-
1
-
-
0035855626
-
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
-
Fulda S, Kufer MU, Meyer E, et al. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001; 20: 5865-5877.
-
(2001)
Oncogene
, vol.20
, pp. 5865-5877
-
-
Fulda, S.1
Kufer, M.U.2
Meyer, E.3
-
3
-
-
0029011539
-
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L, et al. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1: 686-692.
-
(1995)
Nat Med
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
-
4
-
-
15744401773
-
Eukaryotic cytosine methyltransferases
-
Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005; 74: 481-514.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 481-514
-
-
Goll, M.G.1
Bestor, T.H.2
-
5
-
-
4444325603
-
Demethylation of DNA by decitabine in cancer chemotherapy
-
Brown R, Plumb JA. Demethylation of DNA by decitabine in cancer chemotherapy. Expert Rev Anticancer Ther 2004; 4: 501-510.
-
(2004)
Expert Rev Anticancer Ther
, vol.4
, pp. 501-510
-
-
Brown, R.1
Plumb, J.A.2
-
6
-
-
0031964055
-
Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines
-
Bender CM, Pao MM, Jones PA. Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 1998; 58: 95-101.
-
(1998)
Cancer Res
, vol.58
, pp. 95-101
-
-
Bender, C.M.1
Pao, M.M.2
Jones, P.A.3
-
7
-
-
0000206049
-
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
-
DeSimone J, Heller P, Hall L, et al. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci USA 1982; 79: 4428-4431.
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 4428-4431
-
-
DeSimone, J.1
Heller, P.2
Hall, L.3
-
8
-
-
0020563258
-
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia
-
Ley TJ, DeSimone J, Noguchi CT, et al. 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood 1983; 62: 370-380.
-
(1983)
Blood
, vol.62
, pp. 370-380
-
-
Ley, T.J.1
DeSimone, J.2
Noguchi, C.T.3
-
9
-
-
0036625004
-
Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia
-
DeSimone J, Koshy M, Dorn L, et al. Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia. Blood 2002; 99: 3905-3908.
-
(2002)
Blood
, vol.99
, pp. 3905-3908
-
-
DeSimone, J.1
Koshy, M.2
Dorn, L.3
-
11
-
-
21244449980
-
Evaluation of a 7-day continuous intravenous infusion of decitabine: Inhibition of promoter-specific and global genomic DNA methylation
-
Samlowski WE, Leachman SA, Wade M, et al. Evaluation of a 7-day continuous intravenous infusion of decitabine: Inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol 2005; 23: 3897-3905.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3897-3905
-
-
Samlowski, W.E.1
Leachman, S.A.2
Wade, M.3
-
12
-
-
33744918070
-
DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
-
Yang AS, Doshi KD, Choi SW, et al. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res 2006; 66: 5495-5503.
-
(2006)
Cancer Res
, vol.66
, pp. 5495-5503
-
-
Yang, A.S.1
Doshi, K.D.2
Choi, S.W.3
-
13
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment
-
Daskalakis M, Nguyen TT, Nguyen C, et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood 2002; 100: 2957-2964.
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
-
14
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies
-
Issa JP, Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004; 103: 1635-1640.
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
-
15
-
-
0034066405
-
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
-
Teitz T, Wei T, Valentine MB, et al. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nature Med 2000; 6: 529-535.
-
(2000)
Nature Med
, vol.6
, pp. 529-535
-
-
Teitz, T.1
Wei, T.2
Valentine, M.B.3
-
16
-
-
0034886497
-
Aggressive childhood neuroblastomas do not express caspase-8: An important component of programmed cell death
-
Teitz T, Lahti JM, Kidd VJ. Aggressive childhood neuroblastomas do not express caspase-8: An important component of programmed cell death. J Mol Med (Berlin, Germany) 2001; 79: 428-436.
-
(2001)
J Mol Med (Berlin, Germany)
, vol.79
, pp. 428-436
-
-
Teitz, T.1
Lahti, J.M.2
Kidd, V.J.3
-
17
-
-
0035866396
-
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
-
Eggert A, Grotzer MA, Zuzak TJ, et al. Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res 2001; 61: 1314-1319.
-
(2001)
Cancer Res
, vol.61
, pp. 1314-1319
-
-
Eggert, A.1
Grotzer, M.A.2
Zuzak, T.J.3
-
18
-
-
0034662625
-
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
-
Hopkins-Donaldson S, Bodmer JL, Bourloud KB, et al. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2000; 60: 4315-4319.
-
(2000)
Cancer Res
, vol.60
, pp. 4315-4319
-
-
Hopkins-Donaldson, S.1
Bodmer, J.L.2
Bourloud, K.B.3
-
19
-
-
0033658853
-
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis
-
Hopkins-Donaldson S, Bodmer JL, Bourloud KB, et al. Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis. Med Pediatr Oncol 2000; 35: 608-611.
-
(2000)
Med Pediatr Oncol
, vol.35
, pp. 608-611
-
-
Hopkins-Donaldson, S.1
Bodmer, J.L.2
Bourloud, K.B.3
-
20
-
-
0035913193
-
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
-
Takita J, Yang HW, Chen YY, et al. Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene 2001; 20: 4424-4432.
-
(2001)
Oncogene
, vol.20
, pp. 4424-4432
-
-
Takita, J.1
Yang, H.W.2
Chen, Y.Y.3
-
21
-
-
0035829657
-
RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours
-
Astuti D, Agathanggelou A, Honorio S, et al. RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours. Oncogene 2001; 20: 7573-7577.
-
(2001)
Oncogene
, vol.20
, pp. 7573-7577
-
-
Astuti, D.1
Agathanggelou, A.2
Honorio, S.3
-
22
-
-
0037301110
-
Hypermethylation-mediated regulation of CD44 gene expression in human neuroblastoma
-
Yan P, Muhlethaler A, Bourloud KB, et al. Hypermethylation-mediated regulation of CD44 gene expression in human neuroblastoma. Genes Chromosomes Cancer 2003; 36: 129-138.
-
(2003)
Genes Chromosomes Cancer
, vol.36
, pp. 129-138
-
-
Yan, P.1
Muhlethaler, A.2
Bourloud, K.B.3
-
23
-
-
0141885092
-
Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma
-
Yang QW, Liu S, Tian Y, et al. Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. Cancer Res 2003; 63: 6299-6310.
-
(2003)
Cancer Res
, vol.63
, pp. 6299-6310
-
-
Yang, Q.W.1
Liu, S.2
Tian, Y.3
-
24
-
-
3042819501
-
Methylation-associated silencing of the heat shock protein 47 gene in human neuroblastoma
-
Yang Q, Liu S, Tian Y, et al. Methylation-associated silencing of the heat shock protein 47 gene in human neuroblastoma. Cancer Res 2004; 64: 4531-4538.
-
(2004)
Cancer Res
, vol.64
, pp. 4531-4538
-
-
Yang, Q.1
Liu, S.2
Tian, Y.3
-
26
-
-
0034046395
-
Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region
-
Chen B, He L, Savell VH, et al. Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region. Cancer Res 2000; 60: 3290-3298.
-
(2000)
Cancer Res
, vol.60
, pp. 3290-3298
-
-
Chen, B.1
He, L.2
Savell, V.H.3
-
27
-
-
9444229369
-
Doxorubicin inhibits DNMT1, resulting in conditional apoptosis
-
Yokochi T, Robertson KD. Doxorubicin inhibits DNMT1, resulting in conditional apoptosis. Mol Pharmacol 2004; 66: 1415-1420.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1415-1420
-
-
Yokochi, T.1
Robertson, K.D.2
-
28
-
-
0030990163
-
Decitabine (5-Aza-2'-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: Preliminary observations
-
Schwartsmann G, Fernandes MS, Schaan MD, et al. Decitabine (5-Aza-2'-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: Preliminary observations. Leukemia 1997; 11: S28-31.
-
(1997)
Leukemia
, vol.11
-
-
Schwartsmann, G.1
Fernandes, M.S.2
Schaan, M.D.3
-
29
-
-
0027193132
-
Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group
-
Willemze R, Archimbaud E, Muus P. Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group. Leukemia 1993; 7: 49-50.
-
(1993)
Leukemia
, vol.7
, pp. 49-50
-
-
Willemze, R.1
Archimbaud, E.2
Muus, P.3
-
30
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors [see comments]
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors [see comments]. J Natl Cancer Inst 2000; 92: 205-216.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
31
-
-
78249278967
-
-
Analytical method development and validation of decitabine in human plasma: XenoBiotic Laboratories, Inc. (XBL); 2002; May 23, 2002.Report
-
Gu Z, Zhou G. Analytical method development and validation of decitabine in human plasma: XenoBiotic Laboratories, Inc. (XBL); 2002; May 23, 2002.Report. 1-74 pp.
-
(2002)
, pp. 1-74
-
-
Gu, Z.1
Zhou, G.2
-
32
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, CA) 2001; 25: 402-408.
-
(2001)
Methods (San Diego, CA)
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
33
-
-
0042424602
-
Statistical significance for genomewide studies
-
Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003; 100: 9440-9445.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9440-9445
-
-
Storey, J.D.1
Tibshirani, R.2
-
34
-
-
0034907443
-
Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR
-
Cheung IY, Cheung NK. Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR. Clin Cancer Res 2001; 7: 1698-1705.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1698-1705
-
-
Cheung, I.Y.1
Cheung, N.K.2
-
35
-
-
33750326078
-
Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura
-
Schrump DS, Fischette MR, Nguyen DM, et al. Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. Clin Cancer Res 2006; 12: 5777-5785.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5777-5785
-
-
Schrump, D.S.1
Fischette, M.R.2
Nguyen, D.M.3
-
36
-
-
21244431605
-
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
-
Issa JP, Gharibyan V, Cortes J, et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 2005; 23: 3948-3956.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3948-3956
-
-
Issa, J.P.1
Gharibyan, V.2
Cortes, J.3
-
37
-
-
39749155114
-
Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)
-
Cashen AF, Shah AK, Todt L, et al. Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Cancer Chemother Pharmacol 2008; 61: 759-766.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 759-766
-
-
Cashen, A.F.1
Shah, A.K.2
Todt, L.3
-
38
-
-
0030974771
-
Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer
-
Momparler RL, Bouffard DY, Momparler LF, et al. Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anti-Cancer Drugs 1997; 8: 358-368.
-
(1997)
Anti-Cancer Drugs
, vol.8
, pp. 358-368
-
-
Momparler, R.L.1
Bouffard, D.Y.2
Momparler, L.F.3
-
39
-
-
0022501789
-
Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 1277 16) in cancer patients
-
van Groeningen CJ, Leyva A, O'Brien AM, et al. Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 1277 16) in cancer patients. Cancer Res 1986; 46: 4831-4836.
-
(1986)
Cancer Res
, vol.46
, pp. 4831-4836
-
-
van Groeningen, C.J.1
Leyva, A.2
O'Brien, A.M.3
-
40
-
-
0032694084
-
DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter
-
De Smet C, Lurquin C, Lethe B, et al. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol 1999; 19: 7327-7335.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7327-7335
-
-
De Smet, C.1
Lurquin, C.2
Lethe, B.3
-
41
-
-
0031945210
-
A phase II study of 5-aza-2'deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
-
Thibault A, Figg WD, Bergan RC, et al. A phase II study of 5-aza-2'deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori 1998; 84: 87-89.
-
(1998)
Tumori
, vol.84
, pp. 87-89
-
-
Thibault, A.1
Figg, W.D.2
Bergan, R.C.3
-
42
-
-
0344990164
-
Phase I trial of continuous infusion 5-aza-2'-deoxycytidine
-
Aparicio A, Eads CA, Leong LA, et al. Phase I trial of continuous infusion 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol 2003; 51: 231-239.
-
(2003)
Cancer Chemother Pharmacol
, vol.51
, pp. 231-239
-
-
Aparicio, A.1
Eads, C.A.2
Leong, L.A.3
-
43
-
-
33846011361
-
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
-
Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007; 109: 52-57.
-
(2007)
Blood
, vol.109
, pp. 52-57
-
-
Kantarjian, H.1
Oki, Y.2
Garcia-Manero, G.3
-
44
-
-
33847395041
-
Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia
-
Oki Y, Kantarjian HM, Gharibyan V, et al. Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia. Cancer 2007; 109: 899-906.
-
(2007)
Cancer
, vol.109
, pp. 899-906
-
-
Oki, Y.1
Kantarjian, H.M.2
Gharibyan, V.3
-
45
-
-
0029957792
-
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
-
De Smet C, De Backer O, Faraoni I, et al. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci USA 1996; 93: 7149-7153.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7149-7153
-
-
De Smet, C.1
De Backer, O.2
Faraoni, I.3
-
46
-
-
34548414620
-
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
-
Appleton K, Mackay HJ, Judson I, et al. Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol 2007; 25: 4603-4609.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4603-4609
-
-
Appleton, K.1
Mackay, H.J.2
Judson, I.3
-
47
-
-
0037452790
-
Individuality and variation in gene expression patterns in human blood
-
Whitney AR, Diehn M, Popper SJ, et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci USA 2003; 100: 1896-1901.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1896-1901
-
-
Whitney, A.R.1
Diehn, M.2
Popper, S.J.3
-
48
-
-
64149083208
-
Interindividual and interethnic variation in genomewide gene expression: Insights into the biological variation of gene expression and clinical implications
-
Fan HP, Di Liao C, Fu BY, et al. Interindividual and interethnic variation in genomewide gene expression: Insights into the biological variation of gene expression and clinical implications. Clin Chem 2009; 55: 774-785.
-
(2009)
Clin Chem
, vol.55
, pp. 774-785
-
-
Fan, H.P.1
Di Liao, C.2
Fu, B.Y.3
-
49
-
-
17444452612
-
Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
-
Wijermans P, Lubbert M, Verhoef G, et al. Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients. J Clin Oncol 2000; 18: 956-962.
-
(2000)
J Clin Oncol
, vol.18
, pp. 956-962
-
-
Wijermans, P.1
Lubbert, M.2
Verhoef, G.3
-
50
-
-
44149125758
-
Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer
-
Lemaire M, Chabot GG, Raynal NJ, et al. Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer. BMC Cancer 2008; 8: 128.
-
(2008)
BMC Cancer
, vol.8
, pp. 128
-
-
Lemaire, M.1
Chabot, G.G.2
Raynal, N.J.3
|