Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

Psychopharmacology

Volumn 215, Issue 4, 2011, Pages 643-653

  James, Lynette M ^a   Iannone, Robert ^c   Palcza, John ^c   Renger, John J ^c   Calder, Nicole ^c   Cerchio, Kristine ^c   Gottesdiener, Keith ^c   Hargreaves, Richard ^c   Murphy, M Gail ^c   Boyle, Julia ^b   Dijk, Derk Jan ^a,b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Alerting effects; EEG; Excessive daytime sleepiness; H3

Indexed keywords

HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR AGONIST; MK 0249; MODAFINIL; PLACEBO; UNCLASSIFIED DRUG; BENZHYDRYL DERIVATIVE; DOPAMINE RECEPTOR STIMULATING AGENT; HISTAMINE AGONIST; HISTAMINE H3 RECEPTOR ANTAGONIST;

ADULT; ALERTNESS; ALPHA RHYTHM; AROUSAL; ARTICLE; BETA RHYTHM; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELTA RHYTHM; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; ELECTROENCEPHALOGRAPHY; EXPLORATORY RESEARCH; FEMALE; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; NIGHT SLEEP; NONREM SLEEP; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECOVERY SLEEP; REM SLEEP; SINGLE DRUG DOSE; SLEEP; SLEEP DEPRIVATION; SLEEP STAGE; SLEEP TIME; SOMNOLENCE; THETA RHYTHM; VOLUNTEER; ADOLESCENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; INVERSE AGONISM; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; WAKEFULNESS;

ADOLESCENT; ADULT; BENZHYDRYL COMPOUNDS; CROSS-OVER STUDIES; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG INVERSE AGONISM; ELECTROENCEPHALOGRAPHY; HISTAMINE AGONISTS; HISTAMINE H3 ANTAGONISTS; HUMANS; MALE; MIDDLE AGED; RECEPTORS, HISTAMINE H3; SLEEP DEPRIVATION; SLEEP STAGES; WAKEFULNESS; YOUNG ADULT;

EID: 80052912549     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2158-3     Document Type: Article

References (30)

1. Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA (1999) Two circadian rhythms in the human electroencephalogram during wakefulness. Am J Physiol 277:R1771-R1779
2. Akerstedt T, Gillberg M (1990) Subjective and objective sleepiness in the active individual. Int J Neurosci 52:29-37
3. Bonnet MH, Balkin TJ, Dinges DF, Roehrs T, Rogers NL, Wesensten NJ (2005) The use of stimulants to modify performance during sleep loss: a review by the Sleep Deprivation and Stimulant Task Force of the American Academy of Sleep Medicine. Sleep 28:1163-1187
4. Borbely AA, Mattmann P, Loepfe M, Strauch I, Lehmann D (1985) Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol 4:189-194
5. Brunner DP, Dijk DJ, Munch M, Borbely AA (1991) Effect of zolpidem on sleep and sleep EEG spectra in healthy young men. Psychopharmacol Berl 104:1-5
6. Cajochen C, Brunner DP, Krauchi K, Graw P, Wirz-Justice A (1995) Power density in theta/alpha frequencies of the waking EEG progressively increases during sustained wakefulness. Sleep 18:890-894
7. Cajochen C, Wyatt JK, Czeisler CA, Dijk DJ (2002) Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness. Neuroscience 114:1047-1060
8. Caldwell JA Jr, Caldwell JL, Smythe NK III, Hall KK (2000) A doubleblind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacol Berl 150:272-282
9. Chapotot F, Pigeau R, Canini F, Bourdon L, Buguet A (2003) Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian modulation of the human waking EEG. Psychopharmacol Berl 166:127-138
10. Dijk DJ, Czeisler CA (1995) Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci 15:3526-3538
11. Dijk DJ, Beersma DG,Daan S, van den Hoofdakker RH(1989) Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleep stages and EEG power spectra. Eur J Pharmacol 171:207-218
12. Dijk DJ, Brunner DP, Aeschbach D, Tobler I, Borbely AA (1992) The effects of ethanol on human sleep EEG power spectra differ from those of benzodiazepine receptor agonists. Neuropsychopharmacology 7:225-232
13. Dijk DJ, James L, Peters S, Walsh J, Deacon S (2010) Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep. J Psychopharmacol 24:1613-1618
14. Dumont M, Macchi MM, Carrier J, Lafrance C, Hebert M (1999) Time course of narrow frequency bands in the waking EEG during sleep deprivation. NeuroReport 10:403-407
15. Haas HL, Sergeeva OA, Selbach O (2008) Histamine in the nervous system. Physiol Rev 88:1183-1241
16. Iannone R, Palcza J, Renger JJ, Calder N, Cerchio K, Gottesdiener K, Hargreaves R, Dijk DJ, Boyle J, Murphy G (2010) Acute alerting effects of a novel histamine subtype-3 receptor inverse agonist in healthy sleep-deprived male volunteers. Clin Pharmacol Ther 88:831-839
17. Krueger JM, Rector DM, Roy S, Van Dongen HP, Belenky G, Panksepp J (2008) Sleep as a fundamental property of neuronal assemblies. Nat Rev Neurosci 9:910-919
18. Landolt HP, Meier V, Burgess HJ, Finelli LA, Cattelin F, Achermann P, Borbely AA (1999) Serotonin-2 receptors and human sleep: effect of a selective antagonist on EEG power spectra. Neuropsychopharmacology 21:455-466
19. Landolt HP, Retey JV, Tonz K, Gottselig JM, Khatami R, Buckelmuller I, Achermann P (2004) Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans. Neuropsychopharmacology 29:1933-1939
20. Leibowitz SM, Brooks SN, Black JE (2006) Excessive daytime sleepiness: considerations for the psychiatrist. Psychiatr Clin North Am 29:921-945
21. Leurs R, Bakker RA, Timmerman H, de Esch IJP (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov 4:107-120
22. Lin JS, Dauvilliers Y, Arnulf I, Bastuji H, Anaclet C, Parmentier R, Kocher L, Yanagisawa M, Lehert P, Ligneau X, Perrin D, Robert P, RouxM, Lecomte JM, Schwartz JC (2008) An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. Neurobiol Dis 30:74-83
23. Littner MR, Kushida C, Wise M, Davila DG, Morgenthaler T, Lee- Chiong T, Hirshkowitz M, Daniel LL, Bailey D, Berry RB, Kapen S, Kramer M (2005) Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep 28:113-121
24. Parmentier R, Anaclet C, Guhennec C, Brousseau E, Bricout D, Giboulot T, Bozyczko-Coyne D, Spiegel K, Ohtsu H, Williams M, Lin JS (2007) The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. Biochem Pharmacol 73:1157-1171
25. Qu WM, Huang ZL, Xu XH, Matsumoto N, Urade Y (2008) Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 28:8462-8469
26. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. US Government Printing Office, Washington, DC
27. Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257-1263
28. Takahashi K, Lin JS, Sakai K (2006) Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse. J Neurosci 26:10292-10298
29. Tinguely G, Finelli LA, Landolt HP, Borbely AA, Achermann P (2006) Functional EEG topography in sleep and waking: state-dependent and state-independent features. Neuroimage 32:283-292
30. Trachsel L, Dijk DJ, Brunner DP, Klene C, Borbely AA (1990) Effect of zopiclone and midazolam on sleep and EEG spectra in a phaseadvanced sleep schedule. Neuropsychopharmacology 3:11-18