Acute Effects of Modafinil on Brain Resting State Networks in Young Healthy Subjects

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Esposito, Roberto ^a   Cilli, Franco ^a   Pieramico, Valentina ^a   Ferretti, Antonio ^a   Macchia, Antonella ^a   Tommasi, Marco ^a   Saggino, Aristide ^a   Ciavardelli, Domenico ^a,b   Manna, Antonietta ^a   Navarra, Riccardo ^a   Cieri, Filippo ^a   Stuppia, Liborio ^a   Tartaro, Armando ^a   Sensi, Stefano L ^a,c  

^a UNIVERSITY OF CHIETI   (Italy)

^b KORE UNIVERSITY OF ENNA   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MODAFINIL; PLACEBO;

ADULT; ARTICLE; ATTENTION; BOLD SIGNAL; BRAIN REGION; CONTROLLED STUDY; DEPTH PERCEPTION; DIFFUSION TENSOR IMAGING; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; ELECTROENCEPHALOGRAM; FRACTIONAL ANISOTROPY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; MENTAL PERFORMANCE; NEUROIMAGING; NEUROMODULATION; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; RESTING STATE NETWORK; SINGLE DRUG DOSE; TASK PERFORMANCE;

ADULT; ATTENTION; BENZHYDRYL COMPOUNDS; BRAIN; BRAIN MAPPING; DOUBLE-BLIND METHOD; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; NOOTROPIC AGENTS; PLACEBOS;

EID: 84880850407     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069224     Document Type: Article

References (69)

1. Minzenberg MJ, Watrous AJ, Yoon JH, Ursu S, Carter CS, (2008a) Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI. Science. 322(5908): 1700-2.
2. Raggi A, Plazzi G, Pennisi G, Tasca D, Ferri R, (2010) Cognitive evoked potentials in narcolepsy: a review of the literature. Neurosci Biobehav Rev. 35(5): 1144-53.
3. Dawson N, Thompson RJ, McVie A, Thomson DM, Morris BJ, et al. (2012) Modafinil Reverses Phencyclidine-Induced Deficits in Cognitive Flexibility, Cerebral Metabolism, and Functional Brain Connectivity. Schizophr Bull. 38(3): 457-74.
4. Kahbazi M, Ghoreishi A, Rahiminejad F, Mohammadi MR, Kamalipour A, et al. (2009) A randomized, double-blind and placebo-controlled trial of modafinil in children and adolescents with attention deficit and hyperactivity disorder. Psychiatry Res. 15 168(3): 234-7.
5. Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, et al. (2009b) Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA. 302(13): 1420.
6. Ishizuka T, Murotani T, Yamatodani A, (2010) Modanifil activates the histaminergic system through the orexinergic neurons. Neurosci Lett. 483(3): 193-6.
7. James LM, Iannone R, Palcza J, Renger JJ, Calder N, et al. (2011) Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers. Psychopharmacology (Berl). 215(4): 643-53.
8. Huang ZJ, Di Cristo G, (2008) Time to change: retina sends a messenger to promote plasticity in visual cortex. Neuron. 59(3): 355-8.
9. Gass JT, Olive MF, (2008) Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol. 75(1): 218-65.
10. Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, et al. (2009a) Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301(11): 1148-54.
11. Greely H, Sahakian B, Harris J, Kessler RC, Gazzaniga M, et al. (2008) Towards responsible use of cognitive-enhancing drugs by the healthy. Nature. 11 456(7223): 702-5.
12. Kalechstein AD, Mahoney JJ 3rd, Yoon JH, Bennett R, De la Garza R 2nd (2013) Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users. Neuropharmacology. 64: 472-8.
13. Dean AC, Sevak RJ, Monterosso JR, Hellemann G, Sugar CA, et al. (2011) Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans. J Stud Alcohol Drugs. 72(6): 943-53.
14. Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, et al. (2003) Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl). 165(3): 260-9.
15. Ghahremani DG, Tabibnia G, Monterosso J, Hellemann G, Poldrack RA, et al. (2011) Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals. Neuropsychopharmacology. 36(5): 950-9.
16. Moldofsky H, Broughton RJ, Hill JD, (2000) A randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsy. Sleep Med. 1(2): 109-116.
17. Kollins SH, Mac Donald EK, Rush CR, (2001) Assessing the abuse potential of methylphenidate in nonhumans and human subjects: a review. Pharmacol Biochem Behav. 68: 611-627.
18. Carpenter PA, Just MA, Shell P (1990) What one intelligence test measures: A theoretical account of the processing in the Raven Progressive Matrices Test. Psychological Review. 97, 404-431.
19. Raven J, (2000) The Raven's Progressive Matrices: Change and stability over culture and time. Cognitive Psychology. 41: 1-48.
20. Buckner RL, Andrews-Hanna JR, Schacter DL, (2008) The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124: 1-38.
21. Ferreira LK, Busatto GF, (2013) Resting-state functional connectivity in normal brain aging. Neurosci Biobehav Rev. 37(3): 384-400.
22. Fleisher AS, Sherzai A, Taylor C, Langbaum JB, Chen K, et al. (2009) Resting- state BOLD networks versus task-associated functional MRI for distinguishing. Alzheimer's disease risk groups. Neuroimage. 47: 1678-1690.
23. Damoiseaux JS, Rombouts SARB, Barkhof F, Scheltens P, Stam CJ, et al. (2006) Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. 103, 13848-13853.
24. Deco G, Jirka VK, McIntosh AR, (2011) Emerging concepts for the dynamical organization of resting state activity in the brain. Nat Rev Neurosci. 12(1): 43-56.
25. Mantini D, Perrucci MG, Del Gratta C, Romani GL, Corbetta M, (2007) Electrophysiological signatures of resting state networks in the human brain. Proc Natl Acad Sci U S A. 104: 13170-13175.
26. Van den Heuvel MP, Hulshoff Pol HE, (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol. 20(8): 519-34.
27. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, et al. (2001) A default mode of brain function. Proc Natl Acad Sci U S A. 98(2): 676-82.
28. Sestieri C, Corbetta M, Romani GL, Shulman GL, (2011) Episodic memory retrieval, parietal cortex, and the default mode network: functional and topographic analyses. J Neurosci. 31(12): 4407-20.
29. Yuan Z, Qin W, Wang D, Jiang T, Zhang Y, et al. (2012) The salience network contributes to an individual's fluid reasoning capacity. Behav Brain Res. 229(2): 384-90.
30. Phillips JM, Vinck M, Everling S, Womelsdorf T (2013) A Long-Range Fronto-Parietal 5- to 10-Hz Network Predicts "Top-Down" Controlled Guidance in a Task-Switch Paradigm. Cereb Cortex. [Epub ahead of print].
31. Liang P, Wang Z, Yang Y, Li K, (2012) Three subsystems of the inferior parietal cortex are differently affected in mild cognitive impairment. J Alzheimers Dis. 30(3): 475-87.
32. Hayden BY, Gallant JL, (2013) Working memory and decision processes in visual area v4. Front Neurosci. 7: 18.
33. Corbetta M, Shulman GL, (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 3(3): 201-15.
34. Pagani E, Filippi M, Rocca M, Horsfield M, (2005) A method for obtaining tract-specific diffusion tensor MRI measurements in the presence of disease: application to patients with clinically isolated syndromes suggestive of multiple sclerosis. NeuroImage. 26(1): 258-265.
35. Oldfield RC, (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 9(1): 97-113.
36. Horn JL, Cattell RB, (1966) Refinement and test of the theory of fluid and crystallized general intelligences. Journal of Educational Psychology. 57(5): 253-270.
37. Schweizer K, Goldhammer F, Rauch W, Moosbrugger H (2007) On the validity of Raven's matrices test: Does spatial ability contribute to performance? Personality and Individual Differences. 43, 1998-2010.
38. Wobbrock JO, Findlater L, Gergle D, Higgins JJ, (2011) The aligned rank transform for nonparametric factorial analyses using only ANOVA procedures. Proceedings of CHI 2011 Conference on Human Factors in Computing Systems. 1: 143-146.
39. Woolrich MW, Jbabdi S, Patenaude B, Chappell M, Makni S, et al. (2009) Bayesian analysis of neuroimaging data in FSL. NeuroImage. 45: S173-186.
40. Farrell JAD, Landman BA, Jones CK, Smith SA, Prince JL, et al. (2007) Effects of SNR on the Accuracy and Reproducibility of DTI-derived Fractional Anisotropy, Mean Diffusivity, and Principal Eigenvector Measurements at 1.5T. Journal of Magnetic Resonance Imaging. 26: 756-767.
41. Jenkinson M, Bannister P, Brady M, Smith S, (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 17: 825-841.
42. Leemans A, Jones DK, (2009) The B-Matrix Must Be Rotated When Correcting for Subject Motion in DTI Data. Magnetic Resonance in Medicine. 61: 1336-1349.
43. Behrens TEJ, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, et al. (2003) Characterization and Propagation of Uncertainty in Diffusion-Weighted MR Imaging. Magnetic Resonance in Medicine. 50: 1077-1088.
44. Basser PJ, Mattiello J, LeBihan D, (1994) Estimation of Effective Self-Diffusion Tensor from the NMR Spin Echo. Journal of Magnetic Resonance Series B. 103: 247-254.
45. Minzenberg MJ, Yoon JH, Carter CS, (2011) Modafinil modulation of the default mode network. Psychopharmacology (Berl). 215(1): 23-31.
46. Schmaal L, Goudriaan AE, Joos L, Krüse AM, Dom G, et al. (2013) Modafinil Modulates Resting-State Functional Network Connectivity and Cognitive Control in Alcohol-DependentPatients. Biol Psychiatry. pii: S0006-3223(13)00041-3.
47. Piérard C, Liscia P, Valleau M, Drouet I, Chauveau F, et al. (2006) Modafinil-induced modulation of working memory and plasma corticosterone in chronically-stressed mice. Pharmacol Biochem Behav. 83(1): 1-8.
48. Morgan RE, Crowley JM, Smith RH, LaRoche RB, Dopheide MM, (2007) Modafinil improves attention, inhibitory control, and reaction time in healthy, middle-aged rats. Pharmacol Biochem Behav. 86: 531-541.
49. Wesensten NJ, Killgore WD, Balkin TJ, (2005) Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation. J Sleep Res. 14: 255-266.
50. Brady KT, Gray KM, Tolliver BK, (2011) Cognitive enhancers in the treatment of substance use disorders: clinical evidence. Pharmacol Biochem Behav. 99(2): 285-94.
51. Baranski JV, Pigeau R, Dinich P, Jacobs I, (2004) Effects of modafinil on cognitive and meta-cognitive performance. Hum Psychopharmacol. 19(5): 323-32.
52. Minzenberg MJ, Carter CS, (2008b) Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology. 33: 1477-1502.
53. Steketee JD, (2003) Neurotransmitter systems of the medial prefrontal cortex: potential role in sensitization to psychostimulants. Brain Res Brain Res Rev. 41(2-3): 203-28.
54. Tomasi D, Volkow ND, (2010) Functional connectivity density mapping. PNAS. 107(21): 9885-9890.
55. Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P, (2001) The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Ann N Y Acad Sci. 935: 107-117.
56. Jung RE, Haier RJ (2007) The Parieto-Frontal Integration Theory (P-FIT) of intelligence: Converging neuroimaging evidence. Behav Brain Sci. 30: 135-154; discussion 154-187.
57. Finke K, Dodds CM, Bublak P, Regenthal R, Baumann F, et al. (2010) Effects of modafinil and methylphenidate on visual attention capacity: a TVA-based study. Psychopharmacology (Berl). 210(3): 317-29.
58. Randall DC, Fleck NL, Shneerson JM, File SE, (2004) The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers. Pharmacol Biochem Behav. 77(3): 547-55.
59. Zack M, Poulos CX, (2009) Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity. J Psychopharmacol. 23(6): 660-71.
60. Schmaal L, Joos L, Koeleman M, Veltman DJ, van den Brink W, et al. (2013) Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients. Biol Psychiatry. 73(3): 211-8.
61. McNab F, Klingberg T, (2008) Prefrontal cortex and basal ganglia control access to working memory. Nat Neurosci. 11(1): 103-7.
62. McNab F, Varrone A, Farde L, Jucaite A, Bystritsky P, et al. (2009) Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science. 323(5915): 800-2.
63. Sesack SR, Hawrylak VA, Guido MA, Levey AI, (1998) Cellular and subcellular localization of the dopamine transporter in rat cortex. Adv Pharmacol. 42: 171-174.
64. Ciliax BJ, Drash GW, Staley JK, Haber S, Mobley CJ, et al. (1999) Immunocytochemical localization of the dopamine transporter in human brain. J Comp Neurol. 409(1): 38-56.
65. Smith SM, Fox PT, Miller KL, Glahn DC, Fox PM, et al. (2009) Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci U S A. 106(31): 13040-5.
66. Barbey AK, Colom R, Paul EJ, Grafman J (2013) Architecture of fluid intelligence and working memory revealed by lesion mapping. Brain Struct Funct.
67. Driver J, Baylis GC, (1989) Movement and visual attention: the spotlight metaphor breaks down. J Exp Psychol Hum Percept Perform. 15(3): 448-56.
68. Rasetti R, Mattay VS, Stankevich B, Skjei K, Blasi G, et al. (2010) Modulatory effects of modafinil on neural circuits regulating emotion and cognition. Neuropsychopharmacology. 35(10): 2101-9.
69. Müller U, Steffenhagen N, Regenthal R, Bublak P, (2004) Effects of modafinil on working memory processes in humans. Psychopharmacology (Berl). 177(1-2): 161-9.