-
1
-
-
84874801912
-
Answering the ultimate question What is the Proximal Cause of Aging?
-
Blagosklonny MV. Answering the ultimate question "What is the Proximal Cause of Aging?". Aging (Albany. NY). 2012; 4:899- 916.
-
(2012)
Aging (Albany. NY)
, vol.4
, pp. 899-916
-
-
Blagosklonny, M.V.1
-
2
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny MV. Aging: ROS or TOR. Cell Cycle. 2008; 7:3344- 3354.
-
(2008)
Cell Cycle.
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
3
-
-
84880423851
-
Pharmacological approaches to improve ageing
-
InTech.
-
Camello PJ, Camello-Almaraz C, and Pozo MJ, Pharmacological approaches to improve ageing. In: Pharmacology,(Ed. Gallelli L), pp. 257-282. InTech, 2012.
-
(2012)
Pharmacology,(Ed. Gallelli L)
, pp. 257-282
-
-
Camello, P.J.1
Camello-Almaraz, C.2
Pozo, M.J.3
-
4
-
-
70350418625
-
mTOR signaling at a glance
-
Laplante M and Sabatini DM. mTOR signaling at a glance. J. Cell Sci. 2009; 122:3589-3594.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
5
-
-
79551505854
-
Disrupting function of FK506- binding protein 1b/12.6 induces the Ca(2)+-dysregulation aging phenotype in hippocampal neurons
-
Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, and Landfield PW. Disrupting function of FK506- binding protein 1b/12.6 induces the Ca(2)+-dysregulation aging phenotype in hippocampal neurons. J. Neurosci. 2011; 31:1693- 1703.
-
(2011)
J. Neurosci.
, vol.31
, pp. 1693-1703
-
-
Gant, J.C.1
Chen, K.C.2
Norris, C.M.3
Kadish, I.4
Thibault, O.5
Blalock, E.M.6
Porter, N.M.7
Landfield, P.W.8
-
6
-
-
57049114322
-
Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
-
Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, and Klann E. Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008; 60:832-845.
-
(2008)
Neuron.
, vol.60
, pp. 832-845
-
-
Hoeffer, C.A.1
Tang, W.2
Wong, H.3
Santillan, A.4
Patterson, R.J.5
Martinez, L.A.6
Tejada-Simon, M.V.7
Paylor, R.8
Hamilton, S.L.9
Klann, E.10
-
7
-
-
79952269372
-
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
-
Leontieva OV and Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany. NY). 2010; 2:924-935.
-
(2010)
Aging (Albany. NY)
, vol.2
, pp. 924-935
-
-
Leontieva, O.V.1
Blagosklonny, M.V.2
-
8
-
-
84862891914
-
Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
-
Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany. NY). 2012; 4:159-165.
-
(2012)
Aging (Albany. NY)
, vol.4
, pp. 159-165
-
-
Blagosklonny, M.V.1
-
9
-
-
84864927001
-
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
-
Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, and Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012; 75:425-436.
-
(2012)
Neuron.
, vol.75
, pp. 425-436
-
-
Yang, S.B.1
Tien, A.C.2
Boddupalli, G.3
Xu, A.W.4
Jan, Y.N.5
Jan, L.Y.6
-
10
-
-
84874807522
-
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
-
Leontieva OV, Paszkiewicz GM, and Blagosklonny MV. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany. NY). 2012; 4:899-916.
-
(2012)
Aging (Albany. NY)
, vol.4
, pp. 899-916
-
-
Leontieva, O.V.1
Paszkiewicz, G.M.2
Blagosklonny, M.V.3
-
11
-
-
0034526675
-
Parameters of calcium homeostasis in normal neuronal ageing
-
Toescu EC and Verkhratsky A. Parameters of calcium homeostasis in normal neuronal ageing. J. Anat. 2000; 197 Pt 4:563-569.
-
(2000)
J. Anat.
, vol.197
, Issue.PART 4
, pp. 563-569
-
-
Toescu, E.C.1
Verkhratsky, A.2
-
13
-
-
33947493213
-
Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
-
Thibault O, Gant JC, and Landfield PW. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell. 2007; 6:307-317.
-
(2007)
Aging Cell.
, vol.6
, pp. 307-317
-
-
Thibault, O.1
Gant, J.C.2
Landfield, P.W.3
-
14
-
-
14944356256
-
2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing
-
2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing. J. Cell Mol. Med. 2004; 8:181-190.
-
(2004)
J. Cell Mol. Med.
, Issue.8
, pp. 181-190
-
-
Toescu, E.C.1
Verkhratsky, A.2
-
15
-
-
77549086301
-
Calcium and normal brain ageing
-
Toescu EC and Vreugdenhil M. Calcium and normal brain ageing. Cell Calcium. 2010; 47:158-164.
-
(2010)
Cell Calcium.
, vol.47
, pp. 158-164
-
-
Toescu, E.C.1
Vreugdenhil, M.2
-
16
-
-
0026767413
-
Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging
-
Martinez-Serrano A, Blanco P, and Satrustegui J. Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging. J. Biol. Chem. 1992; 267:4672-4679.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 4672-4679
-
-
Martinez-Serrano, A.1
Blanco, P.2
Satrustegui, J.3
-
18
-
-
33751190095
-
Melatonin treatment reverts age-related changes in Guinea pig gallbladder neuromuscular transmission and contractility
-
Gomez-Pinilla PJ, Camello-Almaraz C, Moreno R, Camello PJ, and Pozo MJ. Melatonin treatment reverts age-related changes in Guinea pig gallbladder neuromuscular transmission and contractility. J. Pharmacol. Exp. Ther. 2006; 319:847-856.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.319
, pp. 847-856
-
-
Gomez-Pinilla, P.J.1
Camello-Almaraz, C.2
Moreno, R.3
Camello, P.J.4
Pozo, M.J.5
-
19
-
-
0027669147
-
Changes in calcium channel current densities in rat colonic smooth muscle cells during development and aging
-
Xiong Z, Sperelakis N, Noffsinger A, and Fenoglio-Preiser C. Changes in calcium channel current densities in rat colonic smooth muscle cells during development and aging. Am. J. Physiol. 1993; 265:C617-C625.
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Xiong, Z.1
Sperelakis, N.2
Noffsinger, A.3
Fenoglio-Preiser, C.4
-
21
-
-
33344477939
-
Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells
-
Del CC, Ostrovskaya O, McAllister CE, Murray K, Hatton WJ, Gurney AM, Spencer NJ, and Wilson SM. Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells. Mech. Ageing Dev. 2006; 127:315-323.
-
(2006)
Mech. Ageing Dev.
, vol.127
, pp. 315-323
-
-
Del, C.C.1
Ostrovskaya, O.2
McAllister, C.E.3
Murray, K.4
Hatton, W.J.5
Gurney, A.M.6
Spencer, N.J.7
Wilson, S.M.8
-
22
-
-
0036890906
-
Alterations by age of calcium handling in rat resistance arteries
-
Rubio C, Moreno A, Briones A, Ivorra MD, D'Ocon P, and Vila E. Alterations by age of calcium handling in rat resistance arteries. J. Cardiovasc. Pharmacol. 2002; 40:832-840.
-
(2002)
J. Cardiovasc. Pharmacol.
, vol.40
, pp. 832-840
-
-
Rubio, C.1
Moreno, A.2
Briones, A.3
Ivorra, M.D.4
D'ocon, P.5
Vila, E.6
-
23
-
-
29744468620
-
Aging-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle
-
Lopes GS, Ferreira AT, Oshiro ME, Vladimirova I, Jurkiewicz NH, Jurkiewicz A, and Smaili SS. Aging-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle. Exp. Gerontol. 2006; 41:55-62.
-
(2006)
Exp. Gerontol.
, vol.41
, pp. 55-62
-
-
Lopes, G.S.1
Ferreira, A.T.2
Oshiro, M.E.3
Vladimirova, I.4
Jurkiewicz, N.H.5
Jurkiewicz, A.6
Smaili, S.S.7
-
24
-
-
1242271240
-
Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro
-
Xiong J, Camello PJ, Verkhratsky A, and Toescu EC. Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro. Neurobiol. Aging. 2004; 25:349-359.
-
(2004)
Neurobiol. Aging.
, vol.25
, pp. 349-359
-
-
Xiong, J.1
Camello, P.J.2
Verkhratsky, A.3
Toescu, E.C.4
-
26
-
-
0037081770
-
Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12
-
Dargan SL, Lea EJ, and Dawson AP. Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12. Biochem. J. 2002; 361:401-407.
-
(2002)
Biochem. J.
, vol.361
, pp. 401-407
-
-
Dargan, S.L.1
Lea, E.J.2
Dawson, A.P.3
-
27
-
-
70350135648
-
2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR
-
2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR. Br. J. Pharmacol. 2009; 158:1112-1120.
-
(2009)
Br. J. Pharmacol.
, vol.158
, pp. 1112-1120
-
-
Macmillan, D.1
McCarron, J.G.2
-
29
-
-
84874091715
-
FK506 binding proteins: Cellular regulators of intracellular Ca(2+) signalling
-
Macmillan D. FK506 binding proteins: Cellular regulators of intracellular Ca(2+) signalling. Eur J. Pharmacol. 2013; 700:181- 193.
-
(2013)
Eur J. Pharmacol.
, vol.700
, pp. 181-193
-
-
Macmillan, D.1
-
31
-
-
62449266454
-
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2
-
Copp J, Manning G, and Hunter T. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 2009; 69:1821-1827.
-
(2009)
Cancer Res.
, vol.69
, pp. 1821-1827
-
-
Copp, J.1
Manning, G.2
Hunter, T.3
-
32
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, and Thomas G. Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J. Biol. Chem. 2002; 277:20104-20112.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
34
-
-
0026331408
-
Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.
-
Zhang LB and Buxton IL. Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways. Mol. Pharmacol. 1991; 40:952-959.
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 952-959
-
-
Zhang, L.B.1
Buxton, I.L.2
-
36
-
-
84872008180
-
Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue
-
Niemann B, Pan R, Teschner M, Boening A, Silber RE, and Rohrbach S. Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue. Exp. Gerontol. 2013; 48:55- 63.
-
(2013)
Exp. Gerontol.
, vol.48
-
-
Niemann, B.1
Pan, R.2
Teschner, M.3
Boening, A.4
Silber, R.E.5
Rohrbach, S.6
-
37
-
-
60849111389
-
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment
-
Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, and Landfield PW. Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J. Neurosci. 2009; 29:1805-1816.
-
(2009)
J. Neurosci.
, vol.29
, pp. 1805-1816
-
-
Kadish, I.1
Thibault, O.2
Blalock, E.M.3
Chen, K.C.4
Gant, J.C.5
Porter, N.M.6
Landfield, P.W.7
-
38
-
-
84865401134
-
Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations
-
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, and Melzer D. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech. Ageing Dev. 2012; 133:556-562.
-
(2012)
Mech. Ageing Dev.
, vol.133
, pp. 556-562
-
-
Harries, L.W.1
Fellows, A.D.2
Pilling, L.C.3
Hernandez, D.4
Singleton, A.5
Bandinelli, S.6
Guralnik, J.7
Powell, J.8
Ferrucci, L.9
Melzer, D.10
-
39
-
-
84872620350
-
Gene expression analysis of mTOR pathway: association with human longevity
-
Passtoors WM, Beekman M, Deelen J, van der BR, Maier AB, Guigas B, Derhovanessian E, van HD, de Craen AJ, Gunn DA, Pawelec G, and Slagboom PE. Gene expression analysis of mTOR pathway: association with human longevity. Aging Cell. 2013; 12:24-31.
-
(2013)
Aging Cell.
, vol.12
, pp. 24-31
-
-
Passtoors, W.M.1
Beekman, M.2
Deelen, J.3
van der, B.R.4
Maier, A.B.5
Guigas, B.6
Derhovanessian, E.7
van, H.D.8
de Craen, A.J.9
Gunn, D.A.10
Pawelec, G.11
Slagboom, P.E.12
-
41
-
-
80054776671
-
Endoplasmic-reticulum calcium depletion and disease
-
Mekahli D, Bultynck G, Parys JB, De SH, and Missiaen L. Endoplasmic-reticulum calcium depletion and disease. Cold Spring Harb. Perspect. Biol. 2011; 3.
-
(2011)
Cold Spring Harb. Perspect. Biol.
, pp. 3
-
-
Mekahli, D.1
Bultynck, G.2
Parys, J.B.3
De, S.H.4
Missiaen, L.5
-
43
-
-
34547711243
-
Calcium controls smooth muscle TRPC gene transcription via the CAMK/calcineurin-dependent pathways
-
Morales S, Diez A, Puyet A, Camello P, Camello-Almaraz C, Bautista J, and Pozo MJ. Calcium controls smooth muscle TRPC gene transcription via the CAMK/calcineurin-dependent pathways. Am. J. Physiol Cell Physiol. 2006.
-
(2006)
Am. J. Physiol Cell Physiol.
-
-
Morales, S.1
Diez, A.2
Puyet, A.3
Camello, P.4
Camello-Almaraz, C.5
Bautista, J.6
Pozo, M.J.7
-
44
-
-
51649127565
-
2+ sparks in aging skeletal and cardiac muscle
-
2+ sparks in aging skeletal and cardiac muscle. Ageing Res. Rev. 2008; 7:177-188.
-
(2008)
Ageing Res. Rev.
, vol.7
, pp. 177-188
-
-
Weisleder, N.1
Ma, J.2
-
46
-
-
79952502660
-
Aging differentially modifies agonist-evoked mouse detrusor contraction and calcium signals
-
Gomez-Pinilla PJ, Pozo MJ, and Camello PJ. Aging differentially modifies agonist-evoked mouse detrusor contraction and calcium signals. Age (Dordr. ). 2011; 33:81-88.
-
(2011)
Age (Dordr.)
, vol.33
, pp. 81-88
-
-
Gomez-Pinilla, P.J.1
Pozo, M.J.2
Camello, P.J.3
|