
(2005)
Nature
, vol.435
, pp. 637-645
-
-
Spilianakis, C.G.1
Lalioti, M.D.2
Town, T.3
Lee, G.R.4
Flavell, R.A.5
-
19
-
-
0023936754
-
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
-
Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988, 140:2197-2200.
-
(1988)
J Immunol
, vol.140
, pp. 2197-2200
-
-
Cornacchia, E.1
Golbus, J.2
Maybaum, J.3
Strahler, J.4
Hanash, S.5
Richardson, B.6
-
20
-
-
0028986033
-
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo
-
Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC. Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol 1995, 154:3025-3035.
-
(1995)
J Immunol
, vol.154
, pp. 3025-3035
-
-
Yung, R.L.1
Quddus, J.2
Chrisp, C.E.3
Johnson, K.J.4
Richardson, B.C.5
-
21
-
-
0025666735
-
Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
-
10.1002/art.1780331109, 2242063
-
Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990, 33:1665-1673. 10.1002/art.1780331109, 2242063.
-
(1990)
Arthritis Rheum
, vol.33
, pp. 1665-1673
-
-
Richardson, B.1
Scheinbart, L.2
Strahler, J.3
Gross, L.4
Hanash, S.5
Johnson, M.6
-
22
-
-
0025827949
-
Procainamide inhibits DNA methyltransferase in a human T cell line
-
Scheinbart LS, Johnson MA, Gross LA, Edelstein SR, Richardson BC. Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol 1991, 18:530-534.
-
(1991)
J Rheumatol
, vol.18
, pp. 530-534
-
-
Scheinbart, L.S.1
Johnson, M.A.2
Gross, L.A.3
Edelstein, S.R.4
Richardson, B.C.5
-
23
-
-
0037333972
-
Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling
-
10.1002/art.10833, 12632429
-
Deng C, Lu Q, Zhang Z, Rao T, Attwood J, Yung R, Richardson B. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum 2003, 48:746-756. 10.1002/art.10833, 12632429.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 746-756
-
-
Deng, C.1
Lu, Q.2
Zhang, Z.3
Rao, T.4
Attwood, J.5
Yung, R.6
Richardson, B.7
-
24
-
-
0029046134
-
Regulation of DNA methylation by the Ras signaling pathway
-
10.1074/jbc.270.19.11327, 7744770
-
MacLeod AR, Rouleau J, Szyf M. Regulation of DNA methylation by the Ras signaling pathway. J Biol Chem 1995, 270:11327-11337. 10.1074/jbc.270.19.11327, 7744770.
-
(1995)
J Biol Chem
, vol.270
, pp. 11327-11337
-
-
MacLeod, A.R.1
Rouleau, J.2
Szyf, M.3
-
25
-
-
0028925009
-
Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway
-
10.1074/jbc.270.4.1595, 7829490
-
Rouleau J, MacLeod AR, Szyf M. Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem 1995, 270:1595-1601. 10.1074/jbc.270.4.1595, 7829490.
-
(1995)
J Biol Chem
, vol.270
, pp. 1595-1601
-
-
Rouleau, J.1
MacLeod, A.R.2
Szyf, M.3
-
26
-
-
0036221384
-
MAP kinases in the immune response
-
10.1146/annurev.immunol.20.091301.131133, 11861597
-
Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol 2002, 20:55-72. 10.1146/annurev.immunol.20.091301.131133, 11861597.
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 55-72
-
-
Dong, C.1
Davis, R.J.2
Flavell, R.A.3
-
27
-
-
0036560022
-
Abnormal T cell signal transduction in systemic lupus erythematosus
-
10.1002/art.10192, 12115215
-
Kammer GM, Perl A, Richardson BC, Tsokos GC. Abnormal T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum 2002, 46:1139-1154. 10.1002/art.10192, 12115215.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1139-1154
-
-
Kammer, G.M.1
Perl, A.2
Richardson, B.C.3
Tsokos, G.C.4
-
28
-
-
0037289364
-
Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells
-
10.1016/S1521-6616(02)00052-9, 12584050
-
Cedeño S, Cifarelli DF, Blasini AM, Paris M, Placeres F, Alonso G, Rodriguez MA. Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells. Clin Immunol 2003, 106:41-49. 10.1016/S1521-6616(02)00052-9, 12584050.
-
(2003)
Clin Immunol
, vol.106
, pp. 41-49
-
-
Cedeño, S.1
Cifarelli, D.F.2
Blasini, A.M.3
Paris, M.4
Placeres, F.5
Alonso, G.6
Rodriguez, M.A.7
-
29
-
-
38449104652
-
Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
-
Gorelik G, Fang JY, Wu A, Sawalha AH, Richardson B. Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus. J Immunol 2007, 179:5553-5563.
-
(2007)
J Immunol
, vol.179
, pp. 5553-5563
-
-
Gorelik, G.1
Fang, J.Y.2
Wu, A.3
Sawalha, A.H.4
Richardson, B.5
-
30
-
-
0025871709
-
A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus
-
10.1016/0090-1229(91)90065-I, 2070568
-
Tada Y, Nagasawa K, Yamauchi Y, Tsukamoto H, Niho Y. A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1991, 60:220-231. 10.1016/0090-1229(91)90065-I, 2070568.
-
(1991)
Clin Immunol Immunopathol
, vol.60
, pp. 220-231
-
-
Tada, Y.1
Nagasawa, K.2
Yamauchi, Y.3
Tsukamoto, H.4
Niho, Y.5
-
31
-
-
0037171731
-
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta
-
10.1038/416865a, 11976687
-
Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, Tsukiyama T, Nagahama H, Ohno S, Hatakeyama S, Nakayama KI. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 2002, 416:865-869. 10.1038/416865a, 11976687.
-
(2002)
Nature
, vol.416
, pp. 865-869
-
-
Miyamoto, A.1
Nakayama, K.2
Imaki, H.3
Hirose, S.4
Jiang, Y.5
Abe, M.6
Tsukiyama, T.7
Nagahama, H.8
Ohno, S.9
Hatakeyama, S.10
Nakayama, K.I.11
-
32
-
-
44849087740
-
Defective T-cell ERK signaling induces interferonregulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
-
10.1038/gene.2008.29, 2825163, 18523434
-
Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B. Defective T-cell ERK signaling induces interferonregulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun 2008, 9:368-378. 10.1038/gene.2008.29, 2825163, 18523434.
-
(2008)
Genes Immun
, vol.9
, pp. 368-378
-
-
Sawalha, A.H.1
Jeffries, M.2
Webb, R.3
Lu, Q.4
Gorelik, G.5
Ray, D.6
Osban, J.7
Knowlton, N.8
Johnson, K.9
Richardson, B.10
-
33
-
-
0029744798
-
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
-
10.1126/science.273.5283.1864, 8791592
-
Grewal IS, Foellmer HG, Grewal KD, Xu J, Hardardottir F, Baron JL, Janeway CA, Flavell RA. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 1996, 273:1864-1867. 10.1126/science.273.5283.1864, 8791592.
-
(1996)
Science
, vol.273
, pp. 1864-1867
-
-
Grewal, I.S.1
Foellmer, H.G.2
Grewal, K.D.3
Xu, J.4
Hardardottir, F.5
Baron, J.L.6
Janeway, C.A.7
Flavell, R.A.8
-
34
-
-
0028486131
-
Mice deficient for the CD40 ligand
-
10.1016/1074-7613(94)90073-6, 7882172
-
Xu J, Foy TM, Laman JD, Elliott EA, Dunn JJ, Waldschmidt TJ, Elsemore J, Noelle RJ, Flavell RA. Mice deficient for the CD40 ligand. Immunity 1994, 1:423-431. 10.1016/1074-7613(94)90073-6, 7882172.
-
(1994)
Immunity
, vol.1
, pp. 423-431
-
-
Xu, J.1
Foy, T.M.2
Laman, J.D.3
Elliott, E.A.4
Dunn, J.J.5
Waldschmidt, T.J.6
Elsemore, J.7
Noelle, R.J.8
Flavell, R.A.9
-
35
-
-
0029913381
-
Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
-
10.1172/JCI118643, 507281, 8621796
-
Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996, 97:2063-2073. 10.1172/JCI118643, 507281, 8621796.
-
(1996)
J Clin Invest
, vol.97
, pp. 2063-2073
-
-
Desai-Mehta, A.1
Lu, L.2
Ramsey-Goldman, R.3
Datta, S.K.4
-
36
-
-
38449116161
-
Demethylation of CD40LG on the inactive X in T cells from women with lupus
-
Lu Q, Wu A, Tesmer L, Ray D, Yousif N, Richardson B. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 2007, 179:6352-6358.
-
(2007)
J Immunol
, vol.179
, pp. 6352-6358
-
-
Lu, Q.1
Wu, A.2
Tesmer, L.3
Ray, D.4
Yousif, N.5
Richardson, B.6
-
37
-
-
67651152585
-
T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus
-
10.1016/j.clim.2009.05.011, 2810511, 19520616
-
Zhou Y, Yuan J, Pan Y, Fei Y, Qiu X, Hu N, Luo Y, Lei W, Li Y, Long H, Sawalha AH, Richardson B, Lu Q. T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus. Clin Immunol 2009, 132:362-370. 10.1016/j.clim.2009.05.011, 2810511, 19520616.
-
(2009)
Clin Immunol
, vol.132
, pp. 362-370
-
-
Zhou, Y.1
Yuan, J.2
Pan, Y.3
Fei, Y.4
Qiu, X.5
Hu, N.6
Luo, Y.7
Lei, W.8
Li, Y.9
Long, H.10
Sawalha, A.H.11
Richardson, B.12
Lu, Q.13
-
38
-
-
18544413131
-
Skewed X chromosome inactivation in blood cells of women with scleroderma
-
10.1002/art.21026, 15880831
-
Ozbalkan Z, Bagişlar S, Kiraz S, Akyerli CB, Ozer HT, Yavuz S, Birlik AM, Calgüneri M, Ozçelik T. Skewed X chromosome inactivation in blood cells of women with scleroderma. Arthritis Rheum 2005, 52:1564-1570. 10.1002/art.21026, 15880831.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1564-1570
-
-
Ozbalkan, Z.1
Bagişlar, S.2
Kiraz, S.3
Akyerli, C.B.4
Ozer, H.T.5
Yavuz, S.6
Birlik, A.M.7
Calgüneri, M.8
Ozçelik, T.9
-
39
-
-
49449099801
-
Klinefelter's syndrome (47, XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome
-
10.1002/art.23701, 2824898, 18668569
-
Scofield RH, Bruner GR, Namjou B, Kimberly RP, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Reid J, Harris B, Li S, Kelly JA, Harley JB. Klinefelter's syndrome (47, XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 2008, 58:2511-2517. 10.1002/art.23701, 2824898, 18668569.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2511-2517
-
-
Scofield, R.H.1
Bruner, G.R.2
Namjou, B.3
Kimberly, R.P.4
Ramsey-Goldman, R.5
Petri, M.6
Reveille, J.D.7
Alarcón, G.S.8
Vilá, L.M.9
Reid, J.10
Harris, B.11
Li, S.12
Kelly, J.A.13
Harley, J.B.14
-
40
-
-
0037097819
-
Effect of DNA methylation and chromatin structure on ITGAL expression
-
10.1182/blood.V99.12.4503, 12036881
-
Lu Q, Ray D, Gutsch D, Richardson B. Effect of DNA methylation and chromatin structure on ITGAL expression. Blood 2002, 99:4503-8. 10.1182/blood.V99.12.4503, 12036881.
-
(2002)
Blood
, vol.99
, pp. 4503-4508
-
-
Lu, Q.1
Ray, D.2
Gutsch, D.3
Richardson, B.4
-
41
-
-
0036095885
-
Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
-
10.1002/art.10234, 12115234
-
Lu Q, Kaplan M, Ray D, Ray D, Zacharek S, Gutsch D, Richardson B. Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum 2002, 46:1282-1291. 10.1002/art.10234, 12115234.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1282-1291
-
-
Lu, Q.1
Kaplan, M.2
Ray, D.3
Ray, D.4
Zacharek, S.5
Gutsch, D.6
Richardson, B.7
-
42
-
-
0028063746
-
Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity
-
10.1002/art.1780370915, 7524510
-
Richardson B, Powers D, Hooper F, Yung RL, O'Rourke K. Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity. Arthritis Rheum 1994, 37:1363-1372. 10.1002/art.1780370915, 7524510.
-
(1994)
Arthritis Rheum
, vol.37
, pp. 1363-1372
-
-
Richardson, B.1
Powers, D.2
Hooper, F.3
Yung, R.L.4
O'Rourke, K.5
-
43
-
-
2642556447
-
Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors
-
10.1002/art.20255, 15188362
-
Oelke K, Lu Q, Richardson D, Wu A, Deng C, Hanash S, Richardson B. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum 2004, 50:1850-1860. 10.1002/art.20255, 15188362.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1850-1860
-
-
Oelke, K.1
Lu, Q.2
Richardson, D.3
Wu, A.4
Deng, C.5
Hanash, S.6
Richardson, B.7
-
44
-
-
18644376210
-
Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupusinducing drugs
-
Lu Q, Wu A, Richardson BC. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupusinducing drugs. J Immunol 2005, 174:6212-6219.
-
(2005)
J Immunol
, vol.174
, pp. 6212-6219
-
-
Lu, Q.1
Wu, A.2
Richardson, B.C.3
-
45
-
-
34250376378
-
Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice
-
10.1002/eji.200636872, 17429846
-
Sawalha AH, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol 2007, 37:1407-1413. 10.1002/eji.200636872, 17429846.
-
(2007)
Eur J Immunol
, vol.37
, pp. 1407-1413
-
-
Sawalha, A.H.1
Jeffries, M.2
-
46
-
-
77951231981
-
Demethylation of promoter regulatory elements contributes to CD70 overexpression in CD4+ T cells from patients with subacute cutaneous lupus erythematosus
-
10.1111/j.1365-2230.2009.03611.x, 19874375
-
Luo Y, Zhao M, Lu Q. Demethylation of promoter regulatory elements contributes to CD70 overexpression in CD4+ T cells from patients with subacute cutaneous lupus erythematosus. Clin Exp Dermatol 2010, 35:425-430. 10.1111/j.1365-2230.2009.03611.x, 19874375.
-
(2010)
Clin Exp Dermatol
, vol.35
, pp. 425-430
-
-
Luo, Y.1
Zhao, M.2
Lu, Q.3
-
47
-
-
77953288009
-
Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
-
10.1016/j.jaut.2010.02.002, 20223637
-
Zhao M, Sun Y, Gao F, Wu X, Tang J, Yin H, Luo Y, Richardson B, Lu Q. Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells. J Autoimmun 2010, 35:58-69. 10.1016/j.jaut.2010.02.002, 20223637.
-
(2010)
J Autoimmun
, vol.35
, pp. 58-69
-
-
Zhao, M.1
Sun, Y.2
Gao, F.3
Wu, X.4
Tang, J.5
Yin, H.6
Luo, Y.7
Richardson, B.8
Lu, Q.9
-
48
-
-
78650626621
-
RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
-
10.1186/ar3214, 3046540, 21192791
-
Zhao M, Wu X, Zhang Q, Luo S, Liang G, Su Y, Tan Y, Lu Q. RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1. Arthritis Res Ther 2010, 12:R227. 10.1186/ar3214, 3046540, 21192791.
-
(2010)
Arthritis Res Ther
, vol.12
-
-
Zhao, M.1
Wu, X.2
Zhang, Q.3
Luo, S.4
Liang, G.5
Su, Y.6
Tan, Y.7
Lu, Q.8
-
49
-
-
0036231177
-
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome
-
10.1016/S1074-7613(02)00302-3, 11970874
-
Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, Ashwell JD, Fornace AJ. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 2002, 16:499-508. 10.1016/S1074-7613(02)00302-3, 11970874.
-
(2002)
Immunity
, vol.16
, pp. 499-508
-
-
Salvador, J.M.1
Hollander, M.C.2
Nguyen, A.T.3
Kopp, J.B.4
Barisoni, L.5
Moore, J.K.6
Ashwell, J.D.7
Fornace, A.J.8
-
50
-
-
33846933274
-
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
-
10.1038/nature05515, 17268471
-
Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F, Niehrs C. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007, 445:671-675. 10.1038/nature05515, 17268471.
-
(2007)
Nature
, vol.445
, pp. 671-675
-
-
Barreto, G.1
Schäfer, A.2
Marhold, J.3
Stach, D.4
Swaminathan, S.K.5
Handa, V.6
Döderlein, G.7
Maltry, N.8
Wu, W.9
Lyko, F.10
Niehrs, C.11
-
51
-
-
77951745847
-
Overexpression of the growth arrest and DNA damageinduced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells
-
Li Y, Zhao M, Yin H, Gao F, Wu X, Luo Y, Zhao S, Zhang X, Su Y, Hu N, Long H, Richardson B, Lu Q. Overexpression of the growth arrest and DNA damageinduced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells. Arthritis Rheum 2010, 62:1438-47.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 1438-1447
-
-
Li, Y.1
Zhao, M.2
Yin, H.3
Gao, F.4
Wu, X.5
Luo, Y.6
Zhao, S.7
Zhang, X.8
Su, Y.9
Hu, N.10
Long, H.11
Richardson, B.12
Lu, Q.13
-
52
-
-
0037884760
-
DNA methylation and chromatin structure regulate T cell perforin gene expression
-
Lu Q, Wu A, Ray D, Deng C, Attwood J, Hanash S, Pipkin M, Lichtenheld M, Richardson B. DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol 2003, 170:5124-5132.
-
(2003)
J Immunol
, vol.170
, pp. 5124-5132
-
-
Lu, Q.1
Wu, A.2
Ray, D.3
Deng, C.4
Attwood, J.5
Hanash, S.6
Pipkin, M.7
Lichtenheld, M.8
Richardson, B.9
-
53
-
-
1542724431
-
Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells
-
Kaplan MJ, Lu Q, Wu A, Attwood J, Richardson B. Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells. J Immunol 2004, 172:3652-3661.
-
(2004)
J Immunol
, vol.172
, pp. 3652-3661
-
-
Kaplan, M.J.1
Lu, Q.2
Wu, A.3
Attwood, J.4
Richardson, B.5
-
54
-
-
4444243490
-
Killer immunoglobulin-like receptors
-
10.1016/j.coi.2004.07.010, 15342010
-
Moretta L, Moretta A. Killer immunoglobulin-like receptors. Curr Opin Immunol 2004, 16:626-33. 10.1016/j.coi.2004.07.010, 15342010.
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 626-633
-
-
Moretta, L.1
Moretta, A.2
-
55
-
-
58049132791
-
DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors
-
10.1016/j.clim.2008.08.009, 2655730, 18945643
-
Liu Y, Kuick R, Hanash S, Richardson B. DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors. Clin Immunol 2009, 130:213-224. 10.1016/j.clim.2008.08.009, 2655730, 18945643.
-
(2009)
Clin Immunol
, vol.130
, pp. 213-224
-
-
Liu, Y.1
Kuick, R.2
Hanash, S.3
Richardson, B.4
-
56
-
-
70349260307
-
Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells
-
10.4049/jimmunol.0900034, 2730421, 19675166
-
Basu D, Liu Y, Wu A, Yarlagadda S, Gorelik GJ, Kaplan MJ, Hewagama A, Hinderer RC, Strickland FM, Richardson BC. Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells. J Immunol 2009, 183:3481-3487. 10.4049/jimmunol.0900034, 2730421, 19675166.
-
(2009)
J Immunol
, vol.183
, pp. 3481-3487
-
-
Basu, D.1
Liu, Y.2
Wu, A.3
Yarlagadda, S.4
Gorelik, G.J.5
Kaplan, M.J.6
Hewagama, A.7
Hinderer, R.C.8
Strickland, F.M.9
Richardson, B.C.10
-
57
-
-
0034610978
-
CD5 maintains tolerance in anergic B cells
-
10.1084/jem.191.5.883, 2195862, 10704468
-
Hippen KL, Tze LE, Behrens TW. CD5 maintains tolerance in anergic B cells. J Exp Med 2000, 191:883-890. 10.1084/jem.191.5.883, 2195862, 10704468.
-
(2000)
J Exp Med
, vol.191
, pp. 883-890
-
-
Hippen, K.L.1
Tze, L.E.2
Behrens, T.W.3
-
58
-
-
66949176660
-
IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation
-
10.4049/jimmunol.0802412, 19380809
-
Garaud S, Le Dantec C, Jousse-Joulin S, Hanrotel-Saliou C, Saraux A, Mageed RA, Youinou P, Renaudineau Y. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol 2009, 182:5623-5632. 10.4049/jimmunol.0802412, 19380809.
-
(2009)
J Immunol
, vol.182
, pp. 5623-5632
-
-
Garaud, S.1
Le Dantec, C.2
Jousse-Joulin, S.3
Hanrotel-Saliou, C.4
Saraux, A.5
Mageed, R.A.6
Youinou, P.7
Renaudineau, Y.8
-
59
-
-
40849109768
-
Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles
-
10.1016/j.ajhg.2007.12.011, 2427204, 18304490
-
Bruder CE, Piotrowski A, Gijsbers AA, Andersson R, Erickson S, Diaz de Ståhl T, Menzel U, Sandgren J, von Tell D, Poplawski A, Crowley M, Crasto C, Partridge EC, Tiwari H, Allison DB, Komorowski J, van Ommen GJ, Boomsma DI, Pedersen NL, den Dunnen JT, Wirdefeldt K, Dumanski JP. Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet 2008, 82:763-771. 10.1016/j.ajhg.2007.12.011, 2427204, 18304490.
-
(2008)
Am J Hum Genet
, vol.82
, pp. 763-771
-
-
Bruder, C.E.1
Piotrowski, A.2
Gijsbers, A.A.3
Andersson, R.4
Erickson, S.5
Diaz de Ståhl, T.6
Menzel, U.7
Sandgren, J.8
von Tell, D.9
Poplawski, A.10
Crowley, M.11
Crasto, C.12
Partridge, E.C.13
Tiwari, H.14
Allison, D.B.15
Komorowski, J.16
van Ommen, G.J.17
Boomsma, D.I.18
Pedersen, N.L.19
den Dunnen, J.T.20
Wirdefeldt, K.21
Dumanski, J.P.22
more..
-
60
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
10.1073/pnas.0500398102, 1174919, 16009939
-
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005, 102:10604-10609. 10.1073/pnas.0500398102, 1174919, 16009939.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.1
Ballestar, E.2
Paz, M.F.3
Ropero, S.4
Setien, F.5
Ballestar, M.L.6
Heine-Suñer, D.7
Cigudosa, J.C.8
Urioste, M.9
Benitez, J.10
Boix-Chornet, M.11
Sanchez-Aguilera, A.12
Ling, C.13
Carlsson, E.14
Poulsen, P.15
Vaag, A.16
Stephan, Z.17
Spector, T.D.18
Wu, Y.Z.19
Plass, C.20
Esteller, M.21
more..
-
61
-
-
75649151209
-
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
-
10.1101/gr.100289.109, 2813473, 20028698
-
Javierre BM, Fernandez AF, Richter J, Al-Shahrour F, Martin-Subero JI, Rodriguez-Ubreva J, Berdasco M, Fraga MF, O'Hanlon TP, Rider LG, Jacinto FV, Lopez-Longo FJ, Dopazo J, Forn M, Peinado MA, Carreño L, Sawalha AH, Harley JB, Siebert R, Esteller M, Miller FW, Ballestar E. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res 2010, 20:170-179. 10.1101/gr.100289.109, 2813473, 20028698.
-
(2010)
Genome Res
, vol.20
, pp. 170-179
-
-
Javierre, B.M.1
Fernandez, A.F.2
Richter, J.3
Al-Shahrour, F.4
Martin-Subero, J.I.5
Rodriguez-Ubreva, J.6
Berdasco, M.7
Fraga, M.F.8
O'Hanlon, T.P.9
Rider, L.G.10
Jacinto, F.V.11
Lopez-Longo, F.J.12
Dopazo, J.13
Forn, M.14
Peinado, M.A.15
Carreño, L.16
Sawalha, A.H.17
Harley, J.B.18
Siebert, R.19
Esteller, M.20
Miller, F.W.21
Ballestar, E.22
more..
-
62
-
-
79957550675
-
Genomewide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus
-
10.4161/epi.6.5.15374, 21436623
-
Jeffries MA, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genomewide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics 2011, 6:593-601. 10.4161/epi.6.5.15374, 21436623.
-
(2011)
Epigenetics
, vol.6
, pp. 593-601
-
-
Jeffries, M.A.1
Dozmorov, M.2
Tang, Y.3
Merrill, J.T.4
Wren, J.D.5
Sawalha, A.H.6
-
63
-
-
54549100120
-
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
-
10.1038/ni.1663, 18849990
-
Zhang F, Meng G, Strober W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 2008, 9:1297-1306. 10.1038/ni.1663, 18849990.
-
(2008)
Nat Immunol
, vol.9
, pp. 1297-1306
-
-
Zhang, F.1
Meng, G.2
Strober, W.3
-
65
-
-
33747608638
-
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
-
10.1073/pnas.0605298103, 1567904, 16885212
-
Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006, 103:12481-12486. 10.1073/pnas.0605298103, 1567904, 16885212.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12481-12486
-
-
Taganov, K.D.1
Boldin, M.P.2
Chang, K.J.3
Baltimore, D.4
-
66
-
-
65249138193
-
MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
-
10.1002/art.24436, 19333922
-
Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, Huang X, Zhou H, de Vries N, Tak PP, Chen S, Shen N. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009, 60:1065-1075. 10.1002/art.24436, 19333922.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1065-1075
-
-
Tang, Y.1
Luo, X.2
Cui, H.3
Ni, X.4
Yuan, M.5
Guo, Y.6
Huang, X.7
Zhou, H.8
de Vries, N.9
Tak, P.P.10
Chen, S.11
Shen, N.12
-
67
-
-
78149358596
-
MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus
-
10.1002/art.27632, 20589685
-
Zhao X, Tang Y, Qu B, Cui H, Wang S, Wang L, Luo X, Huang X, Li J, Chen S, Shen N. MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 2010, 62:3425-3435. 10.1002/art.27632, 20589685.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3425-3435
-
-
Zhao, X.1
Tang, Y.2
Qu, B.3
Cui, H.4
Wang, S.5
Wang, L.6
Luo, X.7
Huang, X.8
Li, J.9
Chen, S.10
Shen, N.11
-
68
-
-
78650769641
-
Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus
-
10.1371/journal.pone.0014302, 3000827, 21170274
-
Dai R, Zhang Y, Khan D, Heid B, Caudell D, Crasta O, Ahmed SA. Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus. PLoS One 2010, 5:e14302. 10.1371/journal.pone.0014302, 3000827, 21170274.
-
(2010)
PLoS One
, vol.5
-
-
Dai, R.1
Zhang, Y.2
Khan, D.3
Heid, B.4
Caudell, D.5
Crasta, O.6
Ahmed, S.A.7
-
69
-
-
39749163245
-
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
-
10.1038/ni1575, 2533767, 18327259
-
Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 2008, 9:405-414. 10.1038/ni1575, 2533767, 18327259.
-
(2008)
Nat Immunol
, vol.9
, pp. 405-414
-
-
Xiao, C.1
Srinivasan, L.2
Calado, D.P.3
Patterson, H.C.4
Zhang, B.5
Wang, J.6
Henderson, J.M.7
Kutok, J.L.8
Rajewsky, K.9
-
70
-
-
58149239686
-
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
-
10.1126/science.1165395, 2684823, 19008416
-
Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008, 322:1695-1699. 10.1126/science.1165395, 2684823, 19008416.
-
(2008)
Science
, vol.322
, pp. 1695-1699
-
-
Varambally, S.1
Cao, Q.2
Mani, R.S.3
Shankar, S.4
Wang, X.5
Ateeq, B.6
Laxman, B.7
Cao, X.8
Jing, X.9
Ramnarayanan, K.10
Brenner, J.C.11
Yu, J.12
Kim, J.H.13
Han, B.14
Tan, P.15
Kumar-Sinha, C.16
Lonigro, R.J.17
Palanisamy, N.18
Maher, C.A.19
Chinnaiyan, A.M.20
more..
-
71
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
10.1038/nature04431, 16357870
-
Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006, 439:871-874. 10.1038/nature04431, 16357870.
-
(2006)
Nature
, vol.439
, pp. 871-874
-
-
Viré, E.1
Brenner, C.2
Deplus, R.3
Blanchon, L.4
Fraga, M.5
Didelot, C.6
Morey, L.7
Van Eynde, A.8
Bernard, D.9
Vanderwinden, J.M.10
Bollen, M.11
Esteller, M.12
Di Croce, L.13
de Launoit, Y.14
Fuks, F.15
-
72
-
-
44349087706
-
Abnormal histone modification patterns in lupus CD4+ T cells
-
Hu N, Qiu X, Luo Y, Yuan J, Li Y, Lei W, Zhang G, Zhou Y, Su Y, Lu Q. Abnormal histone modification patterns in lupus CD4+ T cells. J Rheumatol 2008, 35:804-810.
-
(2008)
J Rheumatol
, vol.35
, pp. 804-810
-
-
Hu, N.1
Qiu, X.2
Luo, Y.3
Yuan, J.4
Li, Y.5
Lei, W.6
Zhang, G.7
Zhou, Y.8
Su, Y.9
Lu, Q.10
-
73
-
-
77956410132
-
Identification of unique microRNA signature associated with lupus nephritis
-
10.1371/journal.pone.0010344, 2867940, 20485490
-
Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO. Identification of unique microRNA signature associated with lupus nephritis. PLoS One 2010, 5:e10344. 10.1371/journal.pone.0010344, 2867940, 20485490.
-
(2010)
PLoS One
, vol.5
-
-
Te, J.L.1
Dozmorov, I.M.2
Guthridge, J.M.3
Nguyen, K.L.4
Cavett, J.W.5
Kelly, J.A.6
Bruner, G.R.7
Harley, J.B.8
Ojwang, J.O.9
-
74
-
-
79959784552
-
Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression
-
10.1136/ard.2010.139857, 21602271
-
Stagakis E, Bertsias G, Verginis P, Nakou M, Hatziapostolou M, Kritikos H, Iliopoulos D, Boumpas DT. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis 2011, 70:1496-1506. 10.1136/ard.2010.139857, 21602271.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1496-1506
-
-
Stagakis, E.1
Bertsias, G.2
Verginis, P.3
Nakou, M.4
Hatziapostolou, M.5
Kritikos, H.6
Iliopoulos, D.7
Boumpas, D.T.8
-
75
-
-
79960740957
-
MicroRNAs in systemic rheumatic diseases
-
10.1186/ar3377, 21787439
-
Ceribelli A, Yao B, Dominguez-Gutierrez PR, Nahid MA, Satoh M, Chan EK. MicroRNAs in systemic rheumatic diseases. Arthritis Res Ther 2011, 13:229. 10.1186/ar3377, 21787439.
-
(2011)
Arthritis Res Ther
, vol.13
, pp. 229
-
-
Ceribelli, A.1
Yao, B.2
Dominguez-Gutierrez, P.R.3
Nahid, M.A.4
Satoh, M.5
Chan, E.K.6
-
76
-
-
40949130398
-
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells
-
10.1038/nsmb.1391, 18311153
-
Sinkkonen L, Hugenschmidt T, Berninger P, Gaidatzis D, Mohn F, Artus-Revel CG, Zavolan M, Svoboda P, Filipowicz W. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol 2008, 15:259-267. 10.1038/nsmb.1391, 18311153.
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 259-267
-
-
Sinkkonen, L.1
Hugenschmidt, T.2
Berninger, P.3
Gaidatzis, D.4
Mohn, F.5
Artus-Revel, C.G.6
Zavolan, M.7
Svoboda, P.8
Filipowicz, W.9
-
77
-
-
35649020283
-
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
-
10.1073/pnas.0707628104, 2000384, 17890317
-
Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, Calin GA, Huebner K, Croce CM. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 2007, 104:15805-15810. 10.1073/pnas.0707628104, 2000384, 17890317.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 15805-15810
-
-
Fabbri, M.1
Garzon, R.2
Cimmino, A.3
Liu, Z.4
Zanesi, N.5
Callegari, E.6
Liu, S.7
Alder, H.8
Costinean, S.9
Fernandez-Cymering, C.10
Volinia, S.11
Guler, G.12
Morrison, C.D.13
Chan, K.K.14
Marcucci, G.15
Calin, G.A.16
Huebner, K.17
Croce, C.M.18
-
78
-
-
77953624215
-
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
-
10.4049/jimmunol.0904060, 20483747
-
Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, Li J, Zhou H, Tang Y, Shen N. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010, 184:6773-6781. 10.4049/jimmunol.0904060, 20483747.
-
(2010)
J Immunol
, vol.184
, pp. 6773-6781
-
-
Pan, W.1
Zhu, S.2
Yuan, M.3
Cui, H.4
Wang, L.5
Luo, X.6
Li, J.7
Zhou, H.8
Tang, Y.9
Shen, N.10
-
79
-
-
79955569628
-
MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1
-
10.1002/art.30196, 21538319
-
Zhao S, Wang Y, Liang Y, Zhao M, Long H, Ding S, Yin H, Lu Q. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum 2011, 63:1376-1386. 10.1002/art.30196, 21538319.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1376-1386
-
-
Zhao, S.1
Wang, Y.2
Liang, Y.3
Zhao, M.4
Long, H.5
Ding, S.6
Yin, H.7
Lu, Q.8
-
80
-
-
34249802618
-
P300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice
-
Forster N, Gallinat S, Jablonska J, Weiss S, Elsässer HP, Lutz W. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice. J Immunol 2007, 178:6941-6948.
-
(2007)
J Immunol
, vol.178
, pp. 6941-6948
-
-
Forster, N.1
Gallinat, S.2
Jablonska, J.3
Weiss, S.4
Elsässer, H.P.5
Lutz, W.6
-
81
-
-
33947186736
-
The TNFalpha locus is altered in monocytes from patients with systemic lupus erythematosus
-
10.1016/j.clim.2006.12.008, 1905860, 17276734
-
Sullivan KE, Suriano A, Dietzmann K, Lin J, Goldman D, Petri MA. The TNFalpha locus is altered in monocytes from patients with systemic lupus erythematosus. Clin Immunol 2007, 123:74-81. 10.1016/j.clim.2006.12.008, 1905860, 17276734.
-
(2007)
Clin Immunol
, vol.123
, pp. 74-81
-
-
Sullivan, K.E.1
Suriano, A.2
Dietzmann, K.3
Lin, J.4
Goldman, D.5
Petri, M.A.6
-
82
-
-
77649340053
-
Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes
-
10.1038/gene.2009.66, 2832080, 19710693
-
Zhang Z, Song L, Maurer K, Petri MA, Sullivan KE. Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes. Genes Immun 2010, 11:124-133. 10.1038/gene.2009.66, 2832080, 19710693.
-
(2010)
Genes Immun
, vol.11
, pp. 124-133
-
-
Zhang, Z.1
Song, L.2
Maurer, K.3
Petri, M.A.4
Sullivan, K.E.5
-
83
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
10.1126/science.1079490, 12522256
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061. 10.1126/science.1079490, 12522256.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
84
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
10.1038/ni1428, 17136045
-
Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007, 8:191-197. 10.1038/ni1428, 17136045.
-
(2007)
Nat Immunol
, vol.8
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
85
-
-
33846980131
-
Epigenetic control of the foxp3 locus in regulatory T cells
-
10.1371/journal.pbio.0050038, 1783672, 17298177
-
Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol 2007, 5:e38. 10.1371/journal.pbio.0050038, 1783672, 17298177.
-
(2007)
PLoS Biol
, vol.5
-
-
Floess, S.1
Freyer, J.2
Siewert, C.3
Baron, U.4
Olek, S.5
Polansky, J.6
Schlawe, K.7
Chang, H.D.8
Bopp, T.9
Schmitt, E.10
Klein-Hessling, S.11
Serfling, E.12
Hamann, A.13
Huehn, J.14
-
86
-
-
49649107703
-
DNA methylation controls Foxp3 gene expression
-
10.1002/eji.200838105, 18493985
-
Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J. DNA methylation controls Foxp3 gene expression. Eur J Immunol 2008, 38:1654-1663. 10.1002/eji.200838105, 18493985.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1654-1663
-
-
Polansky, J.K.1
Kretschmer, K.2
Freyer, J.3
Floess, S.4
Garbe, A.5
Baron, U.6
Olek, S.7
Hamann, A.8
von Boehmer, H.9
Huehn, J.10
-
87
-
-
67649528173
-
Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression
-
10.1002/eji.200838509, 19408243
-
Rouas R, Fayyad-Kazan H, El Zein N, Lewalle P, Rothé F, Simion A, Akl H, Mourtada M, El Rifai M, Burny A, Romero P, Martiat P, Badran B. Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol 2009, 39:1608-1618. 10.1002/eji.200838509, 19408243.
-
(2009)
Eur J Immunol
, vol.39
, pp. 1608-1618
-
-
Rouas, R.1
Fayyad-Kazan, H.2
El Zein, N.3
Lewalle, P.4
Rothé, F.5
Simion, A.6
Akl, H.7
Mourtada, M.8
El Rifai, M.9
Burny, A.10
Romero, P.11
Martiat, P.12
Badran, B.13
-
88
-
-
29144516273
-
Global natural regulatory T cell depletion in active systemic lupus erythematosus
-
Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Nochy D, Debré P, Piette JC, Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005, 175:8392-8400.
-
(2005)
J Immunol
, vol.175
, pp. 8392-8400
-
-
Miyara, M.1
Amoura, Z.2
Parizot, C.3
Badoual, C.4
Dorgham, K.5
Trad, S.6
Nochy, D.7
Debré, P.8
Piette, J.C.9
Gorochov, G.10
-
89
-
-
33846900430
-
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
-
Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007, 178:2579-2588.
-
(2007)
J Immunol
, vol.178
, pp. 2579-2588
-
-
Valencia, X.1
Yarboro, C.2
Illei, G.3
Lipsky, P.E.4
-
90
-
-
79251576804
-
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu
-
10.4049/jimmunol.1002218, 21149603
-
Divekar AA, Dubey S, Gangalum PR, Singh RR. Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu. J Immunol 2011, 186:924-930. 10.4049/jimmunol.1002218, 21149603.
-
(2011)
J Immunol
, vol.186
, pp. 924-930
-
-
Divekar, A.A.1
Dubey, S.2
Gangalum, P.R.3
Singh, R.R.4
-
91
-
-
34247584465
-
Requirement of bic/microRNA-155 for normal immune function
-
10.1126/science.1139253, 2610435, 17463290
-
Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A. Requirement of bic/microRNA-155 for normal immune function. Science 2007, 316:608-611. 10.1126/science.1139253, 2610435, 17463290.
-
(2007)
Science
, vol.316
, pp. 608-611
-
-
Rodriguez, A.1
Vigorito, E.2
Clare, S.3
Warren, M.V.4
Couttet, P.5
Soond, D.R.6
van Dongen, S.7
Grocock, R.J.8
Das, P.P.9
Miska, E.A.10
Vetrie, D.11
Okkenhaug, K.12
Enright, A.J.13
Dougan, G.14
Turner, M.15
Bradley, A.16
-
92
-
-
34247594818
-
Regulation of the germinal center response by microRNA-155
-
10.1126/science.1141229, 17463289
-
Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science 2007, 316:604-608. 10.1126/science.1141229, 17463289.
-
(2007)
Science
, vol.316
, pp. 604-608
-
-
Thai, T.H.1
Calado, D.P.2
Casola, S.3
Ansel, K.M.4
Xiao, C.5
Xue, Y.6
Murphy, A.7
Frendewey, D.8
Valenzuela, D.9
Kutok, J.L.10
Schmidt-Supprian, M.11
Rajewsky, N.12
Yancopoulos, G.13
Rao, A.14
Rajewsky, K.15
-
93
-
-
33750499991
-
A role for Dicer in immune regulation
-
10.1084/jem.20061692, 2118134, 17060477
-
Cobb BS, Hertweck A, Smith J, O'Connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M. A role for Dicer in immune regulation. J Exp Med 2006, 203:2519-2527. 10.1084/jem.20061692, 2118134, 17060477.
-
(2006)
J Exp Med
, vol.203
, pp. 2519-2527
-
-
Cobb, B.S.1
Hertweck, A.2
Smith, J.3
O'Connor, E.4
Graf, D.5
Cook, T.6
Smale, S.T.7
Sakaguchi, S.8
Livesey, F.J.9
Fisher, A.G.10
Merkenschlager, M.11
-
94
-
-
51049110261
-
Dicer-dependent microRNA pathway safeguards regulatory T cell function
-
10.1084/jem.20081062, 2526195, 18725526
-
Liston A, Lu LF, O'Carroll D, Tarakhovsky A, Rudensky AY. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med 2008, 205:1993-2004. 10.1084/jem.20081062, 2526195, 18725526.
-
(2008)
J Exp Med
, vol.205
, pp. 1993-2004
-
-
Liston, A.1
Lu, L.F.2
O'Carroll, D.3
Tarakhovsky, A.4
Rudensky, A.Y.5
|