Activation of peroxisome proliferator-activated receptor γ inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer

Journal of Digestive Diseases

Volumn 8, Issue 2, 2007, Pages 82-88

  Lin, Mao Song ^a   Chen, Wei Chang ^b   Bai, Xia ^c   Wang, Ya Dong ^a  

^a Department of Gastroenterology of Taizhou People's Hospital ^*  (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c Institute of Hematology of Jiangsu Province   (China)

Author keywords

Apoptosis; Cell cycle; Colorectal cancer; PPAR .

Indexed keywords

EID: 84876060135     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/j.1443-9573.2007.00290.x     Document Type: Article

References (21)

1. Vamecq J, Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 1999; 354: 141-8.
2. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56.
3. Kliewer SA, Umesono K, Noonan DJ et al. Convergence of 9-cis retinoic acid and peroxisome proliferators signaling pathways through heterodimer formation of their receptors. Nature 1992; 358: 771-4.
4. Forman BM, Tontonoz P, Chen J et al. 15-deoxy-delta-12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995; 83: 803-12.
5. Kubota T, Koshizuka K, Williamson E et al. Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 1998; 58: 3344-52.
6. Leung WK, Bai AHC, Chan VYW et al. Effect of peroxisome proliferators activated receptor γ ligands on growth and gene expression profiles of gastric cancer cells. Gut 2004; 53: 331-8.
7. Tontonoz P, Singer S, Forman BM et al. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc Natl Acad Sci USA 1997; 94: 237-41.
8. Sarraf P, Mueller E, Jones D et al. Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 1998; 4: 1046-52.
9. Kitamura S, Miyazaki Y, Shinomura Y et al. Peroxisome proliferator-activated receptor γ induces growth arrest and differentiation markers of human colon cancers. Jpn J Cancer Res 1999; 90: 75-80.
10. Saez E, Tontonoz P, Nelson MC et al. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med 1998; 4: 1058-61.
11. Lefebvre AM, Chen I, Desreumaux P et al. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J -APC Min/+ mice. Nat Med 1998; 4: 1053-7.
12. Sato H, Ishihara S, Kawashima K et al. Expression of peroxisome proliferator-activated receptor (PPAR) γ in gastric cancer and inhibitory effects of PPARγ agonists. Br J Cancer 2000; 83: 1394-400.
13. Forman BM, Chen J, Evans RM. The peroxisome proliferator-activated receptors: Ligands and activators. Ann N Y Acad Sci 1996; 804: 266-75.
14. Issemann I, Green S. Activation of a number of the steroid receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645-50.
15. kip1 in human pancreatic carcinoma cells. Cancer Res 2000; 60: 5558-64.
16. Shimada T, Kojima K, Yoshiura K et al. Characteristics of the peroxisome proliferator activated receptor γ (PPARγ) ligand induced apoptosis in colon cancer calls. Gut 2002; 50: 658-64.
17. Nishida K, Furumatsu T, Takada I et al. Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferators-activated receptor-γ. Br J Cancer 2002; 86: 1303-9.
18. Chang T-H, Szabo E. Induction of differentiation and apoptosis by ligangs of peroxisome proliferator-activated receptor γ in non-small cell lung cancer. Cancer Res 2000; 60: 1129-38.
19. Possatia L, Rocchettia R, Talevi S et al. The role of peroxisome proliferator-activated receptor g in bladder cancer in relation to angiogenesis and progression. General Pharmacol 2002; 35: 269-75.
20. Elstner E, Muller C, Koshizuka K et al. Ligands for peroxisome proliferators-activated receptor gamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998; 95: 8806-11.
21. Brockman J, Cupta R, Dubois RN. Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology 1998: 1049-55.