Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice

Endocrinology

Volumn 154, Issue 8, 2013, Pages 2843-2856

  Ma, Ben ^a   Xiong, Xiaojv ^a   Chen, Chen ^a   Li, Huaping ^a   Xu, Xizhen ^a   Li, Xuguang ^a   Li, Rui ^a   Chen, Guangzhi ^a   Dackor, Ryan T ^b   Zeldin, Darryl C ^b   Wang, Dao Wen ^a,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2J2; GLUCOSE; INSULIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; ECHOCARDIOGRAPHY; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE WALL; INSULIN RESISTANCE; LIPID DIET; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; ECHOCARDIOGRAPHY; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INSULIN RESISTANCE; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; MYOSIN HEAVY CHAINS; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84880668786     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2166     Document Type: Article

References (54)

1. Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: An update. Hypertension. 2001;37:1053-1059.
2. Dhalla NS, Liu X, Panagia V, Takeda N. Subcellular remodeling and heart dysfunction in chronic diabetes. Cardiovasc Res. 1998;40: 239-247.
3. Brash AR. Arachidonic acid as a bioactive molecule. J Clin Invest 2001;107:1339-1345.
4. Barbosa-Sicard E, Markovic M, Honeck H, Christ B, Muller DN, Schunck WH. Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of theCYP2Csubfamily. Biochem Biophys Res Commun. 2005;329:1275-1281.
5. Node K, Huo Y, Ruan X, et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science. 1999; 285:1276-1279.
6. Xu X, Zhang XA, Wang DW. The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. Adv Drug Deliv Rev. 2011;63:597-609.
7. Fleming I, Michaelis UR, Bredenkötter D, et al. Endothelium-derived hyperpolarizing factor synthase (cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res. 2001;88:44-51.
8. Sun J, Sui X, Bradbury JA, ZeldinDC,ConteMS,Liao JK. Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circ Res. 2002;90:1020-1027.
9. Krötz F, Riexinger T, Buerkle MA, et al. Membrane-potential- dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. Arterioscler Thromb Vasc Biol. 2004;24: 595-600.
10. Yang S, Lin L, Chen J-X, et al. Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-β viaMAPKand PI3K/Akt signaling pathways.AmJ Physiol. 2007;293:H142-H151.
11. Wang Y, Wei X, Xiao X, et al. Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways. J Pharmacol Exp Ther. 2005;314:522-532.
12. Xu X, Zhao CX, Wang L, et al. Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice. Diabetes. 2010;59:997-1005.
13. BurkeMA,Mutharasan RK, Ardehali H. The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel. Circ Res. 2008;102:164-176.
14. Casis O, Echevarria E. Diabetic cardiomyopathy: Electromechanical cellular alterations. Curr Vasc Pharmacol. 2004;2:237-248.
15. Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H. LKB1 and AMPK family signaling: The intimate link between cell polarity and energy metabolism. Physiol Rev. 2009;89:777-798.
16. Miyamoto S, Murphy AN, Brown JH. Akt mediated mitochondrial protection in the heart: Metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009;41:169-180.
17. Lu T, Ye D, Wang X, et al. Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol. 2006;575:627-644.
18. Webler AC, Popp R, Korff T, et al. Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4. Arterioscler Thromb Vasc Biol. 2008;28:1123-1129.
19. Wang H, Lin L, Jiang J, et al. Up-regulation of endothelial nitricoxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways. J Pharmacol Exp Ther. 2003;307:753-764.
20. Zhao CX, Xu X, Cui Y, et al. Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. J Pharmacol Exp Ther. 2009;328:610-620.
21. Zhao G, Wang J, Xu X, et al. Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-β-induced injury. J Lipid Res. 2012;53:456-466.
22. Seubert J, Yang B, Bradbury JA, et al. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP- sensitiveK+channels and p42/p44MAPK pathway. Circ Res. 2004;95:506-514.
23. Luo J, Quan J, Tsai J, et al. Nongenetic mouse models of noninsulin-dependent diabetes mellitus. Metabolism. 1998;47:663-668.
24. Kim JK, Michael MD, Previs SF, et al. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest. 2000;105:1791-1797.
25. Wilkes JJ, NguyenMT,Bandyopadhyay GK, Nelson E, Olefsky JM. Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. Am J Physiol Endocrinol Metab. 2005;289:E1015-E1022.
26. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990; 347:645-650.
27. Rossetti L, Giaccari A. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. J Clin Invest. 1990;85:1785-1792.
28. Youn JH, Buchanan TA. Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. Diabetes. 1993;42:757-763.
29. Feng B, Chen S, Chiu J, George B, Chakrabarti S. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Am J Physiol Endocrinol Metab. 2008;294:E1119-E1126.
30. Dyntar D, Sergeev P, Klisic J, Ambuhl P, Schaub MC, Donath MY. High glucose alters cardiomyocyte contacts and inhibits myofibrillar formation. The J Clin Endocrinol Metab. 2006;91:1961-1967.
31. Ma H, Gong H, Chen Z, et al. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J Mol Cell Cardiol. 2012;52:1282-1290.
32. Shioura KM, Geenen DL, Goldspink PH. Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice. Am J Physiol. 2007;293:H2870-H2877.
33. Slieker LJ, Sundell KL, Heath WF, et al. Glucose transporter levels in tissues of spontaneously diabetic Zucker fa/fa rat (ZDF/drt) and viable yellow mouse (Avy/a). Diabetes. 1992;41:187-193.
34. Wu P, Sato J, Zhao Y, Jaskiewicz J, Popov KM, Harris RA. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J. 1998;329(pt 1):197-201.
35. Barger PM, Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med. 2000;10:238-245.
36. Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001;108:1167-1174.
37. Jiang JG, Chen RJ, Xiao B, et al. Regulation of endothelial nitricoxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. Prostaglandins Other Lipid Mediat. 2007; 82:162-174.
38. Suzuki YJ. Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis. Cell Signal. 2011;23:1094-1099.
39. 2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice. Diabetes. 2006;55:608-615.
40. Zhang L, Cannell MB, Phillips AR, Cooper GJ, Ward ML. Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy. Diabetes. 2008;57:2158-2166.
41. Struthers AD, Morris AD. Screening for and treating left-ventricular abnormalities in diabetes mellitus: A new way of reducing cardiac deaths. Lancet. 2002;359:1430-1432.
42. 2+, calcineurin, and NF-AT. Cell. 1999;96:611-614.
43. Fang ZY, Prins JB, Marwick TH. Diabetic cardiomyopathy: Evidence, mechanisms, and therapeutic implications. Endocr Rev. 2004;25:543-567.
44. Liu Y, Zhang Y, Schmelzer K, et al. The antiinflammatory effect of laminar flow: The role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci USA. 2005;102: 16747-16752.
45. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005;1:15-25.
46. Hue L, Rider MH. The AMP-activated protein kinase: More than an energy sensor. Essays Biochem. 2007;43:121-137.
47. Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A. Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism inhumanskeletal muscle. J BiolChem. 2007;282:19313-19320.
48. Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004;428:569-574.
49. Viollet B, Andreelli F, Jørgensen SB, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest. 2003;111:91-98.
50. Zong H, Ren JM, Young LH, et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA. 2002;99:15983-15987.
51. Kelly RA, Balligand JL, Smith TW. Nitric oxide and cardiac function. Circ Res. 1996;79:363-380.
52. Xie YW, Wolin MS. Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Involvement in response to hypoxia/reoxygenation. Circulation. 1996;94:2580-2586.
53. Borgs M, Bollen M, Keppens S, Yap SH, Stalmans W, Vanstapel F. Modulation of basal hepatic glycogenolysis by nitric oxide. Hepatology. 1996;23:1564-1571.
54. Fromel T, Kohlstedt K, Popp R, et al. Cytochrome P4502S1: A novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. Basic Res Cardiol. 2013;108:319.