Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis

Journal of Ethnopharmacology

Volumn 128, Issue 1, 2010, Pages 184-197

  Gachet, María Salomé ^a   Lecaro, Javier Salazar ^b   Kaiser, Marcel ^c   Brun, Reto ^c   Navarrete, Hugo ^b   Muñoz, Ricardo A ^d   Bauer, Rudolf ^a   Schühly, Wolfgang ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DEL ECUADOR   (Ecuador)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d ESCUELA POLITÉCNICA NACIONAL   (Ecuador)

Author keywords

Ecuadorian plants; In vitro screening; Leishmaniasis; Malaria; Traditional medicine; Trypanosomiasis

Indexed keywords

ANTIINFECTIVE AGENT; ANTIPROTOZOAL AGENT; BOCCONIA INTEGRIFOLIA EXTRACT; CEDRELA ODORATA EXTRACT; CLIBADIUM MICROCEPHALUM EXTRACT; CUPANIA CINEREA EXTRACT; ELEPHANTOPUS MOLLIS EXTRACT; GOUANIA LUPULOIDES EXTRACT; GUAVA EXTRACT; INGA OERSTEDIANA EXTRACT; MINQUARTIA GUIANENSIS EXTRACT; PENTAGONIA MACROPHYLLA EXTRACT; PIPTADENIA PTEROCLADA EXTRACT; PLANT EXTRACT; SPONDIAS PURPUREA EXTRACT; STRUTHANTHUS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BARK; BOCCONIA INTEGRIFOLIA; CEDRELA ODORATA; CLIBADIUM MICROCEPHALUM; CONTROLLED STUDY; CUPANIA CINEREA; DRUG MECHANISM; DRUG SCREENING; ECUADOR; ELEPHANTOPUS MOLLIS; GOUANIA LUPULOIDES; GUAVA; IC 50; IN VITRO STUDY; INGA OERSTEDIANA; LEISHMANIA DONOVANI; MEDICINAL PLANT; MINQUARTIA GUIANENSIS; NONHUMAN; PENTAGONIA MACROPHYLLA; PIPTADENIA PTEROCLADA; PLANT LEAF; PLASMODIUM FALCIPARUM; RAT; SCOPARIA DULCIS; SKIN LEISHMANIASIS; SPONDIAS PURPUREA; STRUTHANTHUS; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; ECUADOR; LEISHMANIA DONOVANI; LEISHMANIASIS; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; RATS;

BOCCONIA INTEGRIFOLIA; BRUGMANSIA; CANDIDA ALBICANS; ELEPHANTOPUS MOLLIS; GOUANIA LUPULOIDES; LEISHMANIA DONOVANI; MINQUARTIA GUIANENSIS; PLASMODIUM FALCIPARUM; POSIBACTERIA; SCOPARIA DULCIS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 76749108892     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.01.007     Document Type: Article

References (40)

1. Berman J. Clinical status of agents being developed for leishmaniasis. Expert Opinion on Investigational Drugs 2005, 14:1337-1346.
2. Brenner K.P., Düzgün F., Kuntz P., Lorek B., Mersch-Sundermann V. Medizinische Mikrobiologie für MTA. Stuttgart 1989.
3. Butler M.S. The role of natural product chemistry in drug discovery. Journal of Natural Products 2004, 67:2141-2153.
4. Butler M.S. Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports 2005, 25:475-516.
5. Calvopiña M., Armijos R., Hashiguchi Y. Epidemiology of Leishmaniasis in Ecuador: Current Status of Knowledge-A Review 2004, 99. Memorias do Instituto Oswaldo Cruz, pp. 663-672.
6. Calvopiña M., Armijos R., Marco J.D., Uezato H., Kato H., Gomez E.A., Korenaga M., Barroso P.A., Mimori T., Cooper P.J., Nonaka S., Hashiguchi Y. Leishmania isoenzyme polymorphisms in Ecuador: relationships with geographic distribution and clinical presentation. BMC Infectious Diseases 2006, 6(139).
7. Chirac P., Torreele E. Global framework on essential health R&D. Lancet 2006, 367:1560-1561.
8. Cunningham I. New culture medium for maintenance of tsetse tissues and growth of trypanosomatids. The Journal of Protozoology 1977, 24:325-329.
9. De la Torre L., Muriel P., Balslev H. Etnobotánica de los Andes del Ecuador. Botánica económica de los andes centrales 2006, 246-267. Universidad Mayor de San Andrés, La Paz. 1st ed. M. Moraes R., B. Ollgaard, L.P. Kvist, F. Borchsenius, H. Balslev (Eds.).
10. Enciclopedia de las Plantas Útiles del Ecuador, Pontificia Universidad Católica del Ecuador 2008, Universidad de Aarhus, Quito. L. De la Torre, H. Navarrete, P.M. Muriel, M.J. Macía, H. Balslev (Eds.).
11. Desjardins R.E., Canfield C.J., Haynes J.D., Chulay J.D. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy 1979, 16:710-718.
12. Eibl H., Unger C. Hexadecylphosphocholine: a new and selective antitumor drug. Cancer Treatment Reviews 1990, 17:233-242.
13. Espinel, V., 2005. Diagnóstico de la Medicina Tradicional Indígena de la Provincia de Napo. Ministerio de Salud Pública, Dirección Provincial de Salud de Napo, Salud Intercultural, Napo.
14. Frei B., Heinrich M., Bork P.M., Herrmann D., Jaki B., Kato T., Kuhnt M., Schmitt J., Schühly W., Volken C., Sticher O. Multiple screening of medicinal plants from Oaxaca, Mexico, Ethnobotany and bioassays as a basis for phytochemical investigation. Phytomedicine 1998, 5:177-186.
15. Fuchino H., Koide T., Takahashi M., Sekita S., Satake M. New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Planta Medica 2001, 67:647-653.
16. Hotez P.J., Molyneuz D.H., Fenwick A., Kumaresan J., Sachs S.E., Sachs J.D., Savioli L. Control of neglected tropical diseases. New England Journal of Medicine 2007, 357:1018-1027.
17. Instituto Nacional de Estadísticas y Censos, 2001. Censo de población y vivienda. Accessed August 04, 2009 at: http://www.ecuadorencifras.com/cifras-inec/main.html.
18. Isaza D.M., Restrepo B.N., Arboleda M., Casas E., Hinestroza H., Yurgaqui T. La leishmaniasis: conocimientos y prácticas en poblaciones de la costa del Pacífico de Colombia. Pan American Journal of Public Health 1999, 6:177-184.
19. Jørgensen, P.M., León-Yánez, S. (Eds.), 1999. Catalogue of the Vascular Plants of Ecuador. Monogr. Syst. Bot. Missouri Bot. Gard. 75 (i-viii) 1-1182.
20. Kato H., Uezato H., Katakura K., Calvopiña M., Marco J.D., Barroso P.A., Gómez E.A., Mimori T., Korenaga M., Iwata H., Nonaka S., Hashiguchi Y. Detection and identification of leishmania species within naturally infected sand flies in the Andean areas of Ecuador by a polymerase chain reaction. American Journal of Tropical Medicine and Hygiene 2005, 72:87-93.
21. Knapp G. Geografía de los Quichua de la sierra del Ecuador: núcleos, dominios, esfera 1991, Abya-Yala, Quito, pp. 9-30. 3 ed.
22. Kvist L.P., Oré I., Gonzáles A., Llapapasca C. Estudio de plantas medicinales en la amazonía peruana: una evaluación de ocho métodos etnobotánicos. Folia Amazónica 2001, 12:53-73.
23. Kvist L.P., Christensen S.B., Rasmussen H.B., Mejia K., Gonzalez A. Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. Journal of Ethnopharmacology 2006, 106:390-402.
24. Macía M.J., García E., Vidaurre P.J. An ethnobotanical survey of medicinal plants commercialized in the markets of La Paz and El Alto, Bolivia. Journal of Ethnopharmacology 2005, 97:337-350.
25. Matile H., Pink J.R.L. Plasmodium falciparum malaria parasite cultures and their use in immunology. Immunological Methods 1990, 221-234. Academic Press, San Diego. I. Lefkovits, B. Pernis (Eds.).
26. Ministerio de Salud Pública del Ecuador, 2007. 10 principales causas de morbilidad según provincias, indicadores epidemiológicos. Vigilancia Epidemiológica, Ecuador. Accessed July 28, 2009 at: http://www.msp.gov.ec./.
27. Manual of Clinical Microbiology 1995, ASM Press, Washington DC. P.R. Murray, E.J. Baron, M.A. Pfaller, F.C. Tenover, R.H. Yolken (Eds.).
28. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. Journal of Natural Products 2007, 70:461-477.
29. Petroecuador, 2003. Dialogo de culturas del noroccidente del Ecuador: Awá, Épera, Chachi, Afroecuatoriano, Mestizo campesino. Instituto Científico de Cultura Indígena, Ecuador, pp. 68-111.
30. Phillips O., Gentry A.H. The useful plants of Tambopata, Peru: I. Statistical hypotheses tests with a new quantitative technique. Economic Botany 1993, 47:15-32.
31. Rasmussen H.B., Christensen S.B., Kvist L.P., Kharazmi A., Huansi A.G. Absolute configuration and antiprotozoal activity of minquartyonic acid. Journal of Natural Products 2000, 63:1295-1296.
32. Räz B., Iten M., Grether-Buhler Y., Kaminsky R., Brun R. The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro. Acta Tropica 1997, 68:139-147.
33. Rios J.L., Recio M.C., Villar A. Screening methods for natural products with antimicrobial activity: a review of the literature. Journal of Ethnopharmacology 1988, 23:127-149.
34. Schultes R.E. The widening panorama in medical botany. Rhodora 1963, 65:97-120.
35. Strohl W.R. The role of natural products in a modern drug discovery program. Drug Discovery Today 2000, 5:39-41.
36. Trouiller P., Olliaro P., Torreele E., Orbinski J., Laing R., Ford N. Drug development for neglected diseases: a deficient market and a public-health policy failure. Lancet 2002, 359:2188-2194.
37. Vázquez M.L., Kroeger A., Lipowsky R., Alzate A. Conceptos populares sobre la leishmaniasis cutanea en Colombia y su aplicabilidad en programas de control. Boletín de la Oficina Sanitaria Panamericana 1991, 110:402-415.
38. Ventura M., Medina H., Álvarez S., Ruíz L., Ehrenreich J.D. Etnografías mínimas del Ecuador: Tsa'chi, Chachis, Cholos, Cofán, Awá, Coaiquer 1997, 14. Abya-Yala, Quito, pp. 33-88.
39. Weigel M.M., Armijos R.X. The traditional and conventional medical treatment of cutaneous leishmaniasis in rural Ecuador. Review Pan American Journal of Public Health 2001, 10:395-399.
40. WHO: World Health Organization. Accessed May 18, 2009. at: http://www.who.int/healthinfo/globalburdendisease/projections/en/index.html,http://www.who.int/mediacentre/factsheets/fs094/en/index.html,http://apps.who.int/malaria/docs/TreatmentGuidelines2006.pdf,http://www.who.int/leishmaniasis/en/,http://www.who.int/trypanosomiasisafrican/en/,http://www.who.int/topics/chagasdisease/en/,http://www.who.int/neglecteddiseases/integratedmedia leishmaniasis/en/index.html