Dietary fish oil regulates gene expression of cholesterol and bile acid transporters in mice

Hepatology Research

Volumn 42, Issue 3, 2012, Pages 321-326

  Kamisako, Toshinori ^a   Tanaka, Yuji ^a   Ikeda, Takanori ^b   Yamamoto, Kazuo ^a   Ogawa, Hiroshi ^b  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Tezukayama Gakuin University   (Japan)

Author keywords

Abcg5; Abcg8; Bile acid; Bile salt export pump; Cholesterol; Fish oil

Indexed keywords

ABC TRANSPORTER G5; ABC TRANSPORTER G8; BILE ACID; BILE ACID COENZYME A AMINO ACID N ACYLTRANSFERASE; BILE ACID TRANSPORTER; BILE SALT EXPORT PUMP; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL; CHOLESTEROL TRANSPORTER; CYTOCHROME P450 8B1; FISH OIL; MESSENGER RNA; MULTIDRUG RESISTANCE GENE PRODUCT 2; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; ORGANIC SOLUTE TRANSPORTER ALPHA; PROTEIN; SOYBEAN OIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILE ACID METABOLISM; CONTROLLED STUDY; DIETARY INTAKE; GENE EXPRESSION; LIPID METABOLISM; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE;

EID: 84863404227     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00924.x     Document Type: Article

References (38)

1. Phillipson BE, Rothrock DW, Connor WE, Harris WS, Illingworth DR. Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 1985; 312: 1210-16.
2. Eritsland J, Arnesen H, Seljeflot I, Hostmark AT. Long-term metabolic effects of n-3 polyunsaturated fatty acids in patients with coronary artery disease. Am J Clin Nutr 1995; 61: 831-6.
3. González-Périz A, Horrillo R, Ferré N etal. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J 2009; 23: 1946-57.
4. Sekiya M, Yahagi N, Matsuzaka T etal. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 2003; 38: 1529-39.
5. Arai T, Kim HJ, Chiba H, Matsumoto A. Anti-obesity effect of fish oil and fish oil-fenofibrate combination in female KK mice. J Atheroscler Thromb 2009; 16: 674-83.
6. Bravo E, Cantafora A, Argiolas L. Hepatic uptake and metabolism of free cholesterol from different lipoprotein classes. An in vivo study in the rat. Biochim Biophys Acta 1989; 1003: 315-20.
7. le Morvan V, Dumon MF, Palos-Pinto A, Bérard AM. n-3 FA increase liver uptake of HDL-cholesterol in mice. Lipids 2002; 37: 767-72.
8. Nishimoto T, Pellizzon MA, Aihara M etal. Fish oil promotes macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol 2009; 29: 1502-8.
9. Jonkers IJ, Smelt AH, Princen HM etal. Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia. J Nutr 2006; 136: 987-91.
10. Smit MJ, Temmerman AM, Wolters H, Kuipers F, Beynen AC, Vonk RJ. Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats. J Clin Invest 1991; 88: 943-51.
11. Zhao A, Yu J, Lew JL, Huang L, Wright SD, Cui J. Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. DNA Cell Biol 2004; 23: 519-26.
12. Reeves PG, Rossow KL, Lindlauf J. Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice. J Nutr 1993; 123: 1923-31.
13. Folch J, Lee M, Stanley GHS. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
14. Denson LA, Bohan A, Held MA, Boyer JL. Organ-specific alterations in RAR alpha: RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology 2002; 123: 599-607.
15. Son PA, Hubbert M, Haywood J etal. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem 2005; 280: 6960-8.
16. Kim I, Ahn SH, Inagaki T etal. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 2007; 48: 2664-72.
17. Lin X, Chen Z, Yue P etal. A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1170-1176.
18. Masson D, Staels B, Gautier T etal. Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse. J Lipid Res 2004; 45: 543-50.
19. Miyata M, Tozawa A, Otsuka H etal. Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. J Pharmacol Exp Ther 2005; 312: 759-66.
20. Nakajima T, Tanaka N, Sugiyama E etal. Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice. Biochem Pharmacol 2008; 76: 108-19.
21. Teng S, Piquette-Miller M. The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther 2005; 312: 841-8.
22. van den Bosch HM, Bünger M, de Groot PJ, van der Meijde J, Hooiveld GJ, Müller M. Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. BMC Genomics 2007; 8: 267.
23. Zhang YL, Hernandez-Ono A, Siri P etal. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem 2006; 281: 37603-15.
24. Smit MJ, Verkade HJ, Havinga R etal. Dietary fish oil potentiates bile acid-induced cholesterol secretion into bile in rats. J Lipid Res 1994; 35: 301-10.
25. Bravo E, Cantafora A, DeLuca V, Tripodi M, Avella M, Botham KM. The mechanism underlying the hypocholesterolemic effect of chronic fish oil feeding in rats is not due to increased excretion of dietary cholesterol. Atherosclerosis 1998; 139: 253-63.
26. Smit JJ, Schinkel AH, Oude Elferink RP etal. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993; 75: 451-62.
27. Oude Elferink RP, Ottenhoff R, van Wijland M, Frijters CM, van Nieuwkerk C, Groen AK. Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein. J Lipid Res 1996; 37: 1065-75.
28. Klett EL, Lee MH, Adams DB, Chavin KD, Patel SB. Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC Gastroenterol 2004; 4: 21.
29. Yu L, Hammer RE, Li-Hawkins J etal. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA 2002; 99: 16237-42.
30. Mast N, Shafaati M, Zaman W etal. Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters. Biochim Biophys Acta 2010; 1801: 674-81.
31. Li T, Chen W, Chiang JY. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res 2007; 48: 373-84.
32. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996; 383: 728-31.
33. Peet DJ, Turley SD, Ma W etal. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1998; 93: 693-704.
34. Bérard AM, Dumon MF, Darmon M. Dietary fish oil up-regulates cholesterol 7alpha-hydroxylase mRNA in mouse liver leading to an increase in bile acid and cholesterol excretion. FEBS Lett 2004; 559: 125-8.
35. Bremer J. The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects. Prog Lipid Res 2001; 40: 231-68.
36. Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG, Pascoe WS. Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 1987; 237: 885-8.
37. Jelenik T, Rossmeisl M, Kuda O etal. AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids. Diabetes 2010; 59: 2737-46.
38. Neschen S, Morino K, Dong J etal. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes 2007; 56: 1034-41.