Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation

Journal of Sleep Research

Volumn 14, Issue 3, 2005, Pages 255-266

  Wesensten, Nancy J ^a   Killgore, William D S ^a   Balkin, Thomas J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Countermeasures; Executive functions; Sleep loss; Stimulants; Vigilance

Indexed keywords

CAFFEINE; DEXAMPHETAMINE; MODAFINIL; PLACEBO;

ADULT; ALERTNESS; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; PERSONALITY TEST; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SLEEP DEPRIVATION; VERBAL MEMORY; WAKEFULNESS;

ADULT; AROUSAL; BENZHYDRYL COMPOUNDS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; COGNITION; DEXTROAMPHETAMINE; DISORDERS OF EXCESSIVE SOMNOLENCE; DOPAMINE AGONISTS; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; POLYSOMNOGRAPHY; PSYCHOMOTOR PERFORMANCE; SLEEP DEPRIVATION; WAKEFULNESS;

EID: 24644483838     PISSN: 09621105     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2869.2005.00468.x     Document Type: Article

References (34)

1. Balkin, T. J., Bliese, P. D., Belenky, G., Sing, H., Thorne, D. R., Thomas, M., Redmond, D. P., Russo, M. and Wesensten, N. J. Comparative utility of instruments for monitoring sleepiness-related performance decrements in the operational environment. J. Sleep Res., 2004, 13: 219-227.
2. Baranski, J. V., Cian, C., Esquivie, D., Pigeau, R. A. and Raphel, C. Modafinil during 64 hr of sleep deprivation: dose-related effects on fatigue, alertness, and cognitive performance. Mil. Psychol., 1998, 10: 173-193.
3. Barr, A. and Brandt, J. Word-list generation deficits in dementia. J. Clin. Exper. Neuropsychol., 1996, 18: 810-822.
4. Bensimon, G., Benoit, D., Lacomblez, L. et al. Antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in 12 healthy volunteers. Eur. Psychiatry, 1991, 6: 93-97.
5. Benton, A. L. and Hamsher, K. D. Multilingual Aphasia Examination. AJA Associates, Iowa City, IA, 1989.
6. Buguet, A., Montmayeur, A., Pigeau, R. and Naitoh, P. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep. J. Sleep Res., 1995, 4: 229-241.
7. Bullard, S. E., Fein, D., Gleeson, M. K., Tischer, N., Mapou, R. L. and Kaplan, E. The Biber cognitive estimation test. Arch. Clin. Neuropsych., 2004, 19: 835-846.
8. Caldwell, J. A., Caldwell, J. L., Smythe, N. K. and Hall, K. K. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology, 2000, 150: 272-282.
9. Dinges, D. F. and Powell, J. W. Microcomputer analyses of performance on a portable, simple visual RT task during sustained operations. Behav. Res. Methods Instrum. Comput., 1985, 17: 652-655.
10. Harrison, Y. and Home, J. A. Sleep loss impairs short and novel language tasks having a prefrontal focus. J. Sleep Res., 1998, 7: 95-100.
11. Harrison, Y. and Home, J. A. One night of sleep loss impairs innovative thinking and flexible decision making. Organ. Behav. Hum. Decis. Process., 1999, 78: 128-145.
12. Hoddes, E., Zarcone, V., Smythe, H., Phillips, R. and Dement, W. C. Quantification of sleepiness: a new approach. J. Clin. Psychol., 1973, 30: 248-250.
13. Kamimori, G. H., Johnson, D., Thorne, D., Kelly, W. and Belenky, G. L. Efficacy of multiple caffeine doses for maintenance of vigilance during early morning operations. Proc. 24th Annu Army Sci. Conf., 2004, JO-04.
14. Kongs, S. K., Thompson, L. L., Iverson, G. L. and Heaton, R. K. The Wisconsin Card Sorting Test (WCST-64): Computer Version 2 Research Edition. Psychological Assessment Resources, Lutz, FL, 2000.
15. Lagarde, D., Batejat, D., Van Beers, P., Sarafian, D. and Pradella, S. Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fundam. Clin. Pharmacol., 1995, 9: 271-279.
16. Lezak, M. D. Neuropsychological Assessment, 3rd edn. Oxford University Press, New York, NY, 1995.
17. Magill, R. A., Waters, W. F., Bray, G. A., Volaufova, J., Smith, S. R., Lieberman, H. R., McNevin, N. and Ryan, D. H. Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. Nutr. Neurosci., 2003, 6: 237-246.
18. Muller, U., Steffenhagen, N., Regenthal, R. and Bublak, P. Effects of modafinil on working memory processes in humans. Psychopharmacology, 2004, 177: 161-169.
19. Newhouse, P. A., Belenky, G., Thomas, M., Thorne, D., Sing, H. C. and Fertig, J. The effects of d-amphetamine on arousal, cognition, and mood after prolonged total sleep deprivation. Neuropsychopharmacology, 1989, 2: 153-164.
20. Penetar, D. M., McCann, U., Thorne, D., Kamimori, G., Galinski, C., Sing, H., Thomas, M. L. and Belenky, G. Caffeine reversal of sleep deprivation effects on alertness and mood. Psychopharmacology, 1993, 112: 359-365.
21. Pigeau, R., Naitoh, P., Buguet, C., McCann, C., Baranski, J., Taylor, M., Thompson, M. and Mack, I. I. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J. Sleep Res., 1995, 4: 212-228.
22. Randall, D. C., Schneerson, J. M., Plaha, K. K. and File, S. E. Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum. Psychopharmacol. Clin. Exp., 2003, 18: 163-173.
23. Randall, D. C., Fleck, N. L., Shneerson, J. M. and File, S. E. The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers. Pharmacol Biochem. Behav., 2004, 77: 547-555.
24. Rechtschaffen, A. and Kales, A. A Manual of Standardized Terminology, Techniques, and Scoring Systems for Sleep Stages of Human Subjects. Brain Information/Brain Research Institute UCLA, Los Angeles, CA, 1968.
25. Rosenthal, L., Merlotti, L., Roehrs, T. and Roth, T. Enforced 24 hr recovery following sleep deprivation. Sleep, 1991, 14: 448-453.
26. Saletu, B., Frey, R., Krupka, M., Adnerer, P., Grunberger, J. and Barbanoj, M. J. Differential effects of the new central adrenergic agonist modafinil and d-amphetamine on sleep and early morning behavior in young healthy volunteers. Int. J. Clin. Pharm. Res., 1989, 9: 183-195.
27. Thomas, M., Sing, H., Belenky, G., Holcomb, H. Mayberg, H. Dannals, R., Wagner, H., Thorne D., Popp, K., Rowland, L., Welsh, A., Balwinski, S. and Redmond, D. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J. Sleep Res., 2000, 9: 335-352.
28. Turner, D. C., Robbins, T. W., Clark, L., Aron, A. R., Dowson, J. and Sahakian, B. J. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology, 2003, 165: 260-269.
29. Walsh, J. K., Randazzo, A. C., Stone, K. L. and Schweitzer, P. K. Modafinil improves alertness, vigilance, and executive function during simulated night shifts. Sleep, 2004, 27: 434-439.
30. Warot, D., Corruble, E., Payan, C., Weil, J. S. and Puech, A. Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo. Eur. Psychiatry, 1993, 8: 201-208.
31. Waters, W.F., Magill, R.A., Bray, G.A., Volaufova, J., Smith, S. R., Lieberman, H. R., Rood, J., Hurry, M., Anderson, T. and Ryan D. H. A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation. Nutr. Neurosci., 2003, 6: 221-235.
32. Wesensten, N. J., Belenky, G., Kautz, M. A., Thorne, D. R., Reichardt, R. M. and Balkin, T. J. Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology, 2002, 159: 238-247.
33. Wong, Y. N., Simcoe, D., Hartman, L. N., Laughton, W. B., King, S. P., McCormick, G. C. and Grebow, P. E. A double-blind, placebo-controlled, ascending - dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. J. Clin. Pharmacol., 1999, 39: 30-40.
34. Wyatt, J. K., Cajochen, C., Ritz-De Cecco, A., Czeisler, C. A. and Dijk, D. Low-dose repeated caffeine administration for circadian phase-dependent performance degradation during extended wakefulness. Sleep, 2004, 27: 374-381.