Age-related changes in the circadian and homeostatic regulation of human sleep

Chronobiology International

Volumn 23, Issue 1-2, 2006, Pages 461-474

  Cajochen, Christian ^a   Münch, Mirjam ^a   Knoblauch, Vera ^a   Blatter, Katharina ^a   Wirz Justice, Anna ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Aging; Constant routine; EEG spectral analysis; Melatonin; Nap protocol; Sleep; Sleep deprivation protocol; Wake maintenance zone

Indexed keywords

MELATONIN; OREXIN;

ADULT; AGED; AGING; AROUSAL; CIRCADIAN RHYTHM; CONFERENCE PAPER; CORE TEMPERATURE; HOMEOSTASIS; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS NUCLEUS; LOCUS CERULEUS; NONREM SLEEP; NORMAL HUMAN; PREOPTIC NUCLEUS; SLEEP; SLEEP DEPRIVATION; SLEEP SPINDLE; SLEEP WAKING CYCLE; SLOW BRAIN WAVE; SUPRACHIASMATIC NUCLEUS; VOLUNTEER;

ADULT; AGED; AGING; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; ELECTROENCEPHALOGRAPHY; HOMEOSTASIS; HUMANS; MELATONIN; MIDDLE AGED; PHYSIOLOGICAL PROCESSES; SLEEP; SLEEP STAGES; WAKEFULNESS;

EID: 33646686852     PISSN: 07420528     EISSN: 15256073     Source Type: Journal    
DOI: 10.1080/07420520500545813     Document Type: Conference Paper

References (59)

1. Abrahamson, E.E., Leak, R.K., Moore, R.Y. (2001). The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems. NeuroReport 12:435-440.
2. Aschoff, J., Gerecke, U., Wever, R. (1967). Desynchronization of human circadian rhythms. Jpn J. Physiol. 17:450-457.
3. Aston-Jones, G. (2005). Brain structures and receptors involved in alertness. Sleep Med. 6(Suppl 1): S3-S7.
4. Bliwise, D.L. (1993). Sleep in normal aging and dementia. Sleep 16:40-81.
5. Bonnet, M.H. (1986). Effect of 64 hours of sleep deprivation upon sleep in geriatric normals and insomniacs. Neurobiol. Aging 7:89-96.
6. Borbély, A.A. (1982). A two process model of sleep regulation. Human Neurobiol. 1:195-204.
7. Brendel, D.H., Reynolds III, C.F., Jennings, J.R., Hoch, C.C., Monk, T.H., Berman, S.R., Hall, F.T., Buysse, D.J., Kupfer, D.J. (1990). Sleep stage physiology, mood, and vigilance responses to total sleep deprivation in healthy 80-year-olds and 20-year-olds. Psychophysiol. 27:677-685.
8. Cajochen, C., Knoblauch, V., Kräuchi, K., Renz, C., Wirz-Justice, A. (2001). Dynamics of frontal EEG activity, sleepiness and body temperature under high and low sleep pressure. NeuroReport 12: 2277-2281.
9. Cajochen, C., Wyatt, J.K., Czeisler, C.A., Dijk, D.J. (2002). Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness. Neuroscience 114:1047-1060.
10. Cajochen, C., Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., Wirz-Justice, A. (2005). High sensitivity of human melatonin, alertness, thermoregulation and heart rate to short wavelength light. J. Clin. Endocrinol. Metab. 90:1311-1316.
11. Carrier, J., Monk, T.H., Reynolds III, C.F., Buysse, D.J., Kupfer, D.J. (1999). Are age differences in sleep due to phase differences in the output of the circadian timing system? Chronobiol. Int. 16:79-91.
12. Carrier, J., Land, S., Buysse, D.J., Kupfer, D.J., Monk, T.H. (2001). The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old). Psychophysiol. 38:232-242.
13. Carskadon, M.A., Dement, W.C. (1985). Sleep loss in elderly volunteers. Sleep 8:207-221.
14. Charman, W.N. (2003). Age, lens transmittance, and the possible effects of light on melatonin suppression. Ophthal. Physiol. Opt. 23:181-187.
15. Czeisler, C.A., Zimmerman, J.C., Ronda, J.M., Moore-Ede, M.C., Weitzman, E.D. (1980). Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep 2:329-346.
16. Czeisler, C.A., Dumont, M., Duffy, J.F., Steinberg, J.D., Richardson, G.S., Brown, E.N., Sànchez, R., Rios, C.D., Ronda, J.M. (1992). Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 340:933-936.
17. Czeisler, C.A., Duffy, J.F., Shanahan, T.L., Brown, E.N., Mitchell, J.F., Rimmer, D.W., Ronda, J.M., Silva, E.J., Allan, J.S., Emens, J.S., Dijk, D.J., Kronauer, R.E. (1999). Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 284:2177-2181.
18. Daan, S., Beersma, D.G.M., Borbély, A.A. (1984). Timing of human sleep: Recovery process gated by a circadian pacemaker. Am. J. Phynol. Regul. Integr. Comp. Physiol. 246:R161-R183.
19. Dacey, D.M., Liao, H.-W., Peterson, B.B., Robinson, F.R., Smith, V.C., Pokorny, J., Yau, K.W., Gamlin, P.D. (2005). Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature 433:749-754.
20. Deurveilher, S., Semba, K. (2005). Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: Implications for the circadian control of behavioural state. Neuroscience 130:165-183.
21. Dijk, D.J.F.D., Czeisler, C.A. (2001). Age-related increase in awakenings: Impaired consolidation of non REM sleep at all circadian phases. Sleep 24:565-577.
22. Dijk, D.J., Czeisler, C.A. (1995). Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J. Neurosci. 15:3526-3538.
23. Dijk, D.J., Beersma, D.G.M., Van Den Hoofdakker, R.H. (1989). All night spectral analysis of EEG sleep in young adult and middle-aged male subjects. Neurobiol. Aging 10:677-682.
24. Dijk, D.J., Duffy, J.F., Riel, E., Shanahan, T.L., Czeisler, C.A. (1999). Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J. Physiol. 516:611-627.
25. Dijk, D.J., Duffy, J.F., Czeisler, C.A. (2000). Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. Chronobiol. Int. 17:285-311.
26. Drapeau, C., Carrier, J. (2004). Fluctuation of waking electroencephalogram and subjective alertness during a 25-hour sleep- deprivation episode in young and middle-aged subjects. Sleep 27:55-60.
27. Duffy, J.F., Czeisler, C.A. (2002). Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans. Neurosci. Lett. 318:117-120.
28. Duffy, J.F., Dijk, D.J.B.K.E., Czeisler, C.A. (1998). Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am. J. Physiol. Regul. Integr. Comp. Physiol. 275: R1478-R1487.
29. Duffy, J.F., Zeitzer, J.M., Rimmer, D.W., Klerman, E.B., Dijk, D.J., Czeisler, C.A. (2002). Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. Am. J. Physiol. Endocrinol. Metab. 282:E297-E303.
30. Gooley, J.J., Lu, J., Fischer, D., Saper, C.B. (2003). A broad role for melanopsin in nonvisual photoreception. J. Neurosci. 23:7093-7106.
31. Gulevich, C., Dement, W., Johnson, L. (1966). Psychiatric and EEG observations on a case of prolonged (264 hours) wakefulness. Arch. Gen. Psychiatry 15:29-35.
32. Haimov, I., Lavie, P. (1997). Circadian characteristics of sleep propensity function in healthy elderly: A comparison with young adults. Sleep 20:294-300.
33. Herljevic, M., MIddleton, B., Thapan, K., Skene, D.J. (2005). Light-induced melatonin suppression: age-related reduction in response to short wavelength light. Exp. Gerontol. 40:237-242.
34. Hiddinga, A.E., Beersma, D.G.M., Van Den Hoofdakker, R.H. (1997). Endogenous and exogenous components in the circadian variation of core body temperature in humans. J. Sleep Res. 6: 156-163.
35. Hofman, M.A., Swaab, D.F. (2005). Living by the clock: The circadian pacemaker in older people. Ageing Res. Rev. 5(1):33-51.
36. Kleitman, N. (1987). Sleep and wakefulness. In: Midway Reprints. Revised and enlarged edition. Chicago and London: The University of Chicago Press.
37. Knoblauch, V., Munch, M., Blatter, K., Martens, L.J., Schröder, C., Schnitzler, C., Wirz-Justice, A., Cajochen, C. (2005). Age -related changes in the circadian modulation of sleep-spindle frequency during nap sleep. Sleep 28:1093-1101.
38. Kripke, D.F., Youngstedt, S.D., Elliott, J.A., Tuunainen, A., Rex, K.M., Hauger, R.L., Marler, M.R. (2005). Circadian phase in adults of contrasting age. Chronobiol. Int. 22:695-709.
39. Landolt, H.P., Dijk, D.J., Achermann, P., Borbèly, A.A. (1996). Effect of age on the sleep EEG: Slow-wave activity and spindle frequency activity in young and middle-aged men. Brain Res. 738: 205-212.
40. Lockley, S.W., Brainard, G.C., Czeisler, C.A. (2003). High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. J. Clin. Endocrinol. Metab. 88:4502-4505.
41. Monk, T.H. (2005). Aging human circadian rhythms: Conventional wisdom may not always be right. J.Biol. Rhythms 20:366-374.
42. Münch, M., Knoblauch, V., Blatter, K., Schröder, C., Schnitzler, C., Kräuchi, K., Wirz-Justice, A., Cajochen, C. (2004). The frontal predominance in human EEG delta activity after sleep loss decreases with age. Eur. J. Neurosci. 20:1402-1410.
43. Münch, M., Knoblauch, V., Blatter, K., Schroder, C., Schnitzler, C., Krauchi, K., Wirz-Justice, A., Cajochen, C. (2005). Age-related attenuation of the evening circadian arousal signal in humans. Neurobiol. Aging 26:1307-1319.
44. Niggemyer, K.A., Begley, A., Monk, T., Buysse, D.J. (2004). Circadian and homeostatic modulation of sleep in older adults during a 90 minute day study. Sleep 27:1535-1541.
45. Saper, C.B., Chou, T.C., Scammell, T.E. (2001). The sleep switch: Hypothalamic control of sleep and wakefulness. Trends Neurosci. 24:726-731.
46. Saper, C.B., Lu, J., Chou, T.C., Gooley, J. (2005). The hypothalamic integrator for circadian rhythms. Trends Neurosci. 28:152-157.
47. Steriade, M. (2003). The corticothalamic system in sleep. Front Biosci. 8:d878-d899.
48. Strogatz, S.H., Kronauer, R.E., Czeisler, C.A. (1986). Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans. Sleep 9:353-364.
49. Strogatz, S.H., Kronauer, R.E., Czeisler, C.A. (1987). Circadian pacemaker interferes with sleep onset at specific times each day: Role in insomnia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 253: R172-R178.
50. Tononi, G., Cirelli, C. (2003). Sleep and synaptic homeostasis: A hypothesis. Brain Res. Bull. 62: 143-150.
51. Van Coevorden, A., Mockel, J., Laurent, E., Kerkhofs, M., L'Hermite-Balèriaux, M., Decoster, C., Néve, P., Van Cauter, E. (1991). Neuroendocrine rhythms and sleep in aging men. Am. J. Physiol. Regul. Integr. Comp. Physiol. 260:E651-E661.
52. Van Someren, E.J. (2000). Circadian rhythms and sleep in human aging. Chronobiol. Int. 17:233-243.
53. Weitzman, E.D., Moline, M.L., Czeisler, C.A., Zimmerman, J.C. (1982). Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment. Neurobiol. Aging 3:299-309.
54. Wyatt, J.K., Ritz-De Cecco, A., Czeisler, C.A., Dijk, D.J. (1999). Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. Am. J. Physiol. Regul. Integr. Comp. Physiol. 277:R1152-R1163.
55. Wyatt, J.K., Cajochen, C., Ritz-De Cecco, A., Czeisler, C.A., Dijk, D.J. (2004). Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness. Sleep 27:374-381.
56. Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B., Matsumura, H., Yoneda, H., Mignot, E., Nishino, S. (2001). Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur. J. Neurosci. 14:1075-1081.
57. Zeitzer, J.M., Daniels, J.E., Duffy, J.F., Klerman, E.B., Shanahan, T.L., Dijk, D.J., Czeisler, C.A. (1999). Do plasma melatonin concentrations decline with age?. Am. J. Med. 107:432-436.
58. Zeitzer, J.M., Buckmaster, C.L., Parker, K.J., Hauck, C.M., Lyons, D.M., Mignot, E. (2003). Circadian and homeostatic regulation of hypocretin in a primate model: Implications for the consolidation of wakefulness. J. Neurosci. 23:3555-3560.
59. Zulley, J. (1980). Distribution of REM sleep in entrained 24 hour and free-running sleep-wake cycles. Sleep 2:377-389.