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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4493-4500

Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators

(11) Kubas, Holger a Meyer, Udo a Krueger, Bjoern a Hechenberger, Mirko a Vanejevs, Maksims b Zemribo, Ronalds b Kauss, Valerjans b Ambartsumova, Raisa c Pyatkin, Ilya c Polosukhin, Alexey I c Abel, Ulrich a

a MERZ PHARMACEUTICALS GMBH (Germany)

b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (Latvia)

c Asinex Ltd (Russian Federation)

Author keywords

Allosteric modulator; l DOPA induced dyskinesia; Metabotropic glutamate receptor; mGluR5; Virtual screening

Indexed keywords

2 (3 TOLYLAMINO) 7,8 DIHYDROQUINAZOLIN 5 (6H) ONE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; DRUG SOLUBILITY; DRUG SYNTHESIS; DYSKINESIA; IC 50; LIPOPHILICITY; MELTING POINT; NONHUMAN; PROCESS OPTIMIZATION; RAT; RECEPTOR BINDING; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC MODULATOR; L-DOPA INDUCED DYSKINESIA; METABOTROPIC GLUTAMATE RECEPTOR; MGLUR5; VIRTUAL SCREENING;

ALLOSTERIC REGULATION; ANIMALS; CELLS, CULTURED; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; QUINAZOLINES; QUINAZOLINONES; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; TOLUIDINES; USER-COMPUTER INTERFACE;

EID: 84880629913 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.06.049 Document Type: Article

Times cited : (11)

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