메뉴 건너뛰기




Volumn 54, Issue 5, 2009, Pages 598-606

Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues

Author keywords

Delta like ligand 4; Human tissues; Nuclear relocation

Indexed keywords

DELTA LIKE LIGAND 4; GROWTH FACTOR; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

EID: 64549114965     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2009.03279.x     Document Type: Article
Times cited : (15)

References (38)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000 100 57 70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 2004 350 2335 2342.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 3
    • 33644870156 scopus 로고    scopus 로고
    • First-line treatment for advanced non-small-cell lung cancer
    • discussion 8-80.
    • Laskin JJ, Sandler AB. First-line treatment for advanced non-small-cell lung cancer. Oncology 2005 19 1671 1676 discussion 8-80.
    • (2005) Oncology , vol.19 , pp. 1671-1676
    • Laskin, J.J.1    Sandler, A.B.2
  • 4
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005 438 967 974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 6
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005 8 299 309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 7
    • 0035692285 scopus 로고    scopus 로고
    • Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches
    • Kerbel RS, Yu J, Tran J et al. Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches. Cancer Metastasis Rev. 2001 20 79 86.
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 79-86
    • Kerbel, R.S.1    Yu, J.2    Tran, J.3
  • 9
    • 0036727125 scopus 로고    scopus 로고
    • Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling
    • Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat. Rev. Mol. Cell Biol. 2002 3 673 684.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 673-684
    • Fortini, M.E.1
  • 10
    • 33847635620 scopus 로고    scopus 로고
    • Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
    • Lobov IB, Renard RA, Papadopoulos N et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl Acad. Sci. USA 2007 104 3219 3224.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 3219-3224
    • Lobov, I.B.1    Renard, R.A.2    Papadopoulos, N.3
  • 11
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellstrom M, Phng LK, Hofmann JJ et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007 445 776 780.
    • (2007) Nature , vol.445 , pp. 776-780
    • Hellstrom, M.1    Phng, L.K.2    Hofmann, J.J.3
  • 12
    • 33847607880 scopus 로고    scopus 로고
    • The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    • Suchting S, Freitas C, le Noble F et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl. Acad. Sci. USA 2007 104 3225 3230.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 3225-3230
    • Suchting, S.1    Freitas, C.2    Le Noble, F.3
  • 13
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos NJ et al. Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis. Nature 2006 444 1032 1037.
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 14
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumor growth by deregulating angiogenesis
    • Ridgway J, Zhang G, Wu Y et al. Inhibition of Dll4 signalling inhibits tumor growth by deregulating angiogenesis. Nature 2006 444 1083 1087.
    • (2006) Nature , vol.444 , pp. 1083-1087
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 15
    • 33847039645 scopus 로고    scopus 로고
    • Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    • Siekmann AF, Lawson ND. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 2007 445 781 784.
    • (2007) Nature , vol.445 , pp. 781-784
    • Siekmann, A.F.1    Lawson, N.D.2
  • 17
    • 31544448010 scopus 로고    scopus 로고
    • Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
    • Williams CK, Li JL, Murga M, Harris AL, Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 2006 107 931 939.
    • (2006) Blood , vol.107 , pp. 931-939
    • Williams, C.K.1    Li, J.L.2    Murga, M.3    Harris, A.L.4    Tosato, G.5
  • 18
    • 37049012486 scopus 로고    scopus 로고
    • Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
    • Li JL, Sainson RC, Shi W et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res. 2007 67 11244 11253.
    • (2007) Cancer Res. , vol.67 , pp. 11244-11253
    • Li, J.L.1    Sainson, R.C.2    Shi, W.3
  • 19
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 1979 76 4350 4354.
    • (1979) Proc. Natl Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 20
    • 0019551730 scopus 로고
    • "western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
    • Burnette WN. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 1981 112 195 203.
    • (1981) Anal. Biochem. , vol.112 , pp. 195-203
    • Burnette, W.N.1
  • 21
    • 0031949854 scopus 로고    scopus 로고
    • A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens
    • Poulsom R, Longcroft JM, Jeffery RE, Rogers LA, Steel JH. A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens. Eur. J. Histochem. 1998 42 121 132.
    • (1998) Eur. J. Histochem. , vol.42 , pp. 121-132
    • Poulsom, R.1    Longcroft, J.M.2    Jeffery, R.E.3    Rogers, L.A.4    Steel, J.H.5
  • 22
    • 0021086321 scopus 로고
    • Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3′ untranslated regions are isotype specific but are conserved in evolution
    • Ponte P, Gunning P, Blau H, Kedes L. Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3′ untranslated regions are isotype specific but are conserved in evolution. Mol. Cell. Biol. 1983 3 1783 1791.
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 1783-1791
    • Ponte, P.1    Gunning, P.2    Blau, H.3    Kedes, L.4
  • 23
    • 8644290828 scopus 로고    scopus 로고
    • Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    • Gale NW, Dominguez MG, Noguera I et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc. Natl Acad. Sci. USA 2004 101 15949 15954.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 15949-15954
    • Gale, N.W.1    Dominguez, M.G.2    Noguera, I.3
  • 24
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara N, Carver-Moore K, Chen H et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996 380 439 442.
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3
  • 25
    • 21744442626 scopus 로고    scopus 로고
    • Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles
    • Benedito R, Duarte A. Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr. Patterns 2005 5 750 755.
    • (2005) Gene Expr. Patterns , vol.5 , pp. 750-755
    • Benedito, R.1    Duarte, A.2
  • 26
    • 34250313956 scopus 로고    scopus 로고
    • Delta-like 4 induces notch signaling in macrophages: Implications for inflammation
    • Fung E, Tang SM, Canner JP et al. Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation 2007 115 2948 2956.
    • (2007) Circulation , vol.115 , pp. 2948-2956
    • Fung, E.1    Tang, S.M.2    Canner, J.P.3
  • 27
    • 36549001590 scopus 로고    scopus 로고
    • Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    • Schaller MA, Neupane R, Rudd BD et al. Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J. Exp. Med. 2007 204 2925 2934.
    • (2007) J. Exp. Med. , vol.204 , pp. 2925-2934
    • Schaller, M.A.1    Neupane, R.2    Rudd, B.D.3
  • 28
    • 37549036325 scopus 로고    scopus 로고
    • Expression of Delta-like protein 4 in the human endometrium
    • Mazella J, Liang S, Tseng L. Expression of Delta-like protein 4 in the human endometrium. Endocrinology 2008 149 15 19.
    • (2008) Endocrinology , vol.149 , pp. 15-19
    • Mazella, J.1    Liang, S.2    Tseng, L.3
  • 29
    • 33947241465 scopus 로고    scopus 로고
    • SnapShot: Notch signaling pathway
    • Ilagan MX, Kopan R. SnapShot: notch signaling pathway. Cell 2007 128 1246.
    • (2007) Cell , vol.128 , pp. 1246
    • Ilagan, M.X.1    Kopan, R.2
  • 30
    • 21844440569 scopus 로고    scopus 로고
    • Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
    • Pelkmans L, Fava E, Grabner H et al. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 2005 436 78 86.
    • (2005) Nature , vol.436 , pp. 78-86
    • Pelkmans, L.1    Fava, E.2    Grabner, H.3
  • 31
    • 33644769212 scopus 로고    scopus 로고
    • Endocytosis conducts the cell signaling orchestra
    • Polo S, Di Fiore PP. Endocytosis conducts the cell signaling orchestra. Cell 2006 124 897 900.
    • (2006) Cell , vol.124 , pp. 897-900
    • Polo, S.1    Di Fiore, P.P.2
  • 32
    • 18844414504 scopus 로고    scopus 로고
    • The roles of receptor and ligand endocytosis in regulating Notch signaling
    • Le Borgne R, Bardin A, Schweisguth F. The roles of receptor and ligand endocytosis in regulating Notch signaling. Development 2005 132 1751 1762.
    • (2005) Development , vol.132 , pp. 1751-1762
    • Le Borgne, R.1    Bardin, A.2    Schweisguth, F.3
  • 33
    • 34447509872 scopus 로고    scopus 로고
    • Notch signaling - Constantly on the move
    • Nichols JT, Miyamoto A, Weinmaster G. Notch signaling - constantly on the move. Traffic 2007 8 959 969.
    • (2007) Traffic , vol.8 , pp. 959-969
    • Nichols, J.T.1    Miyamoto, A.2    Weinmaster, G.3
  • 34
    • 0034051852 scopus 로고    scopus 로고
    • Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
    • Parks AL, Klueg KM, Stout JR, Muskavitch MA. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 2000 127 1373 1385.
    • (2000) Development , vol.127 , pp. 1373-1385
    • Parks, A.L.1    Klueg, K.M.2    Stout, J.R.3    Muskavitch, M.A.4
  • 35
    • 0037238008 scopus 로고    scopus 로고
    • Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
    • Itoh M, Kim CH, Palardy G et al. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 2003 4 67 82.
    • (2003) Dev. Cell , vol.4 , pp. 67-82
    • Itoh, M.1    Kim, C.H.2    Palardy, G.3
  • 36
    • 39149123515 scopus 로고    scopus 로고
    • Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells
    • Harrington LS, Sainson RC, Williams CK et al. Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvasc. Res. 2008 75 144 154.
    • (2008) Microvasc. Res. , vol.75 , pp. 144-154
    • Harrington, L.S.1    Sainson, R.C.2    Williams, C.K.3
  • 37
    • 34548535783 scopus 로고    scopus 로고
    • Anti-Dll4 therapy: Can we block tumor growth by increasing angiogenesis?
    • Sainson RC, Harris AL. Anti-Dll4 therapy: can we block tumor growth by increasing angiogenesis? Trends Mol. Med. 2007 13 389 395.
    • (2007) Trends Mol. Med. , vol.13 , pp. 389-395
    • Sainson, R.C.1    Harris, A.L.2
  • 38
    • 37549030522 scopus 로고    scopus 로고
    • Delta-like 4/Notch signaling and its therapeutic implications
    • Yan M, Plowman GD. Delta-like 4/Notch signaling and its therapeutic implications. Clin. Cancer Res. 2007 13 7243 7246.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7243-7246
    • Yan, M.1    Plowman, G.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.