IL-10 deficiency increases superoxide and endothelial dysfunction during inflammation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Gunnett, Carol A ^a   Heistad, Donald D ^a   Berg, Daniel J ^a   Faraci, Frank M ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Endothelium dependent relaxation; Gene targeted mice; Interleukin 10; Nitric oxide; Reactive oxygen species

Indexed keywords

ALLOPURINOL; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MACROGOL; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PAPAVERINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CAROTID ARTERY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; GENE TARGETING; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0033713365     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.4.h1555     Document Type: Article

References (49)

1. Interleukin-10 inhibits IgE-mediated nitric oxide synthase induction and cytokine synthesis in normal human keratinocytes
2. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
3. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
4. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Schwartzman reaction but not endotoxin tolerance
5. Effects of cytokines on nitric oxide pathways in human vasculature
6. Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
7. Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia
8. Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients
9. Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery
10. Immunosuppressive and anti-inflammatory properties of interleukin 10
11. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
12. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase
13. IL-10 inhibits cytokine production by activated macrophages
14. IL-10 acts on the antigenpresenting cell to inhibit cytokine production by Th1 cells
15. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
16. 2+ signaling pathways
17. Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice
18. Vascular effects of LPS in mice deficient in expression of the gene for inducible nitric oxide synthase
19. Up-regulation of xanthine oxidase by lipopolysaccharide, interleukin- 1, and hypoxia. Role in acute lung injury
20. Endogenous interleukin-10 regulates hemodynamic parameters, leukocyte-endothelial cell interactions, and microvascular permeability during endotoxemia
21. Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling
22. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
23. Inhibition of inducible nitric oxide synthase restores endothelium-dependent relaxations in proinflammatory mediator-induced blood vessels
24. Proinflammatory mediators chronically downregulate the formation of the endothelium-derived hyperpolarizing factor in arteries via a nitric oxide/cyclic GMP-dependent mechanism
25. Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase
26. Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: Regulation by bacterial lipopolysaccharide
27. Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity
28. Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits
29. Protective role of interleukin-10 in atherosclerosis
30. Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia
31. Superoxide dismutase partially restores impaired dilatation of the basilar artery during diabetes mellitus
32. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
33. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
34. Interleukin-10
35. Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10
36. Induction of plasminogen activator inhibitor type 1 and type 1 collagen expression in rat cardiac microvascular endothelial cells by interleukin-1 and its dependence on oxygen-centered free radicals
37. Xanthine oxidoreductase in human mammary epithelial cells: Activation in response to inflammatory cytokines
38. Inhibition of endothelium-dependent vasodilation by Escherichia coli endotoxemia
39. Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation
40. Defective smooth muscle regulation in cGMP kinase I-deficient mice
41. E-selectin expression in human endothelial cells by TNF-α-induced oxidant generation and NF-κB activation
42. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin
43. Inducible nitric oxide synthase and vascular reactivity in rat thoracic aorta: Effect of aminoguanidine
44. Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats
45. Inducible L-arginine/nitric oxide pathway in human internal mammary artery and saphenous vein
46. The role of induction of nitric oxide synthesis in the altered responses of jugular veins from endotoxaemic rabbits
47. Inhibition of copper/zinc superoxide dismutase impairs NO-mediated endothelium-dependent relaxations
48. Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension
49. Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits