-
1
-
-
0036168512
-
Oral artesunate dose-response relationship in acute Falciparum malaria
-
Angus B.J., Thaiaporn I., Chanthapadith K., Suputtamongkol Y., White N.J. Oral artesunate dose-response relationship in acute Falciparum malaria. Antimicrob. Agents Chemother. 2002, 46:778-782.
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 778-782
-
-
Angus, B.J.1
Thaiaporn, I.2
Chanthapadith, K.3
Suputtamongkol, Y.4
White, N.J.5
-
2
-
-
0023911130
-
Arteether, a new antimalarial drug: synthesis and antimalarial properties
-
Brossi A., Venugopalan B., Dominguez G.L., Yeh H.J.C., Flippen-Anderson J.L., Buchs P., Luo X.D., Milhous W., Peters W. Arteether, a new antimalarial drug: synthesis and antimalarial properties. J. Med. Chem. 1988, 31:645.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 645
-
-
Brossi, A.1
Venugopalan, B.2
Dominguez, G.L.3
Yeh, H.J.C.4
Flippen-Anderson, J.L.5
Buchs, P.6
Luo, X.D.7
Milhous, W.8
Peters, W.9
-
3
-
-
78049460573
-
ART-induced biophysical and biochemical alterations of Jurkat cell membrane
-
Cai X., You P., Cai J., Yang X., Chen Q., Huang F. ART-induced biophysical and biochemical alterations of Jurkat cell membrane. Micron 2011, 42:17-28.
-
(2011)
Micron
, vol.42
, pp. 17-28
-
-
Cai, X.1
You, P.2
Cai, J.3
Yang, X.4
Chen, Q.5
Huang, F.6
-
4
-
-
33745144971
-
In vivo genotoxic effects of industrial waste leachates in mice following oral exposure
-
Chandra S., Chauhan L.K.S., Dhawan A., Murthy R.C., Gupta S.K. In vivo genotoxic effects of industrial waste leachates in mice following oral exposure. Environ. Mol. Mutag. 2006, 47:325-333.
-
(2006)
Environ. Mol. Mutag.
, vol.47
, pp. 325-333
-
-
Chandra, S.1
Chauhan, L.K.S.2
Dhawan, A.3
Murthy, R.C.4
Gupta, S.K.5
-
5
-
-
78549287434
-
Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells
-
Chen H., Shi L., Yang X., Li S., Guo X., Pan L. Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells. Int. J. Hematol. 2010, 92:587-597.
-
(2010)
Int. J. Hematol.
, vol.92
, pp. 587-597
-
-
Chen, H.1
Shi, L.2
Yang, X.3
Li, S.4
Guo, X.5
Pan, L.6
-
6
-
-
0033554788
-
Current status of artemisinin and its derivates as antimalarial drugs
-
Dhingra V.K., Rao V., Narasu L.M. Current status of artemisinin and its derivates as antimalarial drugs. Life Sci. 2000, 66:279-300.
-
(2000)
Life Sci.
, vol.66
, pp. 279-300
-
-
Dhingra, V.K.1
Rao, V.2
Narasu, L.M.3
-
7
-
-
77649189381
-
Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo
-
Du J.H., Zhang H.D., Ma Z.J., Ji K.M. Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo. Cancer Chemother. Pharmacol. 2010, 65:895-902.
-
(2010)
Cancer Chemother. Pharmacol.
, vol.65
, pp. 895-902
-
-
Du, J.H.1
Zhang, H.D.2
Ma, Z.J.3
Ji, K.M.4
-
8
-
-
0042844638
-
Molecular modes of action of artesunate in tumor cell lines
-
Efferth T., Sauerbrey A., Olbrich A., Gebhart E., Rauch P., Weber H.O., Hengstler J.G., Halatsch M.E., Volm M., Tew K.D., Ross D.D., Funk J.O. Molecular modes of action of artesunate in tumor cell lines. Mol. Pharmacol. 2003, 64:382-394.
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 382-394
-
-
Efferth, T.1
Sauerbrey, A.2
Olbrich, A.3
Gebhart, E.4
Rauch, P.5
Weber, H.O.6
Hengstler, J.G.7
Halatsch, M.E.8
Volm, M.9
Tew, K.D.10
Ross, D.D.11
Funk, J.O.12
-
9
-
-
40149097301
-
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells
-
Efferth T., Giaisi M., Merling A., Krammer P.H., Weber M.L. Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS One 2007, 2:693.
-
(2007)
PLoS One
, vol.2
, pp. 693
-
-
Efferth, T.1
Giaisi, M.2
Merling, A.3
Krammer, P.H.4
Weber, M.L.5
-
10
-
-
0029162804
-
Sample size for the estimation of polychromatic to normochromatic erythrocyte ratio in the bone marrow micronucleus test
-
Gollapudi B.B., McFadden L.G. Sample size for the estimation of polychromatic to normochromatic erythrocyte ratio in the bone marrow micronucleus test. Mut. Res. 1995, 347:97-99.
-
(1995)
Mut. Res.
, vol.347
, pp. 97-99
-
-
Gollapudi, B.B.1
McFadden, L.G.2
-
11
-
-
0031557136
-
The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay)
-
Hartmann A., Speit G. The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay). Toxicol. Lett. 1997, 90:183-188.
-
(1997)
Toxicol. Lett.
, vol.90
, pp. 183-188
-
-
Hartmann, A.1
Speit, G.2
-
12
-
-
53049086416
-
Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action
-
Hou J., Wang D., Zhang R., Wang H. Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin. Cancer Res. 2008, 14:5519-5530.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5519-5530
-
-
Hou, J.1
Wang, D.2
Zhang, R.3
Wang, H.4
-
13
-
-
0021948029
-
Qinqhaosu (Artemisinin): an antimalarial drug from China
-
Klayman D.L. Qinqhaosu (Artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
-
(1985)
Science
, vol.228
, pp. 1049-1055
-
-
Klayman, D.L.1
-
14
-
-
0034693788
-
In vivo rodent micronucleus assay: protocol, conduct and data interpretation
-
Krishna G., Hayashi M. In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mutat. Res. 2000, 455:155-166.
-
(2000)
Mutat. Res.
, vol.455
, pp. 155-166
-
-
Krishna, G.1
Hayashi, M.2
-
15
-
-
49249122781
-
Artesunate derived from traditional chinese medicine induces DNA damage and repair
-
Li P.C., Lam E., Roos W.P., Zdzienicka M.Z., Kaina B., Efferth T. Artesunate derived from traditional chinese medicine induces DNA damage and repair. Cancer Res. 2008, 68:4347-4351.
-
(2008)
Cancer Res.
, vol.68
, pp. 4347-4351
-
-
Li, P.C.1
Lam, E.2
Roos, W.P.3
Zdzienicka, M.Z.4
Kaina, B.5
Efferth, T.6
-
16
-
-
0028845926
-
Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria
-
Luxemburguer C., Nosten F., Raimond S.D., Chongsuphajaisiddhi T., White N.J. Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria. Am. J. Trop. Med. Hyg. 1995, 53:522-525.
-
(1995)
Am. J. Trop. Med. Hyg.
, vol.53
, pp. 522-525
-
-
Luxemburguer, C.1
Nosten, F.2
Raimond, S.D.3
Chongsuphajaisiddhi, T.4
White, N.J.5
-
17
-
-
0029894037
-
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
-
Meshnick S.R., Taylor T.E., Kamchonwongpaisan S. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol. Rev. 1996, 60:301-315.
-
(1996)
Microbiol. Rev.
, vol.60
, pp. 301-315
-
-
Meshnick, S.R.1
Taylor, T.E.2
Kamchonwongpaisan, S.3
-
18
-
-
0028106706
-
Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination
-
Nosten F., Luxemburguer C., ter Kuile F., Woodrow C., Eh J.P., Chongsuphajaisiddhi T., White N.J. Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination. J. Infect. Dis. 1994, 170:971-977.
-
(1994)
J. Infect. Dis.
, vol.170
, pp. 971-977
-
-
Nosten, F.1
Luxemburguer, C.2
ter Kuile, F.3
Woodrow, C.4
Eh, J.P.5
Chongsuphajaisiddhi, T.6
White, N.J.7
-
19
-
-
0034702506
-
Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study
-
Nosten F., Van Yugt M., Price R.N., Luxemburguer C., Thway K.L., Brockman A., ter Kuile F., Looareesuwan S., White N.J. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. The Lancet 2000, 356:297-302.
-
(2000)
The Lancet
, vol.356
, pp. 297-302
-
-
Nosten, F.1
Van Yugt, M.2
Price, R.N.3
Luxemburguer, C.4
Thway, K.L.5
Brockman, A.6
ter Kuile, F.7
Looareesuwan, S.8
White, N.J.9
-
20
-
-
0035060361
-
Mode of action and mechanism of resistance for antimalarial drug
-
Olliaro P. Mode of action and mechanism of resistance for antimalarial drug. Pharmacol. Therap. 2001, 89:207-219.
-
(2001)
Pharmacol. Therap.
, vol.89
, pp. 207-219
-
-
Olliaro, P.1
-
21
-
-
0028884817
-
Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria
-
Price R.N., Nosten F., Luxemburguer C., Kham A., Brockman A., Chongsuphajaisiddhi T., White N.J. Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 1995, 89:523-527.
-
(1995)
Trans. R. Soc. Trop. Med. Hyg.
, vol.89
, pp. 523-527
-
-
Price, R.N.1
Nosten, F.2
Luxemburguer, C.3
Kham, A.4
Brockman, A.5
Chongsuphajaisiddhi, T.6
White, N.J.7
-
22
-
-
33747224281
-
Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity
-
Rodeiro I., Cancino L., Gonzàlez J.E., Morffi J., Garrido G., Gonzàlez R.M., Nuñez A., Delgado R. Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. Food Chem. Toxicol. 2006, 44:1707-1713.
-
(2006)
Food Chem. Toxicol.
, vol.44
, pp. 1707-1713
-
-
Rodeiro, I.1
Cancino, L.2
Gonzàlez, J.E.3
Morffi, J.4
Garrido, G.5
Gonzàlez, R.M.6
Nuñez, A.7
Delgado, R.8
-
23
-
-
0016437314
-
The micronucleus test
-
Schmid W. The micronucleus test. Mut. Res. 1975, 31:9-15.
-
(1975)
Mut. Res.
, vol.31
, pp. 9-15
-
-
Schmid, W.1
-
24
-
-
55349093018
-
In vivo assessment of DNA damage and protective effects of extracts from Miconia species using the comet assay and micronucleus test
-
Serpeloni J.M., Reis M.B., Rodrigues J., Santos L.C., Vilegas W., Varanda E.A., Dokkedal A.L., Colus I.M. In vivo assessment of DNA damage and protective effects of extracts from Miconia species using the comet assay and micronucleus test. Mutagenesis 2008, 23:501-507.
-
(2008)
Mutagenesis
, vol.23
, pp. 501-507
-
-
Serpeloni, J.M.1
Reis, M.B.2
Rodrigues, J.3
Santos, L.C.4
Vilegas, W.5
Varanda, E.A.6
Dokkedal, A.L.7
Colus, I.M.8
-
25
-
-
0023919963
-
A simple technique for quantitation of low levels of DNA damage in individual cells
-
Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
-
(1988)
Exp. Cell Res.
, vol.175
, pp. 184-191
-
-
Singh, N.P.1
McCoy, M.T.2
Tice, R.R.3
Schneider, E.L.4
-
26
-
-
0346497339
-
-
San Francisco, 404-486, W.H. Freeman (Ed.)
-
Sokal R.R., Rohlf F.J. Biometry 1995, 175-205. San Francisco, 404-486. W.H. Freeman (Ed.).
-
(1995)
Biometry
, pp. 175-205
-
-
Sokal, R.R.1
Rohlf, F.J.2
-
27
-
-
0032604577
-
The Comet Assay (Single-Cell Gel Test)
-
Speit G., Hartmann A. The Comet Assay (Single-Cell Gel Test). In: Methods in Molecular Biology, DNA Repair Protocols: Eukaryotic Systems (Henderson DS, ed.). Humana Press Inc., Totowa 1999, 113:203-212.
-
(1999)
In: Methods in Molecular Biology, DNA Repair Protocols: Eukaryotic Systems (Henderson DS, ed.). Humana Press Inc., Totowa
, vol.113
, pp. 203-212
-
-
Speit, G.1
Hartmann, A.2
-
28
-
-
0034037611
-
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing
-
Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
-
(2000)
Environ. Mol. Mutagen.
, vol.35
, pp. 206-221
-
-
Tice, R.R.1
Agurell, E.2
Anderson, D.3
Burlinson, B.4
Hartmann, A.5
Kobayashi, H.6
Miyamae, Y.7
Rojas, E.8
Ryu, J.C.9
Sasaki, Y.F.10
-
29
-
-
77749320393
-
Combining the in vivo comet and micronucleus assays: a practical approach to genotoxicity testing and data interpretation
-
Vasquez M.Z. Combining the in vivo comet and micronucleus assays: a practical approach to genotoxicity testing and data interpretation. Mutagenesis 2010, 25:187-199.
-
(2010)
Mutagenesis
, vol.25
, pp. 187-199
-
-
Vasquez, M.Z.1
-
30
-
-
79955658584
-
-
WHO (World Health Organization), Malaria. Disponível em: <>Access in June, 03, 2008.
-
WHO (World Health Organization), 2001. Malaria. Disponível em: <>Access in June, 03, 2008. http://www.rbm.who.int/cmc_upload/0/000/015/367/RBMInfosheet_6.htm.
-
(2001)
-
-
-
31
-
-
79955672952
-
-
WHO (World Health Organization), Handbook - Non Clinical Safety Testing. Disponível em: <>Access in Nov., 03, 2009.
-
WHO (World Health Organization), 2004. Handbook - Non Clinical Safety Testing. Disponível em: <>Access in Nov., 03, 2009. http://www.who.int/tdr/publications/publications/safety-handbook.htm.
-
(2004)
-
-
-
32
-
-
79955657026
-
-
WHO (World Health Organization) Handbook: Good Laboratory Practice (GLP). Quality practices for regulated non-clinical research and development. Disponível em: <>Access in: May, 10, 2009.
-
WHO (World Health Organization) 2001. Handbook: Good Laboratory Practice (GLP). Quality practices for regulated non-clinical research and development. Disponível em: <>Access in: May, 10, 2009. http://apps.who.int/tdr/publications/training-guideline-publications/good-laboratory-practicehandbook/pdf/glp-handbook.pdf.
-
(2001)
-
-
|