-
1
-
-
78951491087
-
Signaling role of Cdc42 in regulating mammalian physiology
-
Melendez J, Grogg M, Zheng Y. 2011. Signaling role of Cdc42 in regulating mammalian physiology. J. Biol. Chem. 286:2375-2381.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 2375-2381
-
-
Melendez, J.1
Grogg, M.2
Zheng, Y.3
-
2
-
-
84857236589
-
Cdc42: an important regulator of neuronal morphology
-
Chen C, Wirth A, Ponimaskin E. 2012. Cdc42: an important regulator of neuronal morphology. Int. J. Biochem. Cell Biol. 44: 447-451.
-
(2012)
J. Biochem. Cell Biol.
, vol.44
, pp. 447-451
-
-
Chen, C.1
Wirth, A.2
Ponimaskin, E.3
-
3
-
-
33750493895
-
Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
-
Yang L, Wang L, Zheng Y. 2006. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol. Biol. Cell 17: 4675-4685.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 4675-4685
-
-
Yang, L.1
Wang, L.2
Zheng, Y.3
-
4
-
-
79953032204
-
Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
-
Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y. 2011. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PLoS One 6: e18002. doi: 10.1371/journal.pone.0018002.
-
(2011)
PLoS One
, vol.6
-
-
Guo, F.1
Zhang, S.2
Tripathi, P.3
Mattner, J.4
Phelan, J.5
Sproles, A.6
Mo, J.7
Wills-Karp, M.8
Grimes, H.L.9
Hildeman, D.10
Zheng, Y.11
-
5
-
-
30144446099
-
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and he-matopoietic stem/progenitor cell survival, adhesion, and engraftment
-
Wang L, Yang L, Filippi MD, Williams DA, Zheng Y. 2006. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and he-matopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood 107: 98-105.
-
(2006)
Blood
, vol.107
, pp. 98-105
-
-
Wang, L.1
Yang, L.2
Filippi, M.D.3
Williams, D.A.4
Zheng, Y.5
-
6
-
-
34247621290
-
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
-
Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y. 2007. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc. Natl. Acad. Sci. U. S. A. 104: 5091-5096.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 5091-5096
-
-
Yang, L.1
Wang, L.2
Geiger, H.3
Cancelas, J.A.4
Mo, J.5
Zheng, Y.6
-
7
-
-
37049019099
-
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
-
Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA, Zheng Y. 2007. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood 110: 3853-3861.
-
(2007)
Blood
, vol.110
, pp. 3853-3861
-
-
Yang, L.1
Wang, L.2
Kalfa, T.A.3
Cancelas, J.A.4
Shang, X.5
Pushkaran, S.6
Mo, J.7
Williams, D.A.8
Zheng, Y.9
-
8
-
-
0842288323
-
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL. 2004. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303: 848-851.
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
Gorska, A.E.4
Dumont, N.5
Shappell, S.6
Washington, M.K.7
Neilson, E.G.8
Moses, H.L.9
-
9
-
-
23744452875
-
Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks
-
Cheng N, Bhowmick NA, Chytil A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW, Moses HL. 2005. Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene 24: 5053-5068.
-
(2005)
Oncogene
, vol.24
, pp. 5053-5068
-
-
Cheng, N.1
Bhowmick, N.A.2
Chytil, A.3
Gorksa, A.E.4
Brown, K.A.5
Muraoka, R.6
Arteaga, C.L.7
Neilson, E.G.8
Hayward, S.W.9
Moses, H.L.10
-
10
-
-
0029091682
-
Identification and characterization of a fibroblast marker: FSP1
-
Strutz F, Okada H, Lo CW, DanoffT, Carone RL, Tomaszewski JE, Neilson EG. 1995. Identification and characterization of a fibroblast marker: FSP1. J. Cell Biol. 130: 393-405.
-
(1995)
J. Cell Biol.
, vol.130
, pp. 393-405
-
-
Strutz, F.1
Okada, H.2
Lo, C.W.3
Danoff, T.4
Carone, R.L.5
Tomaszewski, J.E.6
Neilson, E.G.7
-
11
-
-
17644396081
-
Characterization of fibro-blast-specific protein 1 in pulmonary fibrosis
-
Lawson WE, Polosukhin VV, Zoia O, Stathopoulos GT, Han W, Plieth D, Loyd JE, Neilson EG, Blackwell TS. 2005. Characterization of fibro-blast-specific protein 1 in pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 171: 899-907.
-
(2005)
Am. J. Respir. Crit. Care Med.
, vol.171
, pp. 899-907
-
-
Lawson, W.E.1
Polosukhin, V.V.2
Zoia, O.3
Stathopoulos, G.T.4
Han, W.5
Plieth, D.6
Loyd, J.E.7
Neilson, E.G.8
Blackwell, T.S.9
-
12
-
-
34249873891
-
S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes
-
Schneider M, Kostin S, Strom CC, Aplin M, Lyngbaek S, Theilade J, Grigorian M, Andersen CB, Lukanidin E, Lerche Hansen J, Sheikh SP. 2007. S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes. Cardiovasc. Res. 75: 40-50.
-
(2007)
Cardiovasc. Res.
, vol.75
, pp. 40-50
-
-
Schneider, M.1
Kostin, S.2
Strom, C.C.3
Aplin, M.4
Lyngbaek, S.5
Theilade, J.6
Grigorian, M.7
Andersen, C.B.8
Lukanidin, E.9
Lerche Hansen, J.10
Sheikh, S.P.11
-
13
-
-
78651083174
-
Fibroblast-specific protein 1 identifies an inflammatory subpopula-tion of macrophages in the liver
-
Osterreicher CH, Penz-Osterreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopula-tion of macrophages in the liver. Proc. Natl. Acad. Sci. U. S. A. 108: 308-313.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 308-313
-
-
Osterreicher, C.H.1
Penz-Osterreicher, M.2
Grivennikov, S.I.3
Guma, M.4
Koltsova, E.K.5
Datz, C.6
Sasik, R.7
Hardiman, G.8
Karin, M.9
Brenner, D.A.10
-
14
-
-
78149311215
-
Fibroblast expression of an IkappaB dominant-negative transgene attenuates renal fibrosis
-
Inoue T, Takenaka T, Hayashi M, Monkawa T, Yoshino J, Shimoda K, Neilson EG, Suzuki H, Okada H. 2010. Fibroblast expression of an IkappaB dominant-negative transgene attenuates renal fibrosis. J. Am. Soc. Nephrol. 21: 2047-2052.
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 2047-2052
-
-
Inoue, T.1
Takenaka, T.2
Hayashi, M.3
Monkawa, T.4
Yoshino, J.5
Shimoda, K.6
Neilson, E.G.7
Suzuki, H.8
Okada, H.9
-
15
-
-
84863626782
-
Heart repair by reprogramming non-myocytes with cardiac transcription factors
-
Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. 2012. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485: 599-604.
-
(2012)
Nature
, vol.485
, pp. 599-604
-
-
Song, K.1
Nam, Y.J.2
Luo, X.3
Qi, X.4
Tan, W.5
Huang, G.N.6
Acharya, A.7
Smith, C.L.8
Tallquist, M.D.9
Neilson, E.G.10
Hill, J.A.11
Bassel-Duby, R.12
Olson, E.N.13
-
16
-
-
34547676391
-
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
-
Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. 2007. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13: 952-961.
-
(2007)
Nat. Med.
, vol.13
, pp. 952-961
-
-
Zeisberg, E.M.1
Tarnavski, O.2
Zeisberg, M.3
Dorfman, A.L.4
McMullen, J.R.5
Gustafsson, E.6
Chandraker, A.7
Yuan, X.8
Pu, W.T.9
Roberts, A.B.10
Neilson, E.G.11
Sayegh, M.H.12
Izumo, S.13
Kalluri, R.14
-
17
-
-
79954990658
-
Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFbeta type II receptor independent manner
-
Teng Y, Kanasaki K, Bardeesy N, Sugimoto H, Kalluri R. 2011. Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFbeta type II receptor independent manner. Biochem. Biophys. Res. Commun. 407: 633-639.
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.407
, pp. 633-639
-
-
Teng, Y.1
Kanasaki, K.2
Bardeesy, N.3
Sugimoto, H.4
Kalluri, R.5
-
18
-
-
68849093924
-
Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells
-
Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA. 2009. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut 58: 1267-1274.
-
(2009)
Gut
, vol.58
, pp. 1267-1274
-
-
Boomershine, C.S.1
Chamberlain, A.2
Kendall, P.3
Afshar-Sharif, A.R.4
Huang, H.5
Washington, M.K.6
Lawson, W.E.7
Thomas, J.W.8
Blackwell, T.S.9
Bhowmick, N.A.10
-
19
-
-
0032923739
-
Generalized lacZ expression with the ROSA26 Cre reporter strain
-
Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21: 70-71.
-
(1999)
Nat. Genet.
, vol.21
, pp. 70-71
-
-
Soriano, P.1
-
20
-
-
77953897189
-
Mammalian target of rapamycin protein complex2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Mag-nuson MA, Boothby M. 2010. Mammalian target of rapamycin protein complex2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32: 743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Mag-nuson, M.A.7
Boothby, M.8
-
21
-
-
80051898476
-
Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
-
Kehl-Fie TE, Chitayat S, Hood MI, Damo S, Restrepo N, Garcia C, Munro KA, Chazin WJ, Skaar EP. 2011. Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe 10: 158-164.
-
(2011)
Cell Host Microbe
, vol.10
, pp. 158-164
-
-
Kehl-Fie, T.E.1
Chitayat, S.2
Hood, M.I.3
Damo, S.4
Restrepo, N.5
Garcia, C.6
Munro, K.A.7
Chazin, W.J.8
Skaar, E.P.9
-
22
-
-
4644265280
-
Differential expres-sionof collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis
-
Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R. 2004. Differential expres-sionof collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am. J. Physiol. Renal Physiol. 287: F602-F611.
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.287
-
-
Chen, D.1
Roberts, R.2
Pohl, M.3
Nigam, S.4
Kreidberg, J.5
Wang, Z.6
Heino, J.7
Ivaska, J.8
Coffa, S.9
Harris, R.C.10
Pozzi, A.11
Zent, R.12
-
23
-
-
77950366686
-
Identification of ROS using oxidized DCFDA and flow-cytometry
-
Eruslanov E, Kusmartsev S. 2010. Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol. Biol. 594: 57-72.
-
(2010)
Methods Mol. Biol.
, vol.594
, pp. 57-72
-
-
Eruslanov, E.1
Kusmartsev, S.2
-
24
-
-
26244449496
-
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblas-toid cells
-
Czuchra A, Wu X, Meyer H, van Hengel J, Schroeder T, Geffers R, Rottner K, Brakebusch C. 2005. Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblas-toid cells. Mol. Biol. Cell 16: 4473-4484.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4473-4484
-
-
Czuchra, A.1
Wu, X.2
Meyer, H.3
van Hengel, J.4
Schroeder, T.5
Geffers, R.6
Rottner, K.7
Brakebusch, C.8
-
25
-
-
34249813708
-
Inactivation of Cdc42 is necessary for depolymerization of phagosomal F-actin and subsequent phagosomal maturation
-
Lerm M, Brodin VP, Ruishalme I, Stendahl O, Sarndahl E. 2007. Inactivation of Cdc42 is necessary for depolymerization of phagosomal F-actin and subsequent phagosomal maturation. J. Immunol. 178: 7357-7365.
-
(2007)
J. Immunol.
, vol.178
, pp. 7357-7365
-
-
Lerm, M.1
Brodin, V.P.2
Ruishalme, I.3
Stendahl, O.4
Sarndahl, E.5
-
26
-
-
0038281350
-
Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens
-
Zhong B, Jiang K, Gilvary DL, Epling-Burnette PK, Ritchey C, Liu J, Jackson RJ, Hong-Geller E, Wei S. 2003. Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens. Blood 101: 3240-3248.
-
(2003)
Blood
, vol.101
, pp. 3240-3248
-
-
Zhong, B.1
Jiang, K.2
Gilvary, D.L.3
Epling-Burnette, P.K.4
Ritchey, C.5
Liu, J.6
Jackson, R.J.7
Hong-Geller, E.8
Wei, S.9
-
27
-
-
33845511326
-
Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils
-
Szczur K, Xu H, Atkinson S, Zheng Y, Filippi MD. 2006. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood 108: 4205-4213.
-
(2006)
Blood
, vol.108
, pp. 4205-4213
-
-
Szczur, K.1
Xu, H.2
Atkinson, S.3
Zheng, Y.4
Filippi, M.D.5
-
28
-
-
33746648129
-
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity atthe backaswellassignalsatthe front
-
Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR. 2006. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity atthe backaswellassignalsatthe front. J. Cell Biol. 174: 437-445.
-
(2006)
J. Cell Biol.
, vol.174
, pp. 437-445
-
-
Van Keymeulen, A.1
Wong, K.2
Knight, Z.A.3
Govaerts, C.4
Hahn, K.M.5
Shokat, K.M.6
Bourne, H.R.7
-
29
-
-
73349093424
-
The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
-
Szczur K, Zheng Y, Filippi MD. 2009. The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood 114: 4527-4537.
-
(2009)
Blood
, vol.114
, pp. 4527-4537
-
-
Szczur, K.1
Zheng, Y.2
Filippi, M.D.3
-
31
-
-
18244415152
-
Spontaneous skin ulcer-ation and defective T cell function in CD18 null mice
-
Scharffetter-Kochanek K, Lu H, Norman K, van Nood N, Munoz F, Grabbe S, McArthur M, Lorenzo I, Kaplan S, Ley K, Smith CW, Montgomery CA, Rich S, Beaudet AL. 1998. Spontaneous skin ulcer-ation and defective T cell function in CD18 null mice. J. Exp. Med. 188: 119-131.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 119-131
-
-
Scharffetter-Kochanek, K.1
Lu, H.2
Norman, K.3
van Nood, N.4
Munoz, F.5
Grabbe, S.6
McArthur, M.7
Lorenzo, I.8
Kaplan, S.9
Ley, K.10
Smith, C.W.11
Montgomery, C.A.12
Rich, S.13
Beaudet, A.L.14
-
32
-
-
0027257221
-
Gene targeting yields a CD18-mutant mouse for study of inflammation
-
Wilson RW, Ballantyne CM, Smith CW, Montgomery C, Bradley A, O'Brien WE, Beaudet AL. 1993. Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151: 1571-1578.
-
(1993)
J. Immunol.
, vol.151
, pp. 1571-1578
-
-
Wilson, R.W.1
Ballantyne, C.M.2
Smith, C.W.3
Montgomery, C.4
Bradley, A.5
O'Brien, W.E.6
Beaudet, A.L.7
-
33
-
-
34249855929
-
Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II
-
Hellbusch CC, Sperandio M, Frommhold D, Yakubenia S, Wild MK, Popovici D, Vestweber D, Grone HJ, von Figura K, Lubke T, Korner C. 2007. Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. J. Biol. Chem. 282: 10762-10772.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10762-10772
-
-
Hellbusch, C.C.1
Sperandio, M.2
Frommhold, D.3
Yakubenia, S.4
Wild, M.K.5
Popovici, D.6
Vestweber, D.7
Grone, H.J.8
von Figura, K.9
Lubke, T.10
Korner, C.11
-
34
-
-
61949352480
-
Kindlin-3 is required for beta2 integ-rin-mediated leukocyte adhesion to endothelial cells
-
Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, Wang HV, Sperandio M, Fassler R. 2009. Kindlin-3 is required for beta2 integ-rin-mediated leukocyte adhesion to endothelial cells. Nat. Med. 15: 300-305.
-
(2009)
Nat. Med.
, vol.15
, pp. 300-305
-
-
Moser, M.1
Bauer, M.2
Schmid, S.3
Ruppert, R.4
Schmidt, S.5
Sixt, M.6
Wang, H.V.7
Sperandio, M.8
Fassler, R.9
-
35
-
-
40449133970
-
Kind-lin-3 is essential for integrin activation and platelet aggregation
-
Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R. 2008. Kind-lin-3 is essential for integrin activation and platelet aggregation. Nat. Med. 14: 325-330.
-
(2008)
Nat. Med.
, vol.14
, pp. 325-330
-
-
Moser, M.1
Nieswandt, B.2
Ussar, S.3
Pozgajova, M.4
Fassler, R.5
|