The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells

Phytotherapy Research

Volumn 27, Issue 8, 2013, Pages 1154-1161

  Yang, Shih Huang ^a   Liao, Pao Hsin ^a,b   Pan, Ya Fang ^a   Chen, Shiow Ling ^a   Chou, Shih Shen ^a,b   Chou, Ming Yung ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

apoptosis; metastasis; p53; PAI 1; PPAR ; vitexin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN DEPENDENT KINASE INHIBITOR 1; GELATINASE A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIFITHRIN ALPHA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BAX; PROTEIN P53; VITEXIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BAX GENE; CANCER CELL CULTURE; CELL STRAIN OC2; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; METASTASIS; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUTH CANCER; P21 WAF1 GENE; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

CRATAEGUS;

APOPTOSIS; METASTASIS; P53; PAI-1; PPARΓ; VITEXIN;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APIGENIN; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOTHIAZOLES; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLAVONOIDS; HUMANS; MATRIX METALLOPROTEINASE 2; MOUTH NEOPLASMS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PPAR GAMMA; SIGNAL TRANSDUCTION; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84880721583     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4841     Document Type: Article

References (61)

1. Anderson RB,. 2010. Matrix metalloproteinase-2 is involved in the migration and network formation of enteric neural crest-derived cells. Int J Dev Biol 54: 63-69.
2. Baramova EN, Bajou K, Remacle A, et al,. 1997. Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation. FEBS Lett 405: 157-162.
3. Baricos WH, Cortez SL, El-Dahr SS, Schnaper HW,. 1995. ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade. Kidney Int 47: 1039-1047.
4. Bureau of Health Promotion. 2008. Bureau of Health Promotion, Department of Health, Taiwan, R.O.C. Cancer registry annual report.
5. Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA,. 1994. Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135: 798-800.
6. Choi HJ, Eun JS, Kim BG, Kim SY, Jeon H, Soh Y,. 2007. Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells. Mol Cells 22: 291-299.
7. Ciccarelli C, Marampon F, Scoglio A, et al,. 2005. p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells. Mol Cancer 4: 41-58.
8. Danø K, Behrendt N, Høyer-Hansen G, et al,. 2005. Plasminogen activation and cancer. Thromb Haemost 93: 676-681.
9. DeHaan RD, Yazlovitskaya EM, Persons DL,. 2001. Regulation of p53 target gene expression by cisplatin-induced extracellular signal-regulated kinase. Cancer Chemother Pharmacol 48: 383-388.
10. DiMusto PD, Lu G, Ghosh A, et al,. 2012. Increased PAI-1 in females compared with males is protective for abdominal aortic aneurysm formation in a rodent model. Am J Physiol Heart Circ Physiol 302: H1378-H1386.
11. DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA,. 1998. The nuclear eicosanoid receptor, PPARγ, is aberrantly expressed in colonic cancers. Carcinogenesis 19: 49-53.
12. Elstner E, Muller C, Koshizuka K, et al,. 1998. Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. PNAS 95: 8806-8811.
13. Fabre-Guillevin E, Malo M, Cartier-Michaud A, et al,. 2008. PAI-1 and functional blockade of SNAI1 in breast cancer cell migration. Breast Cancer Res 10: R100.
14. Farsi E, Shafaei A, Hor SY, et al,. 2011. Correlation between enzymes inhibitory effects and antioxidant activities of standardized fractions of methanolic extract obtained from Ficus deltoidea leaves. African J Biotech 10: 15184-15194.
15. Floyd ZE, Stephens JM,. 2002. Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes. J Biol Chem 277: 4062-4068.
16. Gaitan E, Cooksey RC, Legan J, Lindsay RH,. 1995. Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet. JCEM 80: 1144-1147.
17. Garcia-Bates TM, Bernstein SH, Phipps RP,. 2008. Peroxisome Proliferator-Activated Receptor; Overexpression suppresses growth and induces apoptosis in human multiple myeloma cells. Clin Cancer Res 14: 6414-6425.
18. Harris SL, Levine AJ,. 2005. The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.
19. Hlawaty H, Juan AS, Jacob MP, Vranckx R, Letourneur D, Feldman LJ,. 2007. Inhibition of MMP-2 gene expression with small interfering RNA in rabbit vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 293: H3593-H3601.
20. Ho CC, Yang XW, Lee TL, et al,. 2003. Activation of p53 signalling in acetylsalicylic acid-induced apoptosis in OC2 human oral cancer cells. Eur J Clin Invest 33: 875-882.
21. Ignatenko NA, Babbar N, Mehta D, Casero Jr RA, Gerner EW,. 2004. Suppression of polyamine catabolism by activated ki-ras in human colon cancer cells. Mol Carcinog 39: 91-102.
22. Jung JY, Yoo CI, Kim HT, Kwon CH, Park JY, Kim YK,. 2007. Role of mitogen-activated protein kinase (MAPK) in troglitazone-induced osteoblastic cell death. Toxicology 234: 73-82.
23. Keelan JA, Sato TA, Marvin KW, Lander J, Gilmour RS, Mitchell MD,. 1999. 15-deoxy-Δ12,14- prostaglandin J2 a ligand for peroxisome proliferatoractivated receptor-γ, induces apoptosis in JEG3 choriocarcinoma cells. Biochem Biophys Res Commun 262: 579-585.
24. Kim JP, Lee IS, Seo JJ, et al,. 2010. Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells. Phytother Res 24: 1543-1548.
25. Kobuke T, Tazuma S, Hyogo H, Chayama K,. 2006. A ligand for peroxisome proliferator-activated receptor γ inhibits human cholangiocarcinoma cell growth: Potential molecular targeting strategy for cholangioma. Dig Dis Sci 51: 1650-1657.
26. Krishna TSR, Kong XP, Gary S, Burger PM, Kuriyan J,. 1994. Crystal structure of the eukaryotic DNA polymerase processivity factor. PCNA Cell 79: 1233-1243.
27. Kunz C, Pebler S, Otte J, von der Ahe D,. 1995. Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53. Nucleic Acids Res 23: 3710-3717.
28. Lassus P, Roux P, Zugasti O, Philips A, Fort P, Hibner U,. 2000. Extinction of Rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway. Oncogene 19: 2377-2385.
29. Lee SJ, Lee JH, Lee HH, et al,. 2011. Effect of nung bean ethanol extract on pro-inflammtory cytokines in LPS stimulated macrophages. Food Sci Biotechnol 20: 519-524.
30. Li DW, Liu JP, Mao YW, et al,. 2005. Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by αB-crystallin through inhibition of RAS activation. Mole Biol Cell 16: 4437-4453.
31. Li M, Lee TW, Yim APC, Mok TSK, Chen GG,. 2006. Apoptosis induced by troglitazone is both peroxisome proliferator-activated receptor-γ- and ERK-dependent in human non-small lung cancer cells. J Cell Physiol 209: 428-438.
32. Li H, Song F, Xing J, Tsao R, Liu Z, Liu S,. 2009. Screening and structural characterization of α-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MSn and SORI-CID FTICR MS. J Am Soc Mass Spectrom 20: 1496-1503.
33. Lin MS, Chen WC, Bai X, Wang YD,. 2007. Activation of peroxisome proliferator-activated receptor γ inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. J Dig Dis 8: 82-88.
34. Lin T, Mak NK, Yang MS,. 2008. MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: Involvement of p53 phosphorylation and acetylation. Toxicology 247: 145-153.
35. Liu J, Mao W, Ding B, Liang CS,. 2008. ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol Heart Circ Physiol 295: H1956-H1965.
36. Liu Y, Yang Y, Ye YC, et al,. 2012. Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 Cells. J Pharmacol Sci 118: 423-432.
37. Luo Y, Liang F, Zhang ZY,. 2009. PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry 48: 1838-1846.
38. Marques AR, Espadinha C, Frias MJ, et al,. 2004. Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ- negative thyroid tumours. Br J Cancer 91: 732-738.
39. Mueller E, Smith M, Sarraf P, et al,. 2000. Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer. Proc Natl Acad Sci 97: 10990-10995.
40. Okumura Y, Sato H, Seiki M, Kido H,. 1997. Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator. FEBS Lett 402: 181-184.
41. Ostrakhovitch EA, Cherian MG,. 2005. Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis. J Cell Biochem 95: 1120-1134.
42. Praus M, Collen D, Gerard RD,. 2002. Both u-PA inhibition and vitronectin binding by plasminogen activator inhibitor 1 regulate HT1080 fibrosarcoma cell metastasis. Int J Cancer 102: 584-591.
43. Ramer R, Rohde A, Merkord J, Rohde H, Hinz B,. 2010. Decrease of plasminogen activator inhibitor-1 may contributeto the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res 27: 2162-2174.
44. Rosen ED, Sarraf P, Troy AE, et al,. 1999. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 4: 611-617.
45. Shetty S, Shetty P, Idell S, Velusamy T, Bhandary YP, Shetty RS,. 2008. Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53. J Biol Chem 283: 19570-19580.
46. Shih AI, Davis FB, Lin HY, Davis PJ,. 2002. Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J Clin Endocrinol Metab 87: 1223-1232.
47. Singh S, Upadhyay AK, Ajay AK, Bhat MK,. 2007. p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: A novel target of p53 in apoptosis. FEBS Lett 581: 289-295.
48. Takahashi N, Okumura T, Motomura W, Fujimoto Y, Kawabata I, Kohgo Y,. 1999. Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett 455: 135-139.
49. Tan Z, Zhang Y, Deng J, Zeng G, Zhang Y,. 2012. Purified vitexin compound 1 suppresses tumor growth and induces cell apoptosis in a mouse model of human choriocarcinoma. Int J Gynecol Cancer 22: 360-366.
50. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM,. 1994a. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8: 1224-1234.
51. Tontonoz P, Hu E, Spiegelman BM,. 1994b. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79: 1147-1156.
52. Tontonoz P, Singer S, Forman BM, et al,. 1997. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc Natl Acad Sci 94 (1): 237-241.
53. Vousden KH,. 2000. p53: death star. Cell 103: 691-694.
54. Whitley BR, Palmieri D, Twerdi CD, Church FC,. 2004. Expression of active plasminogen activator inhibitor-1 reduces cell migration and invasion in breast and gynecological cancer cells. Exp Cell Res 296: 151-162.
55. Wong DYK, Chang KW, Chen CF, Chang RCS,. 1990. Characterization of two new cell lines derived from oral cavity human aquamous cell carcinoma-OC1 and OC2. J Oral Maxillofac Surg 48: 385-390.
56. Xiao D, Singh SV,. 2002. Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Res 62: 3615-3619.
57. Yamaguchi K, Lee SH, Eling TE, Baek SJ,. 2006. A novel peroxisome proliferator-activated receptor; ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol Cancer Ther 5: 1352-1361.
58. Yao PL, Lin YC, Richburg JH,. in press. Mono-(2-Ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells. Biol Reprod DOI 10.1095/biolreprod.111.097295.
59. Yee LD, Guo Y, Bradbury J, Suster S, Clinton SK, Seewaldt VL,. 2003. The antiproliferative effects of PPARγ ligands in normal human mammary epithelial cells. Breast Cancer Res Treat 78: 179-192.
60. 2-induced PPAR-γ activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. J Korean Med Sci 22: 1015-1021.
61. Zhou YJ, Liu YE, Cao JG, et al,. 2009 Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res 15: 5161-5169.