Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers

Chemico-Biological Interactions

Volumn 186, Issue 1, 2010, Pages 30-35

  Zhang, Shiming ^a   Chen, Hui ^a   Gerhard, Glenn S ^a  

^a WEIS CENTER FOR RESEARCH   (United States)

Author keywords

Artemisinin; Cytotoxicity; Heme; Reactive oxygen species

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DICHLORODIHYDROFLUORESCEIN DIACETATE; DIHYDROARTEMISININ; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 2; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME REPRESSION; FLUORESCENCE ANALYSIS; HEME SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; PROTEIN EXPRESSION;

ANTIMALARIALS; ARTEMISININS; CATALASE; CELL DEATH; CELL LINE, TUMOR; CYTOTOXINS; DICARBETHOXYDIHYDROCOLLIDINE; FLUORESCEINS; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; HEME; HUMANS; LEUKEMIA; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 77952951285     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.021     Document Type: Article

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