S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes

Cardiovascular Research

Volumn 75, Issue 1, 2007, Pages 40-50

  Schneider, Mikael ^a   Kostin, Sawa ^b   Strøm, Claes C ^a   Aplin, Mark ^a   Lyngbæk, Stig ^a   Theilade, Juliane ^a   Grigorian, Mariam ^c   Andersen, Claus B ^d   Lukanidin, Eugene ^c   Lerche Hansen, Jakob ^a   Sheikh, Søren P ^a  

^a DANISH NATIONAL RESEARCH FOUNDATION   (Denmark)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d Rigshospitalet   (Denmark)

Author keywords

Apoptosis; Cardiac hypertrophy; Cardiac myocytes; Cardioprotection; Myocardial infarction; S100A4 Mts1

Indexed keywords

CALVASCULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA STENOSIS; APOPTOSIS; ARTICLE; CASE REPORT; CELL COUNT; CELL CULTURE; CELL GROWTH; CELL INVASION; CELL SURVIVAL; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; HEART HYPERTROPHY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE INJURY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IN VITRO STUDY; LEUKOCYTE; MACROPHAGE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CARDIOMEGALY; CELL SURVIVAL; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S100 PROTEINS; UP-REGULATION; VIMENTIN;

EID: 34249873891     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.03.027     Document Type: Article

References (40)

1. Chien K.R., and Braunwald E. Molecular basis of cardiovascular disease: a companion to Braunwald's Heart disease (1999), Saunders, Philadelphia
2. Frey N., and Olson E.N. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65 (2003) 45-79
3. Strøm C.C., Kruhøffer M., Knudsen S., Stensgaard-Hansen F., Jonassen T.E.N., Ørntoft T.F., et al. Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy. Compar Funct Genom 5 (2004) 459-470
4. Stary M., Schneider M., Sheikh S.P., and Weitzer G. Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies. Biochem Biophys Res Commun 343 (2006) 555-563
5. Helfman D.M., Kim E.J., Lukanidin E., and Grigorian M. The metastasis associated protein S100A4: role in tumour progression and metastasis. Br J Cancer 92 (2005) 1955-1958
6. Garrett S.C., Varney K.M., Weber D.J., and Bresnick A.R. S100A4, a mediator of metastasis. J Biol Chem 281 (2006) 677-680
7. Grigorian M., Andresen S., Tulchinsky E., Kriajevska M., Carlberg C., Kruse C., et al. Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction. J Biol Chem 276 (2001) 22699-22708
8. Ambartsumian N., Klingelhofer J., Grigorian M., Christensen C., Kriajevska M., Tulchinsky E., et al. The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor. Oncogene 20 (2001) 4685-4695
9. Schmidt-Hansen B., Klingelhofer J., Grum-Schwensen B., Christensen A., Andresen S., Kruse C., et al. Functional significance of metastasis-inducing S100A4(Mts1) in tumor-stroma interplay. J Biol Chem 279 (2004) 24498-24504
10. Schmidt-Hansen B., Ornas D., Grigorian M., Klingelhofer J., Tulchinsky E., Lukanidin E., et al. Extracellular S100A4 (mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity. Oncogene 23 (2004) 5487-5495
11. Semov A., Moreno M.J., Onichtchenko A., Abulrob A., Ball M., Ekiel I., et al. Metastasis-associated Protein S100A4 Induces Angiogenesis through Interaction with Annexin II and Accelerated Plasmin Formation. J Biol Chem 280 (2005) 20833-20841
12. Lawrie A., Spiekerkoetter E., Martinez E.C., Ambartsumian N., Sheward W.J., Maclean M.R., et al. Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Circ Res 97 (2005) 227-235
13. Kiryushko D., Novitskaya V., Soroka V., Klingelhofer J., Lukanidin E., Berezin V., et al. Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol 26 (2006) 3625-3638
14. Novitskaya V., Grigorian M., Kriajevska M., Tarabykina S., Bronstein I., Berezin V., et al. Oligomeric forms of the metastasis-related Mts1 (S100A4) protein stimulate neuronal differentiation in cultures of rat hippocampal neurons. J Biol Chem 275 (2000) 41278-41286
15. Christoffersen T.E., Aplin M., Strom C.C., Sheikh S.P., Skott O., Busk P.K., et al. Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy. Am J Physiol Heart Circ Physiol 290 (2006) H1635-H1641
16. Strom C.C., Aplin M., Ploug T., Christoffersen T.E., Langfort J., Viese M., et al. Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy. FEBS J 272 (2005) 2684-2695
17. Theilade J., Lerche Hansen J., Haunso S., and Sheikh S.P. Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 (GRK2). FEBS Lett 518 (2002) 195-199
18. Kostin S., Hein S., Bauer E.P., and Schaper J. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Circ Res 85 (1999) 154-167
19. Kostin S., and Schaper J. Tissue-specific patterns of Gap junctions in adult rat atrial and ventricular cardiomyocytes in vivo and in vitro. Circ Res 88 (2001) 933-939
20. Aplin M., Christensen G.L., Schneider M., Heydorn A., Gammeltoft S., Kjølbye A.L., et al. The angiotensin AT1 receptor activates ERK1/2 by G protein-dependent and independent pathways in cardiac myocytes and langendorff perfused hearts. Basic Clin Pharmacol Toxicol 100 (2007) 289-295
21. Aplin M., Christensen G.L., Schneider M., Heydorn A., Gammeltoft S., Kjølbye A.L., et al. Differential ERK1/2 activation by the angiotensin AT1 receptor supports distinct phenotypes of cardiac myocytes. Basic Clin Pharmacol Toxicol 100 (2007) 296-301
22. Busk P.K., Hinrichsen R., Bartkova J., Hansen A.H., Christoffersen T.E., Bartek J., et al. Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy. Exp Cell Res 304 (2005) 149-161
23. Strutz F., Okada H., Lo C.W., Danoff T., Carone R.L., Tomaszewski J.E., et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130 (1995) 393-405
24. Flatmark K., Maelandsmo G.M., Mikalsen S.O., Nustad K., Varaas T., Rasmussen H., et al. Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum. Tumour Biol 25 (2004) 31-40
25. Gibbs F.E., Barraclough R., Platt-Higgins A., Rudland P.S., Wilkinson M.C., and Parry E.W. Immunocytochemical distribution of the calcium-binding protein p9Ka in normal rat tissues: variation in the cellular location in different tissues. J Histochem Cytochem 43 (1995) 169-180
26. Grigorian M., Tulchinsky E., Burrone O., Tarabykina S., Georgiev G., and Lukanidin E. Modulation of mts1 expression in mouse and human normal and tumor cells. Electrophoresis 15 (1994) 463-468
27. Inamoto S., Murao S., Yokoyama M., Kitazawa S., and Maeda S. Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat. Pathol Int 50 (2000) 480-485
28. Klingelhofer J., Ambartsumian N.S., and Lukanidin E.M. Expression of the metastasis-associated mts1 gene during mouse development. Dev Dyn 210 (1997) 87-95
29. Kwapiszewska G., Wilhelm J., Wolff S., Laumanns I., Koenig I.R., Ziegler A., et al. Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension. Respir Res 6 (2005) 109
30. Le Hir M., Hegyi I., Cueni-Loffing D., Loffing J., and Kaissling B. Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem Cell Biol 123 (2005) 335-346
31. Watanabe Y., Usuda N., Tsugane S., Kobayashi R., and Hidaka H. Calvasculin, an encoded protein from mRNA termed pEL-98, 18A2, 42A, or p9Ka, is secreted by smooth muscle cells in culture and exhibits Ca(2+)-dependent binding to 36-kDa microfibril-associated glycoprotein. J Biol Chem 267 (1992) 17136-17140
32. Matturri L., Biondo B., Colombo B., Lavezzi A.M., and Rossi L. Significance of the DNA synthesis in hypertrophic cardiomyopathies. Basic Res Cardiol 92 (1997) 85-89
33. Belot N., Pochet R., Heizmann C.W., Kiss R., and Decaestecker C. Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. Biochim Biophys Acta 1600 (2002) 74-83
34. Pedersen M.V., Kohler L.B., Grigorian M., Novitskaya V., Bock E., Lukanidin E., et al. The Mts1/S100A4 protein is a neuroprotectant. J Neurosci Res 77 (2004) 777-786
35. Merklinger S.L., Wagner R.A., Spiekerkoetter E., Hinek A., Knutsen R.H., Kabir M.G., et al. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res 97 (2005) 596-604
36. Kozlova E.N., and Lukanidin E. Metastasis-associated mts1 (S100A4) protein is selectively expressed in white matter astrocytes and is up-regulated after peripheral nerve or dorsal root injury. Glia 27 (1999) 249-258
37. Kozlova E.N., and Lukanidin E. Mts1 protein expression in the central nervous system after injury. Glia 37 (2002) 337-348
38. Iwano M., Plieth D., Danoff T.M., Xue C., Okada H., and Neilson E.G. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110 (2002) 341-350
39. Lawson W.E., Polosukhin V.V., Zoia O., Stathopoulos G.T., Han W., Plieth D., et al. Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am J Respir Crit Care Med 171 (2005) 899-907
40. Ryan D.G., Taliana L., Sun L., Wei Z.G., Masur S.K., and Lavker R.M. Involvement of S100A4 in stromal fibroblasts of the regenerating cornea. Invest Ophthalmol Vis Sci 44 (2003) 4255-4262