Nutrient Regulation of the Immune Response

Present Knowledge in Nutrition: Tenth Edition

Volumn , Issue , 2012, Pages 688-708

  Calder, Philip C ^a   Yaqoob, Parveen ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

Acquired immune system, and ability for clonal expansion; Approaches, to assess effect of nutrition on immune function; Bidirectional interaction, nutrition, infection and immunity; Cells, in immune responses and mechanisms; Essential fatty acids in immune response, for synthesis of eicosanoids; Helper T cells in immune response regulation; Immune response to infection, on nutritional status, altering body composition; Immune system, the innate (or natural) system and the acquired; Non specific defenses and cell mediated immunity, severely affected; Nutrient regulation of immune response, undernutrition decreasing immune defense

Indexed keywords

EID: 84880869401     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119946045.ch44     Document Type: Chapter

References (103)

1. Agarwal, S. and Busse, P.J. (2010) Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol 104, 183-190.
2. Albers, R., Antoine, J.M., Bourdet-Sicard, R., et al. (2005) Markers to measure immunomodulation in human nutrition intervention studies. Br J Nutr 94, 452-481.
3. Anderson, M. and Fritsche, K.L. (2002) (n-3) Fatty acids and infectious disease resistance. J Nutr 132, 3566-3576.
4. Barone, J., Hebert, J.R., and Reddy, M.M. (1989) Dietary fat and natural-killer-cell activity. Am J Clin Nutr 50, 861-867.
5. Beck, F.W., Prasad, A.S., Kaplan, J., et al. (1997) Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 272, E1002-E1007.
6. Bernt, K.M. and Walker, W.A. (1999) Human milk as a carrier of biochemical messages. Acta Paediatr Suppl 88, 27-41.
7. Broome, C.S., McArdle, F., Kyle, J.A., et al. (2004) An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am J Clin Nutr 80, 154-162.
8. Bruce, D., Ooi, J.H., Yu, S.H., et al. (2010) Vitamin D and host resistance to infection? Putting the cart in front of the horse. Exp Biol Med 235, 921-927.
9. Bunout, D., Barrera, G., Hirsch, S., et al. (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. JPEN J Parenter Enteral Nutr 28, 348-354.
10. Burns, E.A. and Goodwin, J.S. (2004) Effect of aging on immune function. J Nutr Health Aging 8, 9-18.
11. Calder, P.C. (1995) Fuel utilisation by cells of the immune system. Proc Nutr Soc 54, 65-82.
12. Calder, P.C. (2003) N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 343-352.
13. Calder, P.C. (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 1505S-1519S.
14. Calder, P.C. (2007a) Immunological parameters: what do they mean? J Nutr 137, 773S-780S.
15. Calder, P.C. (2007b) Immunonutrition in surgical and critically ill patients. Br J Nutr 98, S133-S139.
16. Calder, P.C. (2008) The relationship between the fatty acid composition of immune cells and their function. Prostaglandins Leukot Essent Fatty Acids 79, 101-108.
17. Calder, P.C. (2009a) Polyunsaturated fatty acids and inflammation: therapeutic potential in rheumatoid arthritis. Curr Rheumatol Rev 5, 214-225.
18. Calder, P.C. (2009b) Fatty acids and immune function: relevance to inflammatory bowel diseases. Int Rev Immunol 28, 506-534.
19. Calder, P.C. and Jackson, A.A. (2000) Undernutrition, infection and immune function. Nutr Res Rev 13, 3-29.
20. Calder, P.C. and Kew, S. (2002) The immune system: a target for functional foods? Br J Nutr 88, S165-S177.
21. Calder, P.C. and Newsholme, P. (2002) Glutamine and the immune system. In P.C. Calder, C.J. Field, and H.S. Gill (eds), Nutrition and Immune Function. CAB International, Wallingford, pp. 109-132.
22. Calder, P.C. and Yaqoob, P. (1999) Glutamine and the immune system. Amino Acids 17, 227-241.
23. Calder, P.C., Albers, R., Antoine, J.M., et al. (2009) Inflammatory disease processes and interactions with nutrition. Br J Nutr 101, S1-S45.
24. Calder, P.C., Field, C.J., and Gill, H.S. (2002) Nutrition and Immune Function. CAB International, Wallingford.
25. Calder, P.C., Krauss-Etschmann, S., de Jong, E.C., et al. (2006) Early nutrition and immunity-progress and perspectives. Br J Nutr 96, 774-790.
26. Cantorna, M.T., Zhu, Y., Froicu, M., et al. (2004) Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 80, 1717S-1720S.
27. Castle, S.C. (2000) Clinical relevance of age-related immune dysfunction. Clin Infect Dis 31, 578-585.
28. Chandra, R.K. (1991) 1990 McCollum Award lecture. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 53, 1087-1101.
29. Chavance, M., Herbeth, B., Fournier, C., et al. (1989) Vitamin status, immunity and infections in an elderly population. Eur J Clin Nutr 43, 827-835.
30. Cummings, J.H., Antoine, J.M., Azpiroz, F., et al. (2004) PASSCLAIM-gut health and immunity. Eur J Nutr 43, II118-II173.
31. Douglas, R.M., Hemil ä, H., Chalker, E., et al. (2007) Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev CD000980.
32. Duff, M.D. and Daly, J.M. (2002) Arginine and immune function. In P.C. Calder, C.J. Field, and H.S. Gill (eds), Nutrition and Immune Function. CAB International, Wallingford, pp. 93-108.
33. Emmett, P.M. and Rogers, I.S. (1997) Properties of human milk and their relationship with maternal nutrition. Early Hum Dev 49, S7-28.
34. Evoy, D., Lieberman, M.D., Fahey, T.J., et al. (1998) Immunonutrition: the role of arginine. Nutrition 14, 611-617.
35. Failla, M.L. and Hopkins, R.G. (1998) Is low copper status immunosuppressive? Nutr Rev 56, S59-S64.
36. Fata, F.T., Herzlich, B.C., Schiffman, G., et al. (1996) Impaired antibody responses to pneumococcal polysaccharide in elderly patients with low serum vitamin B12 levels. Ann Int Med 124, 299-304.
37. Fischer Walker, C. and Black, R.E. (2004) Zinc and the risk for infectious disease. Annu Rev Nutr 24, 255-275.
38. Fraker, P.J. and King, L.E. (2004) Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 24, 277-298.
39. Fraker, P.J., King, L.E., Garvy, B.A., et al. (1993) The immunopathology of zinc deficiency in humans and rodents: a possible role for programmed cell death. In D.M. Klurfeld (ed.), Nutrition and Immunology. Plenum Press, New York, pp. 267-283.
40. Golding, J., Emmett, P.M., and Rogers, I.S. (1997a) Gastroenteritis, diarrhoea and breast feeding. Early Hum Dev 49, S83-103.
41. Golding, J., Emmett, P.M., and Rogers, I.S. (1997b) Does breast feeding protect against non-gastric infections? Early Hum Dev 49, S105-120.
42. Golding, J., Emmett, P.M., and Rogers, I.S. (1997c) Breast feeding and infant mortality. Early Hum Dev 49, S143-155.
43. Graat, J.M., Schouten, E.G., and Kok, F.J. (2002) Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA 288, 715-721.
44. Griffin, M.D., Xing, N., and Kumar, R. (2003) Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 23, 117-145.
45. Grimble, R.F. (2002) Sulphur amino acids, glutathione and immune function. In P.C. Calder, C.J. Field, and H.S. Gill (eds), Nutrition and Immune Function. CAB International, Wallingford, pp. 133-150.
46. Grimble, R.F. and Grimble, G.K. (1998) Immunonutrition: the role of sulfur amino acids, related amino acids and polyamines. Nutrition 14, 605-610.
47. Gross, R.L. and Newberne, P.M. (1980) Role of nutrition in immunologic function. Physiol Rev 60, 188-302.
48. Han, S.N., Leka, L.S., Lichtenstein, A.H., et al. (2003) Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans. J Lipid Res 44, 2304-2310.
49. Hawkes, W.C., Kelley, D.S., and Taylor, P.C. (2001) The effects of dietary selenium on the immune system in healthy men. Biol Trace Elem Res 81, 189-213.
50. Hayes, C.E., Nashold, F.E., Spach, K.M., et al. (2003) The immunological functions of the vitamin D endocrine system. Cell Mol Biol 49, 277-300.
51. Kelley, D.S., Dougherty, R.M., Branch, L.B., et al. (1992) Concentration of dietary N-6 polyunsaturated fatty acids and the human immune status. Clin Immunol Immunopathol 62, 240-244.
52. Kiremidjian-Schumacher, L., Roy, M., Wishe, H.I., et al. (1994) Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol Trace Elem Res 41, 115-127.
53. Kuvibidila, S. and Baliga, B.S. (2002) Role of iron in immunity and infection. In P.C. Calder, C.J. Field, and H.S. Gill (eds), Nutrition and Immune Function. CAB International, Wallingford, pp. 209-228.
54. Kuvibidila, S., Yu, L., Ode, D., et al. (1993) The immune response in protein-energy malnutrition and single nutrient deficiency. In D.M. Klurfield (ed.), Nutrition and Immunology. Plenum Press, New York, pp. 121-155.
55. Lemire, J.M., Archer, D.C., Beck, L., et al. (1995) Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 125, 1704S-1708S.
56. Lomax, A.R. and Calder, P.C. (2009a) Probiotics, immune function, infection and inflammation: a review of the evidence from studies conducted in humans. Curr Pharm Des 15, 1428-1518.
57. Lomax, A.R. and Calder, P.C. (2009b) Prebiotics, immune function, infection and inflammation: a review of the evidence. Br J Nutr 101, 633-658.
58. Lucas, S. (2010) Predictive clinicopathological features derived from systematic autopsy examination of patients who died with A/H1N1 influenza infection in the UK 2009-10 pandemic. Health Technol Assess 14, 83-114.
59. Marshall, I. (2000) Zinc for the common cold. Cochrane Database Syst Rev CD001364.
60. Marti, A., Marcos, A., and Martinez, J.A. (2001) Obesity and immune function relationships. Obes Rev 2, 131-140.
61. Matarese, G., Procaccini, C., De Rosa, V., et al. (2010) Regulatory T cells in obesity: the leptin connection. Trends Mol Med 16, 247-256.
62. McKenzie, R.C., Rafferty, T.S., and Beckett, G.J. (1998) Selenium: an essential element for immune function. Immunol Today 19, 342-345.
63. Meydani, S.N. and Beharka, A.A. (1998) Recent developments in vitamin E and immune response. Nutr Rev 56, S49-S58.
64. Meydani, S.N., Barklund, M.P., Liu, S., et al. (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 52, 557-563.
65. Meydani, S.N., Han, S.N., and Wu, D. (2005) Vitamin E and immune response in the aged: mechanisms and clinical implications. Immunol Rev 205, 269-284
66. Meydani, S.N., Leka, L.S., Fine, B.C., et al. (2004) Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA 292, 828-836.
67. Meydani, S.N., Meydani, M., Blumberg, J.B., et al. (1997) Vitamin E supplementation and in vivo immune response in healthy subjects. JAMA 277, 1380-1386.
68. Meydani, S.N., Ribaya-Mercado, J.D., Russell, R.M., et al. (1991) Vitamin B6 deficiency impairs interleukin-2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 53, 1275-1280.
69. Mowat, A.M. (2003) Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 3, 331-341.
70. Oppenheimer, S.J. (2001) Iron and its relation to immunity and infectious disease. J Nutr 131, 616S-635S.
71. Pallast, E.G., Schouten, E.G., de Waart, F.G., et al. (1999) Effect of 50-and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr 69, 1273-1281.
72. Percival, S.S. (1998) Copper and immunity. Am J Clin Nutr 67, 1064S-1068S.
73. Peretz, A., N è ve, J., Desmedt, J., et al. (1991) Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am J Clin Nutr 53, 1323-1328.
74. Peterson, J.D., Herzenberg, L.A., Vasquez asquez, K., et al. (1998) Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 95, 3071-3076.
75. Prasad, A.S. (2002) Zinc, infection and immune function. In P.C. Calder, C.J. Field, and H.S. Gill (eds), Nutrition and Immune Function. CAB International, Wallingford, pp. 193-207.
76. Prasad, A.S. (2008) Zinc in human health: effect of zinc on immune cells. Mol Med 14, 353-357.
77. Roy, M., Kiremidjian-Schumacher, L., Wishe, H.I., et al. (1994) Supplementation with selenium and human immune cell functions. I. Effect on lymphocyte proliferation and interleukin 2 receptor expression. Biol Trace Elem Res 41, 103-114.
78. Roy, M., Kiremidjian-Schumacher, L., Wishe, H.I., et al. (1995) Supplementation with selenium restores age-related decline in immune cell function. Proc Soc Exp Biol Med 209, 369-375.
79. Sabetta, J.R., DePetrillo, P., Cipriani, R.J., et al. (2010) Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 5, e11088.
80. Saulnier, D.M., Spinler, J.K., Gibson, G.R., et al. (2009) Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol 20, 135-141.
81. Schaible, U.E. and Kaufmann, S.H. (2004) Iron and microbial infection. Nat Rev Microbiol 2, 946-953.
82. Scrimshaw, N.S. and SanGiovanni, J.P. (1997) Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr 66, 464S-477S.
83. Semba, R.D. (1998) The role of vitamin A and related retinoids in immune function. Nutr Rev 56, S38-S48.
84. Semba, R.D. (1999) Vitamin A and immunity to viral, bacterial and protozoan infections. Proc Nutr Soc 58, 719-727.
85. Semba, R.D. (2002) Vitamin A, infection and immune function. In P.C. Calder, C.J. Field, and H.S. Gill (eds), Nutrition and Immune Function. CAB International, Wallingford, pp. 151-169.
86. Serhan, C.N., Chiang, N., and Van Dyke, T.E. (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8, 349-361.
87. Shankar, A.H. and Prasad, A.S. (1998) Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 68, 447S-463S.
88. Sherman, A.R. and Spear, A.T. (1993) Iron and immunity. In D.M. Klurfeld (ed.), Nutrition and Immunology. Plenum Press, New York, pp. 285-307.
89. Stabel, J.R. and Spears, J.W. (1993) Role of selenium in immune responsiveness and disease resistance. In D.M. Klurfeld (ed.), Nutrition and Immunology. Plenum Press, New York, pp. 333-356.
90. Stephensen, C.B. (2001) Vitamin A, infection, and immune function. Annu Rev Nutr 21, 167-192.
91. Tamura, J., Kubota, K., Murakami, H., et al. (1999) Immunomodulation by vitamin B12: augmentation of CD8 + T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 116, 28-32.
92. Tilg, H. and Moschen, A.R. (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772-783.
93. Tilley, S.L., Coffman, T.M., and Koller, B.H. (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108, 15-23.
94. Troen, A.M., Mitchell, B., Sorensen, B., et al. (2006) Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 136, 189-194.
95. Turner, R.B. and Cetnarowski, W.E. (2000) Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds. Clin Infect Dis 31, 1202-1208.
96. Urashima, M., Segawa, T., Okazaki, M., et al. (2010) Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 91, 1255-1260.
97. van Etten, E. and Mathieu, C. (2005) Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 97, 93-101.
98. Villamor, E. and Fawzi, W.W. (2005) Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev 18, 446-464.
99. Weiss, G (2002) Iron and immunity: a double-edged sword. Eur J Clin Invest 32 (Suppl 1), 70-78.
100. Wintergerst, E.S., Maggini, S., and Hornig, D.H. (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 51, 301-323.
101. Woodward, B. (1998) Protein, calories and immune defences. Nutr Rev 56, S84-S92.
102. Woodward, B. (2001) The effect of protein-energy malnutrition on immune competence. In R.M. Suskind and K. Tontisirin (eds), Nutrition, Immunity and Infection in Infants and Children. Lippincott Williams and Wilkins, Philadelphia, pp. 89-120.
103. Yaqoob, P. and Calder, P.C. (2011) The immune and inflammatory systems. In S. Lanham-New, H.M. Roche, and I.A. MacDonald (eds), Nutrition and Metabolism, 2nd Edn. Wiley-Blackwell, Chichester, pp. 312-338.