Portrait of replication stress viewed from telomeres

Cancer Science

Volumn 104, Issue 7, 2013, Pages 790-794

  Ishikawa, Fuyuki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; DNA POLYMERASE; DOUBLE STRANDED DNA; GUANINE NUCLEOTIDE; HELICASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR SUPPRESSOR PROTEIN;

AUTOSOMAL DOMINANT INHERITANCE; BASE PAIRING; BIOLOGICAL MONITORING; CAENORHABDITIS ELEGANS; CHROMOSOME ABERRATION; DNA REPLICATION; DNA SYNTHESIS; DYSKERATOSIS CONGENITA; FIBROSING ALVEOLITIS; GENE LOCUS; GENE REPLICATION; HELA CELL; HEMATOPOIETIC STEM CELL; HUMAN; HYDROGEN BOND; IN VITRO STUDY; INHIBITION KINETICS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCHIZOSACCHAROMYCES POMBE; SOMATIC CELL; TELOMERE; TELOMERE SHORTENING; TRANSCRIPTION INITIATION SITE; XENOPUS;

ANIMALS; DNA REPLICATION; DNA, NEOPLASM; GENOMIC INSTABILITY; HUMANS; MUTATION; NEOPLASMS; TELOMERE;

EID: 84880717504     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12165     Document Type: Review

References (39)

1. Bignell GR, Greenman CD, Davies H et al. Signatures of mutation and selection in the cancer genome. Nature 2010; 463: 893-8.
2. Negrini S, Gorgoulis VG, Halazonetis TD. Genomic instability - an evolving hallmark of cancer. Nat Rev Mol Cell Biol 2010; 11: 220-8.
3. Kipling D, Cooke HJ. Hypervariable ultra-long telomeres in mice. Nature 1990; 347: 400-2.
4. Blasco MA, Lee HW, Hande MP et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91: 25-34.
5. Lejnine S, Makarov VL, Langmore JP. Conserved nucleoprotein structure at the ends of vertebrate and invertebrate chromosomes. Proc Natl Acad Sci U S A 1995; 92: 2393-7.
6. Smogorzewska A, van Steensel B, Bianchi A et al. Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 2000; 20: 1659-68.
7. Ohki R, Ishikawa F. Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res 2004; 32: 1627-37.
8. Dehe PM, Rog O, Ferreira MG, Greenwood J, Cooper JP. Taz1 enforces cell-cycle regulation of telomere synthesis. Mol Cell 2012; 46: 797-808.
9. Miller KM, Rog O, Cooper JP. Semi-conservative DNA replication through telomeres requires Taz1. Nature 2006; 440: 824-8.
10. Sfeir A, Kosiyatrakul ST, Hockemeyer D et al. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 2009; 138: 90-103.
11. Leman AR, Dheekollu J, Deng Z et al. Timeless preserves telomere length by promoting efficient DNA replication through human telomeres. Cell Cycle 2012; 11: 2337-47.
12. Ishikawa F. Timeless tunes: replicating happy endings. Cell Cycle 2012; 11: 2977-8.
13. Ozeri-Galai E, Bester AC, Kerem B. The complex basis underlying common fragile site instability in cancer. Trends Genet 2012; 28: 295-302.
14. Biffi G, Tannahill D, McCafferty J, Balasubramanian S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem 2013; 5: 182-6.
15. Eddy J, Maizels N. Gene function correlates with potential for G4 DNA formation in the human genome. Nucleic Acids Res 2006; 34: 3887-96.
16. Patel DJ, Phan AT, Kuryavyi V. Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res 2007; 35: 7429-55.
17. Kumari S, Bugaut A, Huppert JL, Balasubramanian S. An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation. Nat Chem Biol 2007; 3: 218-21.
18. Ding H, Schertzer M, Wu X et al. Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell 2004; 117: 873-86.
19. Cheung I, Schertzer M, Rose A, Lansdorp PM. Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet 2002; 31: 405-9.
20. Shay JW, Wright WE. Telomerase: a target for cancer therapeutics. Cancer Cell 2002; 2: 257-65.
21. Bartkova J, Rezaei N, Liontos M et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006; 444: 633-7.
22. Pereira B, Ferreira MG. Sowing the seeds of cancer: telomeres and age-associated tumorigenesis. Curr Opin Oncol, 2013; 25: 93-8.
23. Park JI, Venteicher AS, Hong JY et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 2009; 460: 66-72.
24. Maida Y, Yasukawa M, Furuuchi M et al. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 2009; 461: 230-5.
25. Buseman CM, Wright WE, Shay JW. Is telomerase a viable target in cancer? Mutat Res 2012; 730: 90-7.
26. Egan ED, Collins K. Biogenesis of telomerase ribonucleoproteins. RNA 2012; 18: 1747-59.
27. Kiss T, Fayet-Lebaron E, Jady BE. Box H/ACA small ribonucleoproteins. Mol Cell 2010; 37: 597-606.
28. Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet 2012; 13: 693-704.
29. Steele MP, Schwartz DA. Molecular mechanisms in progressive idiopathic pulmonary fibrosis. Annu Rev Med 2012; 64: 265-76.
30. Armanios MY, Chen JJ, Cogan JD et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. New Engl J Med 2007; 356: 1317-26.
31. Cronkhite JT, Xing C, Raghu G et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med 2008; 178: 729-37.
32. Heiss NS, Knight SW, Vulliamy TJ et al. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet 1998; 19: 32-8.
33. Vulliamy T, Marrone A, Goldman F et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 2001; 413: 432-5.
34. Yamaguchi H, Calado RT, Ly H et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. New Engl J Med 2005; 352: 1413-24.
35. Marrone A, Walne A, Dokal I. Dyskeratosis congenita: telomerase, telomeres and anticipation. Curr Opin Genet Dev 2005; 15: 249-57.
36. Miyake Y, Nakamura M, Nabetani A et al. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell 2009; 36: 193-206.
37. Casteel DE, Zhuang S, Zeng Y et al. A DNA polymerase-α· primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem 2009; 284: 5807-18.
38. Nakaoka H, Nishiyama A, Saito M, Ishikawa F. Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract. J Biol Chem 2012; 287: 619-27.
39. Bochman ML, Paeschke K, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet 2012; 13: 770-80.