-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000 100 57 70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 2004 350 2335 2342.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
3
-
-
33644870156
-
First-line treatment for advanced non-small-cell lung cancer
-
discussion 8-80.
-
Laskin JJ, Sandler AB. First-line treatment for advanced non-small-cell lung cancer. Oncology 2005 19 1671 1676 discussion 8-80.
-
(2005)
Oncology
, vol.19
, pp. 1671-1676
-
-
Laskin, J.J.1
Sandler, A.B.2
-
4
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005 438 967 974.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
6
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005 8 299 309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
7
-
-
0035692285
-
Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches
-
Kerbel RS, Yu J, Tran J et al. Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches. Cancer Metastasis Rev. 2001 20 79 86.
-
(2001)
Cancer Metastasis Rev.
, vol.20
, pp. 79-86
-
-
Kerbel, R.S.1
Yu, J.2
Tran, J.3
-
9
-
-
0036727125
-
Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling
-
Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat. Rev. Mol. Cell Biol. 2002 3 673 684.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 673-684
-
-
Fortini, M.E.1
-
10
-
-
33847635620
-
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
-
Lobov IB, Renard RA, Papadopoulos N et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl Acad. Sci. USA 2007 104 3219 3224.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 3219-3224
-
-
Lobov, I.B.1
Renard, R.A.2
Papadopoulos, N.3
-
11
-
-
33847046849
-
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
-
Hellstrom M, Phng LK, Hofmann JJ et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007 445 776 780.
-
(2007)
Nature
, vol.445
, pp. 776-780
-
-
Hellstrom, M.1
Phng, L.K.2
Hofmann, J.J.3
-
12
-
-
33847607880
-
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
-
Suchting S, Freitas C, le Noble F et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl. Acad. Sci. USA 2007 104 3225 3230.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3225-3230
-
-
Suchting, S.1
Freitas, C.2
Le Noble, F.3
-
13
-
-
33845877157
-
Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis
-
Noguera-Troise I, Daly C, Papadopoulos NJ et al. Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis. Nature 2006 444 1032 1037.
-
(2006)
Nature
, vol.444
, pp. 1032-1037
-
-
Noguera-Troise, I.1
Daly, C.2
Papadopoulos, N.J.3
-
14
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumor growth by deregulating angiogenesis
-
Ridgway J, Zhang G, Wu Y et al. Inhibition of Dll4 signalling inhibits tumor growth by deregulating angiogenesis. Nature 2006 444 1083 1087.
-
(2006)
Nature
, vol.444
, pp. 1083-1087
-
-
Ridgway, J.1
Zhang, G.2
Wu, Y.3
-
15
-
-
33847039645
-
Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
-
Siekmann AF, Lawson ND. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 2007 445 781 784.
-
(2007)
Nature
, vol.445
, pp. 781-784
-
-
Siekmann, A.F.1
Lawson, N.D.2
-
16
-
-
33847009903
-
Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis
-
Leslie JD, Ariza-McNaughton L, Bermange AL, McAdow R, Johnson SL, Lewis J. Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development 2007 134 839 844.
-
(2007)
Development
, vol.134
, pp. 839-844
-
-
Leslie, J.D.1
Ariza-Mcnaughton, L.2
Bermange, A.L.3
McAdow, R.4
Johnson, S.L.5
Lewis, J.6
-
17
-
-
31544448010
-
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
-
Williams CK, Li JL, Murga M, Harris AL, Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 2006 107 931 939.
-
(2006)
Blood
, vol.107
, pp. 931-939
-
-
Williams, C.K.1
Li, J.L.2
Murga, M.3
Harris, A.L.4
Tosato, G.5
-
18
-
-
37049012486
-
Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
-
Li JL, Sainson RC, Shi W et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res. 2007 67 11244 11253.
-
(2007)
Cancer Res.
, vol.67
, pp. 11244-11253
-
-
Li, J.L.1
Sainson, R.C.2
Shi, W.3
-
19
-
-
0009482260
-
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
-
Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 1979 76 4350 4354.
-
(1979)
Proc. Natl Acad. Sci. USA
, vol.76
, pp. 4350-4354
-
-
Towbin, H.1
Staehelin, T.2
Gordon, J.3
-
20
-
-
0019551730
-
"western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
-
Burnette WN. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 1981 112 195 203.
-
(1981)
Anal. Biochem.
, vol.112
, pp. 195-203
-
-
Burnette, W.N.1
-
21
-
-
0031949854
-
A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens
-
Poulsom R, Longcroft JM, Jeffery RE, Rogers LA, Steel JH. A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens. Eur. J. Histochem. 1998 42 121 132.
-
(1998)
Eur. J. Histochem.
, vol.42
, pp. 121-132
-
-
Poulsom, R.1
Longcroft, J.M.2
Jeffery, R.E.3
Rogers, L.A.4
Steel, J.H.5
-
22
-
-
0021086321
-
Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3′ untranslated regions are isotype specific but are conserved in evolution
-
Ponte P, Gunning P, Blau H, Kedes L. Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3′ untranslated regions are isotype specific but are conserved in evolution. Mol. Cell. Biol. 1983 3 1783 1791.
-
(1983)
Mol. Cell. Biol.
, vol.3
, pp. 1783-1791
-
-
Ponte, P.1
Gunning, P.2
Blau, H.3
Kedes, L.4
-
23
-
-
8644290828
-
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
-
Gale NW, Dominguez MG, Noguera I et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc. Natl Acad. Sci. USA 2004 101 15949 15954.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 15949-15954
-
-
Gale, N.W.1
Dominguez, M.G.2
Noguera, I.3
-
24
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
Ferrara N, Carver-Moore K, Chen H et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996 380 439 442.
-
(1996)
Nature
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
-
25
-
-
21744442626
-
Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles
-
Benedito R, Duarte A. Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr. Patterns 2005 5 750 755.
-
(2005)
Gene Expr. Patterns
, vol.5
, pp. 750-755
-
-
Benedito, R.1
Duarte, A.2
-
26
-
-
34250313956
-
Delta-like 4 induces notch signaling in macrophages: Implications for inflammation
-
Fung E, Tang SM, Canner JP et al. Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation 2007 115 2948 2956.
-
(2007)
Circulation
, vol.115
, pp. 2948-2956
-
-
Fung, E.1
Tang, S.M.2
Canner, J.P.3
-
27
-
-
36549001590
-
Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
-
Schaller MA, Neupane R, Rudd BD et al. Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J. Exp. Med. 2007 204 2925 2934.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2925-2934
-
-
Schaller, M.A.1
Neupane, R.2
Rudd, B.D.3
-
28
-
-
37549036325
-
Expression of Delta-like protein 4 in the human endometrium
-
Mazella J, Liang S, Tseng L. Expression of Delta-like protein 4 in the human endometrium. Endocrinology 2008 149 15 19.
-
(2008)
Endocrinology
, vol.149
, pp. 15-19
-
-
Mazella, J.1
Liang, S.2
Tseng, L.3
-
29
-
-
33947241465
-
SnapShot: Notch signaling pathway
-
Ilagan MX, Kopan R. SnapShot: notch signaling pathway. Cell 2007 128 1246.
-
(2007)
Cell
, vol.128
, pp. 1246
-
-
Ilagan, M.X.1
Kopan, R.2
-
30
-
-
21844440569
-
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
-
Pelkmans L, Fava E, Grabner H et al. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 2005 436 78 86.
-
(2005)
Nature
, vol.436
, pp. 78-86
-
-
Pelkmans, L.1
Fava, E.2
Grabner, H.3
-
31
-
-
33644769212
-
Endocytosis conducts the cell signaling orchestra
-
Polo S, Di Fiore PP. Endocytosis conducts the cell signaling orchestra. Cell 2006 124 897 900.
-
(2006)
Cell
, vol.124
, pp. 897-900
-
-
Polo, S.1
Di Fiore, P.P.2
-
32
-
-
18844414504
-
The roles of receptor and ligand endocytosis in regulating Notch signaling
-
Le Borgne R, Bardin A, Schweisguth F. The roles of receptor and ligand endocytosis in regulating Notch signaling. Development 2005 132 1751 1762.
-
(2005)
Development
, vol.132
, pp. 1751-1762
-
-
Le Borgne, R.1
Bardin, A.2
Schweisguth, F.3
-
34
-
-
0034051852
-
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
-
Parks AL, Klueg KM, Stout JR, Muskavitch MA. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 2000 127 1373 1385.
-
(2000)
Development
, vol.127
, pp. 1373-1385
-
-
Parks, A.L.1
Klueg, K.M.2
Stout, J.R.3
Muskavitch, M.A.4
-
35
-
-
0037238008
-
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
-
Itoh M, Kim CH, Palardy G et al. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 2003 4 67 82.
-
(2003)
Dev. Cell
, vol.4
, pp. 67-82
-
-
Itoh, M.1
Kim, C.H.2
Palardy, G.3
-
36
-
-
39149123515
-
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells
-
Harrington LS, Sainson RC, Williams CK et al. Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvasc. Res. 2008 75 144 154.
-
(2008)
Microvasc. Res.
, vol.75
, pp. 144-154
-
-
Harrington, L.S.1
Sainson, R.C.2
Williams, C.K.3
-
37
-
-
34548535783
-
Anti-Dll4 therapy: Can we block tumor growth by increasing angiogenesis?
-
Sainson RC, Harris AL. Anti-Dll4 therapy: can we block tumor growth by increasing angiogenesis? Trends Mol. Med. 2007 13 389 395.
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 389-395
-
-
Sainson, R.C.1
Harris, A.L.2
-
38
-
-
37549030522
-
Delta-like 4/Notch signaling and its therapeutic implications
-
Yan M, Plowman GD. Delta-like 4/Notch signaling and its therapeutic implications. Clin. Cancer Res. 2007 13 7243 7246.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7243-7246
-
-
Yan, M.1
Plowman, G.D.2
|