Sleep, its regulation and possible mechanisms of sleep disturbances

Acta Physiologica

Volumn 208, Issue 4, 2013, Pages 311-328

  Porkka Heiskanen, T ^a   Zitting, K M ^a   Wigren, H K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Adenosine; Nitric oxide; Sleep homeostasis

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE; CAFFEINE; CYTOKINE; MELATONIN; NITRIC OXIDE; PROSTAGLANDIN;

AGING; AMNESIA; CARDIOVASCULAR DISEASE; CIRCADIAN RHYTHM; COGNITION; DEPRESSION; ELECTROENCEPHALOGRAM; ELECTROMYOGRAPHY; ELECTROOCULOGRAPHY; ENERGY METABOLISM; ENVIRONMENTAL FACTOR; HEALTH STATUS; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INGESTION; INSOMNIA; JET LAG; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONREM SLEEP; OBESITY; OSCILLATION; PREOPTIC NUCLEUS; PRIORITY JOURNAL; REM SLEEP; REVIEW; SACCADIC EYE MOVEMENT; SEASONAL AFFECTIVE DISORDER; SLEEP DISORDER; SLEEP STAGE; STRESS; THALAMUS; WAKEFULNESS;

ADENOSINE; NITRIC OXIDE; SLEEP HOMEOSTASIS;

AGING; BRAIN; ENERGY METABOLISM; HUMANS; SLEEP; SLEEP DISORDERS;

EID: 84880395594     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12134     Document Type: Review

References (188)

1. Arendt, J. & Skene, D.J. 2005. Melatonin as a chronobiotic. Sleep Med Rev 9, 25-39.
2. Aston-Jones, G. & Bloom, F.E. 1981. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1, 876-886.
3. Attwell, D. & Gibb, A. 2005. Neuroenergetics and the kinetic design of excitatory synapses. Nat Rev Neurosci 6, 841-849.
4. Banks, S., Van Dongen, H.P., Maislin, G. & Dinges, D.F. 2010. Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery. Sleep 33, 1013-1026.
5. Benington, J.H. & Heller, H.C. 1995. Restoration of brain energy metabolism as the function of sleep. Prog Neurobiol 45, 347-360.
6. Bjorvatn, B. & Ursin, R. 1998. Changes in sleep and wakefulness following 5-HT1A ligands given systemically and locally in different brain regions. Rev Neurosci 9, 265-273.
7. Bollinger, T., Bollinger, A., Oster, H. & Solbach, W. 2010. Sleep, immunity, and circadian clocks: a mechanistic model. Gerontology 56, 574-580.
8. Bonnet, M.H. & Arand, D.L. 2010. Hyperarousal and insomnia: state of the science. Sleep Med Rev 14, 9-15.
9. Borbely, A.A. 1982. A two process model of sleep regulation. Hum Neurobiol 1, 195-204.
10. Borbely, A.A., Baumann, F., Brandeis, D., Strauch, I. & Lehmann, D. 1981. Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 51, 483-495.
11. Borbely, A.A., Mattmann, P., Loepfe, M., Strauch, I. & Lehmann, D. 1985. Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol 4, 189-194.
12. Brown, A.M. & Ransom, B.R. 2007. Astrocyte glycogen and brain energy metabolism. Glia 55, 1263-1271.
13. Brown, R.E., Basheer, R., McKenna, J.T., Strecker, R.E. & McCarley, R.W. 2012. Control of sleep and wakefulness. Physiol Rev 92, 1087-1187.
14. Buxton, O.M. & Marcelli, E. 2010. Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States. Soc Sci Med 71, 1027-1036.
15. Buxton, O.M., Cain, S.W., O'Connor, S.P., Porter, J.H., Duffy, J.F., Wang, W., Czeisler, C.A. & Shea, S.A. 2012. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med 4, 129ra43.
16. Buysse, D.J. 2013. Insomnia. JAMA 309, 706-716.
17. Cajochen, C., Munch, M., Knoblauch, V., Blatter, K. & Wirz-Justice, A. 2006. Age-related changes in the circadian and homeostatic regulation of human sleep. Chronobiol Int 23, 461-474.
18. Caliendo, G., Santagada, V., Perissutti, E. & Fiorino, F. 2005. Derivatives as 5HT1A receptor ligands-past and present. Curr Med Chem 12, 1721-1753.
19. Cappuccio, F.P., D'Elia, L., Strazzullo, P. & Miller, M.A. 2010. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 33, 585-592.
20. Carpentieri, A., Diaz de Barboza, G., Areco, V., Peralta Lopez, M. & Tolosa de Talamoni, N. 2012. New perspectives in melatonin uses. Pharmacol Res 65, 437-444.
21. Carrier, J., Viens, I., Poirier, G., Robillard, R., Lafortune, M., Vandewalle, G., Martin, N., Barakat, M., Paquet, J. & Filipini, D. 2011. Sleep slow wave changes during the middle years of life. Eur J Neurosci 33, 758-766.
22. Chauvette, S., Seigneur, J. & Timofeev, I. 2012. Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity. Neuron 75, 1105-1113.
23. Choo, K.L. & Guilleminault, C. 1998. Narcolepsy and idiopathic hypersomnolence. Clin Chest Med 19, 169-181.
24. Cirelli, C. & Tononi, G. 2008. Is sleep essential? PLoS Biol 6, e216.
25. Cirelli, C., Huber, R., Gopalakrishnan, A., Southard, T.L. & Tononi, G. 2005. Locus ceruleus control of slow-wave homeostasis. J Neurosci 25, 4503-4511.
26. Cirelli, C., Faraguna, U. & Tononi, G. 2006. Changes in brain gene expression after long-term sleep deprivation. J Neurochem 98, 1632-1645.
27. Cohen, S., Doyle, W.J., Alper, C.M., Janicki-Deverts, D. & Turner, R.B. 2009. Sleep habits and susceptibility to the common cold. Arch Intern Med 169, 62-67.
28. Czeisler, C.A. 1995. The effect of light on the human circadian pacemaker. Ciba Found Symp 183, 254-290; discussion 290-302.
29. Czeisler, C.A., Duffy, J.F., Shanahan, T.L., Brown, E.N., Mitchell, J.F., Rimmer, D.W., Ronda, J.M., Silva, E.J., Allan, J.S., Emens, J.S., Dijk, D.J. & Kronauer, R.E. 1999. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 284, 2177-2181.
30. Dash, M.B., Tononi, G. & Cirelli, C. 2012. Extracellular levels of lactate, but not oxygen, reflect sleep homeostasis in the rat cerebral cortex. Sleep 35, 909-919.
31. Dash, M.B., Bellesi, M., Tononi, G. & Cirelli, C. 2013. Sleep/wake dependent changes in cortical glucose concentrations. J Neurochem 124, 79-89.
32. Dettoni, J.L., Consolim-Colombo, F.M., Drager, L.F., Rubira, M.C., Souza, S.B., Irigoyen, M.C., Mostarda, C., Borile, S., Krieger, E.M., Moreno, H. Jr & Lorenzi-Filho, G. 2012. Cardiovascular effects of partial sleep deprivation in healthy volunteers. J Appl Physiol 113, 232-236.
33. Diekelmann, S. & Born, J. 2010. The memory function of sleep. Nat Rev Neurosci 11, 114-126.
34. Dijk, D.J., Groeger, J.A., Stanley, N. & Deacon, S. 2010. Age-related reduction in daytime sleep propensity and nocturnal slow wave sleep. Sleep 33, 211-223.
35. Dinges, D.F., Pack, F., Williams, K., Gillen, K.A., Powell, J.W., Ott, G.E., Aptowicz, C. & Pack, A.I. 1997. Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep 20, 267-277.
36. Duffy, J.F., Willson, H.J., Wang, W. & Czeisler, C.A. 2009. Healthy older adults better tolerate sleep deprivation than young adults. J Am Geriatr Soc 57, 1245-1251.
37. Dugovic, C. & Wauquier, A. 1987. 5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat. Eur J Pharmacol 137, 145-146.
38. Everson, C.A. & Toth, L.A. 2000. Systemic bacterial invasion induced by sleep deprivation. Am J Physiol Regul Integr Comp Physiol 278, R905-R916.
39. Fang, J., Sanborn, C.K., Renegar, K.B., Majde, J.A. & Krueger, J.M. 1995. Influenza viral infections enhance sleep in mice. Proc Soc Exp Biol Med 210, 242-252.
40. Gass, N., Porkka-Heiskanen, T. & Kalinchuk, A.V. 2009. The role of the basal forebrain adenosine receptors in sleep homeostasis. NeuroReport 20, 1013-1018.
41. Gath, I. & Bar-On, E. 1983. Classical sleep stages and the spectral content of the EEG signal. Int J Neurosci 22, 147-155.
42. Gritti, I., Mariotti, M. & Mancia, M. 1998. GABAergic and cholinergic basal forebrain and preoptic-anterior hypothalamic projections to the mediodorsal nucleus of the thalamus in the cat. Neuroscience 85, 149-178.
43. Grosmark, A.D., Mizuseki, K., Pastalkova, E., Diba, K. & Buzsaki, G. 2012. REM sleep reorganizes hippocampal excitability. Neuron 75, 1001-1007.
44. Haack, M., Sanchez, E. & Mullington, J.M. 2007. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep 30, 1145-1152.
45. Hanlon, E.C., Faraguna, U., Vyazovskiy, V.V., Tononi, G. & Cirelli, C. 2009. Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat. Sleep 32, 719-729.
46. Harris, J.J., Jolivet, R. & Attwell, D. 2012. Synaptic energy use and supply. Neuron 75, 762-777.
47. Hayaishi, O. 2000. Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2. Philos Trans R Soc Lond B Biol Sci 355, 275-280.
48. Heym, J., Trulson, M.E. & Jacobs, B.L. 1982. Raphe unit activity in freely moving cats: effects of phasic auditory and visual stimuli. Brain Res 232, 29-39.
49. Hofman, M.A. & Swaab, D.F. 2006. Living by the clock: the circadian pacemaker in older people. Ageing Res Rev 5, 33-51.
50. Huber, R., Ghilardi, M.F., Massimini, M. & Tononi, G. 2004. Local sleep and learning. Nature 430, 78-81.
51. Huber, R., Ghilardi, M.F., Massimini, M., Ferrarelli, F., Riedner, B.A., Peterson, M.J. & Tononi, G. 2006. Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity. Nat Neurosci 9, 1169-1176.
52. Ji, D. & Wilson, M.A. 2007. Coordinated memory replay in the visual cortex and hippocampus during sleep. Nat Neurosci 10, 100-107.
53. Jones, B.E. 2004. Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex. Prog Brain Res 145, 157-169.
54. Jung, C.M., Melanson, E.L., Frydendall, E.J., Perreault, L., Eckel, R.H. & Wright, K.P. 2011. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J Physiol 589, 235-244.
55. Kalinchuk, A.V., Lu, Y., Stenberg, D., Rosenberg, P.A. & Porkka-Heiskanen, T. 2006a. Nitric oxide production in the basal forebrain is required for recovery sleep. J Neurochem 99, 483-498.
56. Kalinchuk, A.V., Stenberg, D., Rosenberg, P.A. & Porkka-Heiskanen, T. 2006b. Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction. Eur J Neurosci 24, 1443-1456.
57. Kalinchuk, A.V., McCarley, R.W., Stenberg, D., Porkka-Heiskanen, T. & Basheer, R. 2008. The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience 157, 238-253.
58. Khazaie, H., Rezaie, L., Darvishi, F., Najafi, F. & Avis, K. 2013. Treatment of paradoxical insomnia with atypical antipsychotic drugs. A comparison of olanzapine and risperidone. Neurosciences (Riyadh) 18, 64-69.
59. Kilduff, T.S. & Peyron, C. 2000. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci 23, 359-365.
60. Kim, H.C., Kim, B.K., Min, K.B., Min, J.Y., Hwang, S.H. & Park, S.G. 2011. Association between job stress and insomnia in Korean workers. J Occup Health 53, 164-174.
61. Klerman, E.B., Davis, J.B., Duffy, J.F., Dijk, D.J. & Kronauer, R.E. 2004. Older people awaken more frequently but fall back asleep at the same rate as younger people. Sleep 27, 793-798.
62. Knutson, K.L. 2012. Does inadequate sleep play a role in vulnerability to obesity? Am J Hum Biol 24, 361-371.
63. Knutson, K.L., Van Cauter, E., Rathouz, P.J., DeLeire, T. & Lauderdale, D.S. 2010. Trends in the prevalence of short sleepers in the USA: 1975-2006. Sleep 33, 37-45.
64. Knutsson, A. & Boggild, H. 2010. Gastrointestinal disorders among shift workers. Scand J Work Environ Health 36, 85-95.
65. Knutsson, A., Akerstedt, T., Jonsson, B.G. & Orth-Gomer, K. 1986. Increased risk of ischaemic heart disease in shift workers. Lancet 2, 89-92.
66. Knutsson, A., Alfredsson, L., Karlsson, B., Akerstedt, T., Fransson, E.I., Westerholm, P. & Westerlund, H. 2013. Breast cancer among shift workers: results of the WOLF longitudinal cohort study. Scand J Work Environ Health 39, 170-177.
67. Kompier, M.A., Taris, T.W. & van Veldhoven, M. 2012. Tossing and turning-insomnia in relation to occupational stress, rumination, fatigue, and well-being. Scand J Work Environ Health 38, 238-246.
68. Kong, J., Shepel, P.N., Holden, C.P., Mackiewicz, M., Pack, A.I. & Geiger, J.D. 2002. Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep. J Neurosci 22, 5581-5587.
69. Kronholm, E., Harma, M., Hublin, C., Aro, A.R. & Partonen, T. 2006. Self-reported sleep duration in Finnish general population. J Sleep Res 15, 276-290.
70. Kronholm, E., Partonen, T., Laatikainen, T., Peltonen, M., Harma, M., Hublin, C., Kaprio, J., Aro, A.R., Partinen, M., Fogelholm, M. et al. 2008. Trends in self-reported sleep duration and insomnia-related symptoms in Finland from 1972 to 2005: a comparative review and re-analysis of Finnish population samples. J Sleep Res 17, 54-62.
71. Kronholm, E., Laatikainen, T., Peltonen, M., Sippola, R. & Partonen, T. 2011. Self-reported sleep duration, all-cause mortality, cardiovascular mortality and morbidity in Finland. Sleep Med 12, 215-221.
72. Krueger, J.M. 2008. The role of cytokines in sleep regulation. Curr Pharm Des 14, 3408-3416.
73. Krueger, J.M., Obal, F.J., Fang, J., Kubota, T. & Taishi, P. 2001. The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci 933, 211-221.
74. Krueger, J.M., Majde, J.A. & Rector, D.M. 2011. Cytokines in immune function and sleep regulation. Handb Clin Neurol 98, 229-240.
75. Krystal, A.D., Richelson, E. & Roth, T. 2013. Review of the histamine system and the clinical effects of H(1) antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev 17, 263-272.
76. Landolt, H.P., Dijk, D.J., Achermann, P. & Borbely, A.A. 1996. Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men. Brain Res 738, 205-212.
77. Landolt, H.P., Retey, J.V., Tonz, K., Gottselig, J.M., Khatami, R., Buckelmuller, I. & Achermann, P. 2004. Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans. Neuropsychopharmacology 29, 1933-1939.
78. Landsness, E.C., Crupi, D., Hulse, B.K., Peterson, M.J., Huber, R., Ansari, H., Coen, M., Cirelli, C., Benca, R.M., Ghilardi, M.F. & Tononi, G. 2009. Sleep-dependent improvement in visuomotor learning: a causal role for slow waves. Sleep 32, 1273-1284.
79. Lange, T., Perras, B., Fehm, H.L. & Born, J. 2003. Sleep enhances the human antibody response to hepatitis A vaccination. Psychosom Med 65, 831-835.
80. Lange, T., Dimitrov, S., Bollinger, T., Diekelmann, S. & Born, J. 2011. Sleep after vaccination boosts immunological memory. J Immunol 187, 283-290.
81. Lee, M.G., Hassani, O.K., Alonso, A. & Jones, B.E. 2005. Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep. J Neurosci 25, 4365-4369.
82. van Leeuwen, W.M., Lehto, M., Karisola, P., Lindholm, H., Luukkonen, R., Sallinen, M., Harma, M., Porkka-Heiskanen, T. & Alenius, H. 2009. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS ONE 4, e4589.
83. van Leeuwen, W.M., Hublin, C., Sallinen, M., Harma, M., Hirvonen, A. & Porkka-Heiskanen, T. 2010. Prolonged sleep restriction affects glucose metabolism in healthy young men. Int J Endocrinol 2010, 108641.
84. Lesku, J.A., Vyssotski, A.L., Martinez-Gonzalez, D., Wilzeck, C. & Rattenborg, N.C. 2011. Local sleep homeostasis in the avian brain: convergence of sleep function in mammals and birds? Proc Biol Sci 278, 2419-2428.
85. Lim, J. & Dinges, D.F. 2010. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychol Bull 136, 375-389.
86. Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S. & Mignot, E. 1999. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365-376.
87. Lo, J.C., Groeger, J.A., Santhi, N., Arbon, E.L., Lazar, A.S., Hasan, S., von Schantz, M., Archer, S.N. & Dijk, D.J. 2012. Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase. PLoS ONE 7, e45987.
88. Losier, B.J. & Semba, K. 1993. Dual projections of single cholinergic and aminergic brainstem neurons to the thalamus and basal forebrain in the rat. Brain Res 604, 41-52.
89. Lu, J., Greco, M.A., Shiromani, P. & Saper, C.B. 2000. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep. J Neurosci 20, 3830-3842.
90. Luppi, P.H., Gervasoni, D., Verret, L., Goutagny, R., Peyron, C., Salvert, D., Leger, L. & Fort, P. 2006. Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis. J Physiol Paris 100, 271-283.
91. Luppi, P.H., Clement, O., Sapin, E., Peyron, C., Gervasoni, D., Leger, L. & Fort, P. 2012. Brainstem mechanisms of paradoxical (REM) sleep generation. Pflugers Arch 463, 43-52.
92. Madsen, P.L., Schmidt, J.F., Holm, S., Vorstrup, S., Lassen, N.A. & Wildschiodtz, G. 1991a. Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2). Brain Res 557, 217-220.
93. Madsen, P.L., Schmidt, J.F., Wildschiodtz, G., Friberg, L., Holm, S., Vorstrup, S. & Lassen, N.A. 1991b. Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep. J Appl Physiol 70, 2597-2601.
94. Magistretti, P.J., Sorg, O., Yu, N., Martin, J.L. & Pellerin, L. 1993. Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells. Dev Neurosci 15, 306-312.
95. Maquet, P. 1995. Sleep function(s) and cerebral metabolism. Behav Brain Res 69, 75-83.
96. Martinez-Gomez, D., Eisenmann, J.C., Gomez-Martinez, S., Hill, E.E., Zapatera, B., Veiga, O.L., Marcos, A. & AFINOS Study Group. 2011. Sleep duration and emerging cardiometabolic risk markers in adolescents. The AFINOS study. Sleep Med 12, 997-1002.
97. McCormick, D.A. 1992. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Prog Neurobiol 39, 337-388.
98. McCormick, D.A. & Bal, T. 1994. Sensory gating mechanisms of the thalamus. Curr Opin Neurobiol 4, 550-556.
99. McGinty, D.J. & Harper, R.M. 1976. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 101, 569-575.
100. McGinty, D. & Szymusiak, R. 2000. The sleep-wake switch: a neuronal alarm clock. Nat Med 6, 510-511.
101. Meier-Ewert, H.K., Ridker, P.M., Rifai, N., Regan, M.M., Price, N.J., Dinges, D.F. & Mullington, J.M. 2004. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 43, 678-683.
102. Mendelson, W.B. & Bergmann, B.M. 1999. Age-related changes in sleep in the rat. Sleep 22, 145-150.
103. Mesulam, M.M., Mufson, E.J., Wainer, B.H. & Levey, A.I. 1983. Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10, 1185-1201.
104. Mistlberger, R.E. & Skene, D.J. 2005. Nonphotic entrainment in humans? J Biol Rhythms 20, 339-352.
105. Mohler, H. 2009. Role of GABAA receptors in cognition. Biochem Soc Trans 37, 1328-1333.
106. Moller-Levet, C.S., Archer, S.N., Bucca, G., Laing, E.E., Slak, A., Kabiljo, R., Lo, J.C., Santhi, N., von Schantz, M., Smith, C.P. & Dijk, D.J. 2013. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A 110, E1132-E1141.
107. Moro, M.A., De Alba, J., Leza, J.C., Lorenzo, P., Fernandez, A.P., Bentura, M.L., Bosca, L., Rodrigo, J. & Lizasoain, I. 1998. Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices. Eur J Neurosci 10, 445-456.
108. Mullington, J., Korth, C., Hermann, D.M., Orth, A., Galanos, C., Holsboer, F. & Pollmacher, T. 2000. Dose-dependent effects of endotoxin on human sleep. Am J Physiol Regul Integr Comp Physiol 278, R947-R955.
109. Naidoo, N. 2009. Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev 13, 195-204.
110. Narasimamurthy, R., Hatori, M., Nayak, S.K., Liu, F., Panda, S. & Verma, I.M. 2012. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A 109, 12662-12667.
111. Nathan, C. & Xie, Q.W. 1994. Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918.
112. Nehlig, A., Daval, J.L. & Debry, G. 1992. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev 17, 139-170.
113. Nir, Y., Staba, R.J., Andrillon, T., Vyazovskiy, V.V., Cirelli, C., Fried, I. & Tononi, G. 2011. Regional slow waves and spindles in human sleep. Neuron 70, 153-169.
114. Nobili, L., De Gennaro, L., Proserpio, P., Moroni, F., Sarasso, S., Pigorini, A., De Carli, F. & Ferrara, M. 2012. Local aspects of sleep: observations from intracerebral recordings in humans. Prog Brain Res 199, 219-232.
115. Ohayon, M.M. 2002. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6, 97-111.
116. Ohayon, M.M., Carskadon, M.A., Guilleminault, C. & Vitiello, M.V. 2004. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27, 1255-1273.
117. Opp, M.R., Kapas, L. & Toth, L.A. 1992. Cytokine involvement in the regulation of sleep. Proc Soc Exp Biol Med 201, 16-27.
118. Panula, P., Airaksinen, M.S., Pirvola, U. & Kotilainen, E. 1990. A histamine-containing neuronal system in human brain. Neuroscience 34, 127-132.
119. Partinen, M., Kaprio, J., Koskenvuo, M., Putkonen, P. & Langinvainio, H. 1983. Genetic and environmental determination of human sleep. Sleep 6, 179-185.
120. Paunio, T., Korhonen, T., Hublin, C., Partinen, M., Kivimaki, M., Koskenvuo, M. & Kaprio, J. 2009. Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins. Am J Epidemiol 169, 206-213.
121. Peyron, C., Tighe, D.K., van den Pol, A.N., de Lecea, L., Heller, H.C., Sutcliffe, J.G. & Kilduff, T.S. 1998. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18, 9996-10015.
122. Philip, P., Sagaspe, P., Lagarde, E., Leger, D., Ohayon, M.M., Bioulac, B., Boussuge, J. & Taillard, J. 2010. Sleep disorders and accidental risk in a large group of regular registered highway drivers. Sleep Med 11, 973-979.
123. Pollmacher, T., Mullington, J., Korth, C. & Hinze-Selch, D. 1995. Influence of host defense activation on sleep in humans. Adv Neuroimmunol 5, 155-169.
124. Pollmacher, T., Schuld, A., Kraus, T., Haack, M., Hinze-Selch, D. & Mullington, J. 2000. Experimental immunomodulation, sleep, and sleepiness in humans. Ann N Y Acad Sci 917, 488-499.
125. Porkka-Heiskanen, T. & Kalinchuk, A.V. 2011. Adenosine, energy metabolism and sleep homeostasis. Sleep Med Rev 15, 123-135.
126. Porkka-Heiskanen, T., Strecker, R.E., Thakkar, M., Bjorkum, A.A., Greene, R.W. & McCarley, R.W. 1997. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 276, 1265-1268.
127. Porkka-Heiskanen, T., Alanko, L., Kalinchuk, A., Heiskanen, S. & Stenberg, D. 2004. The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain. Neurobiol Aging 25, 231-238.
128. Preston, B.T., Capellini, I., McNamara, P., Barton, R.A. & Nunn, C.L. 2009. Parasite resistance and the adaptive significance of sleep. BMC Evol Biol 9, 7-2148-9-7.
129. Radulovacki, M., Virus, R.M., Djuricic-Nedelson, M. & Green, R.D. 1984. Adenosine analogs and sleep in rats. J Pharmacol Exp Ther 228, 268-274.
130. Rainnie, D.G., Grunze, H.C., McCarley, R.W. & Greene, R.W. 1994. Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal. Science 263, 689-692.
131. Reid, S., Towell, A.D. & Golding, J.F. 2000. Seasonality, social zeitgebers and mood variability in entrainment of mood. Implications for seasonal affective disorder. J Affect Disord 59, 47-54.
132. Reiter, R.J. 1980. The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1, 109-131.
133. Retey, J.V., Adam, M., Honegger, E., Khatami, R., Luhmann, U.F., Jung, H.H., Berger, W. & Landolt, H.P. 2005. A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A 102, 15676-15681.
134. Retey, J.V., Adam, M., Khatami, R., Luhmann, U.F., Jung, H.H., Berger, W. & Landolt, H.P. 2007. A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81, 692-698.
135. Reyner, L.A., Horne, J.A. & Reyner, A. 1995. Gender- and age-related differences in sleep determined by home-recorded sleep logs and actimetry from 400 adults. Sleep 18, 127-134.
136. Riedner, B.A., Vyazovskiy, V.V., Huber, R., Massimini, M., Esser, S., Murphy, M. & Tononi, G. 2007. Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 30, 1643-1657.
137. Rytkonen, K.M., Wigren, H.K., Kostin, A., Porkka-Heiskanen, T. & Kalinchuk, A.V. 2010. Nitric oxide mediated recovery sleep is attenuated with aging. Neurobiol Aging 31, 2011-2019.
138. Sadowski, J.H., Jones, M.W. & Mellor, J.R. 2011. Ripples make waves: binding structured activity and plasticity in hippocampal networks. Neural Plast 2011, 960389.
139. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S. et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585.
140. Sanchez-Ortuno, M.M. & Edinger, J.D. 2012. Cognitive-behavioral therapy for the management of insomnia comorbid with mental disorders. Curr Psychiatry Rep 14, 519-528.
141. Saper, C.B., Scammell, T.E. & Lu, J. 2005. Hypothalamic regulation of sleep and circadian rhythms. Nature 437, 1257-1263.
142. Sawai, N., Ueta, Y., Nakazato, M. & Ozawa, H. 2010. Developmental and aging change of orexin-A and -B immunoreactive neurons in the male rat hypothalamus. Neurosci Lett 468, 51-55.
143. Scammell, T., Gerashchenko, D., Urade, Y., Onoe, H., Saper, C. & Hayaishi, O. 1998. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proc Natl Acad Sci U S A 95, 7754-7759.
144. Scharf, M.T., Naidoo, N., Zimmerman, J.E. & Pack, A.I. 2008. The energy hypothesis of sleep revisited. Prog Neurobiol 86, 264-280.
145. Shanahan, T.L., Zeitzer, J.M. & Czeisler, C.A. 1997. Resetting the melatonin rhythm with light in humans. J Biol Rhythms 12, 556-567.
146. Shaw, K.M. 1977. The pineal gland: a review of the biochemistry, physiology and pharmacological potential of melatonin and other pineal substances. Adv Drug Res 11, 75-96.
147. Sherin, J.E., Shiromani, P.J., McCarley, R.W. & Saper, C.B. 1996. Activation of ventrolateral preoptic neurons during sleep. Science 271, 216-219.
148. Siepka, S.M., Yoo, S.H., Park, J., Lee, C. & Takahashi, J.S. 2007. Genetics and neurobiology of circadian clocks in mammals. Cold Spring Harb Symp Quant Biol 72, 251-259.
149. Sirota, A., Csicsvari, J., Buhl, D. & Buzsaki, G. 2003. Communication between neocortex and hippocampus during sleep in rodents. Proc Natl Acad Sci U S A 100, 2065-2069.
150. Skene, D.J. & Arendt, J. 2007. Circadian rhythm sleep disorders in the blind and their treatment with melatonin. Sleep Med 8, 651-655.
151. Spiegel, K., Leproult, R. & Van Cauter, E. 1999. Impact of sleep debt on metabolic and endocrine function. Lancet 354, 1435-1439.
152. Spiegel, K., Tasali, E., Penev, P. & Van Cauter, E. 2004. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 141, 846-850.
153. Spruyt, K., Molfese, D.L. & Gozal, D. 2011. Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged children. Pediatrics 127, e345-e352.
154. Steiger, A. 2002. Sleep and the hypothalamo-pituitary-adrenocortical system. Sleep Med Rev 6, 125-138.
155. Steininger, T.L., Gong, H., McGinty, D. & Szymusiak, R. 2001. Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J Comp Neurol 429, 638-653.
156. Stepanski, E.J. & Wyatt, J.K. 2003. Use of sleep hygiene in the treatment of insomnia. Sleep Med Rev 7, 215-225.
157. Steriade, M., Pare, D., Parent, A. & Smith, Y. 1988. Projections of cholinergic and non-cholinergic neurons of the brainstem core to relay and associational thalamic nuclei in the cat and macaque monkey. Neuroscience 25, 47-67.
158. Steriade, M., Dossi, R.C. & Nunez, A. 1991. Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep delta waves: cortically induced synchronization and brainstem cholinergic suppression. J Neurosci 11, 3200-3217.
159. Stickgold, R. & Walker, M.P. 2007. Sleep-dependent memory consolidation and reconsolidation. Sleep Med 8, 331-343.
160. Szymusiak, R., Steininger, T., Alam, N. & McGinty, D. 2001. Preoptic area sleep-regulating mechanisms. Arch Ital Biol 139, 77-92.
161. Terao, A., Steininger, T.L., Hyder, K., Apte-Deshpande, A., Ding, J., Rishipathak, D., Davis, R.W., Heller, H.C. & Kilduff, T.S. 2003. Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep. Neuroscience 116, 187-200.
162. Tononi, G. & Cirelli, C. 2006. Sleep function and synaptic homeostasis. Sleep Med Rev 10, 49-62.
163. Tononi, G. & Cirelli, C. 2012. Time to be SHY? Some comments on sleep and synaptic homeostasis. Neural Plast 2012, 415250.
164. Toth, L.A. & Krueger, J.M. 1989. Effects of microbial challenge on sleep in rabbits. FASEB J 3, 2062-2066.
165. Toth, L.A., Tolley, E.A. & Krueger, J.M. 1993. Sleep as a prognostic indicator during infectious disease in rabbits. Proc Soc Exp Biol Med 203, 179-192.
166. Turrigiano, G.G. 2008. The self-tuning neuron: synaptic scaling of excitatory synapses. Cell 135, 422-435.
167. Urrila, A.S., Hakkarainen, A., Heikkinen, S., Vuori, K., Stenberg, D., Hakkinen, A.M., Lundbom, N. & Porkka-Heiskanen, T. 2003. Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation. J Cereb Blood Flow Metab 23, 942-948.
168. Utge, S., Soronen, P., Partonen, T., Loukola, A., Kronholm, E., Pirkola, S., Nyman, E., Porkka-Heiskanen, T. & Paunio, T. 2010. A population-based association study of candidate genes for depression and sleep disturbance. Am J Med Genet B Neuropsychiatr Genet 153B, 468-476.
169. Utge, S., Kronholm, E., Partonen, T., Soronen, P., Ollila, H.M., Loukola, A., Perola, M., Salomaa, V., Porkka-Heiskanen, T. & Paunio, T. 2011. Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women. Sleep 34, 1309-1316.
170. Van Cauter, E., Leproult, R. & Kupfer, D.J. 1996. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab 81, 2468-2473.
171. Van Cauter, E., Spiegel, K., Tasali, E. & Leproult, R. 2008. Metabolic consequences of sleep and sleep loss. Sleep Med 9(Suppl 1), S23-S28.
172. Van Dongen, H.P., Kerkhof, G.A. & Souverijn, J.H. 1998. Absence of seasonal variation in the phase of the endogenous circadian rhythm in humans. Chronobiol Int 15, 623-632.
173. Van Dongen, H.P., Maislin, G., Mullington, J.M. & Dinges, D.F. 2003. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26, 117-126.
174. Van Wylen, D.G., Park, T.S., Rubio, R. & Berne, R.M. 1986. Increases in cerebral interstitial fluid adenosine concentration during hypoxia, local potassium infusion, and ischemia. J Cereb Blood Flow Metab 6, 522-528.
175. Vanni-Mercier, G., Gigout, S., Debilly, G. & Lin, J.S. 2003. Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats. Behav Brain Res 144, 227-241.
176. Vazquez, J. & Baghdoyan, H.A. 2001. Basal forebrain acetylcholine release during REM sleep is significantly greater than during waking. Am J Physiol Regul Integr Comp Physiol 280, R598-R601.
177. Vermeeren, A. & Coenen, A.M. 2011. Effects of the use of hypnotics on cognition. Prog Brain Res 190, 89-103.
178. Vyazovskiy, V.V. & Tobler, I. 2008. Handedness leads to interhemispheric EEG asymmetry during sleep in the rat. J Neurophysiol 99, 969-975.
179. Vyazovskiy, V., Borbely, A.A. & Tobler, I. 2000. Unilateral vibrissae stimulation during waking induces interhemispheric EEG asymmetry during subsequent sleep in the rat. J Sleep Res 9, 367-371.
180. Vyazovskiy, V.V., Olcese, U., Lazimy, Y.M., Faraguna, U., Esser, S.K., Williams, J.C., Cirelli, C. & Tononi, G. 2009. Cortical firing and sleep homeostasis. Neuron 63, 865-878.
181. Vyazovskiy, V.V., Cirelli, C. & Tononi, G. 2011. Electrophysiological correlates of sleep homeostasis in freely behaving rats. Prog Brain Res 193, 17-38.
182. Watson, N.F., Harden, K.P., Buchwald, D., Vitiello, M.V., Pack, A.I., Weigle, D.S. & Goldberg, J. 2012. Sleep duration and body mass index in twins: a gene-environment interaction. Sleep 35, 597-603.
183. Wigren, H.K., Schepens, M., Matto, V., Stenberg, D. & Porkka-Heiskanen, T. 2007. Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep. Neuroscience 147, 811-823.
184. Wigren, H.K., Rytkonen, K.M. & Porkka-Heiskanen, T. 2009. Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging. J Neurosci 29, 11698-11707.
185. Williams, J.A., Zimmerman, F.J. & Bell, J.F. 2013. Norms and trends of sleep time among US children and adolescents. JAMA Pediatr 167, 55-60.
186. Zant, J.C., Rozov, S., Wigren, H.K., Panula, P. & Porkka-Heiskanen, T. 2012. Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons. J Neurosci 32, 13244-13254.
187. Zeitzer, J.M., Daniels, J.E., Duffy, J.F., Klerman, E.B., Shanahan, T.L., Dijk, D.J. & Czeisler, C.A. 1999. Do plasma melatonin concentrations decline with age? Am J Med 107, 432-436.
188. Zielinski, M.R. & Krueger, J.M. 2011. Sleep and innate immunity. Front Biosci (Schol Ed) 3, 632-642.