The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood

Development and Psychopathology

Volumn 25, Issue 3, 2013, Pages 587-598

  Hayden, Elizabeth P ^a   Olino, Thomas M ^b   Bufferd, Sara J ^b   Miller, Anna ^b   Dougherty, Lea R ^b   Sheikh, Haroon I ^a   Singh, Shiva M ^a   Klein, Daniel N ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN TRANSPORTER;

ADULT; AFFECT; ARTICLE; CHILD; DEPRESSION; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; MALE; MEMORY; MIDDLE AGED; MOTHER; NEUROPSYCHOLOGICAL TEST; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFFECT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD OF IMPAIRED PARENTS; CHILD, PRESCHOOL; DEPRESSIVE DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEMORY; MIDDLE AGED; MOTHERS; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; SELF REPORT; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84880867043     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579413000035     Document Type: Article

References (93)

1. Abela, J. R. Z., & Hankin, B. L. (2008). Cognitive vulnerability to depression in children and adolescents: A developmental psychopathology perspective. New York: Guilford Press.
2. Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H., et al. (2009). Early adversity and 5-HTT/BDNF genes: New evidence of gene-environment interactions on depressive symptoms in a general population. Psychological Medicine, 39, 1425-1432.
3. Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage.
4. Beck, A. T. (1976). Cognitive therapy and the emotional disorders. Oxford: International Universities Press.
5. Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. American Journal of Psychiatry, 165, 969-977.
6. Beevers, C. G., Ellis, A. J.,Wells, T. T., & McGeary, J. E. (2010). Serotonin transporter gene promoter region polymorphism and selective processing of emotional images. Biological Psychology, 83, 260-265.
7. Beevers, C. G., Pacheco, J., Clasen, P., McGeary, J. E.,&Schnyer, D. (2010). Lateral prefrontal cortex morphology and biased attention for emotional stimuli: Moderation by the serotonin transporter promoter region gene. Genes, Brain, and Behavior, 9, 224-233.
8. Beevers, C. G., Scott, W. D., McGeary, C., & McGeary, J. E. (2009). Negative cognitive response to a sad mood induction: Associations with polymorphisms of the serotonin transporter (5-HTTLPR) gene. Cognition and Emotion, 23, 726-738.
9. Beevers, C. G., Wells, T. T., Ellis, A. J., & McGeary, J. E. (2009). Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. Journal of Abnormal Psychology, 118, 670-681.
10. Beevers, C. G.,Wells, T. T., & McGeary, J. E. (2009). The BDNF Val66Met polymorphism is associated with rumination in healthy adults. Emotion, 9, 579-584.
11. Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L., Rossato, J. I., Goldin, A., et al. (2008). BDNF is essential to promote persistence of long-term memory storage. Proceedings of the National Academy of Science, 105, 2711-2716.
12. Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304.
13. Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
14. Blakely, R. D., & Veenstra-VanderWeele, J. (2011). Genetic indeterminism, the 5-HTTLPR, and the paths forward in neuropsychiatric genetics. Archives of General Psychiatry, 68, 457-458.
15. Boulle, F., van den Hove, D. L. A., Jakob, S. B., Rutten, B. P., Hamon, M., van Os, J., et al. (2012). Epigenetic regulation of the BDNF gene: Implications for psychiatric disorders. Molecular Psychiatry, 17, 584-596.
16. Brenner, E. (2000). Mood induction in children: Methodological issues and clinical implications. Review of General Psychology, 4, 264-283.
17. Bueller, J. A., Aftab, M., Sen, S., Gomez-Hassan, D., Burmeister, M., & Zubieta, J-K. (2006). BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biological Psychiatry, 59, 812-815.
18. Carroll, J. B., Davies, P., & Richman, B. (1971). Word frequency book (1st ed.). New York: American Heritage.
19. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509-527.
20. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I.W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
21. Chen, Z-Y., Patel, P. D., Sant, G., Meng, C-X., Teng, K. K., Hempstead, B. L., et al. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. Journal of Neuroscience, 24, 4401-4411.
22. Chorbov,V. M., Lobos, E. A., Todorov,A. A., Health, A. C., Botteron, K. N., & Todd, R. D. (2007). Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. American Journal of Medical Genetics, 114B, 830-833.
23. Cole, D. A., Ciesla, J. A., Dallaire, D. H., Jacquez, F. M., Pineda, A. Q., La-Grange, B., et al. (2008). Emergence of attributional style and its relation to depressive symptoms. Journal of Abnormal Psychology, 117, 16-31.
24. Crisan, L. G., Pana, S., Vulturar, R., Heilman, R. M., Szekely, R., Druga, B., et al. (2009). Genetic contributions of the serotonin transporter to social learning of fear and economic decision making. Social, Cognitive, and Affective Neuroscience, 4, 399-408.
25. Duman, R. S., & Monteggia, L. M. (2006). A neurotrophic model for stressrelated mood disorders. Biological Psychiatry, 59, 1116-1127.
26. Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 1041-1049.
27. Dunn, L. M.,& Dunn, L. M. (1997). Peabody Picture Vocabulary Test 4 (3rd ed.). Circle Pines, MN: American Guidance Service.
28. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., & Bertolino, A. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-269.
29. Ellis, B. J., & Boyce,W. T. (2008). Biological sensitivity to context. Current Directions in Psychological Science, 17, 183-187.
30. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). The Structured Clinical Interview for DSM-IVAxis I Disorders-Non-patient edition (1st ed.). New York: New York State Psychiatric Institute.
31. Fox, E., Ridgewell, A., & Ashwin, C. (2009). Looking on the bright side: Biased attention and the human serotonin transporter gene. Proceedings of the Royal Society Biological Sciences, 276, 1747-1751.
32. Garber, J., Gallerani, C. M., & Frankel, S. A. (2009). Depression in children. In I. H. Gotlib&C. L. Hammen (Eds.), Handbook of depression (2nd ed., pp. 405-443). New York: Guilford Press.
33. Garber, J., & Kaminski, K. M. (2000). Laboratory and performance-based measures of depression in children and adolescents. Journal of Clinical Child Psychology, 29, 509-525.
34. Garber, J., & Martin, N. C. (2002). Negative cognitions in offspring of depressed parents: Mechanisms of risk. In S. H. Goodman & I. H. Gotlib (Eds.), Children of depressed parents: Mechanisms of risk and implications for treatment (pp. 121-153). Washington, DC: American Psychological Association.
35. Gibb, B. E., Benas, J. S., Grassia, M., & McGeary, J. (2009). Children's attentional biases and 5-HTTLPR genotype: Potential mechanisms linking mother and child depression. Journal of Clinical Child and Adolescent Psychology, 38, 415-426.
36. Gibb, B. E., Uhrlass, D. J., Grassia, M., Benas, J. S., & McGeary, J. (2009). Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression. Journal of Abnormal Psychology, 118, 734-745.
37. Goodman, S. H., & Brand, S. R. (2008). Parental psychopathology and its relation to child psychopathology. In M. Hersen & A. M. Gross (Eds.), Handbook of clinical psychology (pp. 937-965). Hoboken, NJ: Wiley.
38. Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847-851.
39. Hankin, B. L. (2008). Stability of cognitive vulnerabilities to depression: A short-term prospective multiwave study. Journal of Abnormal Psychology, 117, 324-333.
40. Hankin, B. L., Nederhof, E., Oppenheimer, C., Jenness, J., Young, J. F., Abela, J. R. Z., et al. (2011). Differential susceptibility in youth: Evidence that 5-HTTLPR-Positive Parenting is associated with positive affect "for better and worse." Translational Psychiatry, 1, e44.
41. Hankin, B. L., Oppenheimer, C., Jenness, J., Barrocas, A., Shapero, B. G., & Goldband, J. (2009). Developmental origins of cognitive vulnerabilities to depression: Review of processes contributing to stability and change across time. Journal of Clinical Psychology, 65, 1327-1338.
42. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146-152.
43. Hariri, A. R., & Holmes, A. (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences, 10, 182-191.
44. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400-403.
45. Hayden, E. P., Dougherty, L. R, Maloney, B., Durbin, C. E., Olino, T. M., Nurnberger, J. I., et al. (2007). Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: A multimethod association study. Psychiatric Genetics, 17, 135-142.
46. Hayden, E. P., Dougherty, L. R., Maloney, B., Olino, T. M., Sheikh, H., Durbin, C. E., et al. (2008). Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism. Journal of Affective Disorders, 107, 227-230.
47. Hayden, E. P., Klein, D. N., Dougherty, L. R., Olino, T. M., Dyson, M. W., Durbin, C. E., et al. (2010). The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality. Psychological Science, 21, 1678-1685.
48. Hayden, E. P., Klein, D. N., Durbin, C. E., & Olino, T. M. (2006). Positive emotionality at age 3 predicts cognitive styles in 7-year-old children. Development and Psychopathology, 18, 409-423.
49. Hayden, E. P., Klein, D. N., Sheikh, H. I., Olino, T. M., Dougherty, L. R., Dyson, M.W., et al. (2010). The serotonin transporter promoter polymorphism and childhood positive and negative emotionality. Emotion, 10, 696-702.
50. Hayden, E. P., Sheikh, H. I., Katsiroumbas, P., Jordan, P., Singh, S. M., Olino, T. M., et al. (2010). Early-emerging depressogenic information processing: Stability across time and associations with childhood individual differences and early contextual factors. Paper presented at the annual meeting of the Association for Cognitive and Behavior Therapies, San Francisco, CA.
51. Hilt, L. M., Sander, L. C., Nolen-Hoeksema, S., & Simen, A. A. (2007). The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers. Neuroscience Letters, 429, 12-16.
52. Hollingshead, A. B. (1975). Four Factor Index of Social Status. Unpublished manuscript.
53. Homberg, J. R., & Lesch, K-P. (2011). Looking on the bright side of serotonin transporter gene variation. Biological Psychiatry, 69, 513-519.
54. Houlihan, L. M., Harris, S. E., Luciano, M., Gow, A. J., Starr, J. M., Visscher, P. M., et al. (2009). Replication study of candidate genes for cognitive abilities: The Lothian birth cohort 1936. Genes, Brain & Behavior, 8, 238-247.
55. Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D., & Schuckit, M. A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism: Clinical and Experimental Research, 29, 8-16.
56. Hutchison, K. E., Stallings, M., McGeary, J., & Bryan, A. (2004). Population stratification in the candidate gene study: Fatal threat or red herring? Psychological Bulletin, 130, 66-79.
57. Ialongo, N. S., Edelsohn, G., & Kellam, S. G. (2001). A further look at the prognostic power of young children's reports of depressed mood. Child Development, 72, 736-747.
58. Jedema, H. P., Gianaros, P. J., Greer, P. J., Kerr, D. D., Liu, S., Higley, J. D., et al. (2009). Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. Molecular Psychiatry, 15, 512-522.
59. Joormann, J. (2009). Cognitive aspects of depression. In I. H. Gotlib & C. L. Hammen (Eds.), Handbook of depression (2nd ed., pp. 298-321). New York: Guilford Press.
60. Joorman, J., Talbot, L., & Gotlib, I. H. (2007). Biased processing of emotional information in girls at risk for depression. Journal of Abnormal Psychology, 116, 135-143.
61. Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression metaanalysis revisited: Evidence of genetic moderation. Archives of General Psychiatry. Advance online publication.
62. Kaufman, J., Yang, B., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor-5-HHTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673-680.
63. Klein, D. N., Riso, L.P., Donaldson, S. K., Schwartz, J. E., Anderson, R. L., Ouimette, P. C., et al. (1995). Family study of early-onset dysthymia: Mood and personality disorders in relatives of outpatients with dysthymia and episodic major depression and normal controls. Archives of General Psychiatry, 52, 487-496.
64. Klein, D. N., Shankman, S. A., Lewinsohn, P. M., Rohde, P., & Seeley, J. R. (2004). Family study of chronic depression in a community sample of young adults. American Journal of Psychiatry, 161, 646-653.
65. Klein, D. N., Shankman, S. A., & Rose, S. (2006). Ten-year prospective follow-up study of the naturalistic course of dysthymic disorder and double depression. American Journal of Psychiatry, 163, 872-880.
66. Kovacs, M., & Beck, A. T. (1977). An empirical-clinical approach toward a definition of childhood depression. In J. G. Schulterbrandt & A. Raskin (Eds.), Depression in childhood: Diagnosis, treatment, and conceptual models (pp. 1-25). New York: Raven Press.
67. Kujawa, A. J., Torpey, D., Kim, J., Hajcak, G., Rose, S., Gotlib, I. H., et al. (2011). Attentional biases for emotional faces in young children of mothers with chronic or recurrent depression. Journal of Abnormal Child Psychology, 39, 125-135.
68. Lesch, K., Bengel, D., Heils, A., & Sabol, S. Z. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
69. Lovejoy,M. C., Graczyk, P. A., O'Hare, E., & Neuman, G. (2000). Maternal depression and parenting behavior: A meta-analytic review. Clinical Psychology Review, 20, 561-592.
70. Mao, L. M., Fibuch, E. E., & Wang, J. Q. (2010). Decoding BDNF-LTP coupling in cocaine addiction. Neuron, 67, 679-681.
71. Mineka, S., Rafaeli, E.,&Yovel, I. (2003). Cognitive biases in emotional disorders: Social- cognitive and information processing perspectives. In R. Davidson, H. Goldsmith, & K. Scherer (Eds.), Handbook of affective science (pp. 976-1009). Oxford: Oxford University Press.
72. Miranda, J., Gross, J. J., Persons, J. B., & Hahn, J. (1998). Mood matters: Negative mood induction activates dysfunctional attitudes in women vulnerable to depression. Cognitive Therapy and Research, 22, 363-376.
73. Moffitt, T. E., Caspi, A., & Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of Genetic Psychiatry, 62, 473-481.
74. Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852-857.
75. Munafò,M R., Freimer, N. B., Ng,W., Ophoff, R., Veijola, J., Miettunen, J., et al. (2009). 5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data. American Journal of Medical Genetics, 150B, 271-281.
76. Nigg, J. T., Blaskey, L. G., Stawicki, J. A., & Sachek, J. (2004). Evaluating the endophenotype model of ADHD neuropsychological deficit: Results for parents and siblings of children with ADHD combined and inattentive subtypes. Journal of Abnormal Psychology, 113, 614-625.
77. Pencea, V., Bingaman, K. D., Wiegand, S. J., & Luskin, M. B. (2001). Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. Journal of Neuroscience, 21, 6706-6717.
78. Perepletchikova, F., & Kaufman, J. (2011). Genetic and environmental predictors of depression. In K. S. Kendler, S. Jaffee, & D. Romer (Eds.), The dynamic genome and mental health: The role of genes and environments in youth development (pp. 272-293). New York: Oxford University Press.
79. Petryshen, T. L., Sabeti, P. C., Aldinger, K. A., Fry, B., Fan, J. B., Schaffner, S. F., et al. (2009). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry, 15, 810-815.
80. Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., et al. (2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. Journal of Neuroscience, 24, 10099-10102.
81. Pine, D. S., Helfinstein, S. M., Bar-Haim, Y., Nelson, E., & Fox, N. A. (2009). Challenges in developing novel treatments for childhood disorders: Lessons from research on anxiety. Neuropsychopharmacology, 34, 213-228.
82. Richey, J. A., Schmidt, N. B., Lonigan, C. J., Phillips, B. M., Catanzaro, S. J., Laurent, J., et al. (2009). The latent structure of child depression: A taxometric analysis. Journal of Child Psychology and Psychiatry, 50, 1147-1155.
83. Risch, N., Herrell, R., Lehner, T., Liang, K., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462-2471.
84. Roiser, J. P., Muller, U., Clark, L., & Sahakian, B. J. (2007). The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention. International Journal of Neuropsychopharmacology, 10, 449-461.
85. Scher,C. D., Ingram, R. E.,&Segal, Z. V. (2005).Cognitive reactivity and vulnerability: Empirical evaluation of construct activation and cognitive diatheses in unipolar depression. Clinical Psychology Review, 25, 487-510.
86. Schule, C., Zill, P., Baghai, T. C., Eser, D., Zwanzger, P., Wenig, N., et al. (2006). Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology, 31, 1019-1025.
87. Segal, Z. V., & Ingram, R. E. (1994). Mood priming and construct activation in tests of cognitive vulnerability to unipolar depression. Clinical Psychology Review, 14, 663-695.
88. Sheikh, H. I., Hayden, E. P., Singh, S. M., Dougherty, L. R., Olino, T. M., Durbin, C. E., et al. (2008). An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood. Personality and Individual Differences, 45, 425-428.
89. Shimizu, E., Hashimoto, K., & Iyo, M. (2004). Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 126B, 122-123.
90. Taylor, L., & Ingram, R. E. (1999). Cognitive reactivity and depressotypic information processing in children of depressed mothers. Journal of Abnormal Psychology, 108, 202-210.
91. Uher, R., & McGuffin, P. (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry, 15, 18-22.
92. Watters, A. J.,&Williams, L. M. (2011). Negative biases and risk for depression: Integrating self-report and emotion task markers. Depression and Anxiety, 28, 703-718.
93. Zimmerman, M., Sheeran, T.,&Young, D. (2004). The Diagnostic Inventory for Depression: A self-report scale to diagnose DSM-IV major depressive disorder. Journal of Clinical Psychology, 60, 87-110.