YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

Biochemical and Biophysical Research Communications

Volumn 382, Issue 3, 2009, Pages 566-570

  Ikonomov, Ognian C ^a   Sbrissa, Diego ^a   Shisheva, Assia ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiretroviral therapy; Glucose transport; GLUT4; Insulin action; Insulin resistance; PI 3 kinase; PIKfyve; YM201636

Indexed keywords

6 AMINO N [3 [4 (4 MORPHOLINYL)PYRIDO[30,20:4,5]FURO[3,2 D]PYRIMIDIN 2 YL]PHENYL] 3 PYRIDINE CARBOXAMIDE; ANTIRETROVIRUS AGENT; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; POLYPHOSPHOINOSITIDE; PROTEIN KINASE B; UNCLASSIFIED DRUG; YM 201636;

ADIPOCYTE; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN 3T3; DRUG INHIBITION; ENZYME ACTIVATION; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; IC 50; INSULIN RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VIROGENESIS; VIROTHERAPY; VIRUS REPLICATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; AMINOPYRIDINES; ANIMALS; ANTIVIRAL AGENTS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HETEROCYCLIC COMPOUNDS, 3-RING; INSULIN; INSULIN ANTAGONISTS; MICE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN TRANSPORT; RETROVIRIDAE; VIRUS REPLICATION;

EID: 64049093487     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.03.063     Document Type: Article

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