Bidens pilosa L. (Asteraceae): Botanical properties, traditional uses, phytochemistry, and pharmacology

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Bartolome, Arlene P ^a,b   Villaseñor, Irene M ^a   Yang, Wen Chin ^b,c,d,e,f  

^a University of the Philippines Diliman   (Philippines)

^b AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC COMPOUND; AROMATIC COMPOUND; BIDENS PILOSA EXTRACT; FATTY ACID DERIVATIVE; FLAVONOID; PHENOL DERIVATIVE; PHENYLPROPANOID; PLANT MEDICINAL PRODUCT; PORPHYRIN DERIVATIVE; PROPIONIC ACID DERIVATIVE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE APPENDICITIS; ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ASTHMA; BACTERIAL INFECTION; BIDENS PILOSA; BIOLOGICAL ACTIVITY; BURN; COLIC; CONJUNCTIVITIS; CONSTIPATION; COUGHING; DIABETES MELLITUS; DIARRHEA; DYSENTERY; DYSMENORRHEA; ENTERITIS; EYE INFECTION; GASTRITIS; HEADACHE; HEMORRHOID; HUMAN; HUMAN CELL; HYPEREMESIS GRAVIDARUM; IMMUNOMODULATION; INFECTIOUS HEPATITIS; INFLUENZA; KIDNEY INFECTION; LUNG TUBERCULOSIS; MENSTRUAL IRREGULARITY; NONHUMAN; OTITIS; PHARYNGITIS; PHYTOCHEMISTRY; PRIORITY JOURNAL; PRURITUS; REVIEW; SNAKEBITE; SORE THROAT; STOMACH ULCER; TRADITIONAL MEDICINE; VASODILATATION; WOUND; YELLOW FEVER;

EID: 84880876751     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/340215     Document Type: Review

References (133)

1. Shen T., Li G. H., Wang X. N., Lou H. X., The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology 142 2 319 330
2. Long C., Sauleau P., David B., Lavaud C., Cassabois V., Ausseil F., Massiot G., Bioactive flavonoids of Tanacetum parthenium revisited. Phytochemistry 2003 64 2 567 569 2-s2.0-0141682676 10.1016/S0031-9422(03)00208-5 (Pubitemid 37168977)
3. Karis P. O., Ryding O., Asteraceae Cladistics and Classification 1994 Portland, Ore, USA Timber press Bremer K. Eds, pp. 559-569
4. Pozharitskaya O. N., Shikov A. N., Makarova M. N., Kosman V. M., Faustova N. M., Tesakova S. V., Makarov V. G., Galambosi B., Anti-inflammatory activity of a HPLC-fingerprinted aqueous infusion of aerial part of Bidens tripartita L. Phytomedicine 2010 17 6 463 468 2-s2.0-77950299601 10.1016/j.phymed.2009.08.001
5. Oliveira F. Q., Andrade-Neto V., Krettli A. U., Brandão M. G. L., New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. Journal of Ethnopharmacology 2004 93 1 39 42 2-s2.0-2942590821 10.1016/j.jep.2004.03.026 (Pubitemid 38739267)
6. Agriculture USDA, Plants database. 2013, in: Natural Resources Conservation Service, http://www.nrcs.usda.gov/wps/portal/nrcs/site/national/ home
7. Chien S. C., Young P. H., Hsu Y. J., Chen C. H., Tien Y. J., Shiu S. Y., Li T. H., Yang C. W., Marimuthu P., Tsai L. F. L., Yang W. C., Anti-diabetic properties of three common Bidens pilosa variants in Taiwan. Phytochemistry 2009 70 10 1246 1254 2-s2.0-69249156977 10.1016/j.phytochem.2009.07.011
8. Alcaraz M. J., Jimenez M. J., Flavonoids as anti-inflammatory agents. Fitoterapia 1988 59 1 25 38 2-s2.0-0023895154
9. FAO, Agriculture Food and Nutrition for Africa-A Resource Book for Teachers of Agriculture 1997 Rome, Italy Publishing Management Group, FAO Information Division
10. Rokaya M. B., Munzbergova Z., Timsina B., Bhattarai K. R., Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology. Journal of Ethnopharmacology 2012 141 3 761 774
11. Young P. H., Hsu Y. J., Yang W. C., Awaad A. S., Singh V. K., Govil J. N., Bidens pilosa L. and its medicinal use. Recent Progress in Medicinal Plants Drug Plant II 2010 Houston, Tex, USA Standium Press
12. Ge C., Cytologic study of Bidens bipinnata L. Zhongguo Zhong Yao Za Zhi 1990 15 2 72 125 2-s2.0-0025380913
13. Chiang L. C., Chang J. S., Chen C. C., Ng L. T., Lin C. C., Anti-herpes simplex virus activity of Bidens pilosa and Houttuynia cordata. American Journal of Chinese Medicine 2003 31 3 355 362 2-s2.0-8444250580 10.1142/ S0192415X03001090 (Pubitemid 41758822)
14. Rybalchenko N. P., Prykhodko V. A., Nagorna S. S., Volynets N. N., Ostapchuk A. N., Klochko V. V., Rybalchenko T. V., Avdeeva L. V., In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts. Fitoterapia 2010 81 5 336 338 2-s2.0-77954214398 10.1016/j.fitote.2009.10.007
15. Zhou Y., Yan X. Z., Experimental study of qi deficiency syndrome and Codonopsis pillosulae and Astragalus injection on the immune response in mice. Zhong Xi Yi Jie He Za Zhi 1989 9 5 286 262 2-s2.0-0024659565
16. Redl K., Breu W., Davis B., Bauer R., Anti-inflammatory active polyacetylenes from Bidens campylotheca. Planta Medica 1994 60 1 58 62 2-s2.0-0028347040 (Pubitemid 24082607)
17. Tan P. V., Dimo T., Dongo E., Effects of methanol, cyclohexane and methylene chlo ride extracts of Bidens pilosa on various gastric ulcer models in rats. Journal of Ethnopharmacology 2000 73 3 415 421 2-s2.0-0033710734 10.1016/S0378-8741(00)00290-7
18. Pereira R. L. C., Ibrahim T., Lucchetti L., Da Silva A. J. R., De Moraes V. L. G., Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L. Immunopharmacology 1999 43 1 31 37 2-s2.0-0033031943 10.1016/S0162-3109(99)00039-9 (Pubitemid 29290568)
19. Dimo T., Azay J., Tan P. V., Pellecuer J., Cros G., Bopelet M., Serrano J. J., Effects of the aqueous and methylene chloride extracts of Bidens pilosa leaf on fructose-hypertensive rats. Journal of Ethnopharmacology 2001 76 3 215 221 2-s2.0-0034936849 10.1016/S0378-8741(01)00229-X (Pubitemid 32633846)
20. Wiart C., Medicinal Plants of Southeast Asia 2000 Selabgor Darul Ehsan, Malaysia Pelanduk
21. Dharmananda S., A Popular Remedy Ecapes Notice of Western Practitioners. 2013, http://www.itmonline.org/arts/bidens.htm
22. Lans C., Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. Journal of Ethnobiology and Ethnomedicine 2007 3, article 3 2-s2.0-34250858197 10.1186/1746-4269-3-3 (Pubitemid 46979442)
23. Ayyanar M., Ignacimuthu S., Traditional knowledge of Kani tribals in Kouthalai of Tirunelveli hills, Tamil Nadu, India. Journal of Ethnopharmacology 2005 102 2 246 255 2-s2.0-27144468362 10.1016/j.jep.2005.06.020 (Pubitemid 41487098)
24. Cano J. H., Volpato G., Herbal mixtures in the traditional medicine of Eastern Cuba. Journal of Ethnopharmacology 2004 90 2-3 293 316 2-s2.0-0842304871 10.1016/j.jep.2003.10.012 (Pubitemid 38180483)
25. Geissberger P., Sequin U., Constituents of Bidens pilosa L.: do the components found so far explain the use of this plant in traditional medicine? Acta Tropica 1991 48 4 251 261 2-s2.0-0026022078 10.1016/0001-706X(91)90013-A
26. Noumi E., Houngue F., Lontsi D., Traditional medicines in primary health care: plants used for the treatment of hypertension in Bafia, Cameroon. Fitoterapia 1999 70 2 134 139 2-s2.0-0033031669 10.1016/S0367-326X(98)00025-2 (Pubitemid 29264393)
27. Silva F. L., Fischer D. C. H., Tavares J. F., Silva M. S., De Athayde-Filho P. F., Barbosa-Filho J. M., Compilation of secondary metabolites from Bidens pilosa L. Molecules 2011 16 2 1070 1102 2-s2.0-79952124586 10.3390/molecules16021070
28. Wu L. W., Chiang Y. M., Chuang H. C., Lo C. P., Yang K. Y., Wang S. Y., Shyur L. F., A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7. Planta Medica 2007 73 7 655 661 2-s2.0-34447544670 10.1055/s-2007-981527 (Pubitemid 47066158)
29. Chang S. L., Chiang Y. M., Chang C. L. T., Yeh H. H., Shyur L. F., Kuo Y. H., Wu T. K., Yang W. C., Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN- γ expression. Journal of Ethnopharmacology 2007 112 2 232 236 2-s2.0-34248545485 10.1016/j.jep.2007.03.001 (Pubitemid 46756068)
30. Kumari P., Misra K., Sisodia B. S., Faridi U., Srivastava S., Luqman S., Darokar M. P., Negi A. S., Gupta M. M., Singh S. C., Kotesh Kumar J., A promising anticancer and antimalarial component from the leaves of Bidens pilosa. Planta Medica 2009 75 1 59 61 2-s2.0-64749104582 10.1055/s-0028-1088362
31. Seelinger G., Merfort I., Wölfle U., Schempp C. M., Anti-carcinogenic effects of the flavonoid luteolin. Molecules 2008 13 10 2628 2651 2-s2.0-55249085887 10.3390/molecules13102628
32. Seelinger G., Merfort I., Schempp C. M., Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Medica 2008 74 14 1667 1677 2-s2.0-57149103144 10.1055/s-0028-1088314
33. Yit C. C., Das N. P., Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Letters 1994 82 1 65 72 2-s2.0-0028336781 10.1016/0304-3835(94)90147-3 (Pubitemid 24211073)
34. Beutler J. A., Hamel E., Vlietinck A. J., Haemers A., Rajan P., Roitman J. N., Cardellina J. H., Boyd M. R., Structure-activity requirements for flavone cytotoxicity and binding to tubulin. Journal of Medicinal Chemistry 1998 41 13 2333 2338 2-s2.0-0032543726 10.1021/jm970842h (Pubitemid 28285735)
35. Kviecinski M. R., Felipe K. B., Schoenfelder T., de Lemos Wiese L. P., Rossi M. H., Gonçalez E., Felicio J. D., Filho D. W., Pedrosa R. C., Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine. Journal of Ethnopharmacology 2008 117 1 69 75 2-s2.0-40949130380 10.1016/j.jep.2008.01.017
36. Sundararajan P., Dey A., Smith A., Doss A. G., Rajappan M., Natarajan S., Studies of anticancer and antipyretic activity of Bidens pilosa whole plant. African Health Sciences 2006 6 1 27 30 2-s2.0-33747221147
37. Horiuchi M., Seyama Y., Improvement of the antiinflammatory and antiallergic activity of Bidens pilosa L. var. radiata SCHERFF treated with enzyme (Cellulosine). Journal of Health Science 2008 54 3 294 301 2-s2.0-44849130975 10.1248/jhs.54.294 (Pubitemid 351798588)
38. Chiang Y. M., Lo C. P., Chen Y. P., Wang S. Y., Yang N. S., Kuo Y. H., Shyur L. F., Ethyl caffeate suppresses NF- B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. British Journal of Pharmacology 2005 146 3 352 363 2-s2.0-27144544615 10.1038/sj.bjp.0706343 (Pubitemid 41486677)
39. Kim J. S., Lee H. J., Lee M. H., Kim J., Jin C., Ryu J. H., Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells. Planta Medica 2006 72 1 65 68 2-s2.0-32644433270 10.1055/s-2005-873145 (Pubitemid 43241595)
40. Ruiz P. A., Haller D., Functional diversity of flavonoids in the inhibition of the proinflammatory NF- B, IRF, and Akt signaling pathways in murine intestinal epithelial cells. Journal of Nutrition 2006 136 3 664 671 2-s2.0-33644847672 (Pubitemid 43363751)
41. Xagorari A., Papapetropoulos A., Mauromatis A., Economou M., Fotsis T., Roussos C., Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. Journal of Pharmacology and Experimental Therapeutics 2001 296 1 181 187 2-s2.0-0035193217 (Pubitemid 32015077)
42. Yoshida N., Kanekura T., Higashi Y., Kanzaki T., Bidens pilosa suppresses interleukin-1 β -induced cyclooxygenase-2 expression through the inhibition of mitogen activated protein kinases phosphorylation in normal human dermal fibroblasts. Journal of Dermatology 2006 33 10 676 683 2-s2.0-33749564091 10.1111/j.1346-8138.2006.00158.x (Pubitemid 44536372)
43. Hsu Y. J., Lee T. H., Chang C. L. T., Huang Y. T., Yang W. C., Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract. Journal of Ethnopharmacology 2009 122 2 379 383 2-s2.0-60849088848 10.1016/j.jep.2008. 12.027
44. Chang S. L., Chang C. L. T., Chiang Y. M., Hsieh R. H., Tzeng C. R., Wu T. K., Sytwu H. K., Shyur L. F., Yang W. C., Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice. Planta Medica 2004 70 11 1045 1051 2-s2.0-9744246006 10.1055/s-2004-832645 (Pubitemid 39587038)
45. Ubillas R. P., Mendez C. D., Jolad S. D., Luo J., King S. R., Carlson T. J., Fort D. M., Antihyperglycemic acetylenic glucosides from Bidens pilosa. Planta Medica 2000 66 1 82 83 2-s2.0-0033974926 (Pubitemid 30097291)
46. Chang C. L. T., Chang S. L., Lee Y. M., Chiang Y. M., Chuang D. Y., Kuo H. K., Yang W. C., Cytopiloyne, a polyacetylenic glucoside, prevents type 1 diabetes in nonobese diabetic mice. Journal of Immunology 2007 178 11 6984 6993 2-s2.0-34249784226
47. Chiang Y. M., Chuang D. Y., Wang S. Y., Kuo Y. H., Tsai P. W., Shyur L. F., Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa. Journal of Ethnopharmacology 2004 95 2-3 409 419 2-s2.0-7044224311 10.1016/j.jep.2004.08.010 (Pubitemid 39422702)
48. Muchuweti M., Mupure C., Ndhlala A., Murenje T., Benhura M. A. N., Screening of antioxidant and radical scavenging activity of Vigna ungiculata, Bidens pilosa and Cleome gynandra. American Journal of Food Technology 2007 2 3 161 168 2-s2.0-34247523313 (Pubitemid 46657816)
49. Yuan L. P., Chen F. H., Ling L., Bo H., Chen Z. W., Li F., Zhong M. M., Xia L. J., Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. Journal of Pharmacy and Pharmacology 2008 60 10 1393 1402 2-s2.0-52949101302 10.1211/jpp/60.10.0016
50. Chiang Y. M., Chang C. L. T., Chang S. L., Yang W. C., Shyur L. F., Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. Journal of Ethnopharmacology 2007 110 3 532 538 2-s2.0-33847761028 10.1016/j.jep.2006.10.007 (Pubitemid 46386358)
51. Tobinaga S., Sharma M. K., Aalbersberg W. G. L., Watanabe K., Iguchi K., Narui K., Sasatsu M., Waki S., Isolation and identification of a potent antimalarial and antibacterial polyacetylene from Bidens pilosa. Planta Medica 2009 75 6 624 628 2-s2.0-68949137483 10.1055/s-0029-1185377
52. Chang S. L., Yeh H. H., Lin Y. S., Chiang Y. M., Wu T. K., Yang W. C., The effect of centaurein on interferon- γ expression and Listeria infection in mice. Toxicology and Applied Pharmacology 2007 219 1 54 61 2-s2.0-33846902830 10.1016/j.taap.2006.11.026 (Pubitemid 46237648)
53. Deba F., Xuan T. D., Yasuda M., Tawata S., Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata. Food Control 2008 19 4 346 352 2-s2.0-35348856290 10.1016/j.foodcont.2007.04.011 (Pubitemid 47571015)
54. Ashafa A. O. T., Afolayan A. J., Screening the root extracts from Biden pilosa L. var. radiata (Asteraceae) for antimicrobial potentials. Journal of Medicinal Plant Research 2009 3 8 568 572 2-s2.0-73449110889
55. Nguelefack T. B., Dimo T., Nguelefack Mbuyo E. P., Tan P. V., Rakotonirina S. V., Kamanyi A., Relaxant effects of the neutral extract of the leaves of Bidens pilosa linn on isolated rat vascular smooth muscle. Phytotherapy Research 2005 19 3 207 210 2-s2.0-20444500483 10.1002/ptr.1646 (Pubitemid 40827643)
56. Abbas A. K., Murphy K. M., Sher A., Functional diversity of helper T lymphocytes. Nature 1996 383 6603 787 793 2-s2.0-0029847368 10.1038/383787a0 (Pubitemid 26372655)
57. Namukobe J., Kasenene J. M., Kiremire B. T., Byamukama R., Kamatenesi-Mugisha M., Krief S., Dumontet V., Kabasa J. D., Traditional plants used for medicinal purposes by local communities around the Northern sector of Kibale National Park, Uganda. Journal of Ethnopharmacology 2011 136 1 236 245 2-s2.0-79958121162 10.1016/j.jep.2011.04.044
58. Chen A. H., Lin S. R., Hong C. H., Phytochemical study on Bidens pilosa L. var. minor. Huaxue 1975 38 42
59. Lee C. K., The low polar constituents from Bidens pilosa L. var. minor (blume) sherff. Journal of the Chinese Chemical Society 2000 47 5 1131 1136 2-s2.0-18844453407
60. Zulueta M. C., Tada M., Ragasa C. Y., A diterpene from Bidens pilosa. Phytochemistry 1995 38 6 1449 1450 2-s2.0-0029141812 10.1016/0031-9422(94)00793- S
61. Wang J., Yang H., Lin Z. W., Sun H. D., Flavonoids from Bidens pilosa var. radiata. Phytochemistry 1997 46 7 1275 1278 2-s2.0-0031449538 10.1016/S0031-9422(97)00420-2 (Pubitemid 28000424)
62. Zhao A., Zhao Q., Peng L., A new chalcone glycoside from Bidens pilosa. Acta Botanica Yunnanica 26 1 121 126
63. Gao P., Wu Y., Cui S., Zou Y., Synthesis and absolute configuration of the 7-phenylhepta-4, 6-diyne-1, 2-diol isolated from Bidens pilosa. Synthesis 2011 13 2131 2135
64. Wang S., Yang B., Zhu D., He D., Wang L., Active components of Bidens pilosa L. Zhongcaoyao 36 20 21
65. Bohlmann F., Burkhardt T., Zdero C., Naturally Occuring Acetylenes 1973 New York, NY, USA Academic Press
66. Sarg T. M., Ateya A. M., Farrag N. M., Abbas F. A., Constituents and biological activity of Bidens pilosa L. grown in Egypt. Acta Pharmaceutica Hungarica 1991 61 6 317 323 2-s2.0-0026343281
67. Valdés H. A. L., Rego H. P., Bidens pilosa Linné Revista Cubana de Plantas Medicinales 6 28 33
68. Bohlmann F., Bornowski H., Kleine K. M., New polyynes from the tribe Heliantheae. Chemische Berichte 97 2135 2138
69. Wang R., Wu Q. X., Shi Y. P., Polyacetylenes and flavonoids from the aerial parts of Bidens pilosa. Planta Medica 2010 76 9 893 896 2-s2.0-77953862737 10.1055/s-0029-1240814
70. Wu L. W., Chiang Y. M., Chuang H. C., Wang S. Y., Yang G. W., Chen Y. H., Lai L. Y., Shyur L. F., Polyacetylenes function as anti-angiogenic agents. Pharmaceutical Research 2004 21 11 2112 2119 2-s2.0-21644437806 10.1023/B:PHAM.0000048204.08865.41 (Pubitemid 40941233)
71. Yang H. L., Chen S. C., Chang N. W., Chang J. M., Lee M. L., Tsai P. C., Fu H. H., Kao W. W., Chiang H. C., Wang H. H., Hseu Y. C., Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes. Food and Chemical Toxicology 2006 44 9 1513 1521 2-s2.0-33745612025 10.1016/j.fct.2006.04.006
72. Wang H. Q., Lu S. J., Li H., Yao Z. H., EDTA-enhanced phytoremediation of lead contaminated soil by Bidens maximowicziana. Journal of Environmental Sciences 2007 19 12 1496 1499 2-s2.0-36849064245 10.1016/S1001-0742(07)60243-5 (Pubitemid 350227203)
73. Chang C. L. T., Kuo H. K., Chang S. L., Chiang Y. M., Lee T. H., Wu W. M., Shyur L. F., Yang W. C., The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. Journal of Biomedical Science 2005 12 1 79 89 2-s2.0-17744367000 10.1007/s11373-004-8172-x (Pubitemid 40576766)
74. Alvarez L., Marquina S., Villarreal M. L., Alonso D., Aranda E., Delgado G., Bioactive polyacetylenes from Bidens pilosa. Planta Medica 1996 62 4 355 357 2-s2.0-0029746507 (Pubitemid 26272516)
75. Kusano G., Kusano A., Seyama Y., Novel Hypoglycemic and Anti-Inflammatory Polyacetylenic Compounds, Their Compositions, Bidens Plant Extract Fractions, and Compositions Containing the Plant or Fraction 2004 Tokyo, Japan JPO
76. Brandão M. G. L., Krettli A. U., Soares L. S. R., Nery C. G. C., Marinuzzi H. C., Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. Journal of Ethnopharmacology 1997 57 2 131 138 2-s2.0-0030763657 10.1016/S0378-8741(97)00060-3 (Pubitemid 27344803)
77. Krettli A. U., Andrade-Neto V. F., Brandão M. D. G. L., Ferrari W. M. S., The search for new anti-malarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Memorias do Instituto Oswaldo Cruz 2001 96 8 1033 1042 2-s2.0-0035522812 (Pubitemid 33637406)
78. Lee C. K., The low polar constituents from Bidens pilosa L. var. minor (blume) sherff. Journal of the Chinese Chemical Society 2000 47 5 1131 1136 2-s2.0-18844453407
79. Wat C. K., Biswas R. K., Graham E. A., Bohm L., Towers G. H. N., Waygood E. R., Ultraviolet-mediated cytotoxic activity of phenylheptatriyne from Bidens pilosa L. Journal of Natural Products 1979 42 1 103 111 2-s2.0-0018402020
80. Sashida Y., Ogawa K., Kitada M., Karikome H., Mimaki Y., Shimomura H., New aurone glucosides and new phenylpropanoid glucosides from Bidens pilosa. Chemical and Pharmaceutical Bulletin 1991 39 3 709 711 2-s2.0-0025884280
81. Yuan L. P., Chen F. H., Ling L., Dou P. F., Bo H., Zhong M. M., Xia L. J., Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis. Journal of Ethnopharmacology 2008 116 3 539 546 2-s2.0-40249088102 10.1016/j.jep.2008.01.010
82. Hoffmann B., Hölzl J., Acylated compounds from Bidens pilosa. Planta Medica 55 108 109
83. Hoffmann B., Hölzl J., A methylated chalcone glucoside from Bidens pilosa. Phytochemistry 1988 27 11 3700 3701 2-s2.0-0000883551
84. Hoffmann B., Hölzl J., Chalcone glucosides from Bidens pilosa. Phytochemistry 1989 28 1 247 250 2-s2.0-0001404415
85. Hoffmann B., Hölzl J., New chalcones from Bidens pilosa. Planta Medica 54 1 52 54
86. Hoffmann B., Hölzl J., Weitere acylierte chalkone aus Bidens pilosa. Planta Medica 1988 54 450 451
87. Pham V. V., K P V. V. T., Hoang V. L., Phan V. K., Flavonoid compounds from the plant Bidens pilosa L., (Asteraceae). Tap Chi Duoc Hoc 50 48 53
88. Sarker S. D., Bartholomew B., Nash R. J., Robinson N., 5-O-methylhoslundin: an unusual flavonoid from Bidens pilosa (Asteraceae). Biochemical Systematics and Ecology 2000 28 6 591 593 2-s2.0-0034070702 10.1016/S0305-1978(99)00091-5 (Pubitemid 30318086)
89. Kusano A., Seyama Y., Usami E., Katayose T., Shibano M., Tsukamoto D., Kusano G., Studies on the antioxidant active constituents of the dried powder from Bidens pilosa L. var. radiata Sch. Natural Medicines 2003 57 3 100 104 2-s2.0-0038125536 (Pubitemid 36764692)
90. Dolečková I., Rárová L., Grúz J., Anti-proliferative and anti-angiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. Fitoterapia 83 6 1000 1007
91. Bairwa K., Kumar R., Sharma R. J., Roy R. K., An updated review on Bidens pilosa L. Der Pharma Chemica 2 3 325 337
92. Xia Q., Liu Y., Li Y., Determination of hyperoside in different parts and different species of Herba Bidens by RP-HPLC. West China Journal of Pharmaceutical Sciences 50 48 53
93. Brandão M. G. L., Nery C. G. C., Mamão M. A. S., Krettli A. U., Two methoxylated flavone glycosides from Bidens pilosa. Phytochemistry 1998 48 2 397 400 2-s2.0-0032077267
94. Grombone-Guaratini M. T., Silva-Brandão K. L., Solferini V. N., Semir J., Trigo J. R., Sesquiterpene and polyacetylene profile of the Bidens pilosa complex (Asteraceae: Heliantheae) from Southeast of Brazil. Biochemical Systematics and Ecology 2005 33 5 479 486 2-s2.0-14944371861 10.1016/j.bse.2004.11.005 (Pubitemid 40359246)
95. Lin L. L., Wu C. Y., Hsiu H. C., Wang M. T., Chuang H., Studies on diabetes mellitus. I. The hypoglycemic activity of phytosterin on alloxan diabetic rats. Taiwan Yi Xue Hui Za Zhi 1967 66 2 58 65 2-s2.0-0014219237
96. Benhura M. A. N., Chitsiku I. C., The extractable β -carotene content of Guku (Bidens pilosa) leaves after cooking, drying and storage. International Journal of Food Science and Technology 1997 32 6 495 500 2-s2.0-0001230074 (Pubitemid 127388178)
97. Deba F., Xuan T. D., Yasuda M., Tawata S., Herbicidal and fungicidal activities and identification of potential phytotoxins from Bidens pilosa L. var. radiata Scherff: research paper. Weed Biology and Management 2007 7 2 77 83 2-s2.0-34247898900 10.1111/j.1445-6664.2007.00239.x (Pubitemid 46699615)
98. Kumar J. K., Sinha A. K., A new disubstituted acetylacetone from the leaves of Bidens pilosa Linn. Natural Product Research 2003 17 1 71 74 2-s2.0-0038393021 10.1080/1478641031000062232 (Pubitemid 36575493)
99. Ogawa K., Sashida Y., Caffeoyl derivatives of a sugar lactone and its hydroxy acid from the leaves of Bidens pilosa. Phytochemistry 1992 31 10 3657 3658 2-s2.0-0000892904
100. Xia Q., Liu Y., Li Y., Determination of gallic acid from different species and different medical parts of Herba Bidens by RP-HPLC. West China Journal of Pharmaceutical Sciences 24 03 308 310
101. Chang J. S., Chiang L. C., Chen C. C., Liu L. T., Wang K. C., Lin C. C., Atileukemic activity of Bidens pilosa l. var. minor (blume) sherff and Houttuynia cordata thunb. American Journal of Chinese Medicine 2001 29 2 303 312 2-s2.0-0035223342
102. Lee W. J., Wu L. F., Chen W. K., Wang C. J., Tseng T. H., Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chemico-Biological Interactions 2006 160 2 123 133 2-s2.0-33644764655 10.1016/j.cbi.2006.01.002 (Pubitemid 43343917)
103. Beutler J. A., Cardellina J. H., Lin C. M., Hamel E., Cragg G. M., Boyd M. R., Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization. Bioorganic and Medicinal Chemistry Letters 1993 3 4 581 584 2-s2.0-0027467331 10.1016/S0960-894X(01)81233-6 (Pubitemid 23109570)
104. Verma A., Su A., Golin A. M., O'Marrah B., Amorosa J. K., The lateral view: a screening method for knee trauma. Academic Radiology 2001 8 5 392 397 2-s2.0-0034917882 10.1016/S1076-6332(03)80546-9 (Pubitemid 32674651)
105. Corren J., Lemay M., Lin Y., Rozga L., Randolph R. K., Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal 2008 7 1, article 20 2-s2.0-48449092966 10.1186/1475-2891-7-20
106. Gachet M. S., Lecaro J. S., Kaiser M., Brun R., Navarrete H., Muñoz R. A., Bauer R., Schühly W., Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of Ethnopharmacology 2010 128 1 184 197 2-s2.0-76749108892 10.1016/j.jep.2010. 01.007
107. Yang W. C., Ghiotto M., Barbarat B., Olive D., The role of Tec protein-tyrosine kinase in T cell signaling. The Journal of Biological Chemistry 1999 274 2 607 617 2-s2.0-0033534460 10.1074/jbc.274.2.607 (Pubitemid 29058023)
108. Tewtrakul S., Miyashiro H., Nakamura N., Hattori M., Kawahata T., Otake T., Yoshinaga T., Fujiwara T., Supavita T., Yuenyongsawad S., Rattanasuwon P., Dej-Adisai S., HIV-1 integrase inhibitory substances from Coleus parvifolius. Phytotherapy Research 2003 17 3 232 239 2-s2.0-0037357211 10.1002/ptr.1111 (Pubitemid 36406753)
109. Dimo T., Nguelefack T. B., Tan P. V., Yewah M. P., Dongo E., Rakotonirina S. V., Kamanyi A., Bopelet M., Possible mechanisms of action of the neutral extract from Bidens pilosa L. leaves on the cardiovascular system of anaesthetized rats. Phytotherapy Research 2003 17 10 1135 1139 2-s2.0-0346095664 10.1002/ptr.1132 (Pubitemid 38057167)
110. Li T. S. C., Chinese and Related North American Herbs 2002 New York, NY, USA CRC Press
111. Wu H., Chen H., Hua X., Shi Z., Zhang L., Chen J., Clinical therapeutic effect of drug-separated moxibustion on chronic diarrhea and its immunologic mechanisms. Journal of Traditional Chinese Medicine 1997 17 4 253 258 2-s2.0-0031292135 (Pubitemid 127705672)
112. Wright S. W., Harris R. R., Kerr J. S., Green A. M., Pinto D. J., Bruin E. M., Collins R. J., Dorow R. L., Mantegna L. R., Sherk S. R., Covington M. B., Nurnberg S. A., Welch P. K., Nelson M. J., Magolda R. L., Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis. Journal of Medicinal Chemistry 1992 35 22 4061 4068 2-s2.0-0026526191 10.1021/jm00100a011
113. Almirón W. R., Brewer M. E., Classification of immature stage habitats of Culicidae (Diptera) collected in Cordoba, Argentina. Memorias do Instituto Oswaldo Cruz 1996 91 1 1 9 2-s2.0-0029692777 (Pubitemid 126460419)
114. Wang N. L., Wang J., Yao X. S., Kitanaka S., Two new monoterpene glycosides and a new (+)-jasmololone glucoside from Bidens parviflora Willd. Journal of Asian Natural Products Research 2007 9 5 473 479 2-s2.0-34547936174 10.1080/10286020500532033 (Pubitemid 47265804)
115. Champagnat P., Role of the terminal bud in the action exercised by the cotyledon of Bidens pilosus L. var. radiatus on its axillary bud. Comptes Rendus des Séances et Mémoires de la Société de Biologie 1951 145 17-18 1374 1376 2-s2.0-77951323992
116. Nielsen S. F., Christensen S. B., Cruciani G., Kharazmi A., Liljefors T., Antileishmaniai chalcones: statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis. Journal of Medicinal Chemistry 1998 41 24 4819 4832 2-s2.0-0032547898 10.1021/jm980410m (Pubitemid 28530457)
117. Hwang Y. C., Chu J. J. H., Yang P. L., Chen W., Yates M. V., Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. Antiviral Research 2008 77 3 232 236 2-s2.0-38749143273 10.1016/j.antiviral.2007.12.009
118. Andrade-Neto V. F., Brandão M. G. L., Oliveira F. Q., Casali V. W. D., Njaine B., Zalis M. G., Oliveira L. A., Krettli A. U., Antimalarial activity of Bidens pilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities or plants cultivated in humus soil. Phytotherapy Research 2004 18 8 634 639 2-s2.0-4944234076 10.1002/ptr.1510 (Pubitemid 39329713)
119. Marles R. J., Farnsworth N. R., Anti-diabetic plants and their active constituents. Phytomedicine 2 2 137 189
120. Habeck M., Diabetes treatments get sweet help from nature. Nature Medicine 2003 9 10 1228 2-s2.0-0142073834 (Pubitemid 37279826)
121. Lin H. W., Han G. Y., Liao S. X., Studies on the active constituents of the Chinese traditional medicine Polygonatum odoratum (Mill.) Druce. Acta Pharmaceutica Sinica 1994 29 3 215 222 2-s2.0-0028251666
122. Chang C. L. T., Chen Y. C., Chen H. M., Yang N. S., Yang W. C., Natural cures for type 1 diabetes: a review of phytochemicals, biological actions, and clinical potential. Current Medicinal Chemistry 2013 20 7 899 907
123. Dey L., Attele A. S., Yuan C. S., Alternative therapies for type 2 diabetes. Alternative Medicine Review 2002 7 1 45 58 2-s2.0-0036197349 (Pubitemid 34203979)
124. Chang C. L. T., Liu H. Y., Kuo T. F., Anti-diabetic effect and mode of action of cytopiloyne. Evidence-Based Complementary and Alternative Medicine 2013 2013 13 685642 10.1155/2013/685642
125. Khan M. R., Kihara M., Omoloso A. D., Anti-microbial activity of Bidens pilosa, Bischofia javanica, Elmerillia papuana and Sigesbekia orientalis. Fitoterapia 2001 72 6 662 665 2-s2.0-0034874240 10.1016/S0367-326X(01)00261-1 (Pubitemid 32799267)
126. Dimo T., Nguelefack T. B., Kamtchouing P., Dongo É., Rakotonirina A., Rakotonirina S. V., Hypotensive effects of methanol extract from Bidens pilosa Linn on hypertensive rats. Comptes Rendus de l'Academie des Sciences. Serie III 1999 322 4 323 329 2-s2.0-0033117177 10.1016/S0764-4469(99)80068-7
127. Hassan A. K., Deogratius O., Nyafuono J. F., Francis O., Engeu O. P., Wound healing potential of the ethanolic extracts of Bidens pilosa and Ocimum suave. African Journal of Pharmacy and Pharmacology 2011 5 2 132 136 2-s2.0-79953654794
128. Hoffmann B., Hölzl J., Chalcone glucosides from Bidens pilosa. Phytochemistry 1989 28 1 247 250 2-s2.0-0001404415
129. Hoffmann B., Holzl J., New chalcones from Bidens pilosa. Planta Medica 54 1 52 54
130. Kandaswami C., Middleton E., Free radical scavenging and antioxidant activity of plant flavonoids. Advances in Experimental Medicine and Biology 1994 366 351 376 2-s2.0-0028644238
131. Yamamoto K., Kakegawa H., Ueda H., Matsumoto H., Sudo T., Miki T., Satoh T., Gastric cytoprotective anti-ulcerogenic actions of hydroxychalcones in rats. Planta Medica 1992 58 5 389 393 2-s2.0-0026669683 10.1055/s-2006-961498
132. Ezeonwumelu J. O. C., Julius A. K., Muhoho C. N., Biochemical and histological studies of aqueous extract of Bidens pilosa leaves from Ugandan Rift valley in rats. British Journal of Pharmacology and Toxicology 2 6 302 309
133. Frida L., Rakotonirina S., Rakotonirina A., Savineau J. P., In vivo and in vitro effects of Bidens pilosa L. (Asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle. African Journal of Traditional, Complementary and Alternative Medicines 2008 5 1 79 91 2-s2.0-42349116803 (Pubitemid 351552212)