Genotoxic action of the sesquiterpene lactone centratherin on mammalian cells in vitro and in vivo

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 21, Issue 6, 2001, Pages 383-393

  Burim, Regislaine Valria ^a   Canalle, Renata ^a   Lopes, Joo Luis Callegari ^a   Vichnewski, Walter ^a   Takahashi, Catarina Satie ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bone marrow cells; Chromosomal aberrations; Genotoxicity; Human lymphocytes; Natural products; Sister chromatid exchange

Indexed keywords

CENTRATHERIN; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE CULTURE; MITOSIS INDEX; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; FEMALE; G2 PHASE; HUMANS; LACTONES; LYMPHOCYTES; MALE; MICE; MUTAGENS; SESQUITERPENES; SISTER CHROMATID EXCHANGE;

EID: 0034751634     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/tcm.1026     Document Type: Article

References (47)

1. Insecticidal effects of essential oils: A study of the effects of essential oils extracted from eleven Greek aromatic plants on Drosophila auraria
2. Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative diseases
3. Medicinal plants in therapy
4. Biological activities of sesquiterpene lactones
5. Cytotoxicity of sesquiterpene lactones
6. Inactivation of glycogen synthase by the tumor inhibitor vernolepin
7. Sesquiterpene antitumor agents: Inhibitors of cellular metabolism
8. The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells
9. Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones
10. Antimicrobial activity of sesquiterpene lactones
11. Inhibition of transcripition factor NF-kappaB by sesquiterpene lactones: A proposed molecular mechanism of action
12. A study of the tripanocidal and analgesic properties from Lychnophora granmongolense (Duarte) Semir & Leitao Filho
13. Sesquiterpene lactones and flavonoids from Eremanthus mattogrossensis and Eremanthus eriopus
14. Chromosome preparations of leukocytes cultured from human peripheral blood
15. New giemsa method for differential staining sister chromatids
16. Giemsa technique for the detection of sister chromatid exchanges
17. Induction of chromosomal aberrations and SCE by camptothecin, an inhibitor of mammalian topoisomerase I
18. A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes
19. Teste de metáfases de medula óssea. Teste com linfócitos do sangue periférico
20. A proposed battery of tests for the initial evaluation of the mutagenic potential of medicinal, industrial chemicals
21. Industrial genotoxicology group collaborative trial to investigate cell cycle parameters in human lymphocyte cytogenetics studies
22. Use of in vivo genetic toxicity data for risk assessment
23. Comparative methods of toxicity testing: Consensus document following an International Life Sciences-Institute-ILSI Europe workshop held in May 1995
24. Tumor inhibitors. 69. Structure-cytotoxicity relationships among the sesquiterpene lactones
25. The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents
26. Relationship between experimental results in mammals and man. I. Cytogenetic analysis of bone marrow injury induced by a single dose of cyclophosphamide
27. Effects of the amino acid glutamine on frequency of chromosomal aberrations induced by gamma radiation in Wistar rats
28. Mutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated from Paepalenthus vellozioides
29. Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo
30. Issues relevant to the assessment of chemically induced chromosome damage in vivo and their relationship to chemical mutagenesis
31. Chromosome aberrations in peripheral blood lymphocytes from control individuals
32. 2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in is parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I
33. Relationship of DNA lesions and their repair to chromosomal aberrations production
34. 2 repair and aging: Influence of donor age on chromosomal aberrations in human lymphocytes
35. DNA damaging effects of three sesquiterpene lactones in repair-deficient mutants o f Bacillus subtilis
36. In vitro and in vivo cytogenetic effects of sesquiterpene lactone parthenin derived from Parthenium hysterophorus Linn
37. Inhibition of DNA biosynthesis in HeLa cells by cytotoxic and antitumor sesquiterpene lactones
38. Evaluation of the genotoxic activity of the sesquiterpene lactone goyazensolide in mammalian systems in vitro and in vivo
39. Sister-chromatid exchange: Second report of the Gene-Tox program
40. On the distribution of spontaneous SCE in human peripheral blood lymphocytes
41. How do in vivo mammalian assays compare to in vitro assays in their ability to detect mutagens?
42. Sister chromatid exchange and gene mutation
43. Sister chromatid exchanges induced in Chinese Hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through S
44. In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone
45. Mammalian in vivo cytogenetic assays: Analysis of chromosome aberrations i n bone marrow cells
46. Chromosomal aberrations in bone marrow and peripheral blood cells from the same rats
47. Mutagenic activity of hymenovin, a sesquiterpene lactone from western bitterweed