Vitamin A and immunity to viral, bacterial and protozoan infections

Proceedings of the Nutrition Society

Volumn 58, Issue 3, 1999, Pages 719-727

  Semba, R D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunity; Infection; Malaria; Measles; Vitamin A

Indexed keywords

KERATIN; MUCIN; RETINOL;

BACTERIAL INFECTION; CONFERENCE PAPER; DIARRHEA; DIET SUPPLEMENTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; MALARIA; MEASLES; PROTOZOAL INFECTION; T LYMPHOCYTE; VIRUS INFECTION; VITAMIN INTAKE;

EID: 0032756346     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0029665199000944     Document Type: Conference Paper

References (95)

1. Aaby P (1988) Malnutrition and overcrowding/intensive exposure in severe measles infection: review of community studies. Reviews of Infections Disease 10, 478-491.
2. Ahmed F, Jones DB & Jackson AA (1990) The interaction of vitamin A deficiency and rotavirus infection in the mouse. British Journal of Nutrition 63, 363-373.
3. Ahmed F, Jones DB & Jackson AA (1991) Effect of vitamin A deficiency on the immune response to epizootic diarrhoea of infant mice (EDIM) rotavirus infection in mice. British Journal of Nutrition 65, 475-485.
4. Alwar AJE (1992) The effect of protein energy malnutrition on morbidity and mortality due to measles at Kenyatta National Hospital, Nairobi, Kenya. East African Medical Journal 69, 415-418.
5. Baird JK (1998) Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum. Annals of Tropical Medicine and Parasitology 92, 367-390.
6. Barclay AJG, Foster A & Sommer A (1987) Vitamin A supplements and mortality related to measles: a randomised clinical trial. British Medical Journal 323, 160-164.
7. Barreto ML, Santos LMP, Assis AMO, Purificação M, Araújo N, Farenzena GG, Santos PAB & Fiaccone RL (1994) Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil. Lancet 344, 228-231.
8. Beaton GH, Martorell R, L'Abbe KA, Edmonston B, McCabe G, Ross AC & Harvey B (1993) Effectiveness of Vitamin A Supplementation in the Control of Young Child Morbidity and Mortality in Developing Countries. ACC/SCN State-of-the-Art Nutrition Policy Discussion Paper no. 13. Geneva: UN.
9. Bellini WJ, Rota JS & Rota PA (1994) Virology of measles virus. Journal of Infectious Diseases 170, Suppl. 1, S15-S23.
10. Bernstein DI, McNeal MM, Schiff GM & Ward RL (1989) Induction and persistence of local rotavirus antibodies in relation to serum antibodies. Journal of Medical Virology 28, 90-95.
11. Blackfan KD & Wolbach SG (1933) Vitamin A deficiency in infants: a clinical and pathological study. Journal of Pediatrics 3, 679-706.
12. Bresee JS, Fischer M, Dowell SF, Johnston BD, Biggs VM, Levine RS, Lingappa JR, Keyserling HL, Petersen KM, Bak JR, Gary HE, Sowell AL, Rubens CE & Anderson LJ (1996) Vitamin A therapy for children with respiratory syncytial virus infection: a multicenter trial in the United States. Pediatric Infectious Diseases Journal 15, 777-782.
13. Brilliant LB, Pokhrel RP, Grasset NC, Lepkowski JM, Kolstad A, Hawks W, Pararajasegaram R, Brilliant GE, Gilbert S, Shrestha SR & Kuo J (1985) Epidemiology of blindness in Nepal. Bulletin of the World Health Organization 63, 375-386.
14. Cantorna MT, Nashold FE & Hayes CE (1994) In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. Journal of Immunology 152, 1515-1522.
15. Cooper AM, Magram J, Ferrante J & Orme IM (1997) Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. Journal of Experimental Medicine 186, 39-45.
16. Coulson BS (1998) Longitudinal studies of neutralizing antibody responses to rotavirus in stools and sera of children following severe rotavirus gastroenteritis. Clinical and Diagnostic Laboratory Immunology 5, 897-901.
17. Coutsoudis A, Bobat RA, Coovadia HM, Kuhn L, Tsai WY & Stein ZA (1995) The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. American Journal of Public Health 85, 1076-1081.
18. Coutsoudis A, Broughton M & Coovadia HM (1991) Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial. American Journal of Clinical Nutrition 54, 890-895.
19. Coutsoudis A, Kiepiela P, Coovadia HM & Broughton M (1992) Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles. Pediatric Infectious Diseases Journal 11, 203-209.
20. Dannenberg AM Jr (1989) Immune mechanisms in the pathogenesis of pulmonary tuberculosis. Reviews of Infectious Diseases 11, Suppl. 2, S369-S378.
21. DeSole G, Belay Y & Zegeye B (1987) Vitamin A deficiency in southern Ethiopia. American Journal of Clinical Nutrition 45, 780-784.
22. Dowell SF, Papic Z, Bresee JS, Larrañaga C, Mendez M, Sowell AL, Gary HE, Anderson LJ & Avendaño LF (1996) Treatment of respiratory syncytial virus infection with vitamin A: a randomized, placebo-controlled trial in Santiago, Chile. Pediatric Infectious Diseases Journal 15, 782-786.
23. Dudley L, Hussey G, Huskissen J & Kessow G (1997) Vitamin A status, other risk factors and acute respiratory infection morbidity in children. South African Medical Journal 87, 65-70.
24. Fawzi WW, Mbise RL, Fataki MR, Herrera MG, Kawau F, Hertzmark E, Spiegelman D & Ndossi G (1998a) Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania. American Journal of Clinical Nutrition 68, 187-192.
25. th World AIDS Conference, Geneva, June 28-July 3, 1998, p. 840, Abstr. 170/42331, Geneva: 12th World Aids Conference Committee.
26. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJN, McGrath N, Mwakagile D, Antelman G, Mbise R, Herrera G, Kapiga S, Willett W, Hunter DJ & Tanzania Vitamin and HIV Infection Trial Team (1998c) Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 351, 1477-1482.
27. Ferraro F, Mattei M & Colizzi V (1988) Low doses of recombinant interleukin-2 enhanced delayed type hypersensitivity to PPD in mice infected with Mycobacterium bovis-BCG and fed a diet supplemented with vitamin A acetate. Zeitschrift für Erkrankungen der Atmungsorgane 171, 45-49.
28. Finkelstein MH (1932) Effect of carotene on course of B. tuberculosis infection of mice fed on a vitamin A deficient diet. Proceedings of the Society for Experimental Biology and Medicine 29, 69-71.
29. Friis H, Mwaniki D, Omondi B, Muniu E, Magnussen P, Geissler W, Thiong'o F & Michaelsen KF (1997) Serum retinol concentrations and Schistosoma mansoni intestinal helminths, and malarial parasitemia: a cross-sectional study in Kenyan preschool and primary school children. American Journal of Clinical Nutrition 66, 665-671.
30. Galan P, Samba C, Luzeau R & Amedee-Manesme O (1990) Vitamin A deficiency in preschool age Congolese children during malaria attacks. Part 2: impact of parasitic disease on vitamin A status. International Journal of Vitamin and Nutrition Research 60, 224-228.
31. Gangopadhyay NN, Moldoveanu Z & Stephensen CB (1996) Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in B ALB/c mice. Journal of Nutrition 126, 2960-2967.
32. Gloyne SR & Page DS (1921) A preliminary note on the relationship between deficiency in vitamin A and tuberculosis. Tubercle 3, 577-579.
33. Göttgens B & Green AR (1995) Retinoic acid and the differentiation of lymphohaemapoietic stem cells. Bioessays 17, 187-189.
34. Griffin DE (1995) Immune responses during measles virus infection. Current Topics in Microbiology and Immunology 191, 117-134.
35. Grimwood K, Lund JC, Coulson BS, Hudson IL, Bishop RF & Barnes GL (1988) Comparison of serum and mucosal antibody responses following severe acute rotavirus gastroenteritis in young children. Journal of Clinical Microbiology 26, 732-738.
36. Gujral S, Abbi R & Gopaldas T (1993) Xerophthalmia, vitamin A supplementation and morbidity in children. Journal of Tropical Pediatrics 39, 89-92.
37. Hanekom WA, Potgieter S, Hughes EJ, Malan H, Kessow G & Hussey GD (1997) Vitamin A status and therapy in childhood pulmonary tuberculosis. Journal of Pediatrics 131, 925-927.
38. Hernández-Pando R, Orozcoe H, Sampieri A, Pavón L, Velasquillo C, Larriva-Sahd J, Alcocer JM & Madrid MV (1996) Correlation between the kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. Immunology 89, 26-33.
39. Høgh B (1996) Clinical and parasitological studies on immunity to Plasmodium falciparum malaria in children. Scandinavian Journal of Infectious Diseases 102, Suppl., 1-53.
40. Hossain S, Biswas R, Kabir I, Sarker S, Dibley M, Fuchs G & Mahalanabis D (1998) Single dose vitamin A treatment in acute shigellosis in Bangladeshi children: randomised double blind controlled trial. British Medical Journal 316, 422-426.
41. Hussey G, Hughes J, Potgieter S, Kessow G, Burgess J, Beatty D, Keraan M & Carlesle E (1996) Vitamin A status and supplementation and its effects on immunity in children with AIDS. In Abstracts of the XVII International Vitamin A Consultative Group Meeting, Guatemala City, p. 6. Washington, DC: International Life Sciences Institute.
42. Hussey GD & Klein M (1990) A randomized, controlled trial of vitamin A in children with severe measles. New England Journal of Medicine 323, 160-164.
43. Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G & Griffin DE (1996) Mechanism of suppression of cell-mediated immunity by measles virus. Science 273, 228-231.
44. Kjolhede CL, Chew FJ, Gadomski AM & Marroquin DP (1995) Clinical trial of vitamin A as adjuvant treatment for lower respiratory tract infections. Journal of Pediatrics 126, 807-812.
45. Lalvani A, Brookes R, Wilkinson RJ, Malin AS, Pathan AA, Andersen P, Dockrell H, Pasvol G & Hill AVS (1998) Human cytolytic and interferon α-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences USA 95, 270-275.
46. McNeal MM & Ward RL (1995) Long-term production of rotavirus antibody and protection against reinfection following a single infection of neonatal mice with murine rotavirus. Virology 211, 474-480.
47. Markowitz L, Nzilambi N, Driskell WJ, Sension MG, Rovira EZ, Nieburg P & Ryder RW (1989) Vitamin A levels and mortality among hospitalized measles patients, Kinshasa, Zaire. Journal of Tropical Pediatrics 35, 109-112.
48. Mitra AK, Alvarez JO, Guay-Woodford L, Fuchs GJ, Wahed MA & Stephensen CB (1998) Urinary retinol excretion and kidney function in children with shigellosis. American Journal of Clinical Nutrition 68, 1095-1103.
49. Moriguchi S, Werner L & Watson RR (1985) High dietary vitamin A (retinyl palmitate) and cellular immune functions in mice. Immunology 56, 169-177.
50. Muhe L, Lulseged S, Mason KE & Simoes EAF (1997) Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 349, 1801-1804.
51. Murphy GS & Oldfield EC (1996) Falciparum malaria. Infectious Disease Clinics of North America 10, 747-775.
52. Nacul LC, Kirkwood BR, Arthur P, Morris SS, Magalhães M & Fink MCDS (1997) Randomised, double blind, placebo controlled clinical trial of efficacy of vitamin A treatment in non-measles childhood pneumonia. British Medical Journal 315, 505-510.
53. Ogaro FO, Orinda VA, Onyango FE & Black RE (1993) Effect of vitamin A on diarrhoeal and respiratory complications of measles. Tropical and Geographical Medicine 45, 283-286.
54. Quinlan KP & Hayani KC (1996) Vitamin A and respiratory syncytial virus infection. Serum levels and supplementation trial. Archives of Pediatric and Adolescent Medicine 150, 25-30.
55. Rahman MM, Mahalanabis D, Alvarez JO, Wahed MA, Islam MA & Habte D (1997) Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 mo. American Journal of Clinical Nutrition 65, 144-148.
56. Rahman MM, Mahalanabis D, Alvarez JO, Wahed MA, Islam MA, Habte D & Khaled MA (1996) Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with vitamin A. Journal of Nutrition 126, 628-633.
57. Reeder JC & Brown GV (1996) Antigenic variation and immune evasion in Plasmodium falciparum malaria. Immunology and Cell Biology 74, 546-554.
58. Roman M, Calhoun WJ, Hinton KL, Avendano LF, Simon V, Escobar AM, Gaggero A & Diaz PV (1997) Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. American Journal of Respiratory and Critical Care Medicine 156, 190-195.
59. Ross DA & Cutts FT (1997) Vindication of policy of vitamin A with measles vaccination. Lancet 350, 81-82.
60. Ruel MT, Rivera JA, Santizo MC, Lonnerdal B & Brown KH (1997) Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among Guatemalan children. Pediatrics 99, 808-813.
61. Ryan M, Gothefors L, Storsaeter J & Mills KH (1997a) Bordetella pertussis-specific Th1/Th2 cells generated following respiratory infection or immunization with an acellular vaccine: comparison of the T cell cytokine profiles in infants and mice. Developments in Biological Standardization 89, 297-305.
62. Ryan M, Murphy G, Gothefors L, Nilsson L, Storsaeter J & Mills KH (1997b) Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells. Journal of Infectious Diseases 175, 1246-1250.
63. Schaumberg DA, O'Connor J & Semba RD (1996) Risk factors for xerophthalmia in the Republic of Kiribati. European Journal of Clinical Nutrition 50, 761-764.
64. Semba RD (1997) Vitamin A supplementation. Lancet 350, 1031-1032.
65. Semba RD (1998) The role of vitamin A and related retinoids in immune function. Nutrition Reviews 56, S38-S48.
66. Semba RD, Akib A, Beeler J, Munasir Z, Permaesih D, Muherdiyantiningsih, Komala, Martuti S & Muhilal (1997) Effect of vitamin A supplementation on measles vaccination in nine-month-old infants. Public Health 111, 245-247.
67. Semba RD, Lyles CM, Margolick JB, Caiaffa WT, Farzadegan H, Cohn S & Vlahov D (1998) Vitamin A supplementation and human immunodeficiency virus load in injection drug users. Journal of Infectious Diseases 177, 611-616.
68. Semba RD, Miotti PG, Chiphangwi JD, Saah AJ, Canner JK, Dallabetta GA & Hoover DR (1994) Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. Lancet 343, 1593-1597.
69. Semba RD, Muhilal, Scott AL, Natadisastra G, Wirasasmita S, Mele L, Ridwan E, West KP Jr & Sommer A (1992) Depressed immune response to tetanus in children with vitamin A deficiency. Journal of Nutrition 122, 101-107.
70. Semba RD, Muhilal, Ward BJ, Griffin DE, Scott AL, Natadisastra G, West KP Jr & Sommer A (1993) Abnormal T-cell subset proportions in vitamin A-deficient children. Lancet 341, 5-8.
71. Semba RD, Munasir Z, Beeler J, Akib A, Muhilal, Audet S & Sommer A (1995) Reduced seroconversion to measles in infants given vitamin A with measles vaccination. Lancet 345, 1330-1332.
72. Semba RD, Park S, Royal W & Griffin DE (1996) Vitamin A deficiency and T-cell subpopulations in HIV-infected adults. Nutrition Research 16, 915-923.
73. Semba RD & Tang AM (1999) Micronutrients and the pathogenesis of human immunodeficiency virus infection. British Journal of Nutrition 81, 181-189.
74. Shankar AH, Genton B, Semba RD, Tielsch J & West KP Jr (1997) Vitamin A supplementation as a nutrient-based intervention to reduce malaria-related morbidity. In Abstracts of the XVIII International Vitamin A Consultative Group Meeting, Cairo, Egypt, p. 31. Washington, DC: The Human Nutrition Institute.
75. Sijtsma SR, Rombout JHWM, van der Zijpp AJ & West CE (1990) Vitamin A deficiency impairs cytotoxic T lymphocyte activity in Newcastle disease virus-infected chickens. Veterinary Immunology and Immunopathology 26, 191-201.
76. Sklan D, Melamed D & Friedman A (1994) The effect of varying levels of dietary vitamin A on immune response in the chick. Poultry Science 73, 843-847.
77. Solotorovsky M, Squibb RL, Wogan GN, Siegel H & Gala R (1961) The effect of dietary fat and vitamin A on avian tuberculosis in chicks. American Review of Respiratory Diseases 84, 226-235.
78. Sommer A, Katz J & Tarwotjo I (1984) Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. American Journal of Clinical Nutrition 40, 1090-1095.
79. Sommer A & West KP Jr (1996) Vitamin A Deficiency: Health, Survival, and Vision. New York: Oxford University Press.
80. Sriramachari S & Gopalan C (1958) Nutrition and tuberculosis: effect of some nutritional factors on resistance to tuberculosis. Indian Journal of Medical Research 46, 105-112.
81. Stabell Benn C, Aaby P, Balé C, Olsen J, Michaelsen KF, George E & Whittle H (1997) Randomised trial of effect of vitamin A supplementation on antibody response to measles vaccine in Guinea-Bissau, west Africa. Lancet 350, 101-105.
82. Stephensen CB, Blount SR, Schoeb TR & Park JY (1993) Vitamin A deficiency impairs some aspects of the host response to influenza A virus infection in BALB/c mice. Journal of Nutrition 123, 823-833.
83. Stephensen CB, Moldaveanu Z & Gangopadhyay NN (1996) Vitamin A deficiency diminishes the salivary immunoglobulin A response and enhances the serum immunoglobulin G response to influenza A virus infection in BALB/c mice. Journal of Nutrition 126, 94-102.
84. Stoltzfus RJ, Jalal F, Harvey PWJ & Nesheim MC (1989) Interactions between vitamin A deficiency and Plasmodium berghei infection in the rat. Journal of Nutrition 119, 2030-2037.
85. Stürchler D, Tanner M, Hanck A, Betschart B, Gautschi K, Weiss N, Burnier E, Del Giudice G & Degrémont A (1987) A longitudinal study on relations of retinol with parasitic infections and the immune response in children of Kikwawila village, Tanzania. Acta Tropica 44, 213-227.
86. Sweet LK & K'ang HJ (1935) Clinical and anatomic study of avitaminosis A among the Chinese. American Journal of Diseases of Childhood 50, 699-734.
87. The Vitamin A and Pneumonia Working Group (1995) Potential interventions for the prevention of childhood pneumonia in developing countries: a meta-analysis of data from field trials to assess the impact of vitamin A supplementation on pneumonia morbidity and mortality. Bulletin of the World Health Organization 73, 609-619.
88. Tielsch JM, West KP, Katz J, Chirambo MC, Schwab L, Johnson GJ, Tizazu T, Swartwood J & Sommer A (1986) Prevalence and severity of xerophthalmia in southern Malawi. American Journal of Epidemiology 124, 561-586.
89. Wagner G, Koram K, McGuinness D, Bennett S, Nkrumah F & Riley E (1998) High incidence of asymptomatic malaria infections in a birth cohort of children less than one year of age in Ghana, detected by multicopy gene polymerase chain reaction. American Journal of Tropical Medicine and Hygiene 59, 115-123.
90. Watson RR, Yahya MD, Darban HR & Prabhala RH (1988) Enhanced survival by vitamin A supplementation during a retrovirus infection causing murine AIDS. Life Sciences 43, 13-18.
91. West CE, Rombout JHWM, van der Zijpp AJ & Sijtsma SR (1991) Vitamin A and immune function. Proceedings of the Nutrition Society 50, 251-262.
92. West KP Jr, Katz J, Shrestha SR, LeClerq SC, Khatry SK, Pradhan EK, Adhikari R, Wu LS, Pokhrel RP & Sommer A (1995) Mortality of infants <6mo of age supplemented with vitamin A: a randomized, double-masked trial in Nepal. American Journal of Clinical Nutrition 62, 143-148.
93. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group (1998) Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. Lancet 352, 1257-1263.
94. Yoneda T & Ellner JJ (1998) CD4+ T cell and natural killer cell-dependent killing of Mycobacterium tuberculosis by human monocytes. American Journal of Respiratory and Critical Care Medicine 158, 395-403.
95. Zhao Z & Ross AC (1995) Retinoic acid repletion restores the number of leukocytes and their subsets and stimulates natural cytotoxicity in vitamin A-deficient rats. Journal of Nutrition 125, 2064-2073.