-
1
-
-
77649179928
-
Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes
-
Al-Zubairi AS, Abdul AB and Syam MM (2010). Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes. Toxicol. In Vitro 24: 707-712.
-
(2010)
Toxicol. In Vitro
, vol.24
, pp. 707-712
-
-
Al-Zubairi, A.S.1
Abdul, A.B.2
Syam, M.M.3
-
2
-
-
79955652743
-
Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice
-
Aquino I, Perazzo FF and Maistro EL (2011). Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice. Food Chem. Toxicol. 49: 1335-1339.
-
(2011)
Food Chem. Toxicol
, vol.49
, pp. 1335-1339
-
-
Aquino, I.1
Perazzo, F.F.2
Maistro, E.L.3
-
3
-
-
0023911130
-
Arteether, a new antimalarial drug: Synthesis and antimalarial properties
-
Brossi A, Venugopalan B, Dominguez Gerpe L, Yeh HJ, et al. (1988). Arteether, a new antimalarial drug: synthesis and antimalarial properties. J. Med. Chem. 31: 645-650.
-
(1988)
J. Med. Chem
, vol.31
, pp. 645-650
-
-
Brossi, A.1
Venugopalan, B.2
Dominguez Gerpe, L.3
Yeh, H.J.4
-
4
-
-
0034751634
-
Genotoxic action of the sesquiterpene lactone centratherin on mammalian cells in vitro and in vivo
-
Burim RV, Canalle R, Lopes JL, Vichnewski W, et al. (2001). Genotoxic action of the sesquiterpene lactone centratherin on mammalian cells in vitro and in vivo. Teratog. Carcinog. Mutagen. 21: 383-393.
-
(2001)
Teratog. Carcinog. Mutagen
, vol.21
, pp. 383-393
-
-
Burim, R.V.1
Canalle, R.2
Lopes, J.L.3
Vichnewski, W.4
-
5
-
-
77749273519
-
Isolation, characterization and quantification of artemisinin by NMR from Argentinean Artemisia annua L
-
Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas
-
Cafferata LFR, Jeandupeux R, Rimada RS and Gatti WO (2009). Isolation, characterization and quantification of artemisinin by NMR from Argentinean Artemisia annua L. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 8: 275-281.
-
(2009)
, vol.8
, pp. 275-281
-
-
Cafferata, L.F.R.1
Jeandupeux, R.2
Rimada, R.S.3
Gatti, W.O.4
-
6
-
-
0035221545
-
Assessment of the cytotoxic and clastogenic activities of the sesquiterpene lactone lynchnopholide in mammalian cells in vitro and in vivo
-
Canalle R, Burim RV, Callegari Lopes JL and Takahashi CS (2001). Assessment of the cytotoxic and clastogenic activities of the sesquiterpene lactone lynchnopholide in mammalian cells in vitro and in vivo. Cancer Detect. Prev. 25: 93101.
-
(2001)
Cancer Detect. Prev
, vol.25
, pp. 93101
-
-
Canalle, R.1
Burim, R.V.2
Callegari Lopes, J.L.3
Takahashi, C.S.4
-
7
-
-
11344258568
-
Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit
-
Clark RL, White TE, Clode A, Gaunt I, et al. (2004). Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit. Birth Defects Res. B Dev. Reprod. Toxicol. 71: 380-394.
-
(2004)
Birth Defects Res. B Dev. Reprod. Toxicol
, vol.71
, pp. 380-394
-
-
Clark, R.L.1
White, T.E.2
Clode, A.3
Gaunt, I.4
-
8
-
-
0036931366
-
Caspases: Keys in the ignition of cell death
-
Denault JB and Salvesen GS (2002). Caspases: keys in the ignition of cell death. Chem. Rev. 102: 4489-4500.
-
(2002)
Chem. Rev
, vol.102
, pp. 4489-4500
-
-
Denault, J.B.1
Salvesen, G.S.2
-
9
-
-
4644256805
-
Differential sensitivity of cancer cells to docosahexaenoic acidinduced cytotoxicity: The potential importance of down-regulation of superoxide dismutase 1 expression
-
Ding WQ, Vaught JL, Yamauchi H and Lind SE (2004). Differential sensitivity of cancer cells to docosahexaenoic acidinduced cytotoxicity: The potential importance of down-regulation of superoxide dismutase 1 expression. Mol. Cancer Ther. 3: 1109-1117.
-
(2004)
Mol. Cancer Ther
, vol.3
, pp. 1109-1117
-
-
Ding, W.Q.1
Vaught, J.L.2
Yamauchi, H.3
Lind, S.E.4
-
10
-
-
28244475056
-
Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo
-
Disbrow GL, Baege AC, Kierpiec KA, Yuan H, et al. (2005). Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. Cancer Res. 65: 10854-10861.
-
(2005)
Cancer Res
, vol.65
, pp. 10854-10861
-
-
Disbrow, G.L.1
Baege, A.C.2
Kierpiec, K.A.3
Yuan, H.4
-
11
-
-
77649189381
-
Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo
-
Du JH, Zhang HD, Ma ZJ and Ji KM (2010). Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo. Cancer Chemother. Pharmacol. 65: 895-902.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 895-902
-
-
Du, J.H.1
Zhang, H.D.2
Ma, Z.J.3
Ji, K.M.4
-
12
-
-
0035315838
-
The anti-malarial artesunate is also active against cancer
-
Efferth T, Dunstan H, Sauerbrey A, Miyachi H, et al. (2001). The anti-malarial artesunate is also active against cancer. Int. J. Oncol. 18: 767-773.
-
(2001)
Int. J. Oncol
, vol.18
, pp. 767-773
-
-
Efferth, T.1
Dunstan, H.2
Sauerbrey, A.3
Miyachi, H.4
-
13
-
-
0042844638
-
Molecular modes of action of artesunate in tumor cell lines
-
Efferth T, Sauerbrey A, Olbrich A, Gebhart E, et al. (2003). Molecular modes of action of artesunate in tumor cell lines. Mol. Pharmacol. 64: 382-394.
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 382-394
-
-
Efferth, T.1
Sauerbrey, A.2
Olbrich, A.3
Gebhart, E.4
-
14
-
-
16244418704
-
Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate
-
Efferth T and Volm M (2005). Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate. In Vivo 19: 225-232.
-
(2005)
In Vivo
, vol.19
, pp. 225-232
-
-
Efferth, T.1
Volm, M.2
-
15
-
-
27644544444
-
In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
-
Fotakis G and Timbrell JA (2006). In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett. 160: 171-177.
-
(2006)
Toxicol. Lett
, vol.160
, pp. 171-177
-
-
Fotakis, G.1
Timbrell, J.A.2
-
16
-
-
79961193678
-
Superoxide dismutases: Role in redox signaling, vascular function, and diseases
-
Fukai T and Ushio-Fukai M (2011). Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid. Redox Signal. 15: 1583-1606.
-
(2011)
Antioxid. Redox Signal
, vol.15
, pp. 1583-1606
-
-
Fukai, T.1
Ushio-Fukai, M.2
-
17
-
-
53049086416
-
Experimental therapy of hepatoma with artemisinin and its derivatives: In vitro and in vivo activity, chemosensitization, and mechanisms of action
-
Hou J, Wang D, Zhang R and Wang H (2008). Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin. Cancer Res. 14: 5519-5530.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 5519-5530
-
-
Hou, J.1
Wang, D.2
Zhang, R.3
Wang, H.4
-
18
-
-
0000711137
-
A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay
-
Kobayashi H, Sugiyama C, Morikawa Y, Hayashi M, et al. (1995). A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay. MMS Commun. 3: 103-115.
-
(1995)
MMS Commun
, vol.3
, pp. 103-115
-
-
Kobayashi, H.1
Sugiyama, C.2
Morikawa, Y.3
Hayashi, M.4
-
19
-
-
49249122781
-
Artesunate derived from traditional Chinese medicine induces DNA damage and repair
-
Li PC, Lam E, Roos WP, Zdzienicka MZ, et al. (2008). Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res. 68: 4347-4351.
-
(2008)
Cancer Res
, vol.68
, pp. 4347-4351
-
-
Li, P.C.1
Lam, E.2
Roos, W.P.3
Zdzienicka, M.Z.4
-
20
-
-
30044436035
-
Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro
-
Longo M, Zanoncelli S, Manera D, Brughera M, et al. (2006). Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro. Reprod. Toxicol. 21: 83-93.
-
(2006)
Reprod. Toxicol
, vol.21
, pp. 83-93
-
-
Longo, M.1
Zanoncelli, S.2
Manera, D.3
Brughera, M.4
-
21
-
-
72049100401
-
Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines
-
Michaelis M, Kleinschmidt MC, Barth S, Rothweiler F, et al. (2010). Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines. Biochem. Pharmacol. 79: 130-136.
-
(2010)
Biochem. Pharmacol
, vol.79
, pp. 130-136
-
-
Michaelis, M.1
Kleinschmidt, M.C.2
Barth, S.3
Rothweiler, F.4
-
22
-
-
79961001204
-
In vitro evaluation of the genotoxic and cytotoxic effects of artesunate, an antimalarial drug, in human lymphocytes
-
Mota TC, Cardoso PC, Gomes LM, Vieira PC, et al. (2011). In vitro evaluation of the genotoxic and cytotoxic effects of artesunate, an antimalarial drug, in human lymphocytes. Environ. Mol. Mutagen. 52: 590-594.
-
(2011)
Environ. Mol. Mutagen
, vol.52
, pp. 590-594
-
-
Mota, T.C.1
Cardoso, P.C.2
Gomes, L.M.3
Vieira, P.C.4
-
23
-
-
1942504778
-
Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review
-
Olliaro PL and Taylor WR (2004). Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review. J. Postgrad. Med. 50: 40-44.
-
(2004)
J. Postgrad. Med
, vol.50
, pp. 40-44
-
-
Olliaro, P.L.1
Taylor, W.R.2
-
24
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl MW (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: e45.
-
(2001)
Nucleic Acids Res
, vol.29
-
-
Pfaffl, M.W.1
-
25
-
-
0036581160
-
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
-
Pfaffl MW, Horgan GW and Dempfle L (2002). Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30: e36.
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Pfaffl, M.W.1
Horgan, G.W.2
Dempfle, L.3
-
26
-
-
0033869568
-
Artemisinin drugs: Novel antimalarial agents
-
Price RN (2000). Artemisinin drugs: novel antimalarial agents. Expert. Opin. Investig. Drugs 9: 1815-1827.
-
(2000)
Expert. Opin. Investig. Drugs
, vol.9
, pp. 1815-1827
-
-
Price, R.N.1
-
27
-
-
33947579614
-
Measurement of local strain on cell membrane at initiation point of calcium signaling response to applied mechanical stimulus in osteoblastic cells
-
Sato K, Adachi T, Ueda D, Hojo M, et al. (2007). Measurement of local strain on cell membrane at initiation point of calcium signaling response to applied mechanical stimulus in osteoblastic cells. J. Biomech. 40: 1246-1255.
-
(2007)
J. Biomech
, vol.40
, pp. 1246-1255
-
-
Sato, K.1
Adachi, T.2
Ueda, D.3
Hojo, M.4
-
29
-
-
0035194318
-
Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells
-
Singh NP and Lai H (2001). Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells. Life Sci. 70: 49-56.
-
(2001)
Life Sci
, vol.70
, pp. 49-56
-
-
Singh, N.P.1
Lai, H.2
-
30
-
-
0031060624
-
Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin
-
Smith SL, Fishwick J, McLean WG, Edwards G, et al. (1997). Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin. Biochem. Pharmacol. 53: 5-10.
-
(1997)
Biochem. Pharmacol
, vol.53
, pp. 5-10
-
-
Smith, S.L.1
Fishwick, J.2
McLean, W.G.3
Edwards, G.4
-
31
-
-
25844530773
-
Down-regulation of SMT3A gene expression in association with DNA synthesis induction after X-ray irradiation in nevoid basal cell carcinoma syndrome (NBCCS) cells
-
Sugaya S, Nakanishi H and Tanzawa H (2005). Down-regulation of SMT3A gene expression in association with DNA synthesis induction after X-ray irradiation in nevoid basal cell carcinoma syndrome (NBCCS) cells. Mutat. Res. 578: 327-332.
-
(2005)
Mutat. Res
, vol.578
, pp. 327-332
-
-
Sugaya, S.1
Nakanishi, H.2
Tanzawa, H.3
-
32
-
-
0034037611
-
Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
-
Tice RR, Agurell E, Anderson D, Burlinson B, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35: 206-221.
-
(2000)
Environ. Mol. Mutagen
, vol.35
, pp. 206-221
-
-
Tice, R.R.1
Agurell, E.2
Anderson, D.3
Burlinson, B.4
-
33
-
-
53049090988
-
NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform
-
Toyoda E, Kagaya S, Cowell IG, Kurosawa A, et al. (2008). NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J. Biol. Chem. 283: 23711-23720.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 23711-23720
-
-
Toyoda, E.1
Kagaya, S.2
Cowell, I.G.3
Kurosawa, A.4
-
34
-
-
33751582721
-
Artesunate and a major metabolite,dihydroartemisinin,diminish mitogen-induced lymphocyte proliferation and activation.Southeast Asian
-
Veerasubramanian P, Gosi P, Limsomwong C and Walsh DS (2006). Artesunate and a major metabolite, dihydroartemisinin, diminish mitogen-induced lymphocyte proliferation and activation. Southeast Asian J. Trop. Med. Public Health 37: 838-847.
-
(2006)
J. Trop. Med. Public Health
, vol.37
, pp. 838-847
-
-
Veerasubramanian, P.1
Gosi, P.2
Limsomwong, C.3
Walsh, D.S.4
-
35
-
-
84888393374
-
Current and future status of herbal medicines
-
Verma S and Singh SP (2008). Current and future status of herbal medicines. Vet. World 1: 347-350.
-
(2008)
Vet. World
, vol.1
, pp. 347-350
-
-
Verma, S.1
Singh, S.P.2
-
36
-
-
84880826297
-
-
WHO (2010). WHO Calls on Malaria-Endemic Countries to Strengthen Monitoring of Antimalarial Drug Efficacy
-
WHO (2010). WHO Calls on Malaria-Endemic Countries to Strengthen Monitoring of Antimalarial Drug Efficacy. Available at [http://www.who.int/mediacentre/news/releases/2010/malaria_20101118]. Accessed November 11, 2010.
-
(2010)
-
-
-
37
-
-
0029094682
-
Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis
-
Yajko DM, Madej JJ, Lancaster MV, Sanders CA, et al. (1995). Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis. J. Clin. Microbiol. 33: 2324-2327.
-
(1995)
J. Clin. Microbiol
, vol.33
, pp. 2324-2327
-
-
Yajko, D.M.1
Madej, J.J.2
Lancaster, M.V.3
Sanders, C.A.4
-
38
-
-
65749103049
-
Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells
-
Youns M, Efferth T, Reichling J, Fellenberg K, et al. (2009). Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells. Biochem. Pharmacol. 78: 273-283.
-
(2009)
Biochem. Pharmacol
, vol.78
, pp. 273-283
-
-
Youns, M.1
Efferth, T.2
Reichling, J.3
Fellenberg, K.4
-
39
-
-
77952951285
-
Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers
-
Zhang S, Chen H and Gerhard GS (2010). Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers. Chem. Biol. Interact. 186: 30-35.
-
(2010)
Chem. Biol. Interact
, vol.186
, pp. 30-35
-
-
Zhang, S.1
Chen, H.2
Gerhard, G.S.3
-
40
-
-
33646950713
-
Artesunate reduces proliferation, interferes DNA replication and cell cycle and enhances apoptosis in vascular smooth muscle cells
-
Zhou Z and Feng Y (2005). Artesunate reduces proliferation, interferes DNA replication and cell cycle and enhances apoptosis in vascular smooth muscle cells. J. Huazhong. Univ. Sci. Technol. Med. Sci. 25: 135-136, 177.
-
(2005)
J. Huazhong. Univ. Sci. Technol. Med. Sci
, vol.25
, Issue.177
, pp. 135-136
-
-
Zhou, Z.1
Feng, Y.2
|