Changes in sleep and wakefulness following 5-HT(1A) ligands given systemically and locally in different brain regions

Reviews in the Neurosciences

Volumn 9, Issue 4, 1998, Pages 265-273

  Bjorvatn, Bjørn ^a   Ursin, Reidun ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

5 HT(1A) agonists; 5 HT(1A) antagonists; Serotonin; Sleep and wakefulness

Indexed keywords

LIGAND; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

MICROINJECTION; NEUROTRANSMISSION; PRIORITY JOURNAL; REM SLEEP; REVIEW; SLOW WAVE SLEEP; SPINAL CORD; WAKEFULNESS;

EID: 0032444645     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.1998.9.4.265     Document Type: Review

References (97)

1. 2 involved in the regulation of sleep and wakefulness? J Sleep Res 1992; 1: 176-177.
2. 1A receptors. Pharmacol Biochem Behav 1997; 57: 301-307.
3. 11C]5-hydroxytryptophan in major depression: a positron emission tomography study on patients and healthy volunteers. Acta Psychiatr Scand 1991; 83: 449-455.
4. Bergmann BM, Winter JB, Rosenberg RS, Rechtschaffen A. NREM sleep with low-voltage EEG in the rat. Sleep 1987; 10: 1-11.
5. 1A agonist 8-OH-DPAT and the NMDA antagonist AP-5 in rats. Brain Res 1995; 692: 251-258.
6. Bjørkum AA, Strecker RE, Porkka-Heiskanen T, McCarley RW. Perfusion of a 5-HT 1A antagonist in the dorsal raphe nucleus (DRN) increases serotonin (5-HT) and decreases REM sleep. Soc Neurosci Abst 1996; 22: 148.
7. 1A antagonist NAN-190. Brain Res Bull 1996; 39: 373-379.
8. Bjorvatn B, Bjørkum AA, Neckelmann D, Ursin R. Sleep/waking and EEG power spectrum effects of a nonselective serotonin (5-HT) antagonist and a selective 5-HT reuptake inhibitor given alone and in combination. Sleep 1995; 18: 451-462.
9. 1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. Brain Res 1997; 770: 81-88.
10. 1A autoreceptors and increases serotonergic dorsal raphe unit activity in behaving cats. Eur J Pharmacol 1998; in press.
11. 1A antagonist (-)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in rats. Pharmacol Biochem Behav 1992; 42: 49-56.
12. 2 antagonist, on waking and sleep stages in rats. Behav Brain Res 1990; 40: 239-246.
13. 1B agonist, CGS-12066B, on sleep/waking stages and EEG power spectrum in rats. J Sleep Res 1994; 3: 97-105.
14. Blier P, De Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol Sci 1994; 15: 220-226.
15. 1A receptors in the dorsal raphe and hippocampus: 1. Effect of spiperone. J Pharmacol Exp Ther 1993; 265: 7-15.
16. Borbely A, Neuhaus HU, Tobler I. Effect of p-chlorophenylalanine and tryptophan on sleep, EEG and motor activity in the rat. Behav Brain Res 1981; 2: 1-22.
17. Cape EG, Jones BE. Differential modulation of high-frequency gamma-electroencephalogram activity and sleep-wake state by noradrenaline and serotonin microinjections into the region of cholinergic basalis neurons. J Neurosci 1998; 18: 2653-2666.
18. Cespuglio R, Faradji H, Gomez M, Jouvet M. Single unit recordings in the nuclei raphe dorsalis and magnus during the sleep-waking cycle of semi-chronic prepared cats. Neurosci Lett 1981; 24: 133-138.
19. 1A agonist, on sleep patterns of healthy subjects. Psychopharmacology 1995; 117: 186-192.
20. 2 receptors in the modulation of the sleep/wakefulness states. J Sleep Res 1992; 1: 163-168.
21. 2 receptors in the regulation of sleep and wakefulness in the rat. Psychopharmacology 1989; 97: 436-442.
22. 1-like receptor agonists enhance wakefulness. Neuropharmacology 1992; 31: 623-633.
23. 1A agonist and antagonist drug administration in behaving cats. J Pharmacol Exp Ther 1994; 270: 1345-1358.
24. 1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats. J Pharmacol Exp Ther 1994; 270: 1359-1366.
25. Fornal CA, Martin FJ, Metzler CW, Jacobs BL. Pindolol suppresses serotonergic neuronal activity (by a WAY-100635-sensitive mechanism) and does not block the neuronal inhibition produced by 8-OH-DPAT in awake cats. Soc Neurosci Abst 1997; 23: 973.
26. 1A antagonist, increases serotonergic neuronal activity in behaving cats: Comparison with (S)-WAY-100135. J Pharmacol Exp Ther 1996; 278: 752-762.
27. 1A receptor antagonist, WAY-100635. Eur J Pharmacol 1995; 281: 81-88.
28. Gallager DW, Aghajanian GK. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. Eur J Pharmacol 1976; 39: 341-355.
29. Gao B, Duncan WC, Wehr TA. Fluoxetine decreases brain temperature and REM sleep in Syrian hamsters. Psychopharmacology (Berl) 1992; 106: 321-329.
30. 1A agonist, suppresses REM sleep equally in unmedicated depressed patients and normal controls. Neuropsychopharmacology 1996; 15: 109-115.
31. Hilakivi I, Kovala T, Leppävuori A, Shvaloff A. Effects of serotonin and noradrenaline uptake blockers on wakefulness and sleep in cats. Pharmacol Toxicol 1987; 60: 161-166.
32. Honda T, Semba K. Serotonergic synaptic input to cholinergic neurons in the rat mesopontine tegmentum. Brain Res 1994; 647: 299-306.
33. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA. VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 1994; 46: 157-203.
34. Hoyer D, Martin G. 5-HT receptor classification and nomenclature: Towards a harmonization with the human genome. Neuropharmacology 1997; 36: 419-428.
35. Idzikowski C, James R, Burton SW. Human SWS in increased dose-dependantly by seganserin and ritanserin. Sleep Res 1989; 18: 55.
36. 1A receptors in the effects of acute and chronic fluoxetine on extracellular serotonin in the frontal cortex. Pharmacol Biochem Behav 1996; 54: 143-147.
37. Jacobs BL, Azmitia EC. Structure and function of the brain serotonin system. Physiol Rev 1992; 72: 165-229.
38. Jouvet M. Biogenic amines and the states of sleep. Science 1969; 163: 32-41.
39. Jouvet M. The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Ergebn Physiol 1972; 64: 166-307.
40. Khateb A, Fort P, Alonso A, Jones BE, Mühlethaler M. Pharmacological and immunohistochemical evidence for serotonergic modulation of cholinergic nucleus basalis neurons. Eur J Neurosci 1993; 5: 541-547.
41. Khateb A, Mühlethaler M, Alonso A, Serafin M, Mainville L, Jones BE. Cholinergic nucleus basalis neurons display the capacity for rhythmic bursting activity mediated by low-threshold calcium spikes. Neuroscience 1992; 51: 489-494.
42. Kleinlogel H, Burki HR. Effects of the selective 5-hydroxytryptamine uptake inhibitors paroxetine and zimeldine on EEG sleep and waking stages in the rat. Neuropsychobiology 1987; 17: 206-212.
43. Koella WP. Serotonin - a hypnogenic transmitter and an antiwaking agent. Adv Biochem Psychopharmacol 1974; 11: 181-186.
44. Koella WP, Feldstein A, Czicman JS. The effect of para-chlorophenylalanine on the sleep of cats. Electroencephalogr Clin Neurophysiol 1968; 25: 481-490.
45. 1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. Eur J Pharmacol 1993; 249: 25-35.
46. 1A ligands of sleep. J Sleep Res 1994; 3: 142.
47. Leonard BE. Serotonin receptors - where are they going. Int Clin Psychopharmacol 1994; 9: 7-17.
48. Leonard CS, Llinas R. Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling REM sleep - an in vitro electrophysiological study. Neuroscience 1994; 59: 309-330.
49. 1 receptors and behavior. Neurosci Biobehav Rev 1992; 16: 83-93.
50. Luebke JI, Greene RW, Semba K, Kamondi A, McCarley RW, Reiner PB. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro. Proc Natl Acad Sci USA 1992; 89: 743-747.
51. McCarley RW, Greene RW, Rainnie D, Portas CM. Brainstem neuromodulation and REM sleep. Semin Neurosci 1995; 7: 341-354.
52. McGinty DJ, Harper RM. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 1976; 101: 569-575.
53. Middlemiss DN, Tricklebank MD. Centrally active 5-HT receptor agonists and antagonists. Neurosci Biobehav Rev 1992; 16: 75-82.
54. 1A antagonists. J Pharmacol Exp Ther 1994; 268: 337-352.
55. 1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat. J Sleep Res 1992; 1: 169-175.
56. Monti JM, Jantos H. Stereoselective antagonism by the pindolol enantiomers of 8-OH-DPAT-induced changes of sleep and wakefulness. Neuropharmacology 1994; 33: 705-708.
57. Monti JM, Jantos H, Silveira R, Reyesparada M, Scorza C. Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone. Pharmacol Biochem Behav 1995; 52: 305-312.
58. Monti JM, Jantos H, Silveira R, Reyesparada M, Scorza C, Prunell G. Depletion of brain serotonin by 5,7-DHT: effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat. Psychopharmacology 1994; 115: 273-277.
59. Moret C, Briley M. The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. J Psychopharmacol 1993; 7: 331-337.
60. Mundal V, Bjorvatn B. Sleep and waking following microdialysis perfusion of a 5-HT antagonist into the dorsal raphe nucleus in rats. Soc Neurosci Abst 1997; 23: 978.
61. Mühlethaler M. Electrophysiological properties and neuromodulation of cholinergic and non-cholinergic basal forebrain neurones. J Sleep Res 1994; 3: 173.
62. 1A antagonist NAN-190 alone and in combination with citalopram. Behav Brain Res 1996; 75: 159-168.
63. Neckelmann D, Olsen ØE, Fagerland S, Ursin R. The reliability and functional validity of visual and semiautomatic sleep/wake scoring in the Møll-Wistar rat. Sleep 1994; 17: 120-131.
64. Nicholson AN, Pascoe PA. 5-Hydroxytryptamine and noradrenaline uptake inhibition: studies on sleep in man. Neuropharmacology 1986; 25: 1079-1084.
65. Nuñez A. Unit activity of rat basal forebrain neurons: Relationship to cortical activity. Neuroscience 1996; 72: 757-766.
66. Olsen ØE, Neckelmann D, Ursin R. Diurnal differences in L-tryptophan sleep and temperature effects in the rat. Behav Brain Res 1994; 65: 195-203.
67. Pastel RH, Fernstrom JD. Short-term effects of fluoxetine and trifluoromethylphenylpiperazine on electroencephalographic sleep in the rat. Brain Res 1987; 436: 92-102.
68. 3 receptor with m-chlorophenylbiguanide on sleep and wakefulness in the rat. Eur J Pharmacol 1993; 249: 259-264.
69. Portas CM, Bjorvatn B, Fagerland S, Grønli J, Mundal V, Sorensen E, Ursin R. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neurosci 1998; 83: 807-814.
70. Portas CM, Thakkar M, Rainnie D, McCarley RW. Microdialysis perfusion of 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. J Neurosci 1996; 16: 2820-2828.
71. Pujol JF, Bouget A, Froment JL, Jones B, Jouvet M. The central metabolism of serotonin in the cat during insomnia. A neurophysiological and biochemical study after administration of p-chlorophenylalanine or destruction of the raphe system. Brain Res 1971; 29: 195-212.
72. Quattrochi JJ, Mamelak A, Binder DK, Williams J. Dynamic suppression of REM sleep by parenteral administration of the serotonin-1 agonist eltoprazine. Sleep 1992; 15: 125-132.
73. Sallanon M, Buda C, Janin M, Jouvet M. 5-HT antagonists suppress sleep and delay its restoration after 5-HTP in p-chlorophenylalanine-pretreated cats. Eur J Pharmacol 1982; 82: 29-35.
74. Sanford LD, Ross RJ, Seggos AE, Morrison AR, Ball WA, Mann GL. Central administration of two 5-HT receptor agonists: Effect on REM sleep initiation and PGO waves. Pharmacol Biochem Behav 1994; 49: 93-100.
75. 2 blockade. Neurosci Lett 1996; 209: 41-44.
76. 1A antagonist pindolol: Possible disinhibition of raphe neuron activity. Brain Res 1997; 759: 84-91.
77. 1A receptor antagonist, SDZ 216-525, decreases 5-HT release in rat hippocampus in vivo. Br J Pharmacol 1993; 109: 699-702.
78. Sommerfelt L, Ursin R. Behavioral, sleep-waking and EEG power spectral effects following the two specific 5-HT uptake inhibitors zimeldine and alaproclate in cats. Behav Brain Res 1991; 45: 105-115.
79. Spinweber CL, Ursin R, Hubert RP, Hilderbrand RL. 1-Tryptophan: Effects on daytime sleep latency and the waking EEG. Electroencephalogr Clin Neurophysiol 1983; 55: 652-661.
80. Steriade M. Basic mechanisms of sleep generation. Neurology 1992; 42: 9-17.
81. Steriade M, McCarley RW. Brainstem control of wakefulness and sleep. New York: Plenum, 1990.
82. 1A antagonist p-MPPI on sleep-wake stages in the rat. J Sleep Res 1998; in press.
83. Sørensen E, Bjorvatn B, Ursin R. p-MPPI antagonizes sleep as well as behavioral effects of 8-OH-DPAT in the freely moving rat. Soc Neurosci Abst 1998; in press.
84. Thielen RJ, Fangon NB, Frazer A. 4-(2′-methoxyphenyl)-1-[2′-[N-(2″-pyridinyl)-p-iodobenzamido]- ethyl]piperazine and 4-(2′-methoxyphenyl)-1-[2′-[N-(2″-pyridinyl)-p- fluorobenzamido]ethyl]piperazine, two new antagonists at pre-and postsynaptic serotonin-1A receptors. J Pharmacol Exp Ther 1996; 277: 661-670.
85. 1A receptor activation in vivo. Life Sci 1995; 56: PL163-PL168.
86. 1A agonist, on sleep/wakefulness cycles: probable post-synaptic action. J Sleep Res 1993; 2: 103-109.
87. Tobler I, Borbely AA. The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat. Behav Brain Res 1990; 36: 73-78.
88. 2 antagonists on rapid eye movement sleep in rats. Brain Res 1989; 485: 294-300.
89. Trulson ME, Jacobs BL. Raphe unit activity in freely moving cats: correlation with level of behavioral arousal. Brain Res 1979; 163: 135-150.
90. Ursin R. Differential effect of para-chlorophenylalanine on the two slow wave sleep stages in the cat. Acta Physiol Scand 1972; 86: 278-285.
91. Ursin R. The effects of 5-hydroxytryptophan and L-tryptophan on wakefulness and sleep patterns in the cat. Brain Res 1976; 106: 105-115.
92. Ursin R, Bjorvatn B, Sommerfelt L, Underland G. Increased waking as well as increased synchronization following administration of selective 5-HT uptake inhibitors to rats. Behav Brain Res 1989; 34: 117-130.
93. Ursin R, Larsen M. Increased sleep following intra-cerebroventricular injection of the delta sleep-inducing peptide in rats. Neurosci Lett 1983; 40: 145-149.
94. Wambebe C. Influence of some agents that affect 5-hydroxytryptamine metabolism and receptors on nitrazepam-induced sleep in mice. Br J Pharmacol 1985; 84: 185-191.
95. Wilson CL, James ML, Yang S, Behnke EJ, Fried I, Bragin A, Simmons G, Mahan C, Engel J Jr, Maidment NT. Direct measures of extracellular serotonin change in the human forebrain during waking, non-REM sleep and REM sleep. Soc Neurosci Abst 1997; 23: 313.
96. Wojcik WJ, Fornal C, Radulovacki M. Effect of tryptophan on sleep in the rat. Neuropharmacology 1980; 19: 163-167.
97. Zamboni G, Perez E, Amici R, Parmeggiani PL. The short term effects of dl-propranolol on the wake-sleep cycle of the rat are related to selective changes in preoptic cyclic AMP concentration. Exp Brain Res 1990; 81: 107-112.