Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis

Blood

Volumn 110, Issue 12, 2007, Pages 3853-3861

  Yang, Linda ^a   Wang, Lei ^a,b   Kalfa, Theodosia A ^a   Cancelas, Jose A ^a   Shang, Xun ^a   Pushkaran, Suvarnamala ^a   Mo, Jun ^a   Williams, David A ^a   Zheng, Yi ^a,b,c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; INTERFERON; INTERLEUKIN 3; PROTEIN CDC42; PROTEIN EBP1ALPHA; PROTEIN GFI 1; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL ACTIVITY; CELL DIFFERENTIATION; CELL INFILTRATION; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; GENE DELETION; GENETIC TRANSCRIPTION; GRANULOCYTE; LEUKOCYTOSIS; MACROPHAGE; MOUSE; MYELOPOIESIS; MYELOPROLIFERATIVE DISORDER; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL; UPREGULATION;

EID: 37049019099     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-03-079582     Document Type: Article

References (39)

1. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91:661-672.
2. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404:193-197.
3. Metcalf D. Stem cells, pre-progenitor cells and lineage-committed cells: are our dogmas correct? Ann N Y Acad Sci. 1999;872:289-303; discussion 303-304.
4. Morrison SJ, Shah NM, Anderson DJ. Regulatory mechanisms in stem cell biology. Cell. 1997;88:287-298.
5. Fuchs E, Segre JA. Stem cells: a new lease on life. Cell. 2000;100:143-155.
6. Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 2000;1:57-64.
7. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002;21:3368-3376.
8. Munugalavadla V, Dore LC, Tan BL, et al. Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation. Mol Cell Biol. 2005;25:6747-6759.
9. Shapiro LH, Look AT. Transcriptional regulation in myeloid cell differentiation. Curr Opin Hematol. 1995;2:3-11.
10. Iwasaki H, Mizuno S, Arinobu Y, et al. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev. 2006;20:3010-3021.
11. Van Aelst L, D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 1997;11:2295-2322.
12. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature. 2002;420:629-635.
13. Allen WE, Zicha D, Ridley AJ, Jones GE. A role for Cdc42 in macrophage chemotaxis. J Cell Biol. 1998;141:1147-1157.
14. Weber KS, Klickstein LB, Weber PC, Weber C. Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes. Eur J Immunol. 1998;28:2245-2251.
15. del Pozo MA, Vicente-Manzanares M, Tejedor R, Serrador JM, Sanchez-Madrid F. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur J Immunol. 1999;29:3609-3620.
16. Westerberg L, Greicius G, Snapper SB, Aspenstrom P, Severinson E. Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes. Blood. 2001;98:1086-1094.
17. Szczur K, Xu H, Atkinson S, Zheng Y, Filippi MD. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood. 2006;108:4205-4213.
18. Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci U S A. 2007;104:5091-5096.
19. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836-841.
20. Wang L, Yang L, Filippi MD, Williams DA, Zheng Y. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/ progenitor cell survival, adhesion, and engraftment. Blood. 2006;107:98-105.
21. Harigae H, Okitsu Y, Yokoyama H, et al. Induction of erythroid-specific genes by overexpression of GATA-2 in K562 cells. Int J Hematol. 2006;84:38-42.
22. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269:1427-1429.
23. Kogan SC, Ward JM, Anver MR, et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002;100:238-245.
24. Van Etten RA, Shannon KM. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell. 2004;6:547-552.
25. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001;98:3261-3273.
26. Fisher RC, Scott EW. Role of PU. 1 in hematopoiesis. Stem Cells. 1998;16:25-37.
27. Reddy VA, Iwama A, Iotzova G, et al. Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU. 1: possible role in lineage commitment decisions. Blood. 2002;100:483-490.
28. Nagamura-Inoue T, Tamura T, Ozato K. Transcription factors that regulate growth and differentiation of myeloid cells. Int Rev Immunol. 2001;20:83-105.
29. Rosmarin AG, Yang Z, Resendes KK. Transcriptional regulation in myelopoiesis: hematopoietic fate choice, myeloid differentiation, and leukemogenesis. Exp Hematol. 2005;33:131-143.
30. Tenen DG, Hromas R, Licht JD, Zhang DE. Transcription factors, normal myeloid development, and leukemia. Blood. 1997;90:489-519.
31. Yamada T, Kondoh N, Matsumoto M, Yoshida M, Maekawa A, Oikawa T. Overexpression of PU. 1 induces growth and differentiation inhibition and apoptotic cell death in murine erythroleukemia cells. Blood. 1997;89:1383-1393.
32. McIvor Z, Hein S, Fiegler H, et al. Transient expression of PU. 1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation. Exp Hematol. 2003;31:39-47.
33. DeKoter RP, Walsh JC, Singh H. PU. 1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 1998;17:4456-4468.
34. Zhuang D, Qiu Y, Kogan SC, Dong F. Increased CCAAT enhancer-binding protein epsilon (C/EB-Pepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. J Biol Chem. 2006;281:10745-10751.
35. Tsai FY, Keller G, Kuo FC, et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994;371:221-226.
36. Walsh JC, DeKoter RP, Lee HJ, et al. Cooperative and antagonistic interplay between PU. 1 and GATA-2 in the specification of myeloid cell fates. Immunity. 2002;17:665-676.
37. Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood. 2004;103:583-585.
38. Takahashi S, Shimizu R, Suwabe N, et al. GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies. Blood. 2000;96:910-916.
39. Yang L, Wang L, Zheng Y. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia formation, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol Biol Cell. 2006;17:4675-4685.