Clinical and biochemical effects of a combination botanical product (ClearGuard™) for allergy: A pilot randomized double-blind placebo-controlled trial

Nutrition Journal

Volumn 7, Issue 1, 2008, Pages

  Corren, Jonathan ^a   Lemay, Marc ^b   Lin, Yumei ^b   Rozga, Lisa ^b   Randolph, R Keith ^c  

^a Allergy Research Foundation   (United States)

^b Nutrilite   (United States)

^c Alticor Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; BOTANICAL PRODUCT; CLEARGUARD; LEUKOTRIENE E4; LORATADINE; PLACEBO; PLANT EXTRACT; PROSTAGLANDIN D2; TRYPTASE; ANTIALLERGIC AGENT; HERBACEOUS AGENT; PLANT EXTRACT, BIDENS PILOSA;

ABSENCE OF SIDE EFFECTS; ADULT; ALLERGIC RHINITIS; ARTICLE; BIOCHEMISTRY; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INFLAMMATION; MALE; NOSE MUCUS; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; ADOLESCENT; AGED; BIDENS; CHEMISTRY; CINNAMOMUM ZEYLANICUM; CROSSOVER PROCEDURE; HAY FEVER; MALPIGHIACEAE; METABOLISM; MIDDLE AGED; NOSE MUCOSA; NOSE PROVOCATION TEST; PHYTOTHERAPY; PILOT STUDY; TREATMENT OUTCOME;

BIDENS PILOSA; CINNAMOMUM VERUM; MALPIGHIA GLABRA;

ADOLESCENT; ADULT; AGED; ANTI-ALLERGIC AGENTS; BIDENS; CINNAMOMUM ZEYLANICUM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; LORATADINE; MALE; MALPIGHIACEAE; MIDDLE AGED; NASAL MUCOSA; NASAL PROVOCATION TESTS; PHYTOTHERAPY; PILOT PROJECTS; PROSTAGLANDIN D2; RHINITIS, ALLERGIC, SEASONAL; TREATMENT OUTCOME;

EID: 48449092966     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-7-20     Document Type: Article

References (22)

1. Alternative therapies among adults with a reported diagnosis of asthma or rhinosinusitis : data from a population-based survey. PD Blanc L Trupin G Earnest PP Katz EH Yelin MD Eisner, Chest 2001 120 5 1461 1467 10.1378/chest.120.5.1461 11713120
2. Complementary and alternative interventions in asthma, allergy, and immunology. L Bielory, Ann Allergy Asthma Immunol 2004 93 2 Suppl 1 S45 54 15330011
3. Unconventional medicine in the United States. Prevalence, costs, and patterns of use. DM Eisenberg RC Kessler C Foster FE Norlock DR Calkins TL Delbanco, N Engl J Med 1993 328 4 246 252 10.1056/NEJM199301283280406 8418405
4. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. YM Chiang CP Lo YP Chen SY Wang NS Yang YH Kuo LF Shyur, Br J Pharmacol 2005 146 3 352 363 16041399 10.1038/sj.bjp.0706343
5. Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors. A Jager Ak Fau - Hutchings J Hutchings A Fau - van Staden J van Staden
6. Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq). I. Anti-allergic action. H Nagai T Shimazawa N Matsuura A Koda, Jpn J Pharmacol 1982 32 5 813 822 10.1254/jjp.32.813 6184511
7. Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication. A Akerlund M Andersson J Leflein T Lildholdt N Mygind, J Allergy Clin Immunol 115 S460 82 15746883 10.1016/j.jaci.2004.12.016
8. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. LJ Johnston Cs Fau - Martin X Martin Lj Fau - Cai X Cai, J Am Coll Nutr 1992 11 2 172 176 1578094
9. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. FL Pearce AD Befus J Bienenstock, J Allergy Clin Immunol 1984 73 6 819 823 10.1016/0091-6749(84)90453-6 6202731
10. Mast cells and mast cell mediators as targets of dietary supplements. TC Theoharides L Bielory, Ann Allergy Asthma Immunol 2004 93 2 Suppl 1 S24 34 15330009
11. Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa. YM Chiang DY Chuang SY Wang YH Kuo PW Tsai LF Shyur, J Ethnopharmacol 2004 95 2-3 409 419 10.1016/j.jep.2004.08.010 15507368
12. New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. FQ Oliveira V Andrade-Neto AU Krettli MG Brandao, J Ethnopharmacol 2004 93 1 39 42 10.1016/j.jep.2004.03.026 15182902
13. Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase. T Yoshimoto M Furukawa S Yamamoto T Horie S Watanabe-Kohno, Biochem Biophys Res Commun 1983 116 2 612 618 6418162
14. Good clinical practice and phytotherapy. J Kusche, Methods Find Exp Clin Pharmacol 1993 15 4 241 247 8361262
15. St. John's wort: role of active compounds for its mechanism of action and efficacy. V Butterweck M Schmidt, Wien Med Wochenschr 2007 157 13-14 356 361 10.1007/s10354-007-0440-8 17704987
16. Revisiting the ancient concept of botanical therapeutics. BM Schmidt DM Ribnicky PE Lipsky I Raskin, Nat Chem Biol 2007 3 7 360 366 10.1038/ nchembio0707-360 17576417
17. Issues related to botanicals. IA Khan, Life Sci 78 18 2033 2038 10.1016/j.lfs.2005.12.019 16487545
18. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model. CE Piersen NL Booth Y Sun W Liang JE Burdette RB van Breemen SE Geller C Gu S Banuvar LP Shulman JL Bolton NR Farnsworth, Curr Med Chem 2004 11 11 1361 1374 15180571
19. Pharmaceutical prerequisites for a multi-target therapy. U Kroll C Cordes, Phytomedicine 2006 13 12 9 16857355 10.1016/j.phymed.2006.03.016
20. Pathophysiology of human basophils and mast cells in allergic disorders. G Marone V Casolaro R Cirillo C Stellato A Genovese, Clin Immunol Immunopathol 1989 50 1 Pt 2 S24 40 10.1016/0090-1229(89)90111-6 2463127
21. Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin. NA Soter RA Lewis EJ Corey KF Austen, J Invest Dermatol 1983 80 2 115 119 10.1111/1523-1747.ep12531738 6296237
22. Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis. EO Meltzer GD Berman J Corren AJ Pedinoff G Doyle JA Waksman P Butkerait SA Cooper RG Berlin S Wason, Ann Allergy Asthma Immunol 2004 93 5 452 459 15562884