A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7

Planta Medica

Volumn 73, Issue 7, 2007, Pages 655-661

  Wu, Li Wha ^a,b   Chiang, Yi Ming ^c   Chuang, Hsiao Ching ^a   Lo, Chiu Ping ^c   Yang, Kai Ying ^a   Wang, Sheng Yang ^d   Shyur, Lie Fen ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Apoptosis; Bidens pilosa; CDK inhibitors; Compositae; HUVEC; Polyacetylenes

Indexed keywords

1,2 DIHYDROXY 5 TRIDECENE 7,9,11 TRIYNE; ADENOSINE DIPHOSPHATE RIBOSE; BIDENS PILOSA EXTRACT; CASPASE 7; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; P21 ACTIVATED KINASE; POLYACETYLENE; PROTEIN BCL 2; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BIDENS PILOSA; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENDOTHELIUM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

ANGIOGENESIS INHIBITORS; APOPTOSIS; BIDENS; CASPASE 7; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; MICROTUBULES; PHYTOTHERAPY; PLANT EXTRACTS; POLYACETYLENES; UMBILICAL VEINS;

ASTERACEAE; BIDENS PILOSA;

EID: 34447544670     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-981527     Document Type: Article

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