Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells: Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways

Experimental Cell Research

Volumn 319, Issue 14, 2013, Pages 2145-2151

  Zheng, Zhen ^a   Li, Zhiliang ^a   Chen, Song ^a   Pan, Jieyi ^a   Ma, Xiaochun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Endothelial cells; Inducible NO synthase; Phosphoinositide 3 kinase; Spleen tyrosine kinase; Tetramethylpyrazine

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PICEATANNOL; PROTEIN KINASE SYK; TETRAMETHYLPYRAZINE; WORTMANNIN;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOLYSIS; DEGRADATION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

EID: 84880741015     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2013.05.018     Document Type: Article

References (31)

1. Liao F. Herbs of activating blood circulation to remove blood stasis. Clin. Hemorheol. Microcirc. 2000, 23:127-131.
2. Liu S.Y., Sylvester D.M. Anti-platelet structure-activity relationship of tetramethylpyrazine. Life Sci. 1994, 55:1317-1326.
3. Ali B.H., Al-Moundhri M., Eldin M.T., et al. Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi. Exp. Biol. Med. 2008, 233:891-896.
4. Yang X.G., Jiang C. Ligustrazine as a salvage agent for patients with relapsed or refractory non-Hodgkin's lymphoma. Chin. Med. J. 2010, 123:3206-3211.
5. Hou Y.Z., Zhao G.R., Yuan Y.J., et al. Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis. J. Ethnopharmacol. 2005, 100(1-2):140-144. 22.
6. Hou Y.Z., Zhao G.R., Yang J., et al. Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide. Life Sci. 2004, 75(14):1775-1786. 20.
7. Zhang Z., Wei T., Hou J., et al. Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes. Life Sci. 2003, 72:2465-2472.
8. Levy R.M., Prince J.M., Billiar T.R. Nitric oxide: a clinical primer. Crit. Care Med. 2005, 33:S492-495.
9. Fierro I.M., Nascimento-DaSilva V., Arruda M.A., et al. Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity. J. Leukoc. Biol. 1999, 65:508-514.
10. Chauhan S.D., Seggara G., Vo P.A., et al. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J. 2003, 17:773-775.
11. Su C.F., Yang F.L., Chen H.I. Inhibition of inducible nitric oxide synthase attenuates acute endotoxin induced lung injury in rats. Clin. Exp. Pharmacol. Physiol. 2007, 34:339-346.
12. Titheradge M.A. Nitric oxide in septic shock. Biochim. Biophys. Acta 1999, 1411:437-455.
13. Morikawa A., Kato Y., Sugiyama T., et al. Role of nitric oxide in lipopolysaccharide-induced hepatic injury in Dgalactosamine-sensitized mice as an experimental endotoxic shock model. Infect. Immun. 1999, 67:1018-1024.
14. Mócsai A., Ruland J., Tybulewicz V.L. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat. Rev. Immunol. 2010, 10(6):387-402.
15. Tsuchida S., Yanagi S., Inatome R., et al. Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: involvement of Syk in signaling events of hepatocytes. J. Biochem. 2000, 127:321-327.
16. Cha H.S., Boyle D.L., Inoue T., et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J. Pharmacol. Exp. Ther. 2006, 317:571-578.
17. Coopman P.J., Do M.T., Barth M., et al. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 2000, 406(6797):742-747.
18. Hamerman J.A., Tchao N.K., Lowell C.A., et al. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 2005, 6:579-586.
19. Han C., Jin J., Xu S., et al. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat. Immunol. 2010, 11:734-742.
20. Inatome R., Yanagi S., Takano T., et al. A critical role for Syk in endothelial cell proliferation and migration. Biochem. Biophys. Res. Commun. 2001 10, 286(1):195-199.
21. Yanagi S., Inatome R., Ding J., et al. Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice. Blood 2001, 98(9):2869-2871.
22. Finder J., Stark W.W., Nakayama D.K., et al. TGF-beta regulates production of NO in pulmonary artery smooth muscle cells by inhibiting expression of NOS. Am. J. Physiol. 1995, 268:L862-L867.
23. Studies of active components of Ligusticum wallichii Franch. III. A report of the treatment of tetramethylpyrazine in 218 patients with ischemia cerebrovascular diseases. Chin. Med. J. 1977, 8:467-469. Beijing Institute of Pharmaceutical Industry.
24. Liao F. Herbs of activating blood circulation to remove blood stasis. Clin. Hemorheol. Microcirc. 2000, 23:127-131.
25. Lu Y.M., Wan F.S., Tang S.B. Effects of tetramethylpyrazine on expression of Bcl-2 and Fas proteins in myocardial injury induced by catecholamine in rats. Chin. J. Clin. Pharmacol. Ther. 2004, 9:197-200.
26. Lee Y.G., Chain B.M., Cho J.Y. Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of κBα via activation of the phosphoinositide-3-kinase and Akt pathways. Int. J. Biochem. Cell Biol. 2009, 41:811-821.
27. Cruz M.T., Duarte C.B., Goncalo M., et al. LPS induction of IkB-α degradation and iNOS expression in a skin dendritic cell line is prevented by the Janus kinase 2 inhibitor, tyrphostin B42. Nitric Oxide 2001, 5:53-61.
28. Lee J.Y., Lowell C.A., Lemay D.G., et al. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem. Pharmacol. 2005, 70:1231-1240.
29. Jefferies C.A., O'Neill L.A.J. Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?. Immunol. Lett. 2004, 92:15-22.
30. Ulanova M., Asfaha S., Stenton G., et al. Involvement of Syk protein tyrosine kinase in LPS-induced responses in macrophages. J. Endotoxin Res. 2007, 13:117-125.
31. Turner M., Schweighoffer E., Colucci F., et al. Tyrosine kinase SYK: essential functions for immunoreceptor signaling. Immunol. Today 2000, 21:148-154.