메뉴 건너뛰기




Volumn 30, Issue 1, 2013, Pages

Elevated DLL4 expression is correlated with VEGF and predicts poor prognosis of nasopharyngeal carcinoma

Author keywords

DLL4; Immunohistochemistry; Nasopharyngeal carcinoma; Prognosis

Indexed keywords

DELTA LIKE LIGAND 4; NOTCH RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; DLL4 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR MARKER; VASCULOTROPIN A;

EID: 84880592124     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-012-0390-x     Document Type: Article
Times cited : (41)

References (43)
  • 1
    • 33750532057 scopus 로고    scopus 로고
    • The enigmatic epidemiology of nasopharyngeal carcinoma
    • 17035381 10.1158/1055-9965.EPI-06-0353 1:CAS:528:DC%2BD28XhtVGktbvL
    • Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:1765-77.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1765-1777
    • Chang, E.T.1    Adami, H.O.2
  • 2
    • 20444472028 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma
    • 15950718 10.1016/S0140-6736(05)66698-6
    • Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005;365:2041-54.
    • (2005) Lancet , vol.365 , pp. 2041-2054
    • Wei, W.I.1    Sham, J.S.2
  • 3
    • 0036435155 scopus 로고    scopus 로고
    • Epidemiology of nasopharyngeal carcinoma
    • 12450728 10.1016/S1044579X02000858
    • Yu MC, Yuan JM. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol. 2002;12:421-9.
    • (2002) Semin Cancer Biol , vol.12 , pp. 421-429
    • Yu, M.C.1    Yuan, J.M.2
  • 4
    • 0038164867 scopus 로고    scopus 로고
    • Prognostic factors and outcome for nasopharyngeal carcinoma
    • 12874084 10.1001/archotol.129.7.794
    • Farias TP, Dias FL, Lima RA, et al. Prognostic factors and outcome for nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129:794-9.
    • (2003) Arch Otolaryngol Head Neck Surg , vol.129 , pp. 794-799
    • Farias, T.P.1    Dias, F.L.2    Lima, R.A.3
  • 5
    • 0023037120 scopus 로고
    • Distant metastases of nasopharyngeal carcinoma: A study of 256 male patients
    • 3773537 10.1002/jso.2930330310 1:STN:280:DyaL2s%2FjvVSktg%3D%3D
    • Ahmad A, Stefani S. Distant metastases of nasopharyngeal carcinoma: a study of 256 male patients. J Surg Oncol. 1986;33:194-7.
    • (1986) J Surg Oncol , vol.33 , pp. 194-197
    • Ahmad, A.1    Stefani, S.2
  • 6
    • 0019946244 scopus 로고
    • Advanced carcinoma of the nasopharynx. A clinical study of 274 patients
    • 6810406 1:STN:280:DyaL383ns1Sksw%3D%3D
    • Petrovich Z, Cox JD, Roswit B, et al. Advanced carcinoma of the nasopharynx. A clinical study of 274 patients. Radiology. 1982;144:905-8.
    • (1982) Radiology , vol.144 , pp. 905-908
    • Petrovich, Z.1    Cox, J.D.2    Roswit, B.3
  • 7
    • 0030891823 scopus 로고    scopus 로고
    • Carcinoma of the nasopharynx treated by radiotherapy alone: Determinants of distant metastasis and survival
    • 9165137 10.1016/S0167-8140(97)01914-2 1:STN:280:DyaK2szgslOqtw%3D%3D
    • Geara FB, Sanguineti G, Tucker SL, et al. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of distant metastasis and survival. Radiother Oncol. 1997;43:53-61.
    • (1997) Radiother Oncol , vol.43 , pp. 53-61
    • Geara, F.B.1    Sanguineti, G.2    Tucker, S.L.3
  • 8
    • 0036699967 scopus 로고    scopus 로고
    • Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
    • 12118254 1:CAS:528:DC%2BD38Xls1Ors70%3D
    • Feng BJ, Huang W, Shugart YY, et al. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet. 2002;31:395-9.
    • (2002) Nat Genet , vol.31 , pp. 395-399
    • Feng, B.J.1    Huang, W.2    Shugart, Y.Y.3
  • 9
    • 77954143076 scopus 로고    scopus 로고
    • A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    • 20512145 10.1038/ng.601 1:CAS:528:DC%2BC3cXmslWmsr8%3D
    • Bei JX, Li Y, Jia WH, et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet. 2010;42:599-603.
    • (2010) Nat Genet , vol.42 , pp. 599-603
    • Bei, J.X.1    Li, Y.2    Jia, W.H.3
  • 10
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    • 19884659 10.1172/JCI39374 1:CAS:528:DC%2BD1MXhsFCit7jL
    • Song LB, Li J, Liao WT, et al. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest. 2009;119:3626-36.
    • (2009) J Clin Invest , vol.119 , pp. 3626-3636
    • Song, L.B.1    Li, J.2    Liao, W.T.3
  • 11
    • 38949112133 scopus 로고    scopus 로고
    • Identification of novel nasopharyngeal carcinoma biomarkers by laser capture microdissection and proteomic analysis
    • 18223218 10.1158/1078-0432.CCR-07-1215 1:CAS:528:DC%2BD1cXhtVKitbo%3D
    • Cheng AL, Huang WG, Chen ZC, et al. Identification of novel nasopharyngeal carcinoma biomarkers by laser capture microdissection and proteomic analysis. Clin Cancer Res. 2008;14:435-45.
    • (2008) Clin Cancer Res , vol.14 , pp. 435-445
    • Cheng, A.L.1    Huang, W.G.2    Chen, Z.C.3
  • 12
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • 10742145 10.1038/74651 1:CAS:528:DC%2BD3cXisVOrur4%3D
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389-95.
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 13
    • 1542344524 scopus 로고    scopus 로고
    • Notch function in the vasculature: Insights from zebrafish, mouse and man
    • 14988924 10.1002/bies.20004 1:CAS:528:DC%2BD2cXis1WqsLc%3D
    • Shawber CJ, Kitajewski J. Notch function in the vasculature: insights from zebrafish, mouse and man. BioEssays. 2004;26:225-34.
    • (2004) BioEssays , vol.26 , pp. 225-234
    • Shawber, C.J.1    Kitajewski, J.2
  • 14
    • 0035826869 scopus 로고    scopus 로고
    • Notch signaling during vascular development
    • 11344278 10.1073/pnas.101138098 1:CAS:528:DC%2BD3MXjs1WgtLY%3D
    • Gridley T. Notch signaling during vascular development. Proc Natl Acad Sci USA. 2001;98:5377-8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5377-5378
    • Gridley, T.1
  • 15
    • 0034195220 scopus 로고    scopus 로고
    • Dll4, a novel Notch ligand expressed in arterial endothelium
    • 10837024 1:CAS:528:DC%2BD3cXjvFOgsb0%3D
    • Shutter JR, Scully S, Fan W, et al. Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 2000;14:1313-8.
    • (2000) Genes Dev , vol.14 , pp. 1313-1318
    • Shutter, J.R.1    Scully, S.2    Fan, W.3
  • 16
    • 0034329423 scopus 로고    scopus 로고
    • Isolation and characterization of the notch ligand delta4
    • 11035934 10.1006/excr.2000.5034 1:CAS:528:DC%2BD3cXntlGhsr8%3D
    • Rao PK, Dorsch M, Chickering T, et al. Isolation and characterization of the notch ligand delta4. Exp Cell Res. 2000;260:379-86.
    • (2000) Exp Cell Res , vol.260 , pp. 379-386
    • Rao, P.K.1    Dorsch, M.2    Chickering, T.3
  • 17
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • 16204037 10.1158/0008-5472.CAN-05-1208 1:CAS:528:DC%2BD2MXhtVKiu77E
    • Patel NS, Li JL, Generali D, et al. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res. 2005;65:8690-7.
    • (2005) Cancer Res , vol.65 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3
  • 18
    • 31544448010 scopus 로고    scopus 로고
    • Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
    • 16219802 10.1182/blood-2005-03-1000 1:CAS:528:DC%2BD28Xht1Onsbg%3D
    • Williams CK, Li JL, Murga M, et al. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood. 2006;107:931-9.
    • (2006) Blood , vol.107 , pp. 931-939
    • Williams, C.K.1    Li, J.L.2    Murga, M.3
  • 19
    • 0037216703 scopus 로고    scopus 로고
    • Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: Implications for modulating arteriogenesis and angiogenesis
    • 12482957 10.1128/MCB.23.1.14-25.2003
    • Liu ZJ, Shirakawa T, Li Y, et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol. 2003;23:14-25.
    • (2003) Mol Cell Biol , vol.23 , pp. 14-25
    • Liu, Z.J.1    Shirakawa, T.2    Li, Y.3
  • 20
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • 17183313 10.1038/nature05355 1:CAS:528:DC%2BD28XhtlemtLnL
    • Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 2006;444:1032-7.
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 21
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • 17183323 10.1038/nature05313 1:CAS:528:DC%2BD28XhtlemtLnP
    • Ridgway J, Zhang G, Wu Y, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature. 2006;444:1083-7.
    • (2006) Nature , vol.444 , pp. 1083-1087
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 22
    • 37049012486 scopus 로고    scopus 로고
    • Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
    • 18056450 10.1158/0008-5472.CAN-07-0969 1:CAS:528:DC%2BD2sXhtlyiurfJ
    • Li JL, Sainson RC, Shi W, et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res. 2007;67:11244-53.
    • (2007) Cancer Res , vol.67 , pp. 11244-11253
    • Li, J.L.1    Sainson, R.C.2    Shi, W.3
  • 23
    • 80052803473 scopus 로고    scopus 로고
    • DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo
    • 21803743 10.1158/0008-5472.CAN-11-1704 1:CAS:528:DC%2BC3MXhtFKntb3E
    • Li JL, Sainson RC, Oon CE, et al. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res. 2011;71:6073-83.
    • (2011) Cancer Res , vol.71 , pp. 6073-6083
    • Li, J.L.1    Sainson, R.C.2    Oon, C.E.3
  • 24
    • 64549114965 scopus 로고    scopus 로고
    • Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues
    • 19413639 10.1111/j.1365-2559.2009.03279.x
    • Martinez JC, Muller MM, Turley H, et al. Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues. Histopathology. 2009;54:598-606.
    • (2009) Histopathology , vol.54 , pp. 598-606
    • Martinez, J.C.1    Muller, M.M.2    Turley, H.3
  • 25
    • 76049091646 scopus 로고    scopus 로고
    • Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma
    • 20103680 10.1158/1078-0432.CCR-09-1299 1:CAS:528:DC%2BC3cXhs1aqsrs%3D
    • Schadler KL, Zweidler-McKay PA, et al. Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma. Clin Cancer Res. 2010;16:848-56.
    • (2010) Clin Cancer Res , vol.16 , pp. 848-856
    • Schadler, K.L.1    Zweidler-Mckay, P.A.2
  • 26
    • 33748359703 scopus 로고    scopus 로고
    • Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer
    • 16914569 10.1158/1078-0432.CCR-06-0285 1:CAS:528:DC%2BD28XotFKgsb8%3D
    • Patel NS, Dobbie MS, Rochester M, et al. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res. 2006;12:4836-44.
    • (2006) Clin Cancer Res , vol.12 , pp. 4836-4844
    • Patel, N.S.1    Dobbie, M.S.2    Rochester, M.3
  • 27
    • 64549149292 scopus 로고    scopus 로고
    • Notch signaling contributes to the pathogenesis of human osteosarcomas
    • 19228774 10.1093/hmg/ddp057 1:CAS:528:DC%2BD1MXktV2hurY%3D
    • Engin F, Bertin T, Ma O, et al. Notch signaling contributes to the pathogenesis of human osteosarcomas. Hum Mol Genet. 2009;18(8):1464-70.
    • (2009) Hum Mol Genet , vol.18 , Issue.8 , pp. 1464-1470
    • Engin, F.1    Bertin, T.2    Ma, O.3
  • 28
    • 77950560825 scopus 로고    scopus 로고
    • Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer
    • 20167860 10.2353/ajpath.2010.090908
    • Jubb AM, Soilleux EJ, Turley H, et al. Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am J Pathol. 2010;176:2019-28.
    • (2010) Am J Pathol , vol.176 , pp. 2019-2028
    • Jubb, A.M.1    Soilleux, E.J.2    Turley, H.3
  • 29
    • 78650082224 scopus 로고    scopus 로고
    • Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: Coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
    • 20737536 10.1002/cncr.25551
    • Donnem T, Andersen S, Al-Shibli K, et al. Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer. 2010;116:5676-85.
    • (2010) Cancer , vol.116 , pp. 5676-5685
    • Donnem, T.1    Andersen, S.2    Al-Shibli, K.3
  • 30
    • 79251473728 scopus 로고    scopus 로고
    • Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer
    • 21224365 10.1158/1078-0432.CCR-10-1791 1:CAS:528:DC%2BC3MXmslyqtQ%3D%3D
    • Jubb AM, Miller KD, Rugo HS, et al. Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clin Cancer Res. 2011;17:372-81.
    • (2011) Clin Cancer Res , vol.17 , pp. 372-381
    • Jubb, A.M.1    Miller, K.D.2    Rugo, H.S.3
  • 31
    • 70449517334 scopus 로고    scopus 로고
    • Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer
    • 19844231 10.1038/sj.bjc.6605368 1:CAS:528:DC%2BD1MXhtl2hs7rE
    • Jubb AM, Turley H, Moeller HC, et al. Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. Br J Cancer. 2009;101:1749-57.
    • (2009) Br J Cancer , vol.101 , pp. 1749-1757
    • Jubb, A.M.1    Turley, H.2    Moeller, H.C.3
  • 32
    • 40149093257 scopus 로고    scopus 로고
    • Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma
    • 18171482 10.1186/1479-5876-6-1
    • Li YH, Hu CF, Shao Q, et al. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. J Transl Med. 2008;6:1.
    • (2008) J Transl Med , vol.6 , pp. 1
    • Li, Y.H.1    Hu, C.F.2    Shao, Q.3
  • 33
    • 0028102935 scopus 로고
    • A new staging system for nasopharyngeal carcinoma in China
    • 7961009 10.1016/0360-3016(94)90307-7 1:STN:280:DyaK2M%2FkvFOnsQ%3D%3D
    • Min H, Hong M, Ma J, et al. A new staging system for nasopharyngeal carcinoma in China. Int J Radiat Oncol Biol Phys. 1994;30:1037-42.
    • (1994) Int J Radiat Oncol Biol Phys , vol.30 , pp. 1037-1042
    • Min, H.1    Hong, M.2    Ma, J.3
  • 34
    • 8444244786 scopus 로고    scopus 로고
    • X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    • 15534099 10.1158/1078-0432.CCR-04-0713 1:CAS:528:DC%2BD2cXpsVKltbc%3D
    • Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10:7252-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 7252-7259
    • Camp, R.L.1    Dolled-Filhart, M.2    Rimm, D.L.3
  • 35
    • 0017277826 scopus 로고
    • Monte Carlo principles and applications
    • 768998 10.1088/0031-9155/21/2/001 1:STN:280:DyaE287lt1Gqtg%3D%3D
    • Raeside DE. Monte Carlo principles and applications. Phys Med Biol. 1976;21:181-97.
    • (1976) Phys Med Biol , vol.21 , pp. 181-197
    • Raeside, D.E.1
  • 36
    • 14544304586 scopus 로고    scopus 로고
    • Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: A pooled data analysis of two phase III trials
    • 15657403 10.1200/JCO.2005.12.081 1:CAS:528:DC%2BD2MXitl2gtbk%3D
    • Chua DT, Ma J, Sham JS, et al. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials. J Clin Oncol. 2005;23:1118-24.
    • (2005) J Clin Oncol , vol.23 , pp. 1118-1124
    • Chua, D.T.1    Ma, J.2    Sham, J.S.3
  • 37
    • 0030851764 scopus 로고    scopus 로고
    • Signaling vascular morphogenesis and maintenance
    • 9229772 10.1126/science.277.5322.48 1:CAS:528:DyaK2sXksVyhtrk%3D
    • Hanahan D. Signaling vascular morphogenesis and maintenance. Science. 1997;277:48-50.
    • (1997) Science , vol.277 , pp. 48-50
    • Hanahan, D.1
  • 38
    • 0026846928 scopus 로고
    • The role of angiogenesis in tumor growth
    • 1378311 1:STN:280:DyaK38zivFOgtA%3D%3D
    • Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol. 1992;3:65-71.
    • (1992) Semin Cancer Biol , vol.3 , pp. 65-71
    • Folkman, J.1
  • 39
    • 67849124654 scopus 로고    scopus 로고
    • DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency
    • 19664991 10.1016/j.stem.2009.05.019 1:CAS:528:DC%2BD1MXhsVCiu77P
    • Hoey T, Yen WC, Axelrod F, et al. DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell. 2009;5:168-77.
    • (2009) Cell Stem Cell , vol.5 , pp. 168-177
    • Hoey, T.1    Yen, W.C.2    Axelrod, F.3
  • 40
    • 63849310246 scopus 로고    scopus 로고
    • Crosstalk of VEGF and Notch pathways in tumour angiogenesis: Therapeutic implications
    • 19273260 10.2741/3438 1:CAS:528:DC%2BD1MXltlWnsbk%3D
    • Li JL, Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci. 2009;14:3094-110.
    • (2009) Front Biosci , vol.14 , pp. 3094-3110
    • Li, J.L.1    Harris, A.L.2
  • 41
    • 37549030522 scopus 로고    scopus 로고
    • Delta-like 4/Notch signaling and its therapeutic implications
    • 18094402 10.1158/1078-0432.CCR-07-1393 1:CAS:528:DC%2BD2sXhsVCktr%2FI
    • Yan M, Plowman GD. Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 2007;13:7243-6.
    • (2007) Clin Cancer Res , vol.13 , pp. 7243-7246
    • Yan, M.1    Plowman, G.D.2
  • 42
    • 63449083667 scopus 로고    scopus 로고
    • Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors
    • 19240176 10.1158/1078-0432.CCR-08-1471 1:CAS:528:DC%2BD1MXisVWrs70%3D
    • Chen FH, Chiang CS, Wang CC, et al. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors. Clin Cancer Res. 2009;15:1721-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 1721-1729
    • Chen, F.H.1    Chiang, C.S.2    Wang, C.C.3
  • 43
    • 0036023422 scopus 로고    scopus 로고
    • Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival
    • 12171890 1:CAS:528:DC%2BD38XmvVahsL8%3D
    • Hui EP, Chan AT, Pezzella F, et al. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin Cancer Res. 2002;8:2595-604.
    • (2002) Clin Cancer Res , vol.8 , pp. 2595-2604
    • Hui, E.P.1    Chan, A.T.2    Pezzella, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.